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UniProtKB - P53779 (MK10_HUMAN)

Entry version 221 (10 Feb 2021)
Sequence version 2 (01 Nov 1997)
Previous versions | rss
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Protein

Mitogen-activated protein kinase 10

Gene

MAPK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei93ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei189Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 78ATP9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • JUN kinase activity Source: UniProtKB
  • MAP kinase activity Source: GO_Central
  • MAP kinase kinase activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processBiological rhythms
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.24, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53779

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2871796, FCERI mediated MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450341, Activation of the AP-1 family of transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P53779

SIGNOR Signaling Network Open Resource

More...SIGNORi		P53779

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase 10 (EC:2.7.11.24)
Short name:
MAP kinase 10
Short name:
MAPK 10
Alternative name(s):
MAP kinase p49 3F12
Stress-activated protein kinase 1b
Short name:
SAPK1b
Stress-activated protein kinase JNK3
c-Jun N-terminal kinase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPK10
Synonyms:JNK3, JNK3A, PRKM10, SAPK1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6872, MAPK10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602897, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53779

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000109339.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi462C → S: Loss of palmitoylation. 1 Publication1
Mutagenesisi463C → S: Loss of palmitoylation. 1 Publication1

Keywords - Diseasei

Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		5602

MalaCards human disease database

More...MalaCardsi		MAPK10

Open Targets

More...OpenTargetsi		ENSG00000109339

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2382, Lennox-Gastaut syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30617

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53779, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2637

Drug and drug target database

More...DrugBanki		DB08011, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
DB08010, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
DB08015, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
DB08555, 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline
DB08026, 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
DB08005, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
DB08021, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
DB03623, 9-(4-Hydroxyphenyl)-2,7-Phenanthroline
DB02388, Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
DB03084, Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
DB12010, Fostamatinib
DB15624, Halicin
DB01017, Minocycline
DB07217, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
DB06933, N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
DB08023, N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
DB08025, N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
DB04395, Phosphoaminophosphonic Acid-Adenylate Ester
DB01782, Pyrazolanthrone

DrugCentral

More...DrugCentrali		P53779

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1498

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAPK10

Domain mapping of disease mutations (DMDM)

More...DMDMi		2507196

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001862771 – 464Mitogen-activated protein kinase 10Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei221Phosphothreonine; by MAP2K71 Publication1
Modified residuei223Phosphotyrosine; by MAP2K41 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi462S-palmitoyl cysteine1 Publication1
Lipidationi463S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro.1 Publication
Palmitoylation regulates subcellular location and axonal development.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53779

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53779

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53779

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53779

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53779

PeptideAtlas

More...PeptideAtlasi		P53779

PRoteomics IDEntifications database

More...PRIDEi		P53779

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56616 [P53779-1]
56617 [P53779-2]
56618 [P53779-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53779

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53779

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P53779

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000109339, Expressed in frontal cortex and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53779, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53779, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000109339, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAPKBP1 (By similarity).

Interacts with MAPK8IP1/JIP-1 and MAPK8IP3/JIP-3/JSAP1 (By similarity).

Interacts with SPAG9/MAPK8IP4/JIP4 (PubMed:15693750).

Interacts with HDAC9 (PubMed:16611996).

Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5 (PubMed:18435604).

Interacts with SARM1 (By similarity).

Interacts with JUND; interaction is inhibited in the presence of MEN1 (PubMed:22327296).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111588, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P53779

Database of interacting proteins

More...DIPi		DIP-1015N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P53779

Protein interaction database and analysis system

More...IntActi		P53779, 24 interactors

Molecular INTeraction database

More...MINTi		P53779

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352157

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P53779

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53779, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53779

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P53779

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 359Protein kinasePROSITE-ProRule annotationAdd BLAST296

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi221 – 223TXY3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0665, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_181_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53779

Identification of Orthologs from Complete Genome Data

More...OMAi		REFKLMN

Database of Orthologous Groups

More...OrthoDBi		741207at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53779

TreeFam database of animal gene trees

More...TreeFami		TF105100

Family and domain databases

Database of protein disorder

More...DisProti		DP02328

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00456

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008351, MAPK_JNK
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01772, JNKMAPKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01351, MAPK, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A similar low level of binding to substrates is observed for isoform alpha-1 and isoform alpha-2. However, there is no correlation between binding and phosphorylation, which is achieved about at the same efficiency by all isoforms.

This entry has 3 described isoforms and 68 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-2 (identifier: P53779-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS 
        60         70         80         90        100
VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ 
       110        120        130        140        150
NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD 
       160        170        180        190        200
ANLCQVIQME LDHERMSYLL YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD 
       210        220        230        240        250
CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG 
       260        270        280        290        300
CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 
       310        320        330        340        350
RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV 
       360        370        380        390        400
DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN 
       410        420        430        440        450
SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD 
       460 
SSLEASAGPL GCCR
Length:464
Mass (Da):52,585
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E20C05EB89CDA66
GO
Isoform Alpha-1 (identifier: P53779-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-464: GAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR → AQVQQ

Show »
Length:422
Mass (Da):48,554
Checksum:iFCC8C11954481C04
GO
Isoform 3 (identifier: P53779-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:426
Mass (Da):48,128
Checksum:i1022B6AC7774A666
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 68 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YEW9A0A286YEW9_HUMAN
Mitogen-activated protein kinase
MAPK10
551Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFD7A0A286YFD7_HUMAN
Mitogen-activated protein kinase
MAPK10
426Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF97A0A286YF97_HUMAN
Mitogen-activated protein kinase
MAPK10
464Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEQ7A0A286YEQ7_HUMAN
Mitogen-activated protein kinase
MAPK10
402Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9R5F8W9R5_HUMAN
Mitogen-activated protein kinase
MAPK10
478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YES9A0A286YES9_HUMAN
Mitogen-activated protein kinase
MAPK10
427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEN5A0A286YEN5_HUMAN
Mitogen-activated protein kinase
MAPK10
435Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF62A0A286YF62_HUMAN
Mitogen-activated protein kinase
MAPK10
473Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFA6A0A286YFA6_HUMAN
Mitogen-activated protein kinase
MAPK10
467Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFI3A0A286YFI3_HUMAN
Mitogen-activated protein kinase
MAPK10
384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG51956 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti162D → G in BAG51956 (PubMed:14702039).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 44070 Da. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0419111 – 38Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_004839418 – 464GAAVN…LGCCR → AQVQQ in isoform Alpha-1. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U07620 mRNA Translation: AAC50101.1
U34819 mRNA Translation: AAC50604.1
U34820 mRNA Translation: AAC50605.1
AK057723 mRNA Translation: BAG51956.1 Different initiation.
AK124791 mRNA Translation: BAG54096.1
AC096953 Genomic DNA No translation available.
AC104059 Genomic DNA No translation available.
AC104827 Genomic DNA No translation available.
AC108054 Genomic DNA No translation available.
AC110076 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05963.1
BC035057 mRNA Translation: AAH35057.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34026.1 [P53779-1]
CCDS3612.1 [P53779-3]
CCDS43247.1 [P53779-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S71104

NCBI Reference Sequences

More...RefSeqi		NP_001304996.1, NM_001318067.1
NP_001304997.1, NM_001318068.1
NP_001304998.1, NM_001318069.1
NP_002744.1, NM_002753.4 [P53779-2]
NP_620446.1, NM_138980.3 [P53779-3]
NP_620448.1, NM_138982.3 [P53779-1]
XP_005263186.1, XM_005263129.2 [P53779-1]
XP_005263187.1, XM_005263130.2 [P53779-1]
XP_005263192.1, XM_005263135.3 [P53779-2]
XP_006714331.1, XM_006714268.2 [P53779-3]
XP_011530419.1, XM_011532117.2 [P53779-1]
XP_011530420.1, XM_011532118.2 [P53779-1]
XP_011530422.1, XM_011532120.2 [P53779-3]
XP_011530423.1, XM_011532121.2 [P53779-3]
XP_016863908.1, XM_017008419.1
XP_016863909.1, XM_017008420.1 [P53779-1]
XP_016863910.1, XM_017008421.1
XP_016863912.1, XM_017008423.1 [P53779-3]
XP_016863913.1, XM_017008424.1
XP_016863914.1, XM_017008425.1
XP_016863915.1, XM_017008426.1
XP_016863918.1, XM_017008429.1 [P53779-2]
XP_016863919.1, XM_017008430.1 [P53779-2]
XP_016863920.1, XM_017008431.1
XP_016863921.1, XM_017008432.1 [P53779-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395157; ENSP00000378586; ENSG00000109339 [P53779-2]
ENST00000395166; ENSP00000378595; ENSG00000109339 [P53779-3]
ENST00000515400; ENSP00000424154; ENSG00000109339 [P53779-1]
ENST00000515650; ENSP00000492204; ENSG00000109339 [P53779-1]
ENST00000638225; ENSP00000491866; ENSG00000109339 [P53779-3]
ENST00000638313; ENSP00000492292; ENSG00000109339 [P53779-1]
ENST00000639175; ENSP00000491160; ENSG00000109339 [P53779-3]
ENST00000639234; ENSP00000491306; ENSG00000109339 [P53779-2]
ENST00000639242; ENSP00000491089; ENSG00000109339 [P53779-3]
ENST00000640858; ENSP00000491122; ENSG00000109339 [P53779-2]
ENST00000640970; ENSP00000492231; ENSG00000109339 [P53779-2]
ENST00000641050; ENSP00000493270; ENSG00000109339 [P53779-2]
ENST00000641051; ENSP00000493275; ENSG00000109339 [P53779-1]
ENST00000641066; ENSP00000493072; ENSG00000109339 [P53779-1]
ENST00000641110; ENSP00000493163; ENSG00000109339 [P53779-3]
ENST00000641157; ENSP00000493363; ENSG00000109339 [P53779-1]
ENST00000641170; ENSP00000493237; ENSG00000109339 [P53779-2]
ENST00000641207; ENSP00000493450; ENSG00000109339 [P53779-1]
ENST00000641274; ENSP00000492929; ENSG00000109339 [P53779-2]
ENST00000641283; ENSP00000493444; ENSG00000109339 [P53779-3]
ENST00000641287; ENSP00000493100; ENSG00000109339 [P53779-3]
ENST00000641297; ENSP00000493092; ENSG00000109339 [P53779-3]
ENST00000641341; ENSP00000493290; ENSG00000109339 [P53779-1]
ENST00000641391; ENSP00000493008; ENSG00000109339 [P53779-3]
ENST00000641410; ENSP00000493208; ENSG00000109339 [P53779-2]
ENST00000641462; ENSP00000493435; ENSG00000109339 [P53779-1]
ENST00000641647; ENSP00000493375; ENSG00000109339 [P53779-1]
ENST00000641657; ENSP00000493105; ENSG00000109339 [P53779-3]
ENST00000641724; ENSP00000493038; ENSG00000109339 [P53779-3]
ENST00000641737; ENSP00000493177; ENSG00000109339 [P53779-3]
ENST00000641803; ENSP00000493049; ENSG00000109339 [P53779-3]
ENST00000641823; ENSP00000493408; ENSG00000109339 [P53779-1]
ENST00000641862; ENSP00000493396; ENSG00000109339 [P53779-2]
ENST00000641902; ENSP00000492903; ENSG00000109339 [P53779-1]
ENST00000641911; ENSP00000493374; ENSG00000109339 [P53779-3]
ENST00000641943; ENSP00000492941; ENSG00000109339 [P53779-3]
ENST00000641952; ENSP00000493013; ENSG00000109339 [P53779-1]
ENST00000641983; ENSP00000493045; ENSG00000109339 [P53779-1]
ENST00000642009; ENSP00000493168; ENSG00000109339 [P53779-3]
ENST00000642015; ENSP00000493040; ENSG00000109339 [P53779-3]
ENST00000642038; ENSP00000492942; ENSG00000109339 [P53779-2]
ENST00000642103; ENSP00000493001; ENSG00000109339 [P53779-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5602

UCSC genome browser

More...UCSCi		uc003hpp.4, human [P53779-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07620 mRNA Translation: AAC50101.1
U34819 mRNA Translation: AAC50604.1
U34820 mRNA Translation: AAC50605.1
AK057723 mRNA Translation: BAG51956.1 Different initiation.
AK124791 mRNA Translation: BAG54096.1
AC096953 Genomic DNA No translation available.
AC104059 Genomic DNA No translation available.
AC104827 Genomic DNA No translation available.
AC108054 Genomic DNA No translation available.
AC110076 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05963.1
BC035057 mRNA Translation: AAH35057.1
CCDSiCCDS34026.1 [P53779-1]
CCDS3612.1 [P53779-3]
CCDS43247.1 [P53779-2]
PIRiS71104
RefSeqiNP_001304996.1, NM_001318067.1
NP_001304997.1, NM_001318068.1
NP_001304998.1, NM_001318069.1
NP_002744.1, NM_002753.4 [P53779-2]
NP_620446.1, NM_138980.3 [P53779-3]
NP_620448.1, NM_138982.3 [P53779-1]
XP_005263186.1, XM_005263129.2 [P53779-1]
XP_005263187.1, XM_005263130.2 [P53779-1]
XP_005263192.1, XM_005263135.3 [P53779-2]
XP_006714331.1, XM_006714268.2 [P53779-3]
XP_011530419.1, XM_011532117.2 [P53779-1]
XP_011530420.1, XM_011532118.2 [P53779-1]
XP_011530422.1, XM_011532120.2 [P53779-3]
XP_011530423.1, XM_011532121.2 [P53779-3]
XP_016863908.1, XM_017008419.1
XP_016863909.1, XM_017008420.1 [P53779-1]
XP_016863910.1, XM_017008421.1
XP_016863912.1, XM_017008423.1 [P53779-3]
XP_016863913.1, XM_017008424.1
XP_016863914.1, XM_017008425.1
XP_016863915.1, XM_017008426.1
XP_016863918.1, XM_017008429.1 [P53779-2]
XP_016863919.1, XM_017008430.1 [P53779-2]
XP_016863920.1, XM_017008431.1
XP_016863921.1, XM_017008432.1 [P53779-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNKX-ray2.30A1-423[»]
1PMNX-ray2.20A40-401[»]
1PMUX-ray2.70A40-401[»]
1PMVX-ray2.50A40-401[»]
2B1PX-ray1.90A46-400[»]
2EXCX-ray2.75X45-400[»]
2O0UX-ray2.10A39-402[»]
2O2UX-ray2.45A39-402[»]
2OK1X-ray2.40A40-402[»]
2P33X-ray2.40A40-402[»]
2R9SX-ray2.40A/B46-401[»]
2WAJX-ray2.40A39-402[»]
2ZDTX-ray2.00A39-402[»]
2ZDUX-ray2.50A39-402[»]
3CGFX-ray3.00A40-402[»]
3CGOX-ray3.00A40-402[»]
3DA6X-ray2.00A39-402[»]
3FI2X-ray2.28A39-402[»]
3FI3X-ray2.20A39-402[»]
3FV8X-ray2.28A39-402[»]
3G90X-ray2.40X40-402[»]
3G9LX-ray2.20X40-402[»]
3G9NX-ray2.80A40-402[»]
3KVXX-ray2.40A39-402[»]
3OXIX-ray2.20A40-401[»]
3OY1X-ray1.70A40-401[»]
3PTGX-ray2.43A40-401[»]
3RTPX-ray2.40A40-401[»]
3TTIX-ray2.20A1-464[»]
3TTJX-ray2.10A1-464[»]
3V6RX-ray2.60A/B39-402[»]
3V6SX-ray2.97A/B39-402[»]
4H36X-ray3.00A45-400[»]
4H39X-ray1.99A45-400[»]
4H3BX-ray2.08A/C45-400[»]
4KKEX-ray2.20A40-402[»]
4KKGX-ray2.40A40-402[»]
4KKHX-ray2.00A40-402[»]
4U79X-ray2.23A39-402[»]
4W4VX-ray2.01A39-402[»]
4W4WX-ray1.90A39-402[»]
4W4XX-ray2.65A39-402[»]
4W4YX-ray2.30A39-402[»]
4WHZX-ray1.79A39-423[»]
4X21X-ray1.95A/B39-402[»]
4Y46X-ray2.04A39-402[»]
4Y5HX-ray2.06A39-402[»]
4Z9LX-ray2.10A40-401[»]
6EKDX-ray2.10A39-402[»]
6EMHX-ray1.76A/B/C/D39-402[»]
6EQ9X-ray1.83A/B39-402[»]
SMRiP53779
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111588, 53 interactors
CORUMiP53779
DIPiDIP-1015N
ELMiP53779
IntActiP53779, 24 interactors
MINTiP53779
STRINGi9606.ENSP00000352157

Chemistry databases

BindingDBiP53779
ChEMBLiCHEMBL2637
DrugBankiDB08011, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
DB08010, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
DB08015, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
DB08555, 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline
DB08026, 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
DB08005, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
DB08021, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
DB03623, 9-(4-Hydroxyphenyl)-2,7-Phenanthroline
DB02388, Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
DB03084, Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
DB12010, Fostamatinib
DB15624, Halicin
DB01017, Minocycline
DB07217, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
DB06933, N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
DB08023, N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
DB08025, N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
DB04395, Phosphoaminophosphonic Acid-Adenylate Ester
DB01782, Pyrazolanthrone
DrugCentraliP53779
GuidetoPHARMACOLOGYi1498

PTM databases

iPTMnetiP53779
PhosphoSitePlusiP53779
SwissPalmiP53779

Genetic variation databases

BioMutaiMAPK10
DMDMi2507196

Proteomic databases

EPDiP53779
jPOSTiP53779
MassIVEiP53779
MaxQBiP53779
PaxDbiP53779
PeptideAtlasiP53779
PRIDEiP53779
ProteomicsDBi56616 [P53779-1]
56617 [P53779-2]
56618 [P53779-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14345, 515 antibodies

The DNASU plasmid repository

More...DNASUi		5602

Genome annotation databases

EnsembliENST00000395157; ENSP00000378586; ENSG00000109339 [P53779-2]
ENST00000395166; ENSP00000378595; ENSG00000109339 [P53779-3]
ENST00000515400; ENSP00000424154; ENSG00000109339 [P53779-1]
ENST00000515650; ENSP00000492204; ENSG00000109339 [P53779-1]
ENST00000638225; ENSP00000491866; ENSG00000109339 [P53779-3]
ENST00000638313; ENSP00000492292; ENSG00000109339 [P53779-1]
ENST00000639175; ENSP00000491160; ENSG00000109339 [P53779-3]
ENST00000639234; ENSP00000491306; ENSG00000109339 [P53779-2]
ENST00000639242; ENSP00000491089; ENSG00000109339 [P53779-3]
ENST00000640858; ENSP00000491122; ENSG00000109339 [P53779-2]
ENST00000640970; ENSP00000492231; ENSG00000109339 [P53779-2]
ENST00000641050; ENSP00000493270; ENSG00000109339 [P53779-2]
ENST00000641051; ENSP00000493275; ENSG00000109339 [P53779-1]
ENST00000641066; ENSP00000493072; ENSG00000109339 [P53779-1]
ENST00000641110; ENSP00000493163; ENSG00000109339 [P53779-3]
ENST00000641157; ENSP00000493363; ENSG00000109339 [P53779-1]
ENST00000641170; ENSP00000493237; ENSG00000109339 [P53779-2]
ENST00000641207; ENSP00000493450; ENSG00000109339 [P53779-1]
ENST00000641274; ENSP00000492929; ENSG00000109339 [P53779-2]
ENST00000641283; ENSP00000493444; ENSG00000109339 [P53779-3]
ENST00000641287; ENSP00000493100; ENSG00000109339 [P53779-3]
ENST00000641297; ENSP00000493092; ENSG00000109339 [P53779-3]
ENST00000641341; ENSP00000493290; ENSG00000109339 [P53779-1]
ENST00000641391; ENSP00000493008; ENSG00000109339 [P53779-3]
ENST00000641410; ENSP00000493208; ENSG00000109339 [P53779-2]
ENST00000641462; ENSP00000493435; ENSG00000109339 [P53779-1]
ENST00000641647; ENSP00000493375; ENSG00000109339 [P53779-1]
ENST00000641657; ENSP00000493105; ENSG00000109339 [P53779-3]
ENST00000641724; ENSP00000493038; ENSG00000109339 [P53779-3]
ENST00000641737; ENSP00000493177; ENSG00000109339 [P53779-3]
ENST00000641803; ENSP00000493049; ENSG00000109339 [P53779-3]
ENST00000641823; ENSP00000493408; ENSG00000109339 [P53779-1]
ENST00000641862; ENSP00000493396; ENSG00000109339 [P53779-2]
ENST00000641902; ENSP00000492903; ENSG00000109339 [P53779-1]
ENST00000641911; ENSP00000493374; ENSG00000109339 [P53779-3]
ENST00000641943; ENSP00000492941; ENSG00000109339 [P53779-3]
ENST00000641952; ENSP00000493013; ENSG00000109339 [P53779-1]
ENST00000641983; ENSP00000493045; ENSG00000109339 [P53779-1]
ENST00000642009; ENSP00000493168; ENSG00000109339 [P53779-3]
ENST00000642015; ENSP00000493040; ENSG00000109339 [P53779-3]
ENST00000642038; ENSP00000492942; ENSG00000109339 [P53779-2]
ENST00000642103; ENSP00000493001; ENSG00000109339 [P53779-3]
GeneIDi5602
KEGGihsa:5602
UCSCiuc003hpp.4, human [P53779-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5602
DisGeNETi5602

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAPK10
HGNCiHGNC:6872, MAPK10
HPAiENSG00000109339, Tissue enhanced (brain)
MalaCardsiMAPK10
MIMi602897, gene
neXtProtiNX_P53779
OpenTargetsiENSG00000109339
Orphaneti2382, Lennox-Gastaut syndrome
PharmGKBiPA30617
VEuPathDBiHostDB:ENSG00000109339.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0665, Eukaryota
GeneTreeiENSGT00940000153692
HOGENOMiCLU_000288_181_1_1
InParanoidiP53779
OMAiREFKLMN
OrthoDBi741207at2759
PhylomeDBiP53779
TreeFamiTF105100

Enzyme and pathway databases

BRENDAi2.7.11.24, 2681
PathwayCommonsiP53779
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2871796, FCERI mediated MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450341, Activation of the AP-1 family of transcription factors
SignaLinkiP53779
SIGNORiP53779

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5602, 5 hits in 907 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAPK10, human
EvolutionaryTraceiP53779

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAPK10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5602
PharosiP53779, Tchem

Protein Ontology

More...PROi		PR:P53779
RNActiP53779, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000109339, Expressed in frontal cortex and 198 other tissues
ExpressionAtlasiP53779, baseline and differential
GenevisibleiP53779, HS

Family and domain databases

DisProtiDP02328
IDEALiIID00456
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008351, MAPK_JNK
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PRINTSiPR01772, JNKMAPKINASE
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351, MAPK, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMK10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53779
Secondary accession number(s): A6NFS3
, A6NG28, B3KQ94, Q15707, Q49AP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: February 10, 2021
This is version 221 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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