UniProtKB - P53700 (CCHL_CANAW)
Protein
Holocytochrome-c synthase
Gene
CYC3
Organism
Candida albicans (strain WO-1) (Yeast)
Status
Functioni
Lyase that probably catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.1 Publication
Catalytic activityi
GO - Molecular functioni
- holocytochrome-c synthase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.4.1.17, 1096 |
Names & Taxonomyi
Protein namesi | Recommended name: Holocytochrome-c synthase1 Publication (EC:4.4.1.171 Publication)Alternative name(s): Cytochrome c heme lyase1 Publication Short name: CCHL |
Gene namesi | Name:CYC3 ORF Names:CAWG_04502 |
Organismi | Candida albicans (strain WO-1) (Yeast) |
Taxonomic identifieri | 294748 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121717 | 1 – 264 | Holocytochrome-c synthaseAdd BLAST | 264 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 25 – 30 | HRM 1 | 6 | |
Repeati | 39 – 44 | HRM 2 | 6 |
Sequence similaritiesi
Belongs to the cytochrome c-type heme lyase family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
HOGENOMi | CLU_048602_0_1_1 |
OMAi | YPSKFGT |
Family and domain databases
InterProi | View protein in InterPro IPR000511, Cyt_C/C1_haem_lyase |
PANTHERi | PTHR12743, PTHR12743, 1 hit |
Pfami | View protein in Pfam PF01265, Cyto_heme_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00821, CYTO_HEME_LYASE_1, 1 hit PS00822, CYTO_HEME_LYASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P53700-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGWFWADKPS QDTVKATSSF TTPSACPIDH SKLASSSPTC PVKLNNDNDE
60 70 80 90 100
VLNPLNNMPM AISSERAPGQ RIKLSTERTI STIPRGESED QGLWEYPSPQ
110 120 130 140 150
QMLNAMLSKG KGDGVPEDAV ESMVEVHNFL NEGAWQQILT WEDQYTQQTK
160 170 180 190 200
VEPRLKKFTG RPHDLSPKAR MYLWLGQLFP ETFNTIPPFD RHDWTVLRSC
210 220 230 240 250
GRNQGWKEVR YVIDYYGAPD DEETGMPAFM LDTRPALDNL TNARDRFTHW
260
AYPLWKKAMG EVRD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | G → V in AAB04135 (PubMed:9786186).Curated | 1 | |
Sequence conflicti | 224 | T → A in AAB04135 (PubMed:9786186).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62148 Genomic DNA Translation: AAB04135.1 CM000311 Genomic DNA Translation: EEQ46157.1 |
Genome annotation databases
EnsemblFungii | EEQ46157; EEQ46157; CAWG_04502 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62148 Genomic DNA Translation: AAB04135.1 CM000311 Genomic DNA Translation: EEQ46157.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblFungii | EEQ46157; EEQ46157; CAWG_04502 |
Phylogenomic databases
HOGENOMi | CLU_048602_0_1_1 |
OMAi | YPSKFGT |
Enzyme and pathway databases
BRENDAi | 4.4.1.17, 1096 |
Family and domain databases
InterProi | View protein in InterPro IPR000511, Cyt_C/C1_haem_lyase |
PANTHERi | PTHR12743, PTHR12743, 1 hit |
Pfami | View protein in Pfam PF01265, Cyto_heme_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00821, CYTO_HEME_LYASE_1, 1 hit PS00822, CYTO_HEME_LYASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCHL_CANAW | |
Accessioni | P53700Primary (citable) accession number: P53700 Secondary accession number(s): C4YR04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 19, 2011 | |
Last modified: | February 10, 2021 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |