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Protein

Protein COS1

Gene

COS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1730 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-33319-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS1
Gene namesi
Name:COS1
Ordered Locus Names:YNL336W
ORF Names:N0275
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

SGDiS000005280 COS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 72ExtracellularSequence analysis9
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 231CytoplasmicSequence analysisAdd BLAST138
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 254ExtracellularSequence analysis2
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 381CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075131 – 381Protein COS1Add BLAST381

Proteomic databases

MaxQBiP53822
PaxDbiP53822
PRIDEiP53822

Interactioni

Protein-protein interaction databases

BioGridi35505, 81 interactors
DIPiDIP-7523N
IntActiP53822, 2 interactors
MINTiP53822
STRINGi4932.YNL336W

Structurei

3D structure databases

ProteinModelPortaliP53822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009322
HOGENOMiHOG000000864
InParanoidiP53822
OMAiKRISNIX
OrthoDBiEOG092C2BGY

Family and domain databases

InterProiView protein in InterPro
IPR001142 DUP/COS
PfamiView protein in Pfam
PF00674 DUP, 2 hits

Sequencei

Sequence statusi: Complete.

P53822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS
110 120 130 140 150
KQLIQFCKEV TENTPSSDPH DWEVVAANLN SYLYENKAWN TKYFFFNAMV
160 170 180 190 200
CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL
210 220 230 240 250
FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TFYLGWILFM LVQGFQNMRM IVLSVKMEHK MQFLSTIINE
310 320 330 340 350
QESGANGWDE IAKKMNRYLF EKKVWKNEEF FFDGIDCEWF FSHFFYRVLS
360 370 380
AKKSMRALSL NVELWPYIKE AQLSCSEESL A
Length:381
Mass (Da):45,288
Last modified:October 1, 1996 - v1
Checksum:iF9AF930CB1935131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71612 Genomic DNA Translation: CAA96270.1
BK006947 Genomic DNA Translation: DAA10227.1
PIRiS63322
RefSeqiNP_014063.1, NM_001183174.1

Genome annotation databases

EnsemblFungiiYNL336W; YNL336W; YNL336W
GeneIDi855380
KEGGisce:YNL336W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71612 Genomic DNA Translation: CAA96270.1
BK006947 Genomic DNA Translation: DAA10227.1
PIRiS63322
RefSeqiNP_014063.1, NM_001183174.1

3D structure databases

ProteinModelPortaliP53822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35505, 81 interactors
DIPiDIP-7523N
IntActiP53822, 2 interactors
MINTiP53822
STRINGi4932.YNL336W

Proteomic databases

MaxQBiP53822
PaxDbiP53822
PRIDEiP53822

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL336W; YNL336W; YNL336W
GeneIDi855380
KEGGisce:YNL336W

Organism-specific databases

SGDiS000005280 COS1

Phylogenomic databases

GeneTreeiENSGT00390000009322
HOGENOMiHOG000000864
InParanoidiP53822
OMAiKRISNIX
OrthoDBiEOG092C2BGY

Enzyme and pathway databases

BioCyciYEAST:G3O-33319-MONOMER

Miscellaneous databases

PROiPR:P53822

Family and domain databases

InterProiView protein in InterPro
IPR001142 DUP/COS
PfamiView protein in Pfam
PF00674 DUP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCOS1_YEAST
AccessioniPrimary (citable) accession number: P53822
Secondary accession number(s): D6W0L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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