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Protein

Phosphatidylinositol transfer protein beta isoform

Gene

Pitpnb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

GO - Molecular functioni

GO - Biological processi

  • in utero embryonic development Source: MGI
  • phospholipid transport Source: MGI

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-1483196 PI and PC transport between ER and Golgi membranes

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein beta isoform
Short name:
PI-TP-beta
Short name:
PtdIns transfer protein beta
Short name:
PtdInsTP beta
Gene namesi
Name:Pitpnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927542 Pitpnb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi165S → A: No effect on phosphorylation by PKC; abolishes phospholipid transfer activity. 1 Publication1
Mutagenesisi262S → A: Abolishes phosphorylation by PKC and impairs Golgi targeting; no effect on phospholipid transfer activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916441 – 271Phosphatidylinositol transfer protein beta isoformAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215N6-acetyllysineBy similarity1
Modified residuei262Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP53811
MaxQBiP53811
PaxDbiP53811
PeptideAtlasiP53811
PRIDEiP53811

PTM databases

iPTMnetiP53811
PhosphoSitePlusiP53811
SwissPalmiP53811

Expressioni

Gene expression databases

BgeeiENSMUSG00000050017 Expressed in 286 organ(s), highest expression level in ear
CleanExiMM_PITPNB
ExpressionAtlasiP53811 baseline and differential
GenevisibleiP53811 MM

Interactioni

Protein-protein interaction databases

BioGridi207889, 1 interactor
IntActiP53811, 2 interactors
MINTiP53811
STRINGi10090.ENSMUSP00000083835

Structurei

3D structure databases

ProteinModelPortaliP53811
SMRiP53811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOGENOMiHOG000006717
HOVERGENiHBG058915
InParanoidiP53811
OMAiAIHEEAW
PhylomeDBiP53811
TreeFamiTF313279

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P53811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEN
60 70 80 90 100
DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN
110 120 130 140 150
EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE
160 170 180 190 200
PADYKADEDP ALFHSVKTKR GPLGPNWKKE LANTPDCPRM CAYKLVTIKF
210 220 230 240 250
KWWGLQSKVE NFIQKQEKRI FTNLHRQLFC WIDKWIDLTM EDIRRMEDET
260 270
QKELETMRKK GSVRGTSAAD A
Length:271
Mass (Da):31,487
Last modified:January 23, 2007 - v2
Checksum:i9111B615909548CD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8JZZ5Q8JZZ5_MOUSE
Phosphatidylinositol transfer prote...
Pitpnb
272Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46934 mRNA Translation: AAA87593.1
AK028235 mRNA Translation: BAC25830.1
CCDSiCCDS39213.1
RefSeqiNP_001288573.1, NM_001301644.1
NP_062614.1, NM_019640.5
UniGeneiMm.200516
Mm.474970

Genome annotation databases

EnsembliENSMUST00000086635; ENSMUSP00000083835; ENSMUSG00000050017
GeneIDi56305
KEGGimmu:56305
UCSCiuc008ysb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46934 mRNA Translation: AAA87593.1
AK028235 mRNA Translation: BAC25830.1
CCDSiCCDS39213.1
RefSeqiNP_001288573.1, NM_001301644.1
NP_062614.1, NM_019640.5
UniGeneiMm.200516
Mm.474970

3D structure databases

ProteinModelPortaliP53811
SMRiP53811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207889, 1 interactor
IntActiP53811, 2 interactors
MINTiP53811
STRINGi10090.ENSMUSP00000083835

PTM databases

iPTMnetiP53811
PhosphoSitePlusiP53811
SwissPalmiP53811

Proteomic databases

EPDiP53811
MaxQBiP53811
PaxDbiP53811
PeptideAtlasiP53811
PRIDEiP53811

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086635; ENSMUSP00000083835; ENSMUSG00000050017
GeneIDi56305
KEGGimmu:56305
UCSCiuc008ysb.2 mouse

Organism-specific databases

CTDi23760
MGIiMGI:1927542 Pitpnb

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOGENOMiHOG000006717
HOVERGENiHBG058915
InParanoidiP53811
OMAiAIHEEAW
PhylomeDBiP53811
TreeFamiTF313279

Enzyme and pathway databases

ReactomeiR-MMU-1483196 PI and PC transport between ER and Golgi membranes

Miscellaneous databases

PROiPR:P53811
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050017 Expressed in 286 organ(s), highest expression level in ear
CleanExiMM_PITPNB
ExpressionAtlasiP53811 baseline and differential
GenevisibleiP53811 MM

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNB_MOUSE
AccessioniPrimary (citable) accession number: P53811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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