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Protein

Squalene synthase

Gene
N/A
Organism
Nicotiana benthamiana
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processIsoprene biosynthesis
LigandMagnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
OrganismiNicotiana benthamiana
Taxonomic identifieri4100 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674561 – 411Squalene synthaseAdd BLAST411

Structurei

3D structure databases

ProteinModelPortaliP53800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiView protein in InterPro
IPR008949. Isoprenoid_synthase_dom_sf.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth-like.
IPR019845. Squalene/phytoene_synthase_CS.
IPR033904. Trans_IPPS_HH.
PfamiView protein in Pfam
PF00494. SQS_PSY. 1 hit.
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR01559. squal_synth. 1 hit.
PROSITEiView protein in PROSITE
PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P53800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLRAILKN PEDLYPLVKL KLAARHAEKQ IPPSPNWGFC YSMLHKVSRS
60 70 80 90 100
FALVIQQLPV ELRDAVCIFY LVLRALDTVE DDTSIPTDVK VPILISFHQH
110 120 130 140 150
VYDREWHFSC GTKEYKVLMD QFHHVSTAFL ELRKHYQQAI EDITMRMGAG
160 170 180 190 200
MAKFICKEVE TTDDYDEYCH YVAGLVGLGL SKLFHASEKE DLASDSLSNS
210 220 230 240 250
MGLFLQKTNI IRDYLEDINE VPKCRMFWPR EIWSKYVNKL EELKYEDNSA
260 270 280 290 300
KAVQCLNDMV TNALPHVEDC LTYMSALRDP SIFRFCAIPQ VMAIGTLAMC
310 320 330 340 350
YDNIEVFRGV VKMRRGLTAK VIDRTRTIAD VYGAFFDFSC MLKSKVNNND
360 370 380 390 400
PNATKTLKRL EVILKTCRDS GTLNKRKSYI IRSEPNYSPV LIVVIFIILA
410
IILAQLSGNR S
Length:411
Mass (Da):47,083
Last modified:October 1, 1996 - v1
Checksum:i5DE209E9BB70A42A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46000 mRNA. Translation: AAA87048.1.
PIRiS71771.

Similar proteinsi

Entry informationi

Entry nameiFDFT_NICBE
AccessioniPrimary (citable) accession number: P53800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program