UniProtKB - P53792 (SC5A2_RAT)
Sodium/glucose cotransporter 2
Slc5a2
Functioni
Electrogenic Na+-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump (PubMed:7493971).
Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
By similarity1 PublicationCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- alpha-glucoside transmembrane transporter activity Source: RGD
- D-glucose transmembrane transporter activity Source: RGD
- glucose:sodium symporter activity Source: RGD
GO - Biological processi
- alpha-glucoside transport Source: RGD
- glucose import across plasma membrane Source: RGD
- glucose transmembrane transport Source: RGD
- negative regulation of urine volume Source: RGD
- renal potassium excretion Source: RGD
- sodium ion import across plasma membrane Source: RGD
- sodium ion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Sugar transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-189200, Cellular hexose transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/glucose cotransporter 2Short name: Na(+)/glucose cotransporter 2 Alternative name(s): Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2 |
Gene namesi | Name:Slc5a2 Synonyms:Sglt21 Publication |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620217, Slc5a2 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- brush border membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- integral component of membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 42 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 43 – 59 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 100 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 166 | ExtracellularSequence analysisAdd BLAST | 45 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 203 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 268 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 312 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 313 – 332 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 333 – 421 | ExtracellularSequence analysisAdd BLAST | 89 | |
Transmembranei | 422 – 441 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 442 – 453 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 454 – 474 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 475 – 524 | ExtracellularSequence analysisAdd BLAST | 50 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 546 – 648 | CytoplasmicSequence analysisAdd BLAST | 103 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4316 |
DrugCentrali | P53792 |
GuidetoPHARMACOLOGYi | 916 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105375 | 1 – 670 | Sodium/glucose cotransporter 2Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 248 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P53792 |
PTM databases
GlyGeni | P53792, 1 site |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Forms a heterodimer with PDZK1IP1; this interaction enhances the transporter activity over a hundred-fold.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027265 |
Chemistry databases
BindingDBi | P53792 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2349, Eukaryota |
InParanoidi | P53792 |
OrthoDBi | 243316at2759 |
PhylomeDBi | P53792 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEGHVEEGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGRRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAVTSLTV SKDPAVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG GLPWPALLLG LTIVSGWHWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDREL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLIGG LLMGLARLIP
510 520 530 540 550
EFFFGTGSCV RPSACPAIFC RVHYLYFAII LFFCSGFLTL AISRCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDAEELEGPA PPPVQNGCQE CAMGIEEVQS
610 620 630 640 650
PAPGLLRQCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPSWARV
660 670
VNLNALLMMT VAVFLWGFYA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LMI6 | F1LMI6_RAT | Sodium/glucose cotransporter 2 | Slc5a2 | 674 | Annotation score: | ||
A0A0G2JZF9 | A0A0G2JZF9_RAT | Sodium/glucose cotransporter 2 | Slc5a2 | 596 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29881 mRNA Translation: AAC52325.1 |
RefSeqi | NP_072112.2, NM_022590.2 |
Genome annotation databases
GeneIDi | 64522 |
KEGGi | rno:64522 |
UCSCi | RGD:620217, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29881 mRNA Translation: AAC52325.1 |
RefSeqi | NP_072112.2, NM_022590.2 |
3D structure databases
AlphaFoldDBi | P53792 |
SMRi | P53792 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027265 |
Chemistry databases
BindingDBi | P53792 |
ChEMBLi | CHEMBL4316 |
DrugCentrali | P53792 |
GuidetoPHARMACOLOGYi | 916 |
PTM databases
GlyGeni | P53792, 1 site |
Proteomic databases
PaxDbi | P53792 |
Genome annotation databases
GeneIDi | 64522 |
KEGGi | rno:64522 |
UCSCi | RGD:620217, rat |
Organism-specific databases
CTDi | 6524 |
RGDi | 620217, Slc5a2 |
Phylogenomic databases
eggNOGi | KOG2349, Eukaryota |
InParanoidi | P53792 |
OrthoDBi | 243316at2759 |
PhylomeDBi | P53792 |
Enzyme and pathway databases
Reactomei | R-RNO-189200, Cellular hexose transport |
Miscellaneous databases
PROi | PR:P53792 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC5A2_RAT | |
Accessioni | P53792Primary (citable) accession number: P53792 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families