UniProtKB - P53742 (NOG2_YEAST)
Protein
Nucleolar GTP-binding protein 2
Gene
NOG2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.1 Publication
Miscellaneous
Present with 67700 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 322 – 329 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 366 – 370 | GTPSequence analysis | 5 |
GO - Molecular functioni
- GTPase activity Source: SGD
- GTP binding Source: UniProtKB-KW
- large ribosomal subunit rRNA binding Source: SGD
GO - Biological processi
- regulation of ribosomal subunit export from nucleus Source: SGD
- ribosomal large subunit export from nucleus Source: SGD
Keywordsi
Biological process | Ribosome biogenesis |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar GTP-binding protein 2 |
Gene namesi | Name:NOG2 Ordered Locus Names:YNR053C ORF Names:N3484 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNR053C |
SGDi | S000005336, NOG2 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: SGD
- nucleoplasm Source: SGD
- nucleus Source: SGD
Other locations
- preribosome, large subunit precursor Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215817 | 1 – 486 | Nucleolar GTP-binding protein 2Add BLAST | 486 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Modified residuei | 155 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53742 |
PaxDbi | P53742 |
PRIDEi | P53742 |
PTM databases
iPTMneti | P53742 |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 35878, 414 interactors |
DIPi | DIP-976N |
IntActi | P53742, 58 interactors |
MINTi | P53742 |
STRINGi | 4932.YNR053C |
Miscellaneous databases
RNActi | P53742, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 373 | CP-type GPROSITE-ProRule annotationAdd BLAST | 162 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2423, Eukaryota |
GeneTreei | ENSGT00810000125524 |
HOGENOMi | CLU_011106_4_0_1 |
InParanoidi | P53742 |
OMAi | KTGDGMG |
Family and domain databases
Gene3Di | 1.10.1580.10, 1 hit |
InterProi | View protein in InterPro IPR030378, G_CP_dom IPR023179, GTP-bd_ortho_bundle_sf IPR006073, GTP_binding_domain IPR024929, NOG2 IPR012971, NOG2_N_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11089:SF9, PTHR11089:SF9, 1 hit |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit PF08153, NGP1NT, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51721, G_CP, 1 hit |
i Sequence
Sequence statusi: Complete.
P53742-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN
60 70 80 90 100
KKGNLIRAAS FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ
110 120 130 140 150
KDTYQVLLRR NKLPMSLLEE KDADESPKAR ILDTESYADA FGPKAQRKRP
160 170 180 190 200
RLAASNLEDL VKATNEDITK YEEKQVLDAT LGLMGNQEDK ENGWTSAAKE
210 220 230 240 250
AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK SVEEYMKKET
260 270 280 290 300
PHKHLIYVLN KCDLVPTWVA AAWVKHLSKE RPTLAFHASI TNSFGKGSLI
310 320 330 340 350
QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET
360 370 380 390 400
KVWQYITLMK RIFLIDCPGI VPPSSKDSEE DILFRGVVRV EHVTHPEQYI
410 420 430 440 450
PGVLKRCQVK HLERTYEISG WKDATEFIEI LARKQGRLLK GGEPDESGVS
460 470 480
KQILNDFNRG KIPWFVLPPE KEGEEKPKKK EVEKTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71668 Genomic DNA Translation: CAA96334.1 BK006947 Genomic DNA Translation: DAA10594.1 |
PIRi | S63384 |
RefSeqi | NP_014451.1, NM_001183230.1 |
Genome annotation databases
EnsemblFungii | YNR053C_mRNA; YNR053C; YNR053C |
GeneIDi | 855789 |
KEGGi | sce:YNR053C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71668 Genomic DNA Translation: CAA96334.1 BK006947 Genomic DNA Translation: DAA10594.1 |
PIRi | S63384 |
RefSeqi | NP_014451.1, NM_001183230.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCT | electron microscopy | 3.08 | m | 1-486 | [»] | |
6FT6 | electron microscopy | 3.90 | m | 1-486 | [»] | |
6M62 | electron microscopy | 3.20 | m | 1-486 | [»] | |
6N8J | electron microscopy | 3.50 | m | 1-486 | [»] | |
6YLG | electron microscopy | 3.00 | m | 1-486 | [»] | |
6YLH | electron microscopy | 3.10 | m | 1-486 | [»] | |
SMRi | P53742 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35878, 414 interactors |
DIPi | DIP-976N |
IntActi | P53742, 58 interactors |
MINTi | P53742 |
STRINGi | 4932.YNR053C |
PTM databases
iPTMneti | P53742 |
Proteomic databases
MaxQBi | P53742 |
PaxDbi | P53742 |
PRIDEi | P53742 |
Genome annotation databases
EnsemblFungii | YNR053C_mRNA; YNR053C; YNR053C |
GeneIDi | 855789 |
KEGGi | sce:YNR053C |
Organism-specific databases
EuPathDBi | FungiDB:YNR053C |
SGDi | S000005336, NOG2 |
Phylogenomic databases
eggNOGi | KOG2423, Eukaryota |
GeneTreei | ENSGT00810000125524 |
HOGENOMi | CLU_011106_4_0_1 |
InParanoidi | P53742 |
OMAi | KTGDGMG |
Miscellaneous databases
PROi | PR:P53742 |
RNActi | P53742, protein |
Family and domain databases
Gene3Di | 1.10.1580.10, 1 hit |
InterProi | View protein in InterPro IPR030378, G_CP_dom IPR023179, GTP-bd_ortho_bundle_sf IPR006073, GTP_binding_domain IPR024929, NOG2 IPR012971, NOG2_N_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11089:SF9, PTHR11089:SF9, 1 hit |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit PF08153, NGP1NT, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51721, G_CP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOG2_YEAST | |
Accessioni | P53742Primary (citable) accession number: P53742 Secondary accession number(s): D6W1M8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD