UniProtKB - P53690 (MMP14_MOUSE)

BLAST

>sp|P53690|MMP14_MOUSE Matrix metalloproteinase-14 OS=Mus musculus OX=10090 GN=Mmp14 PE=2 SV=3
MSPAPRPSRSLLLPLLTLGTALASLGWAQGSNFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADLATMMAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIL
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHE
LGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTT
SRPSVPDKPKNPAYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEEFRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGSGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV

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History
Entry version 176 (07 Nov 2018)
Sequence version 3 (27 Jul 2011)
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Protein

Matrix metalloproteinase-14

Gene

Mmp14

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity).By similarity1 Publication

Catalytic activityⁱ

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.

Cofactorⁱ

Protein has several cofactor binding sites:

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity
Ca²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	93	Zinc; in inhibited formBy similarity	1
Metal bindingⁱ	239	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	240	PROSITE-ProRule annotation	1
Metal bindingⁱ	243	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	249	Zinc; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

endopeptidase activity Source: MGI
integrin binding Source: MGI
metalloaminopeptidase activity Source: MGI
metalloendopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21572390
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
astrocyte cell migration Source: Ensembl
bone development
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
branching morphogenesis of an epithelial tube
Source: MGI
Inferred from mutant phenotypeⁱ
- 15572153
cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 15572153
chondrocyte proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
collagen catabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
craniofacial suture morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
embryonic cranial skeleton morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
endochondral ossification
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
endodermal cell differentiation Source: Ensembl
endothelial cell proliferation Source: Ensembl
head development
Source: MGI
Inferred from mutant phenotypeⁱ
- 26234751
lung development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15572153
male gonad development Source: Ensembl
negative regulation of focal adhesion assembly Source: MGI
negative regulation of Notch signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21572390
ossification
Source: MGI
Inferred from genetic interactionⁱ
- 18022611
ovarian follicle development Source: Ensembl
positive regulation of B cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21572390
positive regulation of cell growth Source: MGI
positive regulation of cell migration Source: MGI
positive regulation of macrophage migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24990232
positive regulation of myotube differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21572390
positive regulation of protein processing Source: MGI
proteolysis Source: MGI
regulation of protein localization to plasma membrane Source: MGI
response to estrogen Source: Ensembl
response to hormone Source: MGI
response to hypoxia Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to odorant Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to oxidative stress Source: Ensembl
tissue remodeling Source: MGI
zymogen activation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15572153

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Metalloprotease, Protease
Biological process	Collagen degradation
Ligand	Calcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1592389 Activation of Matrix Metalloproteinases

Reactomeⁱ

R-MMU-1442490 Collagen degradation
R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M10.014

MEROPSⁱ

M10.014

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Matrix metalloproteinase-14 (EC:3.4.24.80) Short name: MMP-14 Alternative name(s): MMP-X1 MT-MMP Membrane-type matrix metalloproteinase 1 Short name: MT-MMP 1 Short name: MTMMP1 Membrane-type-1 matrix metalloproteinase Short name: MT1-MMP Short name: MT1MMP
Gene namesⁱ	Name:Mmp14 Synonyms:Mtmmp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:101900 Mmp14

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	112 – 541	ExtracellularSequence analysisAdd BLAST	430
Transmembraneⁱ	542 – 562	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	563 – 582	CytoplasmicSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
PropeptideⁱPRO_0000028800	21 – 111	By similarityAdd BLAST	91
ChainⁱPRO_0000028801	112 – 582	Matrix metalloproteinase-14Add BLAST	471

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	319 ↔ 508	By similarity
Modified residueⁱ	399	Phosphotyrosine; by PKDCCBy similarity		1

Post-translational modificationⁱ

The precursor is cleaved by a furin endopeptidase.By similarity

Tyrosine phosphorylated by PKDCC/VLK.By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53690
PaxDbⁱ	P53690
PeptideAtlas More...PeptideAtlasⁱ	P53690
PRIDEⁱ	P53690

PTM databases

iPTMnetⁱ	P53690
PhosphoSitePlusⁱ	P53690
SwissPalmⁱ	P53690

Expressionⁱ

Tissue specificityⁱ

Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues.

Developmental stageⁱ

Not detected before day 10.5. At day 12.5, prominently expressed in large arteries and the umbilical arteries, expressed at lower levels in the myocardium, craniofacial mesenchyme, nasal epithelium and liver capsule. At days 14.5 and 17.5, expressed in the musculoskeletal system, and ossification areas, with continued expression in the arterial tunica media.

Gene expression databases

Bgeeⁱ	ENSMUSG00000000957 Expressed in 276 organ(s), highest expression level in uterus
CleanExⁱ	MM_MMP14
ExpressionAtlasⁱ	P53690 baseline and differential
Genevisibleⁱ	P53690 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling.By similarity

GO - Molecular functionⁱ

integrin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P53690, 1 interactor
Molecular INTeraction database More...MINTⁱ	P53690
STRINGⁱ	10090.ENSMUSP00000087119

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P53690
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	316 – 364	Hemopexin 1Add BLAST	49
Repeatⁱ	365 – 410	Hemopexin 2Add BLAST	46
Repeatⁱ	412 – 460	Hemopexin 3Add BLAST	49
Repeatⁱ	461 – 508	Hemopexin 4Add BLAST	48

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	91 – 98	Cysteine switchBy similarity		8

Domainⁱ

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesⁱ

Belongs to the peptidase M10A family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1565 Eukaryota ENOG410XQ5D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118870
HOGENOMⁱ	HOG000217928
HOVERGENⁱ	HBG052484
InParanoidⁱ	P53690
KEGG Orthology (KO) More...KOⁱ	K07763
OMAⁱ	NAVMFPW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03DP
TreeFamⁱ	TF352396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00094 HX, 1 hit cd04278 ZnMc_MMP, 1 hit
Gene3Dⁱ	1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR000585 Hemopexin-like_dom IPR036375 Hemopexin-like_dom_sf IPR018487 Hemopexin-like_repeat IPR018486 Hemopexin_CS IPR033739 M10A_MMP IPR024079 MetalloPept_cat_dom_sf IPR028693 MMP14 IPR001818 Pept_M10_metallopeptidase IPR021190 Pept_M10A IPR021805 Pept_M10A_metallopeptidase_C IPR021158 Pept_M10A_Zn_BS IPR006026 Peptidase_Metallo IPR002477 Peptidoglycan-bd-like IPR036365 PGBD-like_sf IPR036366 PGBDSf
PANTHERⁱ	PTHR10201:SF24 PTHR10201:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11857 DUF3377, 1 hit PF00045 Hemopexin, 4 hits PF00413 Peptidase_M10, 1 hit PF01471 PG_binding_1, 1 hit
PIRSFⁱ	PIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSⁱ	PR00138 MATRIXIN
SMARTⁱ	View protein in SMART SM00120 HX, 4 hits SM00235 ZnMc, 1 hit
SUPFAMⁱ	SSF47090 SSF47090, 1 hit SSF50923 SSF50923, 1 hit
PROSITEⁱ	View protein in PROSITE PS00546 CYSTEINE_SWITCH, 1 hit PS00024 HEMOPEXIN, 1 hit PS51642 HEMOPEXIN_2, 4 hits PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P53690-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSPAPRPSRS LLLPLLTLGT ALASLGWAQG SNFSPEAWLQ QYGYLPPGDL 
        60         70         80         90        100
RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DLATMMAMRR PRCGVPDKFG 
       110        120        130        140        150
TEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT FEAIRKAFRV 
       160        170        180        190        200
WESATPLRFR EVPYAYIREG HEKQADIMIL FAEGFHGDST PFDGEGGFLA 
       210        220        230        240        250
HAYFPGPNIG GDTHFDSAEP WTVQNEDLNG NDIFLVAVHE LGHALGLEHS 
       260        270        280        290        300
NDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGSKSGSP TKMPPQPRTT 
       310        320        330        340        350
SRPSVPDKPK NPAYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM 
       360        370        380        390        400
DGYPMPIGQF WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP 
       410        420        430        440        450
KHIKELGRGL PTDKIDAALF WMPNGKTYFF RGNKYYRFNE EFRAVDSEYP 
       460        470        480        490        500
KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG NKYWKFNNQK LKVEPGYPKS 
       510        520        530        540        550
ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGSGAVSAA AVVLPVLLLL 
       560        570        580 
LVLAVGLAVF FFRRHGTPKR LLYCQRSLLD KV

Length:582

Mass (Da):65,919

Last modified:July 27, 2011 - v3

Checksum:ⁱ6CA95CFD5811B093

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JE78	A0A0G2JE78_MOUSE	Matrix metalloproteinase Matrix metalloproteinase, EC 3.4.24.-	Mmp14	43	Annotation score:
A0A0G2JF39	A0A0G2JF39_MOUSE	Matrix metalloproteinase Matrix metalloproteinase, EC 3.4.24.-	Mmp14	11	Annotation score:
A0A286YED2	A0A286YED2_MOUSE	Matrix metalloproteinase Matrix metalloproteinase, EC 3.4.24.-	Mmp14	558	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	133	P → S in AAB86602 (PubMed:9325265).Curated	1
Sequence conflictⁱ	255	A → D in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	258	A → S in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	258	A → S in AAB51753 (PubMed:9648071).Curated	1
Sequence conflictⁱ	341	F → L in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	346	N → P in AAB86602 (PubMed:9325265).Curated	1
Sequence conflictⁱ	378	K → T in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	390 – 391	FD → CV in CAA58520 (PubMed:7708715).Curated	2
Sequence conflictⁱ	400 – 401	PK → AN in CAA58520 (PubMed:7708715).Curated	2
Sequence conflictⁱ	407	G → V in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	412	T → S in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	417	A → T in CAA58520 (PubMed:7708715).Curated	1
Sequence conflictⁱ	512	G → R in AAB51753 (PubMed:9648071).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83536 mRNA Translation: CAA58520.2 AF022432 AF022431 Genomic DNA Translation: AAB86602.1 U54984 mRNA Translation: AAB51753.1 DQ249870 mRNA Translation: ABB45784.1 AK088476 mRNA Translation: BAC40377.1 AK138611 mRNA Translation: BAE23719.1 AK149907 mRNA Translation: BAE29158.1 AK149988 mRNA Translation: BAE29216.1 AK165014 mRNA Translation: BAE38000.1 CH466535 Genomic DNA Translation: EDL36348.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36922.1
PIRⁱ	I48673
NCBI Reference Sequences More...RefSeqⁱ	NP_032634.3, NM_008608.4
UniGeneⁱ	Mm.280175 Mm.486486

Genome annotation databases

Ensemblⁱ	ENSMUST00000089688; ENSMUSP00000087119; ENSMUSG00000000957
GeneIDⁱ	17387
KEGGⁱ	mmu:17387
UCSC genome browser More...UCSCⁱ	uc007twc.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53690	Matrix metalloproteinase-14	)	HUMAN		582	UniRef90_P50281
Matrix metalloproteinase-14		RAT		582
Matrix metalloproteinase-14		PONAB		582
Matrix metalloproteinase-14		BOVIN		582
Matrix metalloproteinase-14		PIG		580
+113

Protein	Similar proteins		Species	Score	Length	Source
P53690	Matrix metalloproteinase-14	)	HUMAN		582	UniRef50_P50281
Matrix metalloproteinase-14		PONAB		582
Matrix metalloproteinase-14		BOVIN		582
Matrix metalloproteinase-14		RAT		582
Matrix metalloproteinase-14		PIG		580
+260

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83536 mRNA Translation: CAA58520.2 AF022432 AF022431 Genomic DNA Translation: AAB86602.1 U54984 mRNA Translation: AAB51753.1 DQ249870 mRNA Translation: ABB45784.1 AK088476 mRNA Translation: BAC40377.1 AK138611 mRNA Translation: BAE23719.1 AK149907 mRNA Translation: BAE29158.1 AK149988 mRNA Translation: BAE29216.1 AK165014 mRNA Translation: BAE38000.1 CH466535 Genomic DNA Translation: EDL36348.1
CCDSⁱ	CCDS36922.1
PIRⁱ	I48673
RefSeqⁱ	NP_032634.3, NM_008608.4
UniGeneⁱ	Mm.280175 Mm.486486

3D structure databases

ProteinModelPortalⁱ	P53690
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P53690, 1 interactor
MINTⁱ	P53690
STRINGⁱ	10090.ENSMUSP00000087119

Protein family/group databases

MEROPSⁱ	M10.014

MEROPSⁱ

M10.014

PTM databases

iPTMnetⁱ	P53690
PhosphoSitePlusⁱ	P53690
SwissPalmⁱ	P53690

Proteomic databases

MaxQBⁱ	P53690
PaxDbⁱ	P53690
PeptideAtlasⁱ	P53690
PRIDEⁱ	P53690

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000089688; ENSMUSP00000087119; ENSMUSG00000000957
GeneIDⁱ	17387
KEGGⁱ	mmu:17387
UCSCⁱ	uc007twc.2 mouse

Organism-specific databases

CTDⁱ	4323
MGIⁱ	MGI:101900 Mmp14

Phylogenomic databases

eggNOGⁱ	KOG1565 Eukaryota ENOG410XQ5D LUCA
GeneTreeⁱ	ENSGT00760000118870
HOGENOMⁱ	HOG000217928
HOVERGENⁱ	HBG052484
InParanoidⁱ	P53690
KOⁱ	K07763
OMAⁱ	NAVMFPW
OrthoDBⁱ	EOG091G03DP
TreeFamⁱ	TF352396

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1592389 Activation of Matrix Metalloproteinases

Reactomeⁱ

R-MMU-1442490 Collagen degradation
R-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1592389 Activation of Matrix Metalloproteinases

Miscellaneous databases

ChiTaRSⁱ	Mmp14 mouse
Protein Ontology More...PROⁱ	PR:P53690
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000957 Expressed in 276 organ(s), highest expression level in uterus
CleanExⁱ	MM_MMP14
ExpressionAtlasⁱ	P53690 baseline and differential
Genevisibleⁱ	P53690 MM

Family and domain databases

CDDⁱ	cd00094 HX, 1 hit cd04278 ZnMc_MMP, 1 hit
Gene3Dⁱ	1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR000585 Hemopexin-like_dom IPR036375 Hemopexin-like_dom_sf IPR018487 Hemopexin-like_repeat IPR018486 Hemopexin_CS IPR033739 M10A_MMP IPR024079 MetalloPept_cat_dom_sf IPR028693 MMP14 IPR001818 Pept_M10_metallopeptidase IPR021190 Pept_M10A IPR021805 Pept_M10A_metallopeptidase_C IPR021158 Pept_M10A_Zn_BS IPR006026 Peptidase_Metallo IPR002477 Peptidoglycan-bd-like IPR036365 PGBD-like_sf IPR036366 PGBDSf
PANTHERⁱ	PTHR10201:SF24 PTHR10201:SF24, 1 hit
Pfamⁱ	View protein in Pfam PF11857 DUF3377, 1 hit PF00045 Hemopexin, 4 hits PF00413 Peptidase_M10, 1 hit PF01471 PG_binding_1, 1 hit
PIRSFⁱ	PIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSⁱ	PR00138 MATRIXIN
SMARTⁱ	View protein in SMART SM00120 HX, 4 hits SM00235 ZnMc, 1 hit
SUPFAMⁱ	SSF47090 SSF47090, 1 hit SSF50923 SSF50923, 1 hit
PROSITEⁱ	View protein in PROSITE PS00546 CYSTEINE_SWITCH, 1 hit PS00024 HEMOPEXIN, 1 hit PS51642 HEMOPEXIN_2, 4 hits PS00142 ZINC_PROTEASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MMP14_MOUSE
Accessionⁱ	P53690Primary (citable) accession number: P53690 Secondary accession number(s): O08645, O35369, Q8BTX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P53690 (MMP14_MOUSE)

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Matrix metalloproteinase-14

Mmp14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ