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UniProtKB - P53708 (ITA8_HUMAN)

Entry version 174 (02 Dec 2020)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
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Protein

Integrin alpha-8

Gene

ITGA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi329 – 337Sequence analysis9
Calcium bindingi395 – 403Sequence analysis9
Calcium bindingi459 – 467Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Integrin, Receptor
Biological processCell adhesion, Differentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53708

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2129379, Molecules associated with elastic fibres
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000178, ECM proteoglycans

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P53708

SIGNOR Signaling Network Open Resource

More...SIGNORi		P53708

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-8
Cleaved into the following 2 chains:
Integrin alpha-8 heavy chain
Integrin alpha-8 light chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000077943.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:6144, ITGA8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604063, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53708

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini39 – 1012ExtracellularSequence analysisAdd BLAST974
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1013 – 1033HelicalSequence analysisAdd BLAST21
Topological domaini1034 – 1063CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal hypodysplasia/aplasia 1 (RHDA1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071106255T → M in RHDA1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777281EnsemblClinVar.1
Natural variantiVAR_071107407G → R in RHDA1; the mutant does not localize at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs374664941EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		8516

MalaCards human disease database

More...MalaCardsi		ITGA8
MIMi191830, phenotype

Open Targets

More...OpenTargetsi		ENSG00000077943

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1848, Renal agenesis, bilateral

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29944

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53708, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ITGA8

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001631039 – 1063Integrin alpha-8Add BLAST1025
ChainiPRO_000001631139 – 906Integrin alpha-8 heavy chainSequence analysisAdd BLAST868
ChainiPRO_0000016312907 – 1063Integrin alpha-8 light chainSequence analysisAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi96 ↔ 106By similarity
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 171By similarity
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi187 ↔ 200By similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi507 ↔ 518By similarity
Disulfide bondi524 ↔ 580By similarity
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi641 ↔ 647By similarity
Disulfide bondi713 ↔ 726By similarity
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi753N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi867 ↔ 924Interchain (between heavy and light chains)By similarity
Glycosylationi896N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi923N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi929 ↔ 934By similarity
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53708

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53708

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53708

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53708

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53708

PeptideAtlas

More...PeptideAtlasi		P53708

PRoteomics IDEntifications database

More...PRIDEi		P53708

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56614

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P53708, 16 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53708

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53708

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077943, Expressed in thoracic aorta and 202 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53708, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077943, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114088, 25 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1815, Integrin alpha8-beta1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P53708

Protein interaction database and analysis system

More...IntActi		P53708, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367316

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P53708

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53708, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53708

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati44 – 105FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati122 – 183FG-GAP 2PROSITE-ProRule annotationAdd BLAST62
Repeati188 – 240FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati253 – 306FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati307 – 372FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati373 – 431FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati435 – 498FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi455 – 457Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3637, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004111_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53708

Identification of Orthologs from Complete Genome Data

More...OMAi		NNEDAFE

Database of Orthologous Groups

More...OrthoDBi		743479at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53708

TreeFam database of animal gene trees

More...TreeFami		TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00191, Int_alpha, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69179, SSF69179, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P53708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPGASRGPR GSQAPLIAPL CCAAAALGML LWSPACQAFN LDVEKLTVYS 
        60         70         80         90        100
GPKGSYFGYA VDFHIPDART ASVLVGAPKA NTSQPDIVEG GAVYYCPWPA 
       110        120        130        140        150
EGSAQCRQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC 
       160        170        180        190        200
APLYHWRTLK PTPEKDPVGT CYVAIQNFSA YAEFSPCRNS NADPEGQGYC 
       210        220        230        240        250
QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ASVADIIANY SFKDILRKLA 
       260        270        280        290        300
GEKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQELVAGIPR GAQNFGYVSI 
       310        320        330        340        350
INSTDMTFIQ NFTGEQMASY FGYTVVVSDV NSDGLDDVLV GAPLFMEREF 
       360        370        380        390        400
ESNPREVGQI YLYLQVSSLL FRDPQILTGT ETFGRFGSAM AHLGDLNQDG 
       410        420        430        440        450
YNDIAIGVPF AGKDQRGKVL IYNGNKDGLN TKPSQVLQGV WASHAVPSGF 
       460        470        480        490        500
GFTLRGDSDI DKNDYPDLIV GAFGTGKVAV YRARPVVTVD AQLLLHPMII 
       510        520        530        540        550
NLENKTCQVP DSMTSAACFS LRVCASVTGQ SIANTIVLMA EVQLDSLKQK 
       560        570        580        590        600
GAIKRTLFLD NHQAHRVFPL VIKRQKSHQC QDFIVYLRDE TEFRDKLSPI 
       610        620        630        640        650
NISLNYSLDE STFKEGLEVK PILNYYRENI VSEQAHILVD CGEDNLCVPD 
       660        670        680        690        700
LKLSARPDKH QVIIGDENHL MLIINARNEG EGAYEAELFV MIPEEADYVG 
       710        720        730        740        750
IERNNKGFRP LSCEYKMENV TRMVVCDLGN PMVSGTNYSL GLRFAVPRLE 
       760        770        780        790        800
KTNMSINFDL QIRSSNKDNP DSNFVSLQIN ITAVAQVEIR GVSHPPQIVL 
       810        820        830        840        850
PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISDTIL EVGWPFSARD 
       860        870        880        890        900
EFLLYIFHIQ TLGPLQCQPN PNINPQDIKP AASPEDTPEL SAFLRNSTIP 
       910        920        930        940        950
HLVRKRDVHV VEFHRQSPAK ILNCTNIECL QISCAVGRLE GGESAVLKVR 
       960        970        980        990       1000
SRLWAHTFLQ RKNDPYALAS LVSFEVKKMP YTDQPAKLPE GSIVIKTSVI 
      1010       1020       1030       1040       1050
WATPNVSFSI PLWVIILAIL LGLLVLAILT LALWKCGFFD RARPPQEDMT 
      1060 
DREQLTNDKT PEA
Length:1,063
Mass (Da):117,474
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F9614BDBB897D77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47T → A in AAA93514 (PubMed:7768999).Curated1
Sequence conflicti166D → G in AAA93514 (PubMed:7768999).Curated1
Sequence conflicti188R → G in AAA93514 (PubMed:7768999).Curated1
Sequence conflicti304T → Y in AAA93514 (PubMed:7768999).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018673216V → L1 PublicationCorresponds to variant dbSNP:rs7895372EnsemblClinVar.1
Natural variantiVAR_071106255T → M in RHDA1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777281EnsemblClinVar.1
Natural variantiVAR_071107407G → R in RHDA1; the mutant does not localize at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs374664941EnsemblClinVar.1
Natural variantiVAR_034682567V → L1 Publication1
Natural variantiVAR_018674577S → F2 PublicationsCorresponds to variant dbSNP:rs2298033Ensembl.1
Natural variantiVAR_018675581Q → P2 PublicationsCorresponds to variant dbSNP:rs9333269Ensembl.1
Natural variantiVAR_018676748R → H2 PublicationsCorresponds to variant dbSNP:rs9333174EnsemblClinVar.1
Natural variantiVAR_018677993I → V2 PublicationsCorresponds to variant dbSNP:rs9333241EnsemblClinVar.1
Natural variantiVAR_018678994V → A3 PublicationsCorresponds to variant dbSNP:rs1041135Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY371697 Genomic DNA Translation: AAQ56848.2
EF444991 Genomic DNA Translation: ACA06009.1
AL359645 Genomic DNA No translation available.
AL590636 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86235.1
L36531 mRNA Translation: AAA93514.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31155.1

NCBI Reference Sequences

More...RefSeqi		NP_003629.2, NM_003638.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378076; ENSP00000367316; ENSG00000077943

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8516

UCSC genome browser

More...UCSCi		uc001ioc.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY371697 Genomic DNA Translation: AAQ56848.2
EF444991 Genomic DNA Translation: ACA06009.1
AL359645 Genomic DNA No translation available.
AL590636 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86235.1
L36531 mRNA Translation: AAA93514.1
CCDSiCCDS31155.1
RefSeqiNP_003629.2, NM_003638.2

3D structure databases

SMRiP53708
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114088, 25 interactors
ComplexPortaliCPX-1815, Integrin alpha8-beta1 complex
CORUMiP53708
IntActiP53708, 15 interactors
STRINGi9606.ENSP00000367316

Chemistry databases

BindingDBiP53708

PTM databases

GlyGeniP53708, 16 sites
iPTMnetiP53708
PhosphoSitePlusiP53708

Polymorphism and mutation databases

BioMutaiITGA8
DMDMi311033437

Proteomic databases

EPDiP53708
jPOSTiP53708
MassIVEiP53708
MaxQBiP53708
PaxDbiP53708
PeptideAtlasiP53708
PRIDEiP53708
ProteomicsDBi56614

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		961, 202 antibodies

The DNASU plasmid repository

More...DNASUi		8516

Genome annotation databases

EnsembliENST00000378076; ENSP00000367316; ENSG00000077943
GeneIDi8516
KEGGihsa:8516
UCSCiuc001ioc.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8516
DisGeNETi8516
EuPathDBiHostDB:ENSG00000077943.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		ITGA8
HGNCiHGNC:6144, ITGA8
HPAiENSG00000077943, Low tissue specificity
MalaCardsiITGA8
MIMi191830, phenotype
604063, gene
neXtProtiNX_P53708
OpenTargetsiENSG00000077943
Orphaneti1848, Renal agenesis, bilateral
PharmGKBiPA29944

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3637, Eukaryota
GeneTreeiENSGT00940000156737
HOGENOMiCLU_004111_4_0_1
InParanoidiP53708
OMAiNNEDAFE
OrthoDBi743479at2759
PhylomeDBiP53708
TreeFamiTF105391

Enzyme and pathway databases

PathwayCommonsiP53708
ReactomeiR-HSA-2129379, Molecules associated with elastic fibres
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000178, ECM proteoglycans
SignaLinkiP53708
SIGNORiP53708

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8516, 1 hit in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITGA8, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ITGA8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8516
PharosiP53708, Tbio

Protein Ontology

More...PROi		PR:P53708
RNActiP53708, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077943, Expressed in thoracic aorta and 202 other tissues
GenevisibleiP53708, HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 6 hits
SUPFAMiSSF69179, SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53708
Secondary accession number(s): B0YJ31, Q5VX94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2010
Last modified: December 2, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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