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Protein

E3 ubiquitin-protein ligase TTC3

Gene

TTC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1957 – 1997RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP53804
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3 (EC:2.3.2.27)
Alternative name(s):
Protein DCRR1
RING finger protein 105
RING-type E3 ubiquitin transferase TTC3Curated
TPR repeat protein D
Tetratricopeptide repeat protein 3
Short name:
TPR repeat protein 3
Gene namesi
Name:TTC3
Synonyms:DCRR1, RNF105, TPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000182670.13
HGNCiHGNC:12393 TTC3
MIMi602259 gene
neXtProtiNX_P53804

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi378S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. 1 Publication1

Organism-specific databases

DisGeNETi7267
OpenTargetsiENSG00000182670
PharmGKBiPA37058

Polymorphism and mutation databases

BioMutaiTTC3
DMDMi313104040

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063781 – 2025E3 ubiquitin-protein ligase TTC3Add BLAST2025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei378Phosphoserine; by PKB/AKT21 Publication1
Modified residuei1009PhosphoserineBy similarity1
Modified residuei1061PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53804
MaxQBiP53804
PaxDbiP53804
PeptideAtlasiP53804
PRIDEiP53804
ProteomicsDBi56623
56624 [P53804-2]
56625 [P53804-3]

PTM databases

iPTMnetiP53804
PhosphoSitePlusiP53804

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiENSG00000182670 Expressed in 242 organ(s), highest expression level in forebrain
CleanExiHS_TTC3
ExpressionAtlasiP53804 baseline and differential
GenevisibleiP53804 HS

Organism-specific databases

HPAiHPA016810
HPA023964
HPA036304

Interactioni

Subunit structurei

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.2 Publications

Protein-protein interaction databases

BioGridi113118, 28 interactors
ELMiP53804
IntActiP53804, 27 interactors
MINTiP53804
STRINGi9606.ENSP00000346791

Structurei

3D structure databases

ProteinModelPortaliP53804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati231 – 264TPR 1Add BLAST34
Repeati266 – 298TPR 2Add BLAST33
Repeati536 – 572TPR 3Add BLAST37
Repeati576 – 609TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi453 – 456Poly-Ser4
Compositional biasi1018 – 1029Arg/Lys-rich (basic)Add BLAST12
Compositional biasi1020 – 1029Poly-Lys10
Compositional biasi1172 – 1185Arg/Lys-rich (basic)Add BLAST14
Compositional biasi1563 – 1579Arg/Lys-rich (basic)Add BLAST17
Compositional biasi1899 – 1902Poly-Lys4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1957 – 1997RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410JR26 Eukaryota
ENOG41103HK LUCA
GeneTreeiENSGT00530000063254
HOVERGENiHBG007494
InParanoidiP53804
KOiK15712
OMAiCCYQKCH
OrthoDBiEOG091G00EM
PhylomeDBiP53804
TreeFamiTF333981

Family and domain databases

Gene3Di1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform TPRDI (identifier: P53804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV
60 70 80 90 100
QYKDYIQSER NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS
110 120 130 140 150
SVISRLHPCV DANNSRASEI NLKKLQHLEL MEDIVDLAKK VANDSFLIGG
160 170 180 190 200
LLRIGCKIEN KILAMEEALN WIKYAGDVTI LTKLGSIDNC WPMLSIFFTE
210 220 230 240 250
YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE EFSKERFDIA
260 270 280 290 300
IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK
310 320 330 340 350
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI
360 370 380 390 400
EDLQGRTANK DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH
410 420 430 440 450
EMANGGNQNL KVADEALKVD DCDCHPEFSP PSSQPPKHKG KQKSRNNESE
460 470 480 490 500
KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML RSLIQDGYMA
510 520 530 540 550
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG
560 570 580 590 600
QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE
610 620 630 640 650
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI
660 670 680 690 700
CCYQKCHGYS KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF
710 720 730 740 750
NDKIDKDFLQ GICLTPDCEG VISKIIIFSS GGEVKCEFEH KVIKEKVPPR
760 770 780 790 800
PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE DLRESNPPKN
810 820 830 840 850
EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV
860 870 880 890 900
LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE
910 920 930 940 950
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD
960 970 980 990 1000
SIEGKQLDYF SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR
1010 1020 1030 1040 1050
CTVLRKQDSG EAPFSSTKVK NKSKKKKPKD SKPMLVGSGT TSVTSNNEII
1060 1070 1080 1090 1100
TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF EALYDQHSNE YVVRNKKLWD
1110 1120 1130 1140 1150
MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE ETRQILEKAG
1160 1170 1180 1190 1200
GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY
1210 1220 1230 1240 1250
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE
1260 1270 1280 1290 1300
DVKAKPVSDN SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL
1310 1320 1330 1340 1350
EDVKPTYWAQ SHLVTGYCTY LPFQRFDITQ TPPAYINVLP GLPQYTSIYT
1360 1370 1380 1390 1400
PLASLSPEYQ LPRSVPVVPS FVANDRADKN AAAYFEGHHL NAENVAGHQI
1410 1420 1430 1440 1450
ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN SNNKCEVIPE
1460 1470 1480 1490 1500
STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ
1510 1520 1530 1540 1550
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ
1560 1570 1580 1590 1600
DLEREIKKWQ QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL
1610 1620 1630 1640 1650
HLDQSLEISN TLTNEKMKIE EYIKKGKEDY EESHQRAVAA EVSVLENWKE
1660 1670 1680 1690 1700
SEVYKLQIME SQAEAFLKKL GLISRDPAAY PDMESDIRSW ELFLSNVTKE
1710 1720 1730 1740 1750
IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV HPELLPESSG
1760 1770 1780 1790 1800
DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE
1810 1820 1830 1840 1850
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH
1860 1870 1880 1890 1900
LSVVFPCYNS TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK
1910 1920 1930 1940 1950
KKPNPGKDKR TYEPSSATPV TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI
1960 1970 1980 1990 2000
ALGASSCEIC HEVFKSKNVR VLKCGHKYHK GCFKQWLKGQ SACPACQGRD
2010 2020
LLTEESPSGR GWPSQNQELP SCSSR
Length:2,025
Mass (Da):229,869
Last modified:November 30, 2010 - v2
Checksum:iC80BC8E1970B6725
GO
Isoform TPRDII (identifier: P53804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:1,792
Mass (Da):203,189
Checksum:iCCF6AE90171F496F
GO
Isoform TPRDIII (identifier: P53804-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:1,715
Mass (Da):194,059
Checksum:i443B4C9A7FD955B2
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMP8E9PMP8_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
1,179Annotation score:
E9PCE7E9PCE7_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
1,165Annotation score:
E9PMS7E9PMS7_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
780Annotation score:
A8MT23A8MT23_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
300Annotation score:
B4DSZ9B4DSZ9_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
612Annotation score:
H7C3Z1H7C3Z1_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
277Annotation score:
H7C097H7C097_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
317Annotation score:
H7BZ57H7BZ57_HUMAN
E3 ubiquitin-protein ligase TTC3
TTC3
298Annotation score:

Sequence cautioni

The sequence AAH63033 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH92466 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → Y in AAH92466 (PubMed:15489334).Curated1
Sequence conflicti121N → D in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti139K → R in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti232E → G in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti276L → P in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti437K → Q in AAH63033 (PubMed:15489334).Curated1
Sequence conflicti495Q → P in BAA23666 (PubMed:9254009).Curated1
Sequence conflicti1700E → V in BAA23666 (PubMed:9254009).Curated1
Sequence conflicti1822A → T in BAA23666 (PubMed:9254009).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020312840M → T1 PublicationCorresponds to variant dbSNP:rs1053808Ensembl.1
Natural variantiVAR_0444281154P → S. Corresponds to variant dbSNP:rs1053840Ensembl.1
Natural variantiVAR_0358681289K → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0246761751D → H2 PublicationsCorresponds to variant dbSNP:rs1053966Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065551 – 310Missing in isoform TPRDIII. 1 PublicationAdd BLAST310
Alternative sequenceiVSP_0065541 – 233Missing in isoform TPRDII. 1 PublicationAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83077 mRNA Translation: BAA11769.1
D84294 mRNA Translation: BAA12301.1
D84295 mRNA Translation: BAA12302.1
D84296 mRNA Translation: BAA12303.1
AP001429 Genomic DNA No translation available.
AP001432 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09716.1
CH471079 Genomic DNA Translation: EAX09717.1
CH471079 Genomic DNA Translation: EAX09718.1
CH471079 Genomic DNA Translation: EAX09719.1
CH471079 Genomic DNA Translation: EAX09720.1
CH471079 Genomic DNA Translation: EAX09721.1
CH471079 Genomic DNA Translation: EAX09722.1
CH471079 Genomic DNA Translation: EAX09723.1
BC063033 mRNA Translation: AAH63033.1 Sequence problems.
BC092466 mRNA Translation: AAH92466.1 Sequence problems.
BC137345 mRNA Translation: AAI37346.1
AK291992 mRNA Translation: BAF84681.1
D83327 mRNA Translation: BAA23666.1
AJ001866 mRNA Translation: CAA05057.1
CCDSiCCDS13651.1 [P53804-1]
PIRiJC5020
RefSeqiNP_001001894.1, NM_001001894.2 [P53804-1]
NP_001307633.1, NM_001320704.1
NP_001317610.1, NM_001330681.1 [P53804-3]
NP_001317611.1, NM_001330682.1 [P53804-3]
NP_001317612.1, NM_001330683.1 [P53804-1]
NP_003307.3, NM_003316.3 [P53804-1]
XP_011528042.1, XM_011529740.2 [P53804-2]
UniGeneiHs.368214

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670 [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670 [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670 [P53804-1]
GeneIDi7267
KEGGihsa:7267
UCSCiuc002yvz.4 human [P53804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83077 mRNA Translation: BAA11769.1
D84294 mRNA Translation: BAA12301.1
D84295 mRNA Translation: BAA12302.1
D84296 mRNA Translation: BAA12303.1
AP001429 Genomic DNA No translation available.
AP001432 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09716.1
CH471079 Genomic DNA Translation: EAX09717.1
CH471079 Genomic DNA Translation: EAX09718.1
CH471079 Genomic DNA Translation: EAX09719.1
CH471079 Genomic DNA Translation: EAX09720.1
CH471079 Genomic DNA Translation: EAX09721.1
CH471079 Genomic DNA Translation: EAX09722.1
CH471079 Genomic DNA Translation: EAX09723.1
BC063033 mRNA Translation: AAH63033.1 Sequence problems.
BC092466 mRNA Translation: AAH92466.1 Sequence problems.
BC137345 mRNA Translation: AAI37346.1
AK291992 mRNA Translation: BAF84681.1
D83327 mRNA Translation: BAA23666.1
AJ001866 mRNA Translation: CAA05057.1
CCDSiCCDS13651.1 [P53804-1]
PIRiJC5020
RefSeqiNP_001001894.1, NM_001001894.2 [P53804-1]
NP_001307633.1, NM_001320704.1
NP_001317610.1, NM_001330681.1 [P53804-3]
NP_001317611.1, NM_001330682.1 [P53804-3]
NP_001317612.1, NM_001330683.1 [P53804-1]
NP_003307.3, NM_003316.3 [P53804-1]
XP_011528042.1, XM_011529740.2 [P53804-2]
UniGeneiHs.368214

3D structure databases

ProteinModelPortaliP53804
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113118, 28 interactors
ELMiP53804
IntActiP53804, 27 interactors
MINTiP53804
STRINGi9606.ENSP00000346791

PTM databases

iPTMnetiP53804
PhosphoSitePlusiP53804

Polymorphism and mutation databases

BioMutaiTTC3
DMDMi313104040

Proteomic databases

EPDiP53804
MaxQBiP53804
PaxDbiP53804
PeptideAtlasiP53804
PRIDEiP53804
ProteomicsDBi56623
56624 [P53804-2]
56625 [P53804-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670 [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670 [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670 [P53804-1]
GeneIDi7267
KEGGihsa:7267
UCSCiuc002yvz.4 human [P53804-1]

Organism-specific databases

CTDi7267
DisGeNETi7267
EuPathDBiHostDB:ENSG00000182670.13
GeneCardsiTTC3
H-InvDBiHIX0027791
HIX0041033
HIX0148527
HGNCiHGNC:12393 TTC3
HPAiHPA016810
HPA023964
HPA036304
MIMi602259 gene
neXtProtiNX_P53804
OpenTargetsiENSG00000182670
PharmGKBiPA37058
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JR26 Eukaryota
ENOG41103HK LUCA
GeneTreeiENSGT00530000063254
HOVERGENiHBG007494
InParanoidiP53804
KOiK15712
OMAiCCYQKCH
OrthoDBiEOG091G00EM
PhylomeDBiP53804
TreeFamiTF333981

Enzyme and pathway databases

UniPathwayi
UPA00143

SIGNORiP53804

Miscellaneous databases

ChiTaRSiTTC3 human
GeneWikiiTTC3
GenomeRNAii7267
PROiPR:P53804
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182670 Expressed in 242 organ(s), highest expression level in forebrain
CleanExiHS_TTC3
ExpressionAtlasiP53804 baseline and differential
GenevisibleiP53804 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTC3_HUMAN
AccessioniPrimary (citable) accession number: P53804
Secondary accession number(s): A8K7H7
, B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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