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Protein

Calcipressin-1

Gene

RCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase regulator activity Source: GO_Central
  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity Source: ProtInc
  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P53805

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Adapt78
Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCAN1
Synonyms:ADAPT78, CSP1, DSC1, DSCR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159200.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3040 RCAN1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602917 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P53805

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163S → A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-167. 1 Publication1
Mutagenesisi163S → E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-167. 1 Publication1
Mutagenesisi167S → A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-163. 1 Publication1
Mutagenesisi167S → E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-163. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1827

Open Targets

More...
OpenTargetsi
ENSG00000159200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400946

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114141 – 252Calcipressin-1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163Phosphoserine1 Publication1
Modified residuei167Phosphoserine1 Publication1
Modified residuei218PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P53805

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53805

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P53805

PeptideAtlas

More...
PeptideAtlasi
P53805

PRoteomics IDEntifications database

More...
PRIDEi
P53805

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56626
56627 [P53805-2]
56628 [P53805-3]
56629 [P53805-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53805

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P53805

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By calcium.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159200 Expressed in 232 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

More...
CleanExi
HS_DSC1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P53805 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P53805 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAF1 (PubMed:15935327). Interacts with PPP3CA and PPP3R1 (PubMed:12809556).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108161, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P53805

Protein interaction database and analysis system

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IntActi
P53805, 6 interactors

Molecular INTeraction database

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MINTi
P53805

STRING: functional protein association networks

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STRINGi
9606.ENSP00000320768

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P53805

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P53805

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi221 – 229Poly-Glu9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4019 Eukaryota
ENOG4111I50 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159870

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018932

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53805

KEGG Orthology (KO)

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KOi
K17901

Identification of Orthologs from Complete Genome Data

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OMAi
PNALIAC

Database for complete collections of gene phylogenies

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PhylomeDBi
P53805

TreeFam database of animal gene trees

More...
TreeFami
TF313579

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12708 RRM_RCAN1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM

The PANTHER Classification System

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PANTHERi
PTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04847 Calcipressin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53805-1) [UniParc]FASTAAdd to basket
Also known as: CALP1-L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS
60 70 80 90 100
FIDCEMEEVD LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF
110 120 130 140 150
QYFKSFKRVR INFSNPFSAA DARLQLHKTE FLGKEMKLYF AQTLHIGSSH
160 170 180 190 200
LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI SKLGPGEKYE
210 220 230 240 250
LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH

LS
Length:252
Mass (Da):28,079
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B17133D03BD7AFA
GO
Isoform 2 (identifier: P53805-2) [UniParc]FASTAAdd to basket
Also known as: CALP1-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MEDGVAGPQL...DPRVFVDGLC → MHFRNFNYSFSSLIACVANSDIFSESET

Show »
Length:197
Mass (Da):22,767
Checksum:i980A1FD7AA54A238
GO
Isoform 3 (identifier: P53805-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MEDGVAGPQL...PRVFVDGLCR → MVY

Show »
Length:171
Mass (Da):19,805
Checksum:i1330107875A36BD9
GO
Isoform 4 (identifier: P53805-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:117
Mass (Da):13,291
Checksum:i447ABCBB7DDD4826
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDJ2E9PDJ2_HUMAN
Calcipressin-1
RCAN1
277Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW9V9GYW9_HUMAN
Calcipressin-1
RCAN1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD55E9PD55_HUMAN
Calcipressin-1
RCAN1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202H → R in AAK92478 (PubMed:12809556).Curated1
Sequence conflicti214H → Q in AAF21218 (PubMed:10830953).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0013161 – 135Missing in isoform 4. 2 PublicationsAdd BLAST135
Alternative sequenceiVSP_0013151 – 84MEDGV…DGLCR → MVY in isoform 3. 3 PublicationsAdd BLAST84
Alternative sequenceiVSP_0013141 – 83MEDGV…VDGLC → MHFRNFNYSFSSLIACVANS DIFSESET in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28833 mRNA Translation: AAB81557.1
U85265 mRNA Translation: AAB84370.1
U85266 mRNA Translation: AAB84371.2
U85267 mRNA Translation: AAB84372.1
AY325903 mRNA Translation: AAP96743.1
AF400429 mRNA Translation: AAK92478.1
AK092184 mRNA Translation: BAG52494.1
CR456878 mRNA Translation: CAG33159.1
AP000326 Genomic DNA No translation available.
AP000327 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09779.1
CH471079 Genomic DNA Translation: EAX09782.1
U53821 Genomic DNA Translation: AAF21218.1
BC002864 mRNA Translation: AAH02864.1
BT007363 mRNA Translation: AAP36027.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13637.1 [P53805-1]
CCDS33551.1 [P53805-2]
CCDS42921.1 [P53805-4]
CCDS74790.1 [P53805-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001272318.1, NM_001285389.2 [P53805-3]
NP_001272320.2, NM_001285391.2
NP_001272321.1, NM_001285392.2 [P53805-4]
NP_001272322.1, NM_001285393.2 [P53805-4]
NP_004405.3, NM_004414.6 [P53805-1]
NP_981962.1, NM_203417.2 [P53805-4]
NP_981963.1, NM_203418.2 [P53805-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.282326

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313806; ENSP00000320768; ENSG00000159200 [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200 [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200 [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200 [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200 [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200 [P53805-4]
ENST00000620920; ENSP00000477646; ENSG00000159200 [P53805-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1827

UCSC genome browser

More...
UCSCi
uc002yuc.5 human [P53805-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28833 mRNA Translation: AAB81557.1
U85265 mRNA Translation: AAB84370.1
U85266 mRNA Translation: AAB84371.2
U85267 mRNA Translation: AAB84372.1
AY325903 mRNA Translation: AAP96743.1
AF400429 mRNA Translation: AAK92478.1
AK092184 mRNA Translation: BAG52494.1
CR456878 mRNA Translation: CAG33159.1
AP000326 Genomic DNA No translation available.
AP000327 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09779.1
CH471079 Genomic DNA Translation: EAX09782.1
U53821 Genomic DNA Translation: AAF21218.1
BC002864 mRNA Translation: AAH02864.1
BT007363 mRNA Translation: AAP36027.1
CCDSiCCDS13637.1 [P53805-1]
CCDS33551.1 [P53805-2]
CCDS42921.1 [P53805-4]
CCDS74790.1 [P53805-3]
RefSeqiNP_001272318.1, NM_001285389.2 [P53805-3]
NP_001272320.2, NM_001285391.2
NP_001272321.1, NM_001285392.2 [P53805-4]
NP_001272322.1, NM_001285393.2 [P53805-4]
NP_004405.3, NM_004414.6 [P53805-1]
NP_981962.1, NM_203417.2 [P53805-4]
NP_981963.1, NM_203418.2 [P53805-2]
UniGeneiHs.282326

3D structure databases

ProteinModelPortaliP53805
SMRiP53805
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108161, 27 interactors
CORUMiP53805
IntActiP53805, 6 interactors
MINTiP53805
STRINGi9606.ENSP00000320768

PTM databases

iPTMnetiP53805
PhosphoSitePlusiP53805

Polymorphism and mutation databases

DMDMi215274235

Proteomic databases

EPDiP53805
MaxQBiP53805
PaxDbiP53805
PeptideAtlasiP53805
PRIDEiP53805
ProteomicsDBi56626
56627 [P53805-2]
56628 [P53805-3]
56629 [P53805-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313806; ENSP00000320768; ENSG00000159200 [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200 [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200 [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200 [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200 [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200 [P53805-4]
ENST00000620920; ENSP00000477646; ENSG00000159200 [P53805-4]
GeneIDi1827
KEGGihsa:1827
UCSCiuc002yuc.5 human [P53805-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1827
DisGeNETi1827
EuPathDBiHostDB:ENSG00000159200.17

GeneCards: human genes, protein and diseases

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GeneCardsi
RCAN1
HGNCiHGNC:3040 RCAN1
HPAiCAB037218
MIMi602917 gene
neXtProtiNX_P53805
OpenTargetsiENSG00000159200
PharmGKBiPA162400946

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00940000159870
HOVERGENiHBG018932
InParanoidiP53805
KOiK17901
OMAiPNALIAC
PhylomeDBiP53805
TreeFamiTF313579

Enzyme and pathway databases

SIGNORiP53805

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RCAN1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DSCR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1827

Protein Ontology

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PROi
PR:P53805

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159200 Expressed in 232 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_DSC1
ExpressionAtlasiP53805 baseline and differential
GenevisibleiP53805 HS

Family and domain databases

CDDicd12708 RRM_RCAN1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCAN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53805
Secondary accession number(s): D3DSF9
, O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03, Q9BU69, Q9UF15, Q9UME4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 156 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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