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Protein

Phosphatidylcholine transfer protein

Gene

Pctp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72PhosphatidylcholineBy similarity1
Binding sitei78PhosphatidylcholineBy similarity1
Binding sitei157PhosphatidylcholineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cholesterol metabolic process Source: MGI
  • phospholipid transport Source: UniProtKB

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

SABIO-RKiP53808

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine transfer protein
Short name:
PC-TP
Alternative name(s):
START domain-containing protein 2
Short name:
StARD2
StAR-related lipid transfer protein 2
Gene namesi
Name:Pctp
Synonyms:Stard2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107375 Pctp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206591 – 214Phosphatidylcholine transfer proteinAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP53808
MaxQBiP53808
PaxDbiP53808
PeptideAtlasiP53808
PRIDEiP53808

PTM databases

iPTMnetiP53808
PhosphoSitePlusiP53808

Expressioni

Tissue specificityi

Abundant in liver of pups but levels in liver decrease 10-fold about 2 weeks after birth. In adult, highly expressed in epididymis, testis, kidney and bone-marrow derived mast cells.1 Publication

Gene expression databases

CleanExiMM_PCTP

Interactioni

Subunit structurei

Interacts with ACOT13/THEM2.1 Publication

Protein-protein interaction databases

BioGridi202066, 2 interactors
STRINGi10090.ENSMUSP00000020864

Structurei

3D structure databases

ProteinModelPortaliP53808
SMRiP53808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 212STARTPROSITE-ProRule annotationAdd BLAST212

Phylogenomic databases

eggNOGiENOG410IPC9 Eukaryota
ENOG4111CP6 LUCA
HOGENOMiHOG000261644
HOVERGENiHBG008237
InParanoidiP53808
PhylomeDBiP53808

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00234 START, 1 hit
PROSITEiView protein in PROSITE
PS50848 START, 1 hit

Sequencei

Sequence statusi: Complete.

P53808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAACCFSD EQFREACAEL QKPALTGADW QLLVEASGIT IYRLLDQPSG
60 70 80 90 100
LYEYKVFGVL EGCSPALLTD VYMDLDYRKQ WDQYVKELYE KESDEQMVAY
110 120 130 140 150
WEVKYPFPLS NRDYVYTRQR RDLDVDRRKI YVVLAQSISA PQFPEKSGVI
160 170 180 190 200
RVKQYKQSLA IESDGKKGSR VFMYYFDNPG GQIPSWLINW AAKNGVPNFL
210
KDMVKACQNY HKKT
Length:214
Mass (Da):24,785
Last modified:August 14, 2001 - v2
Checksum:i8BE2B046314DAE70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90E → D in AAF08346 (PubMed:10542325).Curated1
Sequence conflicti127R → G in AAF08346 (PubMed:10542325).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151639 mRNA Translation: AAF02537.1
Z50024 mRNA Translation: CAA90328.1
AF114437 mRNA Translation: AAF08346.1
CCDSiCCDS25238.1
PIRiS68246
UniGeneiMm.5062

Similar proteinsi

Entry informationi

Entry nameiPPCT_MOUSE
AccessioniPrimary (citable) accession number: P53808
Secondary accession number(s): Q9QZX0, Q9R058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 14, 2001
Last modified: November 22, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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