Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 104 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Alpha-factor-transporting ATPase

Gene

HST6

Organism
Candida albicans (strain WO-1) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi408 – 415ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1071 – 1078ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-factor-transporting ATPase (EC:7.4.2.7)
Alternative name(s):
ATP-dependent permease HST6
STE6 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HST6
ORF Names:CAWG_02961
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain WO-1) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri294748 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei93 – 113HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei169 – 189HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei192 – 212HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei281 – 301HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei315 – 335HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei677 – 697HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei724 – 744HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei801 – 821HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei828 – 848HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei909 – 929HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei941 – 961HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1120 – 1140HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1170 – 1190HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933711 – 1323Alpha-factor-transporting ATPaseAdd BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi777N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1030N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1097N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1192N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 337ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST293
Domaini373 – 609ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini678 – 969ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST292
Domaini1035 – 1321ABC transporter 2PROSITE-ProRule annotationAdd BLAST287

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni1194 – 1217DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_17_8_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPTIFPG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR030246, Ste6/Hst6

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF372, PTHR24223:SF372, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53706-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQEKSEKSS FPKRSSSLRS PSDSPAITSK NVFMFVNYSK DWPLILVGIL
60 70 80 90 100
LMGGSAIATL MNTYIYGEIM GKLSQFYLQD QSNHSFSQDI VKLCVGLIGI
110 120 130 140 150
GCCKMILVWL GMFTWLKFGE IQQSRARMQI YNKIINESQS WYDSKQNLIG
160 170 180 190 200
QLTQINRCIE ELRSCNGEIL ASLMQTIVLI LALLIMSFYQ SWSTTLIIMA
210 220 230 240 250
SFPIMALCGW YFGKLTYKAQ QDENEVTSKA SKVFNWCYVN PEMVRFFNSK
260 270 280 290 300
NIELTKFKQL IEKSAQFYYK LSHAVAANTA VLKTLTLMMF VQGFWFGNYL
310 320 330 340 350
LSHKTITINQ LFTCFSSCLM LGQAVSGITE LLAILNTGHA AADKISGFLL
360 370 380 390 400
QPPSKAKLLL LHSKYPPFEI GSIYFKNVWF ESNSQNSVAI LQDVSFGILQ
410 420 430 440 450
NQFNYVIGKS GSGKSTIAKL LMRLYSVSRG TIEIDTVSID KLDPKYICQN
460 470 480 490 500
ITLLEQNPVI FDDKTIAENI AIAIVDDYDS LQAIPYYLIE QSAHFALLSD
510 520 530 540 550
LDLNMKVNHL TLSGGQQQRI SIARAYLKNS PVLIMDESFS ALDTETKQGL
560 570 580 590 600
IEKVKKWRIG KTTIFITHEY KNILDDENVI ILDQGMIKNQ GQFKKMKNEE
610 620 630 640 650
IVQNYKSQGI ETSSYETTSQ SFSDNTKLPD GDYNYKTNPY ILKDLESQIK
660 670 680 690 700
EDTDNEKLMG VLAILRYCSS TINGKSLLGF GILLAIFQGV SSPVFSYCFS
710 720 730 740 750
KLLSTSLDSS IGLNSTQKIL QWSCISLSIA IFTGVTSYLS EFILNYCGEN
760 770 780 790 800
WIVSLRQLTF FKLNNQDLSF FTGFDTNWSS SEITALLMND TRDLRNLISQ
810 820 830 840 850
FFPLLANLVS MTLIGIIWSI VSGWKLALVG ISFVPLVLLV TVLYGKILES
860 870 880 890 900
IENKYKCKVN NVELDLYRTI TTIRTIKIFN IQQYFETVFK EDLKVLNSIG
910 920 930 940 950
VYRALQTGIG FAISDLFSSI GQAIILFYGM KLISQFQYNY SQLLQVITLL
960 970 980 990 1000
SFTISNASIL IHQLPEITRG QRAGTFIVKL LKDITSTMEV NDSCGVSSVR
1010 1020 1030 1040 1050
KRNSKSGSDS IGTIGPVKDN QLFKKVTTDN DTLAISFNNV SFSYPNKLPY
1060 1070 1080 1090 1100
ILQLKSISLD VKKFTTIGIV GQSGSGKSTI LKILFRLYDI KISPDSNTTK
1110 1120 1130 1140 1150
KYHDQTVKIF NQNLYLINSG LLCQTIAIVP QFPKFFSGTI YDNLTYGINN
1160 1170 1180 1190 1200
TNSAGSNSSS SVSDSEIIKI LKLVNLHQFI VSLPQGLLTI MNDSDNDNDN
1210 1220 1230 1240 1250
GNENENENEN GNTISTSSST SFTFSGGQLQ LLAIARALLR NPKILLLDEC
1260 1270 1280 1290 1300
TSNLDPITTK IIINVIKSLH GKLTILFVTH DKELMRIADN LIVMKDGQIV
1310 1320
EQGDFQQLIS NDGEFTKITK TII
Length:1,323
Mass (Da):148,502
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DB102B209869C53
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13193 Genomic DNA Translation: AAC49910.1
CM000310 Genomic DNA Translation: EEQ44685.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18214

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EEQ44685; EEQ44685; CAWG_02961

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13193 Genomic DNA Translation: AAC49910.1
CM000310 Genomic DNA Translation: EEQ44685.1
PIRiT18214

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiEEQ44685; EEQ44685; CAWG_02961

Phylogenomic databases

HOGENOMiCLU_000604_17_8_1
OMAiQPTIFPG

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR030246, Ste6/Hst6
PANTHERiPTHR24223:SF372, PTHR24223:SF372, 2 hits
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHST6_CANAW
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53706
Secondary accession number(s): C4YP26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 2, 2021
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again