UniProtKB - P53779 (MK10_HUMAN)
Mitogen-activated protein kinase 10
MAPK10
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 93 | ATP | 1 | |
Active sitei | 189 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 70 – 78 | ATP | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- JUN kinase activity Source: UniProtKB
- MAP kinase activity Source: GO_Central
- MAP kinase kinase activity Source: ProtInc
GO - Biological processi
- Fc-epsilon receptor signaling pathway Source: Reactome
- intracellular signal transduction Source: GO_Central
- JNK cascade Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of DNA-binding transcription factor activity Source: Reactome
- regulation of gene expression Source: GO_Central
- response to light stimulus Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Biological rhythms |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | P53779 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2871796, FCERI mediated MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450341, Activation of the AP-1 family of transcription factors |
SignaLinki | P53779 |
SIGNORi | P53779 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase 10 (EC:2.7.11.24)Short name: MAP kinase 10 Short name: MAPK 10 Alternative name(s): MAP kinase p49 3F12 Stress-activated protein kinase 1b Short name: SAPK1b Stress-activated protein kinase JNK3 c-Jun N-terminal kinase 3 |
Gene namesi | Name:MAPK10 Synonyms:JNK3, JNK3A, PRKM10, SAPK1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6872, MAPK10 |
MIMi | 602897, gene |
neXtProti | NX_P53779 |
VEuPathDBi | HostDB:ENSG00000109339.18 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Mitochondrion
- Mitochondrion 1 Publication
Other locations
- Cytoplasm 1 Publication
- Membrane 1 Publication; Lipid-anchor 1 Publication
Note: Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity).By similarity
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 462 | C → S: Loss of palmitoylation. 1 Publication | 1 | |
Mutagenesisi | 463 | C → S: Loss of palmitoylation. 1 Publication | 1 |
Keywords - Diseasei
Epilepsy, Mental retardationOrganism-specific databases
DisGeNETi | 5602 |
MalaCardsi | MAPK10 |
OpenTargetsi | ENSG00000109339 |
Orphaneti | 2382, Lennox-Gastaut syndrome |
PharmGKBi | PA30617 |
Miscellaneous databases
Pharosi | P53779, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2637 |
DrugBanki | DB08011, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime DB08010, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime DB08015, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime DB08555, 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline DB08026, 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide DB08005, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide DB08021, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide DB03623, 9-(4-Hydroxyphenyl)-2,7-Phenanthroline DB02388, Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine DB03084, Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine DB12010, Fostamatinib DB15624, Halicin DB01017, Minocycline DB07217, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide DB06933, N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE DB08023, N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine DB08025, N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB01782, Pyrazolanthrone |
DrugCentrali | P53779 |
GuidetoPHARMACOLOGYi | 1498 |
Genetic variation databases
BioMutai | MAPK10 |
DMDMi | 2507196 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186277 | 1 – 464 | Mitogen-activated protein kinase 10Add BLAST | 464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 221 | Phosphothreonine; by MAP2K71 Publication | 1 | |
Modified residuei | 223 | Phosphotyrosine; by MAP2K41 Publication | 1 | |
Lipidationi | 462 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 463 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | P53779 |
jPOSTi | P53779 |
MassIVEi | P53779 |
MaxQBi | P53779 |
PaxDbi | P53779 |
PeptideAtlasi | P53779 |
PRIDEi | P53779 |
ProteomicsDBi | 56616 [P53779-1] 56617 [P53779-2] 56618 [P53779-3] |
PTM databases
iPTMneti | P53779 |
PhosphoSitePlusi | P53779 |
SwissPalmi | P53779 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000109339, Expressed in frontal cortex and 198 other tissues |
ExpressionAtlasi | P53779, baseline and differential |
Genevisiblei | P53779, HS |
Organism-specific databases
HPAi | ENSG00000109339, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with MAPKBP1 (By similarity).
Interacts with MAPK8IP1/JIP-1 and MAPK8IP3/JIP-3/JSAP1 (By similarity).
Interacts with SPAG9/MAPK8IP4/JIP4 (PubMed:15693750).
Interacts with HDAC9 (PubMed:16611996).
Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5 (PubMed:18435604).
Interacts with SARM1 (By similarity).
Interacts with JUND; interaction is inhibited in the presence of MEN1 (PubMed:22327296).
By similarity4 PublicationsBinary interactionsi
Hide detailsP53779
With | #Exp. | IntAct |
---|---|---|
ARRB1 [P49407] | 2 | EBI-713543,EBI-743313 |
JUN [P05412] | 4 | EBI-713543,EBI-852823 |
JUND [P17535] | 2 | EBI-713543,EBI-2682803 |
RELA [Q04206] | 2 | EBI-713543,EBI-73886 |
Protein-protein interaction databases
BioGRIDi | 111588, 53 interactors |
CORUMi | P53779 |
DIPi | DIP-1015N |
ELMi | P53779 |
IntActi | P53779, 24 interactors |
MINTi | P53779 |
STRINGi | 9606.ENSP00000352157 |
Chemistry databases
BindingDBi | P53779 |
Miscellaneous databases
RNActi | P53779, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P53779 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53779 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 359 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 296 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 221 – 223 | TXY | 3 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0665, Eukaryota |
GeneTreei | ENSGT00940000153692 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | P53779 |
OMAi | REFKLMN |
OrthoDBi | 741207at2759 |
PhylomeDBi | P53779 |
TreeFami | TF105100 |
Family and domain databases
DisProti | DP02328 |
IDEALi | IID00456 |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008351, MAPK_JNK IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01772, JNKMAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 68 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS
60 70 80 90 100
VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ
110 120 130 140 150
NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD
160 170 180 190 200
ANLCQVIQME LDHERMSYLL YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD
210 220 230 240 250
CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG
260 270 280 290 300
CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN
310 320 330 340 350
RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV
360 370 380 390 400
DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN
410 420 430 440 450
SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD
460
SSLEASAGPL GCCR
The sequence of this isoform differs from the canonical sequence as follows:
418-464: GAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR → AQVQQ
Computationally mapped potential isoform sequencesi
There are 68 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YEW9 | A0A286YEW9_HUMAN | Mitogen-activated protein kinase | MAPK10 | 551 | Annotation score: | ||
A0A286YFD7 | A0A286YFD7_HUMAN | Mitogen-activated protein kinase | MAPK10 | 426 | Annotation score: | ||
A0A286YF97 | A0A286YF97_HUMAN | Mitogen-activated protein kinase | MAPK10 | 464 | Annotation score: | ||
A0A286YEQ7 | A0A286YEQ7_HUMAN | Mitogen-activated protein kinase | MAPK10 | 402 | Annotation score: | ||
F8W9R5 | F8W9R5_HUMAN | Mitogen-activated protein kinase | MAPK10 | 478 | Annotation score: | ||
A0A286YES9 | A0A286YES9_HUMAN | Mitogen-activated protein kinase | MAPK10 | 427 | Annotation score: | ||
A0A286YEN5 | A0A286YEN5_HUMAN | Mitogen-activated protein kinase | MAPK10 | 435 | Annotation score: | ||
A0A286YF62 | A0A286YF62_HUMAN | Mitogen-activated protein kinase | MAPK10 | 473 | Annotation score: | ||
A0A286YFA6 | A0A286YFA6_HUMAN | Mitogen-activated protein kinase | MAPK10 | 467 | Annotation score: | ||
A0A286YFI3 | A0A286YFI3_HUMAN | Mitogen-activated protein kinase | MAPK10 | 384 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 162 | D → G in BAG51956 (PubMed:14702039).Curated | 1 |
Mass spectrometryi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041911 | 1 – 38 | Missing in isoform 3. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_004839 | 418 – 464 | GAAVN…LGCCR → AQVQQ in isoform Alpha-1. 3 PublicationsAdd BLAST | 47 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JNK | X-ray | 2.30 | A | 1-423 | [»] | |
1PMN | X-ray | 2.20 | A | 40-401 | [»] | |
1PMU | X-ray | 2.70 | A | 40-401 | [»] | |
1PMV | X-ray | 2.50 | A | 40-401 | [»] | |
2B1P | X-ray | 1.90 | A | 46-400 | [»] | |
2EXC | X-ray | 2.75 | X | 45-400 | [»] | |
2O0U | X-ray | 2.10 | A | 39-402 | [»] | |
2O2U | X-ray | 2.45 | A | 39-402 | [»] | |
2OK1 | X-ray | 2.40 | A | 40-402 | [»] | |
2P33 | X-ray | 2.40 | A | 40-402 | [»] | |
2R9S | X-ray | 2.40 | A/B | 46-401 | [»] | |
2WAJ | X-ray | 2.40 | A | 39-402 | [»] | |
2ZDT | X-ray | 2.00 | A | 39-402 | [»] | |
2ZDU | X-ray | 2.50 | A | 39-402 | [»] | |
3CGF | X-ray | 3.00 | A | 40-402 | [»] | |
3CGO | X-ray | 3.00 | A | 40-402 | [»] | |
3DA6 | X-ray | 2.00 | A | 39-402 | [»] | |
3FI2 | X-ray | 2.28 | A | 39-402 | [»] | |
3FI3 | X-ray | 2.20 | A | 39-402 | [»] | |
3FV8 | X-ray | 2.28 | A | 39-402 | [»] | |
3G90 | X-ray | 2.40 | X | 40-402 | [»] | |
3G9L | X-ray | 2.20 | X | 40-402 | [»] | |
3G9N | X-ray | 2.80 | A | 40-402 | [»] | |
3KVX | X-ray | 2.40 | A | 39-402 | [»] | |
3OXI | X-ray | 2.20 | A | 40-401 | [»] | |
3OY1 | X-ray | 1.70 | A | 40-401 | [»] | |
3PTG | X-ray | 2.43 | A | 40-401 | [»] | |
3RTP | X-ray | 2.40 | A | 40-401 | [»] | |
3TTI | X-ray | 2.20 | A | 1-464 | [»] | |
3TTJ | X-ray | 2.10 | A | 1-464 | [»] | |
3V6R | X-ray | 2.60 | A/B | 39-402 | [»] | |
3V6S | X-ray | 2.97 | A/B | 39-402 | [»] | |
4H36 | X-ray | 3.00 | A | 45-400 | [»] | |
4H39 | X-ray | 1.99 | A | 45-400 | [»] | |
4H3B | X-ray | 2.08 | A/C | 45-400 | [»] | |
4KKE | X-ray | 2.20 | A | 40-402 | [»] | |
4KKG | X-ray | 2.40 | A | 40-402 | [»] | |
4KKH | X-ray | 2.00 | A | 40-402 | [»] | |
4U79 | X-ray | 2.23 | A | 39-402 | [»] | |
4W4V | X-ray | 2.01 | A | 39-402 | [»] | |
4W4W | X-ray | 1.90 | A | 39-402 | [»] | |
4W4X | X-ray | 2.65 | A | 39-402 | [»] | |
4W4Y | X-ray | 2.30 | A | 39-402 | [»] | |
4WHZ | X-ray | 1.79 | A | 39-423 | [»] | |
4X21 | X-ray | 1.95 | A/B | 39-402 | [»] | |
4Y46 | X-ray | 2.04 | A | 39-402 | [»] | |
4Y5H | X-ray | 2.06 | A | 39-402 | [»] | |
4Z9L | X-ray | 2.10 | A | 40-401 | [»] | |
6EKD | X-ray | 2.10 | A | 39-402 | [»] | |
6EMH | X-ray | 1.76 | A/B/C/D | 39-402 | [»] | |
6EQ9 | X-ray | 1.83 | A/B | 39-402 | [»] | |
SMRi | P53779 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111588, 53 interactors |
CORUMi | P53779 |
DIPi | DIP-1015N |
ELMi | P53779 |
IntActi | P53779, 24 interactors |
MINTi | P53779 |
STRINGi | 9606.ENSP00000352157 |
Chemistry databases
BindingDBi | P53779 |
ChEMBLi | CHEMBL2637 |
DrugBanki | DB08011, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime DB08010, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime DB08015, (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime DB08555, 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline DB08026, 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide DB08005, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide DB08021, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide DB03623, 9-(4-Hydroxyphenyl)-2,7-Phenanthroline DB02388, Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine DB03084, Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine DB12010, Fostamatinib DB15624, Halicin DB01017, Minocycline DB07217, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide DB06933, N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE DB08023, N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine DB08025, N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB01782, Pyrazolanthrone |
DrugCentrali | P53779 |
GuidetoPHARMACOLOGYi | 1498 |
PTM databases
iPTMneti | P53779 |
PhosphoSitePlusi | P53779 |
SwissPalmi | P53779 |
Genetic variation databases
BioMutai | MAPK10 |
DMDMi | 2507196 |
Proteomic databases
EPDi | P53779 |
jPOSTi | P53779 |
MassIVEi | P53779 |
MaxQBi | P53779 |
PaxDbi | P53779 |
PeptideAtlasi | P53779 |
PRIDEi | P53779 |
ProteomicsDBi | 56616 [P53779-1] 56617 [P53779-2] 56618 [P53779-3] |
Protocols and materials databases
Antibodypediai | 14345, 515 antibodies |
DNASUi | 5602 |
Genome annotation databases
Organism-specific databases
CTDi | 5602 |
DisGeNETi | 5602 |
GeneCardsi | MAPK10 |
HGNCi | HGNC:6872, MAPK10 |
HPAi | ENSG00000109339, Tissue enhanced (brain) |
MalaCardsi | MAPK10 |
MIMi | 602897, gene |
neXtProti | NX_P53779 |
OpenTargetsi | ENSG00000109339 |
Orphaneti | 2382, Lennox-Gastaut syndrome |
PharmGKBi | PA30617 |
VEuPathDBi | HostDB:ENSG00000109339.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0665, Eukaryota |
GeneTreei | ENSGT00940000153692 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | P53779 |
OMAi | REFKLMN |
OrthoDBi | 741207at2759 |
PhylomeDBi | P53779 |
TreeFami | TF105100 |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | P53779 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2871796, FCERI mediated MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450341, Activation of the AP-1 family of transcription factors |
SignaLinki | P53779 |
SIGNORi | P53779 |
Miscellaneous databases
BioGRID-ORCSi | 5602, 5 hits in 907 CRISPR screens |
ChiTaRSi | MAPK10, human |
EvolutionaryTracei | P53779 |
GeneWikii | MAPK10 |
GenomeRNAii | 5602 |
Pharosi | P53779, Tchem |
PROi | PR:P53779 |
RNActi | P53779, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109339, Expressed in frontal cortex and 198 other tissues |
ExpressionAtlasi | P53779, baseline and differential |
Genevisiblei | P53779, HS |
Family and domain databases
DisProti | DP02328 |
IDEALi | IID00456 |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008351, MAPK_JNK IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01772, JNKMAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MK10_HUMAN | |
Accessioni | P53779Primary (citable) accession number: P53779 Secondary accession number(s): A6NFS3 Q49AP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 221 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families