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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

POLR2K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi36ZincBy similarity1
Metal bindingi39ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72086 mRNA Capping
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
ABC10-alpha
DNA-directed RNA polymerase II subunit K
RNA polymerase II 7.0 kDa subunit
Short name:
RPB7.0
RPB10alpha
Gene namesi
Name:POLR2K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147669.10
HGNCiHGNC:9198 POLR2K
MIMi606033 gene
neXtProtiNX_P53803

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5440
OpenTargetsiENSG00000147669
PharmGKBiPA33518

Polymorphism and mutation databases

BioMutaiPOLR2K
DMDMi1710664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597501 – 58DNA-directed RNA polymerases I, II, and III subunit RPABC4Add BLAST58

Proteomic databases

EPDiP53803
MaxQBiP53803
PaxDbiP53803
PeptideAtlasiP53803
PRIDEiP53803
ProteomicsDBi56622
TopDownProteomicsiP53803

PTM databases

iPTMnetiP53803
PhosphoSitePlusiP53803

Expressioni

Gene expression databases

BgeeiENSG00000147669 Expressed in 238 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_POLR2K
ExpressionAtlasiP53803 baseline and differential
GenevisibleiP53803 HS

Organism-specific databases

HPAiHPA063185

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi111436, 27 interactors
CORUMiP53803
DIPiDIP-32968N
IntActiP53803, 10 interactors
STRINGi9606.ENSP00000342889

Structurei

3D structure databases

ProteinModelPortaliP53803
SMRiP53803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3507 Eukaryota
COG1996 LUCA
GeneTreeiENSGT00390000008918
HOVERGENiHBG054239
InParanoidiP53803
KOiK03009
OMAiLMVYDAR
PhylomeDBiP53803
TreeFamiTF103045

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR029040 RPABC4/Spt4
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P53803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK

RLVVFDAR
Length:58
Mass (Da):7,004
Last modified:October 1, 1996 - v1
Checksum:i239BA3A67416F02C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGX2E5RGX2_HUMAN
DNA-directed RNA polymerases I, II,...
POLR2K
67Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47727 mRNA Translation: CAA87656.1
AJ252078 Genomic DNA Translation: CAB91873.1
CR456870 mRNA Translation: CAG33151.1
CH471060 Genomic DNA Translation: EAW91798.1
BC000806 mRNA Translation: AAH00806.1
BC018157 mRNA Translation: AAH18157.1
CCDSiCCDS6285.1
PIRiI37558
RefSeqiNP_005025.1, NM_005034.3
UniGeneiHs.351475

Genome annotation databases

EnsembliENST00000353107; ENSP00000342889; ENSG00000147669
GeneIDi5440
KEGGihsa:5440
UCSCiuc003yjf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47727 mRNA Translation: CAA87656.1
AJ252078 Genomic DNA Translation: CAB91873.1
CR456870 mRNA Translation: CAG33151.1
CH471060 Genomic DNA Translation: EAW91798.1
BC000806 mRNA Translation: AAH00806.1
BC018157 mRNA Translation: AAH18157.1
CCDSiCCDS6285.1
PIRiI37558
RefSeqiNP_005025.1, NM_005034.3
UniGeneiHs.351475

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IY6electron microscopy7.20L1-58[»]
5IY7electron microscopy8.60L1-58[»]
5IY8electron microscopy7.90L1-58[»]
5IY9electron microscopy6.30L1-58[»]
5IYAelectron microscopy5.40L1-58[»]
5IYBelectron microscopy3.90L1-58[»]
5IYCelectron microscopy3.90L1-58[»]
5IYDelectron microscopy3.90L1-58[»]
ProteinModelPortaliP53803
SMRiP53803
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111436, 27 interactors
CORUMiP53803
DIPiDIP-32968N
IntActiP53803, 10 interactors
STRINGi9606.ENSP00000342889

PTM databases

iPTMnetiP53803
PhosphoSitePlusiP53803

Polymorphism and mutation databases

BioMutaiPOLR2K
DMDMi1710664

Proteomic databases

EPDiP53803
MaxQBiP53803
PaxDbiP53803
PeptideAtlasiP53803
PRIDEiP53803
ProteomicsDBi56622
TopDownProteomicsiP53803

Protocols and materials databases

DNASUi5440
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353107; ENSP00000342889; ENSG00000147669
GeneIDi5440
KEGGihsa:5440
UCSCiuc003yjf.4 human

Organism-specific databases

CTDi5440
DisGeNETi5440
EuPathDBiHostDB:ENSG00000147669.10
GeneCardsiPOLR2K
HGNCiHGNC:9198 POLR2K
HPAiHPA063185
MIMi606033 gene
neXtProtiNX_P53803
OpenTargetsiENSG00000147669
PharmGKBiPA33518
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3507 Eukaryota
COG1996 LUCA
GeneTreeiENSGT00390000008918
HOVERGENiHBG054239
InParanoidiP53803
KOiK03009
OMAiLMVYDAR
PhylomeDBiP53803
TreeFamiTF103045

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72086 mRNA Capping
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-9018519 Estrogen-dependent gene expression

Miscellaneous databases

GeneWikiiPOLR2K
GenomeRNAii5440
PROiPR:P53803
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147669 Expressed in 238 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_POLR2K
ExpressionAtlasiP53803 baseline and differential
GenevisibleiP53803 HS

Family and domain databases

InterProiView protein in InterPro
IPR006591 RNAP_P/RPABC4
IPR029040 RPABC4/Spt4
PfamiView protein in Pfam
PF03604 DNA_RNApol_7kD, 1 hit
SMARTiView protein in SMART
SM00659 RPOLCX, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPAB4_HUMAN
AccessioniPrimary (citable) accession number: P53803
Secondary accession number(s): Q6IBD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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