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Protein

LIM/homeobox protein Lhx4

Gene

Lhx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi157 – 216HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • medial motor column neuron differentiation Source: MGI
  • motor neuron axon guidance Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • placenta development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx4
Short name:
LIM homeobox protein 4
Gene namesi
Name:Lhx4
Synonyms:Gsh-4, Gsh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:101776 Lhx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757881 – 390LIM/homeobox protein Lhx4Add BLAST390

Proteomic databases

PaxDbiP53776
PRIDEiP53776

PTM databases

iPTMnetiP53776
PhosphoSitePlusiP53776

Expressioni

Tissue specificityi

Transient expression in ventrolateral regions of the developing neural tube and hindbrain.

Gene expression databases

BgeeiENSMUSG00000026468
CleanExiMM_LHX4
ExpressionAtlasiP53776 baseline and differential
GenevisibleiP53776 MM

Interactioni

Protein-protein interaction databases

BioGridi201157, 3 interactors
STRINGi10090.ENSMUSP00000027740

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni31 – 33Combined sources3
Beta strandi40 – 45Combined sources6
Beta strandi48 – 50Combined sources3
Helixi52 – 54Combined sources3
Turni58 – 60Combined sources3
Beta strandi66 – 71Combined sources6
Beta strandi74 – 76Combined sources3
Helixi78 – 82Combined sources5
Turni90 – 92Combined sources3
Beta strandi102 – 105Combined sources4
Beta strandi108 – 110Combined sources3
Turni112 – 114Combined sources3
Turni118 – 120Combined sources3
Beta strandi129 – 133Combined sources5
Beta strandi138 – 140Combined sources3
Helixi141 – 146Combined sources6

3D structure databases

ProteinModelPortaliP53776
SMRiP53776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 87LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini88 – 150LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 181Interaction with DNABy similarityAdd BLAST21
Regioni199 – 211Interaction with 5-mCpG DNABy similarityAdd BLAST13

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG4577 Eukaryota
ENOG410XPDC LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000231629
HOVERGENiHBG006263
InParanoidiP53776
KOiK09374
OMAiCSQHILD
OrthoDBiEOG091G0BSD
PhylomeDBiP53776
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

P53776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQSAAVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW
60 70 80 90 100
HSSCLKCADC QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ
110 120 130 140 150
VVRKAQDFVY HLHCFACIIC NRQLATGDEF YLMEDGRLVC KEDYETAKQN
160 170 180 190 200
DDSEAGAKRP RTTITAKQLE TLKNAYKNSP KPARHVREQL SSETGLDMRV
210 220 230 240 250
VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGGSKQ EKESSAEDCG
260 270 280 290 300
VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ
310 320 330 340 350
DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ
360 370 380 390
TLRAMAGGPT SDLSTGSSVG YPDFPTSPAS WLDEMDHPPF
Length:390
Mass (Da):43,078
Last modified:October 14, 2008 - v4
Checksum:iFF70967D30C724C4
GO

Sequence cautioni

The sequence AAD30125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377S → T in AAH49834 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049834 mRNA Translation: AAH49834.1
AF135415 mRNA Translation: AAD30125.1 Different initiation.
U89343 mRNA Translation: AAC53336.1
S71659 mRNA Translation: AAB31260.1
CCDSiCCDS48399.1
PIRiS46332
RefSeqiNP_034842.2, NM_010712.2
UniGeneiMm.103624
Mm.351266

Genome annotation databases

EnsembliENSMUST00000027740; ENSMUSP00000027740; ENSMUSG00000026468
GeneIDi16872
KEGGimmu:16872
UCSCiuc007dbn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLHX4_MOUSE
AccessioniPrimary (citable) accession number: P53776
Secondary accession number(s): O08916, Q810K7, Q9R280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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