Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pituitary tumor-transforming gene 1 protein-interacting protein

Gene

PTTG1IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May facilitate PTTG1 nuclear translocation.

GO - Molecular functioni

  • p53 binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein
Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name:
PBF
Short name:
PTTG-binding factor
Gene namesi
Name:PTTG1IP
Synonyms:C21orf1, C21orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000183255.11
HGNCiHGNC:13524 PTTG1IP
MIMi603784 gene
neXtProtiNX_P53801

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 96ExtracellularSequence analysisAdd BLAST64
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 180CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi754
OpenTargetsiENSG00000183255
PharmGKBiPA34034

Polymorphism and mutation databases

BioMutaiPTTG1IP
DMDMi1711387

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002218433 – 180Pituitary tumor-transforming gene 1 protein-interacting proteinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei174PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP53801
MaxQBiP53801
PaxDbiP53801
PeptideAtlasiP53801
PRIDEiP53801
ProteomicsDBi56621

PTM databases

GlyConnecti1607
iPTMnetiP53801
PhosphoSitePlusiP53801
SwissPalmiP53801

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

By transcription factor RUNX2.1 Publication

Gene expression databases

BgeeiENSG00000183255 Expressed in 233 organ(s), highest expression level in visceral pleura
CleanExiHS_PTTG1IP
ExpressionAtlasiP53801 baseline and differential
GenevisibleiP53801 HS

Organism-specific databases

HPAiCAB034146
HPA061827

Interactioni

Subunit structurei

Interacts with PTTG1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107210, 9 interactors
IntActiP53801, 19 interactors
MINTiP53801
STRINGi9606.ENSP00000328325

Structurei

3D structure databases

ProteinModelPortaliP53801
SMRiP53801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 92PSIAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 165Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 121Poly-Cys6

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXF7 Eukaryota
ENOG4111WR4 LUCA
GeneTreeiENSGT00390000004977
HOGENOMiHOG000015370
HOVERGENiHBG000902
InParanoidiP53801
OMAiELSSARW
OrthoDBiEOG091G0X6V
PhylomeDBiP53801
TreeFamiTF329310

Family and domain databases

InterProiView protein in InterPro
IPR016201 PSI
SMARTiView protein in SMART
SM00423 PSI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P53801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE
60 70 80 90 100
CLKNVSCLWC NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII
110 120 130 140 150
TMSVVGGTLL LGIAICCCCC CRRKRSRKPD RSEEKAMRER EERRIRQEER
160 170 180
RAEMKTRHDE IRKKYGLFKE ENPYARFENN
Length:180
Mass (Da):20,324
Last modified:October 1, 1996 - v1
Checksum:iF1E66014D49EC1DE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXQ1A8MXQ1_HUMAN
Pituitary tumor-transforming gene 1...
PTTG1IP
159Annotation score:
A8MZH8A8MZH8_HUMAN
Pituitary tumor-transforming gene 1...
PTTG1IP
107Annotation score:
B4DPZ0B4DPZ0_HUMAN
Pituitary tumor-transforming gene 1...
PTTG1IP
142Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 19PTPYWRLRLGG → ARRTGGCASV in AAF73770 (PubMed:10781616).CuratedAdd BLAST11
Sequence conflicti108 – 114TLLLGIA → NPPPGHC in AAF73770 (PubMed:10781616).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50022 mRNA Translation: CAA90325.1
AF149785 mRNA Translation: AAF73770.1
AK315626 mRNA Translation: BAG37994.1
AL163300 Genomic DNA Translation: CAB90552.1
CH471079 Genomic DNA Translation: EAX09386.1
CH471079 Genomic DNA Translation: EAX09388.1
BC000415 mRNA Translation: AAH00415.1
BC012858 mRNA Translation: AAH12858.1
BC019295 mRNA Translation: AAH19295.1
BC020983 mRNA Translation: AAH20983.1
BC031097 mRNA Translation: AAH31097.1
BC034250 mRNA Translation: AAH34250.1
CCDSiCCDS13715.1
RefSeqiNP_001273751.1, NM_001286822.1
NP_004330.1, NM_004339.3
UniGeneiHs.474010

Genome annotation databases

EnsembliENST00000330938; ENSP00000328325; ENSG00000183255
GeneIDi754
KEGGihsa:754
UCSCiuc002zgb.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50022 mRNA Translation: CAA90325.1
AF149785 mRNA Translation: AAF73770.1
AK315626 mRNA Translation: BAG37994.1
AL163300 Genomic DNA Translation: CAB90552.1
CH471079 Genomic DNA Translation: EAX09386.1
CH471079 Genomic DNA Translation: EAX09388.1
BC000415 mRNA Translation: AAH00415.1
BC012858 mRNA Translation: AAH12858.1
BC019295 mRNA Translation: AAH19295.1
BC020983 mRNA Translation: AAH20983.1
BC031097 mRNA Translation: AAH31097.1
BC034250 mRNA Translation: AAH34250.1
CCDSiCCDS13715.1
RefSeqiNP_001273751.1, NM_001286822.1
NP_004330.1, NM_004339.3
UniGeneiHs.474010

3D structure databases

ProteinModelPortaliP53801
SMRiP53801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107210, 9 interactors
IntActiP53801, 19 interactors
MINTiP53801
STRINGi9606.ENSP00000328325

PTM databases

GlyConnecti1607
iPTMnetiP53801
PhosphoSitePlusiP53801
SwissPalmiP53801

Polymorphism and mutation databases

BioMutaiPTTG1IP
DMDMi1711387

Proteomic databases

EPDiP53801
MaxQBiP53801
PaxDbiP53801
PeptideAtlasiP53801
PRIDEiP53801
ProteomicsDBi56621

Protocols and materials databases

DNASUi754
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330938; ENSP00000328325; ENSG00000183255
GeneIDi754
KEGGihsa:754
UCSCiuc002zgb.3 human

Organism-specific databases

CTDi754
DisGeNETi754
EuPathDBiHostDB:ENSG00000183255.11
GeneCardsiPTTG1IP
HGNCiHGNC:13524 PTTG1IP
HPAiCAB034146
HPA061827
MIMi603784 gene
neXtProtiNX_P53801
OpenTargetsiENSG00000183255
PharmGKBiPA34034
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXF7 Eukaryota
ENOG4111WR4 LUCA
GeneTreeiENSGT00390000004977
HOGENOMiHOG000015370
HOVERGENiHBG000902
InParanoidiP53801
OMAiELSSARW
OrthoDBiEOG091G0X6V
PhylomeDBiP53801
TreeFamiTF329310

Miscellaneous databases

ChiTaRSiPTTG1IP human
GeneWikiiPTTG1IP
GenomeRNAii754
PROiPR:P53801
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183255 Expressed in 233 organ(s), highest expression level in visceral pleura
CleanExiHS_PTTG1IP
ExpressionAtlasiP53801 baseline and differential
GenevisibleiP53801 HS

Family and domain databases

InterProiView protein in InterPro
IPR016201 PSI
SMARTiView protein in SMART
SM00423 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTTG_HUMAN
AccessioniPrimary (citable) accession number: P53801
Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again