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Protein

Smoothelin

Gene

SMTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural protein of the cytoskeleton.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • structural constituent of muscle Source: ProtInc

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • muscle organ development Source: ProtInc
  • smooth muscle contraction Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothelin
Gene namesi
Name:SMTN
Synonyms:SMSMO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000183963.18
HGNCiHGNC:11126 SMTN
MIMi602127 gene
neXtProtiNX_P53814

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi6525
OpenTargetsiENSG00000183963
PharmGKBiPA35975

Polymorphism and mutation databases

BioMutaiSMTN
DMDMi338817991

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000719762 – 917SmoothelinAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei351PhosphothreonineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei373PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Modified residuei792PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP53814
MaxQBiP53814
PaxDbiP53814
PeptideAtlasiP53814
PRIDEiP53814
ProteomicsDBi56630
56631 [P53814-2]
56632 [P53814-5]
56633 [P53814-6]

PTM databases

iPTMnetiP53814
PhosphoSitePlusiP53814

Expressioni

Tissue specificityi

Smooth muscle; contractile or vascular (for the long form).

Gene expression databases

BgeeiENSG00000183963 Expressed in 192 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiP53814 baseline and differential
GenevisibleiP53814 HS

Organism-specific databases

HPAiCAB001721
HPA051778
HPA058590

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112416, 10 interactors
IntActiP53814, 19 interactors
STRINGi9606.ENSP00000351593

Structurei

Secondary structure

1917
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53814
SMRiP53814
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53814

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini799 – 906Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 89Sequence analysisAdd BLAST66
Coiled coili603 – 630Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 282Pro-richAdd BLAST89
Compositional biasi710 – 715Poly-Ser6

Sequence similaritiesi

Belongs to the smoothelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOVERGENiHBG076678
InParanoidiP53814
TreeFamiTF316716

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR022189 SMTN
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12510 Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P53814-1) [UniParc]FASTAAdd to basket
Also known as: Long, B1, L1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA
60 70 80 90 100
SKRFRAERQD NKENWLHSQQ REAEQRAALA RLAGQLESMN DVEELTALLR
110 120 130 140 150
SAGEYEERKL IRAAIRRVRA QEIEAATLAG RLYSGRPNSG SREDSKGLAA
160 170 180 190 200
HRLEQCEVPE REEQEQQAEV SKPTPTPEGT SQDVTTVTLL LRAPPGSTSS
210 220 230 240 250
SPASPSSSPT PASPEPPLEP AEAQCLTAEV PGSPEPPPSP PKTTSPEPQE
260 270 280 290 300
SPTLPSTEGQ VVNKLLSGPK ETPAAQSPTR GPSDTKRADV AGPRPCQRSL
310 320 330 340 350
SVLSPRQPAQ NRESTPLASG PSSFQRAGSV RDRVHKFTSD SPMAARLQDG
360 370 380 390 400
TPQAALSPLT PARLLGPSLT STTPASSSSG SSSRGPSDTS SRFSKEQRGV
410 420 430 440 450
AQPLAQLRSC PQEEGPRGRG LAARPLENRA GGPVARSEEP GAPLPVAVGT
460 470 480 490 500
AEPGGSMKTT FTIEIKDGRG QASTGRVLLP TGNQRAELTL GLRAPPTLLS
510 520 530 540 550
TSSGGKSTIT RVNSPGTLAR LGSVTHVTSF SHAPPSSRGG CSIKMEAEPA
560 570 580 590 600
EPLAAAVEAA NGAEQTRVNK APEGRSPLSA EELMTIEDEG VLDKMLDQST
610 620 630 640 650
DFEERKLIRA ALRELRQRKR DQRDKERERR LQEARGRPGE GRGNTATETT
660 670 680 690 700
TRHSQRAADG SAVSTVTKTE RLVHSNDGTR TARTTTVESS FVRRSENGSG
710 720 730 740 750
STMMQTKTFS SSSSSKKMGS IFDREDQASP RAGSLAALEK RQAEKKKELM
760 770 780 790 800
KAQSLPKTSA SQARKAMIEK LEKEGAAGSP GGPRAAVQRS TSFGVPNANS
810 820 830 840 850
IKQMLLDWCR AKTRGYEHVD IQNFSSSWSD GMAFCALVHN FFPEAFDYGQ
860 870 880 890 900
LSPQNRRQNF EVAFSSAEML VDCVPLVEVD DMMIMGKKPD PKCVFTYVQS
910
LYNHLRRHEL RLRGKNV
Length:917
Mass (Da):99,059
Last modified:June 28, 2011 - v7
Checksum:iEC508A8239AA6B36
GO
Isoform A (identifier: P53814-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-456: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:461
Mass (Da):50,572
Checksum:iFE6EDC0D644E1B5D
GO
Isoform B2 (identifier: P53814-5) [UniParc]FASTAAdd to basket
Also known as: L2

The sequence of this isoform differs from the canonical sequence as follows:
     869-917: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:915
Mass (Da):98,919
Checksum:iFF0ABC36BBEC9B30
GO
Isoform B3 (identifier: P53814-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: E → ETHADCPQLLDTEDMVRLREPDWK

Show »
Length:940
Mass (Da):101,810
Checksum:iE9C48F69CEEE2847
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1R1A0A087X1R1_HUMAN
Smoothelin
SMTN
1,002Annotation score:
A0A087WVP4A0A087WVP4_HUMAN
Smoothelin
SMTN
971Annotation score:
B5MCI0B5MCI0_HUMAN
Smoothelin
SMTN
438Annotation score:
A0A096LNK9A0A096LNK9_HUMAN
Smoothelin
SMTN
311Annotation score:
H7BZZ8H7BZZ8_HUMAN
Smoothelin
SMTN
216Annotation score:
C9JQZ8C9JQZ8_HUMAN
Smoothelin
SMTN
158Annotation score:
C9JV14C9JV14_HUMAN
Smoothelin
SMTN
141Annotation score:
H7C372H7C372_HUMAN
Smoothelin
SMTN
127Annotation score:
C9JYU8C9JYU8_HUMAN
Smoothelin
SMTN
151Annotation score:
C9JP19C9JP19_HUMAN
Smoothelin
SMTN
98Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAL36149 differs from that shown. Reason: Frameshift at positions 362 and 384.Curated
The sequence AAL36150 differs from that shown. Reason: Frameshift at positions 362 and 384.Curated
The sequence CAA73884 differs from that shown. Reason: Frameshift at positions 362 and 384.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279T → P in AAF03562 (PubMed:12176134).Curated1
Sequence conflicti279T → P in AAL36149 (PubMed:12176134).Curated1
Sequence conflicti279T → P in AAL36150 (PubMed:12176134).Curated1
Sequence conflicti279T → P in CAA73884 (PubMed:12176134).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038785455G → D4 PublicationsCorresponds to variant dbSNP:rs1064178Ensembl.1
Natural variantiVAR_038786547A → P4 PublicationsCorresponds to variant dbSNP:rs3205187Ensembl.1
Natural variantiVAR_038787559A → V. Corresponds to variant dbSNP:rs5997872Ensembl.1
Natural variantiVAR_038788580A → T. Corresponds to variant dbSNP:rs12158015Ensembl.1
Natural variantiVAR_035657637R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777851029Ensembl.1
Natural variantiVAR_062223642R → C. Corresponds to variant dbSNP:rs34292278Ensembl.1
Natural variantiVAR_035658763A → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0043981 – 456Missing in isoform A. 2 PublicationsAdd BLAST456
Alternative sequenceiVSP_031242868E → ETHADCPQLLDTEDMVRLRE PDWK in isoform B3. 1 Publication1
Alternative sequenceiVSP_007020869 – 917MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform B2. 4 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49989 mRNA Translation: CAA90281.2
AJ010306 mRNA Translation: CAA09077.2
Y13492 mRNA Translation: CAA73884.2 Frameshift.
AY061971 mRNA Translation: AAL36149.1 Frameshift.
AY061972 mRNA Translation: AAL36150.1 Frameshift.
AF115570
, AF115552, AF115553, AF115554, AF115555, AF115556, AF115557, AF115558, AF115559, AF115560, AF115561, AF115562, AF115563, AF115564, AF115565, AF115566, AF115567, AF115568, AF115569 Genomic DNA Translation: AAF03562.1
AF115570
, AF115560, AF115561, AF115562, AF115563, AF115564, AF115565, AF115566, AF115567, AF115568, AF115569 Genomic DNA Translation: AAF03563.1
AF064238 mRNA Translation: AAF01481.3
AC005005 Genomic DNA Translation: AAD15619.1
CH471095 Genomic DNA Translation: EAW59930.1
BC034237 mRNA Translation: AAH34237.1
CCDSiCCDS13886.1 [P53814-1]
CCDS13887.1 [P53814-6]
CCDS13888.1 [P53814-5]
PIRiT09575
RefSeqiNP_001193946.1, NM_001207017.1
NP_001193947.1, NM_001207018.1
NP_008863.3, NM_006932.4 [P53814-1]
NP_599031.1, NM_134269.2 [P53814-5]
NP_599032.2, NM_134270.2 [P53814-6]
UniGeneiHs.149098

Genome annotation databases

EnsembliENST00000333137; ENSP00000329532; ENSG00000183963 [P53814-5]
ENST00000347557; ENSP00000328635; ENSG00000183963 [P53814-1]
ENST00000358743; ENSP00000351593; ENSG00000183963 [P53814-6]
GeneIDi6525
KEGGihsa:6525
UCSCiuc003ajk.3 human [P53814-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49989 mRNA Translation: CAA90281.2
AJ010306 mRNA Translation: CAA09077.2
Y13492 mRNA Translation: CAA73884.2 Frameshift.
AY061971 mRNA Translation: AAL36149.1 Frameshift.
AY061972 mRNA Translation: AAL36150.1 Frameshift.
AF115570
, AF115552, AF115553, AF115554, AF115555, AF115556, AF115557, AF115558, AF115559, AF115560, AF115561, AF115562, AF115563, AF115564, AF115565, AF115566, AF115567, AF115568, AF115569 Genomic DNA Translation: AAF03562.1
AF115570
, AF115560, AF115561, AF115562, AF115563, AF115564, AF115565, AF115566, AF115567, AF115568, AF115569 Genomic DNA Translation: AAF03563.1
AF064238 mRNA Translation: AAF01481.3
AC005005 Genomic DNA Translation: AAD15619.1
CH471095 Genomic DNA Translation: EAW59930.1
BC034237 mRNA Translation: AAH34237.1
CCDSiCCDS13886.1 [P53814-1]
CCDS13887.1 [P53814-6]
CCDS13888.1 [P53814-5]
PIRiT09575
RefSeqiNP_001193946.1, NM_001207017.1
NP_001193947.1, NM_001207018.1
NP_008863.3, NM_006932.4 [P53814-1]
NP_599031.1, NM_134269.2 [P53814-5]
NP_599032.2, NM_134270.2 [P53814-6]
UniGeneiHs.149098

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D87NMR-A801-868[»]
ProteinModelPortaliP53814
SMRiP53814
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112416, 10 interactors
IntActiP53814, 19 interactors
STRINGi9606.ENSP00000351593

PTM databases

iPTMnetiP53814
PhosphoSitePlusiP53814

Polymorphism and mutation databases

BioMutaiSMTN
DMDMi338817991

Proteomic databases

EPDiP53814
MaxQBiP53814
PaxDbiP53814
PeptideAtlasiP53814
PRIDEiP53814
ProteomicsDBi56630
56631 [P53814-2]
56632 [P53814-5]
56633 [P53814-6]

Protocols and materials databases

DNASUi6525
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333137; ENSP00000329532; ENSG00000183963 [P53814-5]
ENST00000347557; ENSP00000328635; ENSG00000183963 [P53814-1]
ENST00000358743; ENSP00000351593; ENSG00000183963 [P53814-6]
GeneIDi6525
KEGGihsa:6525
UCSCiuc003ajk.3 human [P53814-1]

Organism-specific databases

CTDi6525
DisGeNETi6525
EuPathDBiHostDB:ENSG00000183963.18
GeneCardsiSMTN
H-InvDBiHIX0016383
HGNCiHGNC:11126 SMTN
HPAiCAB001721
HPA051778
HPA058590
MIMi602127 gene
neXtProtiNX_P53814
OpenTargetsiENSG00000183963
PharmGKBiPA35975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOVERGENiHBG076678
InParanoidiP53814
TreeFamiTF316716

Miscellaneous databases

ChiTaRSiSMTN human
EvolutionaryTraceiP53814
GeneWikiiSMTN
GenomeRNAii6525
PROiPR:P53814
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183963 Expressed in 192 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiP53814 baseline and differential
GenevisibleiP53814 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR022189 SMTN
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12510 Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMTN_HUMAN
AccessioniPrimary (citable) accession number: P53814
Secondary accession number(s): O00569
, O95769, O95937, Q8N4H8, Q8WWW1, Q8WWW2, Q9P1S8, Q9UIT1, Q9UIT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 168 of the entry and version 7 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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