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Entry version 182 (12 Aug 2020)
Sequence version 7 (28 Jun 2011)
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Protein

Smoothelin

Gene

SMTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural protein of the cytoskeleton.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P53814

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Smoothelin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMTN
Synonyms:SMSMO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183963.18

Human Gene Nomenclature Database

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HGNCi
HGNC:11126, SMTN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602127, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P53814

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6525

Open Targets

More...
OpenTargetsi
ENSG00000183963

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35975

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P53814, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMTN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
338817991

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000719762 – 917SmoothelinAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei351PhosphothreonineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei373PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Modified residuei792PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P53814

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P53814

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P53814

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53814

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53814

PeptideAtlas

More...
PeptideAtlasi
P53814

PRoteomics IDEntifications database

More...
PRIDEi
P53814

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56630 [P53814-1]
56631 [P53814-2]
56632 [P53814-5]
56633 [P53814-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53814

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P53814

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Smooth muscle; contractile or vascular (for the long form).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183963, Expressed in lower esophagus muscularis layer and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P53814, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P53814, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183963, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112416, 18 interactors

Protein interaction database and analysis system

More...
IntActi
P53814, 24 interactors

Molecular INTeraction database

More...
MINTi
P53814

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53814, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1917
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53814

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53814

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini799 – 906Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 89Sequence analysisAdd BLAST66
Coiled coili603 – 630Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 282Pro-richAdd BLAST89
Compositional biasi710 – 715Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the smoothelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4678, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014660_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53814

TreeFam database of animal gene trees

More...
TreeFami
TF316716

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR022189, SMTN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12510, Smoothelin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P53814-1) [UniParc]FASTAAdd to basket
Also known as: Long, B1, L1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA
60 70 80 90 100
SKRFRAERQD NKENWLHSQQ REAEQRAALA RLAGQLESMN DVEELTALLR
110 120 130 140 150
SAGEYEERKL IRAAIRRVRA QEIEAATLAG RLYSGRPNSG SREDSKGLAA
160 170 180 190 200
HRLEQCEVPE REEQEQQAEV SKPTPTPEGT SQDVTTVTLL LRAPPGSTSS
210 220 230 240 250
SPASPSSSPT PASPEPPLEP AEAQCLTAEV PGSPEPPPSP PKTTSPEPQE
260 270 280 290 300
SPTLPSTEGQ VVNKLLSGPK ETPAAQSPTR GPSDTKRADV AGPRPCQRSL
310 320 330 340 350
SVLSPRQPAQ NRESTPLASG PSSFQRAGSV RDRVHKFTSD SPMAARLQDG
360 370 380 390 400
TPQAALSPLT PARLLGPSLT STTPASSSSG SSSRGPSDTS SRFSKEQRGV
410 420 430 440 450
AQPLAQLRSC PQEEGPRGRG LAARPLENRA GGPVARSEEP GAPLPVAVGT
460 470 480 490 500
AEPGGSMKTT FTIEIKDGRG QASTGRVLLP TGNQRAELTL GLRAPPTLLS
510 520 530 540 550
TSSGGKSTIT RVNSPGTLAR LGSVTHVTSF SHAPPSSRGG CSIKMEAEPA
560 570 580 590 600
EPLAAAVEAA NGAEQTRVNK APEGRSPLSA EELMTIEDEG VLDKMLDQST
610 620 630 640 650
DFEERKLIRA ALRELRQRKR DQRDKERERR LQEARGRPGE GRGNTATETT
660 670 680 690 700
TRHSQRAADG SAVSTVTKTE RLVHSNDGTR TARTTTVESS FVRRSENGSG
710 720 730 740 750
STMMQTKTFS SSSSSKKMGS IFDREDQASP RAGSLAALEK RQAEKKKELM
760 770 780 790 800
KAQSLPKTSA SQARKAMIEK LEKEGAAGSP GGPRAAVQRS TSFGVPNANS
810 820 830 840 850
IKQMLLDWCR AKTRGYEHVD IQNFSSSWSD GMAFCALVHN FFPEAFDYGQ
860 870 880 890 900
LSPQNRRQNF EVAFSSAEML VDCVPLVEVD DMMIMGKKPD PKCVFTYVQS
910
LYNHLRRHEL RLRGKNV
Length:917
Mass (Da):99,059
Last modified:June 28, 2011 - v7
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC508A8239AA6B36
GO
Isoform A (identifier: P53814-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-456: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:461
Mass (Da):50,572
Checksum:iFE6EDC0D644E1B5D
GO
Isoform B2 (identifier: P53814-5) [UniParc]FASTAAdd to basket
Also known as: L2

The sequence of this isoform differs from the canonical sequence as follows:
     869-917: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:915
Mass (Da):98,919
Checksum:iFF0ABC36BBEC9B30
GO
Isoform B3 (identifier: P53814-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: E → ETHADCPQLLDTEDMVRLREPDWK

Show »
Length:940
Mass (Da):101,810
Checksum:iE9C48F69CEEE2847
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1R1A0A087X1R1_HUMAN
Smoothelin
SMTN
1,002Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQZ8C9JQZ8_HUMAN
Smoothelin
SMTN
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYU8C9JYU8_HUMAN
Smoothelin
SMTN
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVP4A0A087WVP4_HUMAN
Smoothelin
SMTN
971Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCI0B5MCI0_HUMAN
Smoothelin
SMTN
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C372H7C372_HUMAN
Smoothelin
SMTN
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNK9A0A096LNK9_HUMAN
Smoothelin
SMTN
311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZZ8H7BZZ8_HUMAN
Smoothelin
SMTN
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP19C9JP19_HUMAN
Smoothelin
SMTN
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JV14C9JV14_HUMAN
Smoothelin
SMTN
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL36149 differs from that shown. Reason: Frameshift.Curated
The sequence AAL36150 differs from that shown. Reason: Frameshift.Curated
The sequence CAA73884 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279T → P in AAF03562 (PubMed:12176134).Curated1
Sequence conflicti279T → P in AAL36149 (PubMed:12176134).Curated1
Sequence conflicti279T → P in AAL36150 (PubMed:12176134).Curated1
Sequence conflicti279T → P in CAA73884 (PubMed:12176134).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038785455G → D4 PublicationsCorresponds to variant dbSNP:rs1064178Ensembl.1
Natural variantiVAR_038786547A → P4 PublicationsCorresponds to variant dbSNP:rs3205187Ensembl.1
Natural variantiVAR_038787559A → V. Corresponds to variant dbSNP:rs5997872Ensembl.1
Natural variantiVAR_038788580A → T. Corresponds to variant dbSNP:rs12158015Ensembl.1
Natural variantiVAR_035657637R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777851029Ensembl.1
Natural variantiVAR_062223642R → C. Corresponds to variant dbSNP:rs34292278Ensembl.1
Natural variantiVAR_035658763A → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0043981 – 456Missing in isoform A. 2 PublicationsAdd BLAST456
Alternative sequenceiVSP_031242868E → ETHADCPQLLDTEDMVRLRE PDWK in isoform B3. 1 Publication1
Alternative sequenceiVSP_007020869 – 917MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform B2. 4 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49989 mRNA Translation: CAA90281.2
AJ010306 mRNA Translation: CAA09077.2
Y13492 mRNA Translation: CAA73884.2 Frameshift.
AY061971 mRNA Translation: AAL36149.1 Frameshift.
AY061972 mRNA Translation: AAL36150.1 Frameshift.
AF115570 AF115569 Genomic DNA Translation: AAF03562.1
AF115570 AF115569 Genomic DNA Translation: AAF03563.1
AF064238 mRNA Translation: AAF01481.3
AC005005 Genomic DNA Translation: AAD15619.1
CH471095 Genomic DNA Translation: EAW59930.1
BC034237 mRNA Translation: AAH34237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13886.1 [P53814-1]
CCDS13887.1 [P53814-6]
CCDS13888.1 [P53814-5]

Protein sequence database of the Protein Information Resource

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PIRi
T09575

NCBI Reference Sequences

More...
RefSeqi
NP_001193946.1, NM_001207017.1
NP_001193947.1, NM_001207018.1
NP_008863.3, NM_006932.4 [P53814-1]
NP_599031.1, NM_134269.2 [P53814-5]
NP_599032.2, NM_134270.2 [P53814-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333137; ENSP00000329532; ENSG00000183963 [P53814-5]
ENST00000347557; ENSP00000328635; ENSG00000183963 [P53814-1]
ENST00000358743; ENSP00000351593; ENSG00000183963 [P53814-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6525

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6525

UCSC genome browser

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UCSCi
uc003ajk.3, human [P53814-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49989 mRNA Translation: CAA90281.2
AJ010306 mRNA Translation: CAA09077.2
Y13492 mRNA Translation: CAA73884.2 Frameshift.
AY061971 mRNA Translation: AAL36149.1 Frameshift.
AY061972 mRNA Translation: AAL36150.1 Frameshift.
AF115570 AF115569 Genomic DNA Translation: AAF03562.1
AF115570 AF115569 Genomic DNA Translation: AAF03563.1
AF064238 mRNA Translation: AAF01481.3
AC005005 Genomic DNA Translation: AAD15619.1
CH471095 Genomic DNA Translation: EAW59930.1
BC034237 mRNA Translation: AAH34237.1
CCDSiCCDS13886.1 [P53814-1]
CCDS13887.1 [P53814-6]
CCDS13888.1 [P53814-5]
PIRiT09575
RefSeqiNP_001193946.1, NM_001207017.1
NP_001193947.1, NM_001207018.1
NP_008863.3, NM_006932.4 [P53814-1]
NP_599031.1, NM_134269.2 [P53814-5]
NP_599032.2, NM_134270.2 [P53814-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D87NMR-A801-868[»]
SMRiP53814
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112416, 18 interactors
IntActiP53814, 24 interactors
MINTiP53814
STRINGi9606.ENSP00000484398

PTM databases

iPTMnetiP53814
PhosphoSitePlusiP53814

Polymorphism and mutation databases

BioMutaiSMTN
DMDMi338817991

Proteomic databases

EPDiP53814
jPOSTiP53814
MassIVEiP53814
MaxQBiP53814
PaxDbiP53814
PeptideAtlasiP53814
PRIDEiP53814
ProteomicsDBi56630 [P53814-1]
56631 [P53814-2]
56632 [P53814-5]
56633 [P53814-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3445, 169 antibodies

The DNASU plasmid repository

More...
DNASUi
6525

Genome annotation databases

EnsembliENST00000333137; ENSP00000329532; ENSG00000183963 [P53814-5]
ENST00000347557; ENSP00000328635; ENSG00000183963 [P53814-1]
ENST00000358743; ENSP00000351593; ENSG00000183963 [P53814-6]
GeneIDi6525
KEGGihsa:6525
UCSCiuc003ajk.3, human [P53814-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6525
DisGeNETi6525
EuPathDBiHostDB:ENSG00000183963.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMTN
HGNCiHGNC:11126, SMTN
HPAiENSG00000183963, Tissue enhanced (intestine)
MIMi602127, gene
neXtProtiNX_P53814
OpenTargetsiENSG00000183963
PharmGKBiPA35975

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4678, Eukaryota
GeneTreeiENSGT00940000161655
HOGENOMiCLU_014660_0_0_1
InParanoidiP53814
TreeFamiTF316716

Enzyme and pathway databases

PathwayCommonsiP53814

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6525, 15 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMTN, human
EvolutionaryTraceiP53814

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SMTN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6525
PharosiP53814, Tbio

Protein Ontology

More...
PROi
PR:P53814
RNActiP53814, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183963, Expressed in lower esophagus muscularis layer and 207 other tissues
ExpressionAtlasiP53814, baseline and differential
GenevisibleiP53814, HS

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR022189, SMTN
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12510, Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMTN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53814
Secondary accession number(s): O00569
, O95769, O95937, Q8N4H8, Q8WWW1, Q8WWW2, Q9P1S8, Q9UIT1, Q9UIT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 28, 2011
Last modified: August 12, 2020
This is version 182 of the entry and version 7 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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