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UniProtKB - P53829 (CAF40_YEAST)
Protein
Protein CAF40
Gene
CAF40
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Miscellaneous
Present with 18800 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- mRNA catabolic process Source: InterPro
- negative regulation of translation Source: GO_Central
- positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein CAF40Alternative name(s): 40 kDa CCR4-associated factor |
Gene namesi | Name:CAF40 Ordered Locus Names:YNL288W ORF Names:N0540 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005232, CAF40 |
VEuPathDBi | FungiDB:YNL288W |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- CCR4-NOT core complex Source: SGD
- P-body Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203375 | 1 – 373 | Protein CAF40Add BLAST | 373 |
Proteomic databases
MaxQBi | P53829 |
PaxDbi | P53829 |
PRIDEi | P53829 |
Interactioni
Subunit structurei
Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.
1 PublicationBinary interactionsi
P53829
Protein-protein interaction databases
BioGRIDi | 35549, 243 interactors |
ComplexPortali | CPX-1800, CCR4-NOT mRNA deadenylase complex |
DIPi | DIP-1995N |
IntActi | P53829, 45 interactors |
MINTi | P53829 |
STRINGi | 4932.YNL288W |
Miscellaneous databases
RNActi | P53829, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 91 | DisorderedSequence analysisAdd BLAST | 91 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 91 | Polar residuesSequence analysisAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the CNOT9 family.Curated
Phylogenomic databases
eggNOGi | KOG3036, Eukaryota |
GeneTreei | ENSGT00390000001225 |
HOGENOMi | CLU_039962_1_0_1 |
InParanoidi | P53829 |
OMAi | PLLWHSY |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR007216, CNOT9 |
PANTHERi | PTHR12262:SF0, PTHR12262:SF0, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
P53829-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG
60 70 80 90 100
GPMLMGNTPN NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA
110 120 130 140 150
LDDPNVYHWI CQLTYGPQKE QALLELGRKR EQFDDLAVVL WSSFGVMTSL
160 170 180 190 200
LNEIISVYPM LQPQMLSNNL SNRVCNALVL LQCVASHPET KHLFLQAHIP
210 220 230 240 250
LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT FLLRTDIVPL
260 270 280 290 300
CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM
310 320 330 340 350
VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV
360 370
LRDDVGSKRC LAQLLLTLNE ETS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71564 Genomic DNA Translation: CAA96205.1 BK006947 Genomic DNA Translation: DAA10271.1 |
PIRi | S63262 |
RefSeqi | NP_014111.1, NM_001183126.1 |
Genome annotation databases
EnsemblFungii | YNL288W_mRNA; YNL288W; YNL288W |
GeneIDi | 855428 |
KEGGi | sce:YNL288W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71564 Genomic DNA Translation: CAA96205.1 BK006947 Genomic DNA Translation: DAA10271.1 |
PIRi | S63262 |
RefSeqi | NP_014111.1, NM_001183126.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CV5 | X-ray | 3.81 | B/D | 54-373 | [»] | |
SMRi | P53829 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35549, 243 interactors |
ComplexPortali | CPX-1800, CCR4-NOT mRNA deadenylase complex |
DIPi | DIP-1995N |
IntActi | P53829, 45 interactors |
MINTi | P53829 |
STRINGi | 4932.YNL288W |
Proteomic databases
MaxQBi | P53829 |
PaxDbi | P53829 |
PRIDEi | P53829 |
Genome annotation databases
EnsemblFungii | YNL288W_mRNA; YNL288W; YNL288W |
GeneIDi | 855428 |
KEGGi | sce:YNL288W |
Organism-specific databases
SGDi | S000005232, CAF40 |
VEuPathDBi | FungiDB:YNL288W |
Phylogenomic databases
eggNOGi | KOG3036, Eukaryota |
GeneTreei | ENSGT00390000001225 |
HOGENOMi | CLU_039962_1_0_1 |
InParanoidi | P53829 |
OMAi | PLLWHSY |
Miscellaneous databases
PROi | PR:P53829 |
RNActi | P53829, protein |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR007216, CNOT9 |
PANTHERi | PTHR12262:SF0, PTHR12262:SF0, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAF40_YEAST | |
Accessioni | P53829Primary (citable) accession number: P53829 Secondary accession number(s): D6W0Q5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families