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Entry version 106 (10 Feb 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Bypass of stop codon protein 4

Gene

BSC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Open reading frame that exhibits genomic organization compatible with a translational readthrough-dependent mode of expression. The sequence can give a readthrough frequency of 9% when cloned in a plasmid with reporter genes. When the initial stop codon is bypassed, translation will go on to the second stop codon 321 bp downstream.
This protein has no orthologs in any species other than the S.cerevisiae lineage. It may be the result of de novo origination of a protein-coding gene.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bypass of stop codon protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BSC4
Ordered Locus Names:YNL269W
ORF Names:N0670
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005213, BSC4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL269W

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649941 – 131Bypass of stop codon protein 4Add BLAST131

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53841

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35571, 139 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YNL269W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53841, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2039888_0_0_1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIVLRKSNK KNKNCITSKF YTIHIIKIST PVFRAPIAIG ESPYVEWSCL
60 70 80 90 100
QVVFRKDMVT KKTTFAQLIT RLNHFLCQAL KRRDSKTYIL CRTAVFGAMT
110 120 130
PFSPRKSHIN NKLPMQPRKK KIVIIYVVRF H
Length:131
Mass (Da):15,314
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9B0C290CB317BBC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti3I → V in strain: XH1549. 1 Publication1
Natural varianti6R → Q in strain: AS2.101, AS2.1406, AS2.179, AS2.7, AS2.724, AS2.771, AS2.820 and AS2.93. 1 Publication1
Natural varianti9 – 10NK → T in strain: XH1549. 2
Natural varianti16I → L in strain: XH1549. 1 Publication1
Natural varianti19K → Q in strain: XH1549. 1 Publication1
Natural varianti22T → S in strain: XH1549. 1 Publication1
Natural varianti32V → G in strain: XH1549. 1 Publication1
Natural varianti42S → N in strain: AS2.101, AS2.1406, AS2.179, AS2.7, AS2.724, AS2.771, AS2.820, AS2.93 and XH1549. 1 Publication1
Natural varianti92R → H in strain: AS2.724 and AS2.820. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU375912 Genomic DNA Translation: ACB40933.1
EU375913 Genomic DNA Translation: ACB40934.1
EU375914 Genomic DNA Translation: ACB40935.1
EU375915 Genomic DNA Translation: ACB40936.1
EU375916 Genomic DNA Translation: ACB40937.1
EU375917 Genomic DNA Translation: ACB40938.1
EU375918 Genomic DNA Translation: ACB40939.1
EU375919 Genomic DNA Translation: ACB40940.1
EU375920 Genomic DNA Translation: ACB40941.1
EU375921 Genomic DNA Translation: ACB40942.1
EU375922 Genomic DNA Translation: ACB40943.1
EU375923 Genomic DNA Translation: ACB40944.1
EU375924 Genomic DNA Translation: ACB40945.1
EU375925 Genomic DNA Translation: ACB40946.1
X92494 Genomic DNA Translation: CAA63229.1
Z71545 Genomic DNA Translation: CAA96176.1
BK006947 Genomic DNA Translation: DAA10291.1

Protein sequence database of the Protein Information Resource

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PIRi
S60913

NCBI Reference Sequences

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RefSeqi
NP_014130.1, NM_001183107.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL269W_mRNA; YNL269W; YNL269W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL269W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU375912 Genomic DNA Translation: ACB40933.1
EU375913 Genomic DNA Translation: ACB40934.1
EU375914 Genomic DNA Translation: ACB40935.1
EU375915 Genomic DNA Translation: ACB40936.1
EU375916 Genomic DNA Translation: ACB40937.1
EU375917 Genomic DNA Translation: ACB40938.1
EU375918 Genomic DNA Translation: ACB40939.1
EU375919 Genomic DNA Translation: ACB40940.1
EU375920 Genomic DNA Translation: ACB40941.1
EU375921 Genomic DNA Translation: ACB40942.1
EU375922 Genomic DNA Translation: ACB40943.1
EU375923 Genomic DNA Translation: ACB40944.1
EU375924 Genomic DNA Translation: ACB40945.1
EU375925 Genomic DNA Translation: ACB40946.1
X92494 Genomic DNA Translation: CAA63229.1
Z71545 Genomic DNA Translation: CAA96176.1
BK006947 Genomic DNA Translation: DAA10291.1
PIRiS60913
RefSeqiNP_014130.1, NM_001183107.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35571, 139 interactors
STRINGi4932.YNL269W

Proteomic databases

PaxDbiP53841

Genome annotation databases

EnsemblFungiiYNL269W_mRNA; YNL269W; YNL269W
GeneIDi855452
KEGGisce:YNL269W

Organism-specific databases

SGDiS000005213, BSC4
VEuPathDBiFungiDB:YNL269W

Phylogenomic databases

HOGENOMiCLU_2039888_0_0_1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53841
RNActiP53841, protein

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBSC4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53841
Secondary accession number(s): B2Y304
, B2Y305, B2Y306, B2Y308, D6W0S5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 10, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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