UniProtKB - P53634 (CATC_HUMAN)
Protein
Dipeptidyl peptidase 1
Gene
CTSC
Organism
Homo sapiens (Human)
Status
Functioni
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.1 Publication
Catalytic activityi
- Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro. EC:3.4.14.1
Cofactori
chlorideNote: Binds 1 Cl- ion per heavy chain.
Activity regulationi
Strongly inhibited by the cysteine peptidase inhibitors mersalyl acid, iodoacetic acid and cystatin. Inhibited by N-ethylmaleimide, Gly-Phe-diazomethane, TLCK, TPCK and, at low pH, by dithiodipyridine. Not inhibited by the serine peptidase inhibitor PMSF, the aminopeptidase inhibitor bestatin, or metal ion chelators.1 Publication
pH dependencei
High activity at pH 4.5-6.8.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 258 | 1 | ||
Binding sitei | 302 | Chloride | 1 | |
Binding sitei | 304 | Chloride; via amide nitrogen | 1 | |
Binding sitei | 347 | Chloride | 1 | |
Active sitei | 405 | 1 | ||
Active sitei | 427 | 1 |
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- chloride ion binding Source: Ensembl
- cysteine-type endopeptidase activity Source: GO_Central
- cysteine-type peptidase activity Source: UniProtKB
- identical protein binding Source: Ensembl
- peptidase activator activity involved in apoptotic process Source: Ensembl
- phosphatase binding Source: BHF-UCL
- protein self-association Source: Ensembl
- serine-type endopeptidase activity Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- COPII vesicle coating Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- immune response Source: ProtInc
- negative regulation of myelination Source: Ensembl
- neutrophil degranulation Source: Reactome
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of microglial cell activation Source: Ensembl
- positive regulation of proteolysis involved in cellular protein catabolic process Source: ParkinsonsUK-UCL
- proteolysis Source: UniProtKB
- proteolysis involved in cellular protein catabolic process Source: GO_Central
- response to organic substance Source: Ensembl
- T cell mediated cytotoxicity Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Ligand | Chloride |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03265-MONOMER |
BRENDAi | 3.4.14.1, 2681 |
PathwayCommonsi | P53634 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-2132295, MHC class II antigen presentation R-HSA-5694530, Cargo concentration in the ER R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P53634 |
Protein family/group databases
MEROPSi | C01.070 |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl peptidase 1 (EC:3.4.14.1)Alternative name(s): Cathepsin C Cathepsin J Dipeptidyl peptidase I Short name: DPP-I Short name: DPPI Dipeptidyl transferase Cleaved into the following 3 chains: Alternative name(s): Dipeptidyl peptidase I exclusion domain chain Alternative name(s): Dipeptidyl peptidase I heavy chain Alternative name(s): Dipeptidyl peptidase I light chain |
Gene namesi | Name:CTSC Synonyms:CPPI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109861.15 |
HGNCi | HGNC:2528, CTSC |
MIMi | 602365, gene |
neXtProti | NX_P53634 |
Subcellular locationi
Lysosome
Cytoskeleton
- centrosome Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: GOC
Lysosome
- azurophil granule lumen Source: Reactome
- lysosome Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
Other locations
- COPII-coated ER to Golgi transport vesicle Source: Reactome
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
LysosomePathology & Biotechi
Involvement in diseasei
Papillon-Lefevre syndrome (PLS)13 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016933 | 39 | W → S in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894210Ensembl. | 1 | |
Natural variantiVAR_019035 | 67 – 74 | Missing in PLS. 1 Publication | 8 | |
Natural variantiVAR_016934 | 127 | H → P in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894216Ensembl. | 1 | |
Natural variantiVAR_019036 | 129 | V → E in PLS. 1 PublicationCorresponds to variant dbSNP:rs760130711Ensembl. | 1 | |
Natural variantiVAR_019037 | 139 | G → R in PLS. 2 PublicationsCorresponds to variant dbSNP:rs749103588Ensembl. | 1 | |
Natural variantiVAR_019038 | 236 | D → Y in PLS. 2 PublicationsCorresponds to variant dbSNP:rs764724707Ensembl. | 1 | |
Natural variantiVAR_009541 | 249 | V → F in PLS. 2 Publications | 1 | |
Natural variantiVAR_009542 | 252 | Q → L in PLS. 2 PublicationsCorresponds to variant dbSNP:rs104894207EnsemblClinVar. | 1 | |
Natural variantiVAR_019039 | 272 | R → H in PLS. 1 PublicationCorresponds to variant dbSNP:rs587777534EnsemblClinVar. | 1 | |
Natural variantiVAR_009543 | 272 | R → P in PLS. 5 PublicationsCorresponds to variant dbSNP:rs587777534EnsemblClinVar. | 1 | |
Natural variantiVAR_016935 | 286 | Q → R in HMS and PLS. 2 PublicationsCorresponds to variant dbSNP:rs104894208EnsemblClinVar. | 1 | |
Natural variantiVAR_019040 | 291 | C → Y in PLS. 1 PublicationCorresponds to variant dbSNP:rs748729285EnsemblClinVar. | 1 | |
Natural variantiVAR_039686 | 294 | Y → H in PLS. 1 Publication | 1 | |
Natural variantiVAR_019041 | 300 | G → D in PLS. 2 Publications | 1 | |
Natural variantiVAR_019042 | 300 | G → S in PLS. 1 Publication | 1 | |
Natural variantiVAR_009544 | 301 | G → S in PLS. 4 PublicationsCorresponds to variant dbSNP:rs104894214Ensembl. | 1 | |
Natural variantiVAR_019043 | 301 | G → V in PLS. 1 Publication | 1 | |
Natural variantiVAR_019044 | 304 | Y → N in PLS. 1 Publication | 1 | |
Natural variantiVAR_019045 | 312 | Q → R in PLS. 1 PublicationCorresponds to variant dbSNP:rs1484758757Ensembl. | 1 | |
Natural variantiVAR_019046 | 319 | E → G in PLS. 1 PublicationCorresponds to variant dbSNP:rs1294233227Ensembl. | 1 | |
Natural variantiVAR_009545 | 339 | R → C in PLS. 5 PublicationsCorresponds to variant dbSNP:rs1044703733Ensembl. | 1 | |
Natural variantiVAR_016944 | 340 | Y → C in PLS. 2 Publications | 1 | |
Natural variantiVAR_009546 | 347 | Y → C in PLS and AP1. 3 PublicationsCorresponds to variant dbSNP:rs104894211EnsemblClinVar. | 1 | |
Natural variantiVAR_027249 | 405 | H → N in PLS. 1 Publication | 1 | |
Natural variantiVAR_027250 | 405 | H → R in PLS. 1 PublicationCorresponds to variant dbSNP:rs151269219Ensembl. | 1 | |
Natural variantiVAR_016936 | 429 | W → C in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894215Ensembl. | 1 | |
Natural variantiVAR_019048 | 447 | E → G in PLS. 2 Publications | 1 |
Haim-Munk syndrome (HMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016935 | 286 | Q → R in HMS and PLS. 2 PublicationsCorresponds to variant dbSNP:rs104894208EnsemblClinVar. | 1 |
Periodontititis, aggressive, 1 (AP1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by severe and protracted gingival infections, generalized or localized, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009546 | 347 | Y → C in PLS and AP1. 3 PublicationsCorresponds to variant dbSNP:rs104894211EnsemblClinVar. | 1 | |
Natural variantiVAR_019047 | 412 | Y → C in AP1. 1 PublicationCorresponds to variant dbSNP:rs28937571EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Palmoplantar keratodermaOrganism-specific databases
DisGeNETi | 1075 |
MalaCardsi | CTSC |
MIMi | 170650, phenotype 245000, phenotype 245010, phenotype |
OpenTargetsi | ENSG00000109861 |
Orphaneti | 2342, Haim-Munk syndrome 678, Papillon-Lefevre syndrome |
PharmGKBi | PA27028 |
Miscellaneous databases
Pharosi | P53634, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2252 |
GuidetoPHARMACOLOGYi | 2344 |
Polymorphism and mutation databases
BioMutai | CTSC |
DMDMi | 317373330 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 3 PublicationsAdd BLAST | 24 | |
ChainiPRO_0000026338 | 25 – 134 | Dipeptidyl peptidase 1 exclusion domain chainAdd BLAST | 110 | |
PropeptideiPRO_0000026339 | 135 – 230 | 3 PublicationsAdd BLAST | 96 | |
ChainiPRO_0000026340 | 231 – 394 | Dipeptidyl peptidase 1 heavy chainAdd BLAST | 164 | |
ChainiPRO_0000026341 | 395 – 463 | Dipeptidyl peptidase 1 light chainAdd BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 30 ↔ 118 | |||
Glycosylationi | 53 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 54 ↔ 136 | |||
Glycosylationi | 119 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 255 ↔ 298 | |||
Glycosylationi | 276 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 291 ↔ 331 | |||
Disulfide bondi | 321 ↔ 337 |
Post-translational modificationi
N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.5 Publications
In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | P53634 |
jPOSTi | P53634 |
MassIVEi | P53634 |
MaxQBi | P53634 |
PaxDbi | P53634 |
PeptideAtlasi | P53634 |
PRIDEi | P53634 |
ProteomicsDBi | 56595 [P53634-1] 56596 [P53634-2] 56597 [P53634-3] |
TopDownProteomicsi | P53634-1 [P53634-1] |
PTM databases
GlyConnecti | 1175, 58 N-Linked glycans (4 sites) |
GlyGeni | P53634, 5 sites, 2 N-linked glycans (1 site) |
iPTMneti | P53634 |
PhosphoSitePlusi | P53634 |
SwissPalmi | P53634 |
Expressioni
Tissue specificityi
Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.1 Publication
Inductioni
Up-regulated in lymphocytes by IL2/interleukin-2.1 Publication
Gene expression databases
Bgeei | ENSG00000109861, Expressed in palpebral conjunctiva and 233 other tissues |
ExpressionAtlasi | P53634, baseline and differential |
Genevisiblei | P53634, HS |
Organism-specific databases
HPAi | ENSG00000109861, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
2 PublicationsBinary interactionsi
P53634
With | #Exp. | IntAct |
---|---|---|
CST7 [O76096] | 2 | EBI-1047323,EBI-2807448 |
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- identical protein binding Source: Ensembl
- phosphatase binding Source: BHF-UCL
- protein self-association Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107502, 27 interactors |
IntActi | P53634, 23 interactors |
MINTi | P53634 |
STRINGi | 9606.ENSP00000227266 |
Chemistry databases
BindingDBi | P53634 |
Miscellaneous databases
RNActi | P53634, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P53634 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53634 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000155787 |
HOGENOMi | CLU_048219_0_0_1 |
InParanoidi | P53634 |
OMAi | FVTPVRN |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P53634 |
TreeFami | TF313225 |
Family and domain databases
CDDi | cd02621, Peptidase_C1A_CathepsinC, 1 hit |
Gene3Di | 2.40.128.80, 1 hit |
InterProi | View protein in InterPro IPR039412, CatC IPR014882, CathepsinC_exc IPR036496, CathepsinC_exc_dom_sf IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C |
Pfami | View protein in Pfam PF08773, CathepsinC_exc, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF75001, SSF75001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P53634-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR
60 70 80 90 100
DVNCSVMGPQ EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY
160 170 180 190 200
VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD
210 220 230 240 250
MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR
260 270 280 290 300
NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG
310 320 330 340 350
GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG
360 370 380 390 400
FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF
410 420 430 440 450
ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGENGYFR IRRGTDECAI
460
ESIAVAATPI PKL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCY8 | H0YCY8_HUMAN | Cathepsin C | CTSC | 244 | Annotation score: | ||
H0YDA2 | H0YDA2_HUMAN | Dipeptidyl peptidase 1 | CTSC | 36 | Annotation score: |
Sequence cautioni
The sequence CAD97897 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | K → I in BAD96758 (Ref. 6) Curated | 1 | |
Sequence conflicti | 237 | W → V AA sequence (PubMed:1586157).Curated | 1 | |
Sequence conflicti | 321 | C → S AA sequence (PubMed:1586157).Curated | 1 | |
Sequence conflicti | 355 | C → M AA sequence (PubMed:1586157).Curated | 1 | |
Sequence conflicti | 366 | H → R AA sequence (PubMed:1586157).Curated | 1 | |
Sequence conflicti | 376 – 378 | VYD → YVY AA sequence (PubMed:1586157).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016933 | 39 | W → S in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894210Ensembl. | 1 | |
Natural variantiVAR_019035 | 67 – 74 | Missing in PLS. 1 Publication | 8 | |
Natural variantiVAR_016934 | 127 | H → P in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894216Ensembl. | 1 | |
Natural variantiVAR_019036 | 129 | V → E in PLS. 1 PublicationCorresponds to variant dbSNP:rs760130711Ensembl. | 1 | |
Natural variantiVAR_019037 | 139 | G → R in PLS. 2 PublicationsCorresponds to variant dbSNP:rs749103588Ensembl. | 1 | |
Natural variantiVAR_016943 | 153 | I → T12 PublicationsCorresponds to variant dbSNP:rs217086EnsemblClinVar. | 1 | |
Natural variantiVAR_019038 | 236 | D → Y in PLS. 2 PublicationsCorresponds to variant dbSNP:rs764724707Ensembl. | 1 | |
Natural variantiVAR_009541 | 249 | V → F in PLS. 2 Publications | 1 | |
Natural variantiVAR_009542 | 252 | Q → L in PLS. 2 PublicationsCorresponds to variant dbSNP:rs104894207EnsemblClinVar. | 1 | |
Natural variantiVAR_019039 | 272 | R → H in PLS. 1 PublicationCorresponds to variant dbSNP:rs587777534EnsemblClinVar. | 1 | |
Natural variantiVAR_009543 | 272 | R → P in PLS. 5 PublicationsCorresponds to variant dbSNP:rs587777534EnsemblClinVar. | 1 | |
Natural variantiVAR_016935 | 286 | Q → R in HMS and PLS. 2 PublicationsCorresponds to variant dbSNP:rs104894208EnsemblClinVar. | 1 | |
Natural variantiVAR_019040 | 291 | C → Y in PLS. 1 PublicationCorresponds to variant dbSNP:rs748729285EnsemblClinVar. | 1 | |
Natural variantiVAR_039686 | 294 | Y → H in PLS. 1 Publication | 1 | |
Natural variantiVAR_019041 | 300 | G → D in PLS. 2 Publications | 1 | |
Natural variantiVAR_019042 | 300 | G → S in PLS. 1 Publication | 1 | |
Natural variantiVAR_009544 | 301 | G → S in PLS. 4 PublicationsCorresponds to variant dbSNP:rs104894214Ensembl. | 1 | |
Natural variantiVAR_019043 | 301 | G → V in PLS. 1 Publication | 1 | |
Natural variantiVAR_019044 | 304 | Y → N in PLS. 1 Publication | 1 | |
Natural variantiVAR_019045 | 312 | Q → R in PLS. 1 PublicationCorresponds to variant dbSNP:rs1484758757Ensembl. | 1 | |
Natural variantiVAR_019046 | 319 | E → G in PLS. 1 PublicationCorresponds to variant dbSNP:rs1294233227Ensembl. | 1 | |
Natural variantiVAR_009545 | 339 | R → C in PLS. 5 PublicationsCorresponds to variant dbSNP:rs1044703733Ensembl. | 1 | |
Natural variantiVAR_016944 | 340 | Y → C in PLS. 2 Publications | 1 | |
Natural variantiVAR_009546 | 347 | Y → C in PLS and AP1. 3 PublicationsCorresponds to variant dbSNP:rs104894211EnsemblClinVar. | 1 | |
Natural variantiVAR_016945 | 401 | E → K1 PublicationCorresponds to variant dbSNP:rs200627023Ensembl. | 1 | |
Natural variantiVAR_027249 | 405 | H → N in PLS. 1 Publication | 1 | |
Natural variantiVAR_027250 | 405 | H → R in PLS. 1 PublicationCorresponds to variant dbSNP:rs151269219Ensembl. | 1 | |
Natural variantiVAR_019047 | 412 | Y → C in AP1. 1 PublicationCorresponds to variant dbSNP:rs28937571EnsemblClinVar. | 1 | |
Natural variantiVAR_016936 | 429 | W → C in PLS. 1 PublicationCorresponds to variant dbSNP:rs104894215Ensembl. | 1 | |
Natural variantiVAR_019048 | 447 | E → G in PLS. 2 Publications | 1 | |
Natural variantiVAR_016946 | 453 | I → V Rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs3888798EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043232 | 107 – 141 | YKEEG…FTGKK → DVTDFISHLFMQLGTVGIYD LPHLRNKLAMNRRWG in isoform 3. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_039123 | 107 – 137 | YKEEG…NWACF → DVTDFISHLFMQLGTVGIYD LPHLRNKLVIK in isoform 2. 3 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_039124 | 138 – 463 | Missing in isoform 2. 3 PublicationsAdd BLAST | 326 | |
Alternative sequenceiVSP_043233 | 142 – 463 | Missing in isoform 3. 1 PublicationAdd BLAST | 322 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87212 mRNA Translation: CAA60671.1 U79415 Genomic DNA Translation: AAC51341.1 AF234263 mRNA Translation: AAL48191.1 AF234264 mRNA Translation: AAL48192.1 AF254757 mRNA Translation: AAL48195.1 AF525032 mRNA Translation: AAQ08887.1 AF525033 mRNA Translation: AAQ08888.1 AK292117 mRNA Translation: BAF84806.1 AK311923 mRNA Translation: BAG34864.1 AK223038 mRNA Translation: BAD96758.1 BX537913 mRNA Translation: CAD97897.1 Different initiation. AC011088 Genomic DNA No translation available. CH471185 Genomic DNA Translation: EAW59364.1 BC054028 mRNA Translation: AAH54028.1 BC100891 mRNA Translation: AAI00892.1 BC100892 mRNA Translation: AAI00893.1 BC100893 mRNA Translation: AAI00894.1 BC100894 mRNA Translation: AAI00895.1 BC109386 mRNA Translation: AAI09387.1 BC110071 mRNA Translation: AAI10072.1 BC113850 mRNA Translation: AAI13851.1 BC113897 mRNA Translation: AAI13898.1 |
CCDSi | CCDS31654.1 [P53634-2] CCDS44693.1 [P53634-3] CCDS8282.1 [P53634-1] |
PIRi | S23941 S66504 |
RefSeqi | NP_001107645.1, NM_001114173.2 [P53634-3] NP_001805.3, NM_001814.5 [P53634-1] NP_680475.1, NM_148170.4 [P53634-2] |
Genome annotation databases
Ensembli | ENST00000227266; ENSP00000227266; ENSG00000109861 [P53634-1] ENST00000524463; ENSP00000432541; ENSG00000109861 [P53634-2] ENST00000529974; ENSP00000433539; ENSG00000109861 [P53634-3] |
GeneIDi | 1075 |
KEGGi | hsa:1075 |
UCSCi | uc001pck.5, human [P53634-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
CTSCbase CTSC mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87212 mRNA Translation: CAA60671.1 U79415 Genomic DNA Translation: AAC51341.1 AF234263 mRNA Translation: AAL48191.1 AF234264 mRNA Translation: AAL48192.1 AF254757 mRNA Translation: AAL48195.1 AF525032 mRNA Translation: AAQ08887.1 AF525033 mRNA Translation: AAQ08888.1 AK292117 mRNA Translation: BAF84806.1 AK311923 mRNA Translation: BAG34864.1 AK223038 mRNA Translation: BAD96758.1 BX537913 mRNA Translation: CAD97897.1 Different initiation. AC011088 Genomic DNA No translation available. CH471185 Genomic DNA Translation: EAW59364.1 BC054028 mRNA Translation: AAH54028.1 BC100891 mRNA Translation: AAI00892.1 BC100892 mRNA Translation: AAI00893.1 BC100893 mRNA Translation: AAI00894.1 BC100894 mRNA Translation: AAI00895.1 BC109386 mRNA Translation: AAI09387.1 BC110071 mRNA Translation: AAI10072.1 BC113850 mRNA Translation: AAI13851.1 BC113897 mRNA Translation: AAI13898.1 |
CCDSi | CCDS31654.1 [P53634-2] CCDS44693.1 [P53634-3] CCDS8282.1 [P53634-1] |
PIRi | S23941 S66504 |
RefSeqi | NP_001107645.1, NM_001114173.2 [P53634-3] NP_001805.3, NM_001814.5 [P53634-1] NP_680475.1, NM_148170.4 [P53634-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K3B | X-ray | 2.15 | A | 25-143 | [»] | |
B | 231-394 | [»] | ||||
C | 395-463 | [»] | ||||
2DJF | X-ray | 2.00 | A | 25-143 | [»] | |
B | 231-394 | [»] | ||||
C | 395-463 | [»] | ||||
2DJG | X-ray | 2.05 | A | 25-143 | [»] | |
B | 231-394 | [»] | ||||
C | 395-463 | [»] | ||||
3PDF | X-ray | 1.85 | A | 25-463 | [»] | |
4CDC | X-ray | 2.40 | A/D/G/J | 25-143 | [»] | |
B/E/H/K | 230-394 | [»] | ||||
C/F/I/L | 395-463 | [»] | ||||
4CDD | X-ray | 2.35 | A/D | 25-144 | [»] | |
B/E | 230-394 | [»] | ||||
C/F | 395-463 | [»] | ||||
4CDE | X-ray | 2.40 | A/D | 25-143 | [»] | |
B/E | 230-394 | [»] | ||||
C/F | 395-463 | [»] | ||||
4CDF | X-ray | 2.20 | A/D | 25-144 | [»] | |
B/E | 229-394 | [»] | ||||
C/F | 395-463 | [»] | ||||
4OEL | X-ray | 1.40 | A | 25-394 | [»] | |
B | 395-463 | [»] | ||||
4OEM | X-ray | 1.52 | A | 25-394 | [»] | |
B | 395-463 | [»] | ||||
SMRi | P53634 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107502, 27 interactors |
IntActi | P53634, 23 interactors |
MINTi | P53634 |
STRINGi | 9606.ENSP00000227266 |
Chemistry databases
BindingDBi | P53634 |
ChEMBLi | CHEMBL2252 |
GuidetoPHARMACOLOGYi | 2344 |
Protein family/group databases
MEROPSi | C01.070 |
PTM databases
GlyConnecti | 1175, 58 N-Linked glycans (4 sites) |
GlyGeni | P53634, 5 sites, 2 N-linked glycans (1 site) |
iPTMneti | P53634 |
PhosphoSitePlusi | P53634 |
SwissPalmi | P53634 |
Polymorphism and mutation databases
BioMutai | CTSC |
DMDMi | 317373330 |
Proteomic databases
EPDi | P53634 |
jPOSTi | P53634 |
MassIVEi | P53634 |
MaxQBi | P53634 |
PaxDbi | P53634 |
PeptideAtlasi | P53634 |
PRIDEi | P53634 |
ProteomicsDBi | 56595 [P53634-1] 56596 [P53634-2] 56597 [P53634-3] |
TopDownProteomicsi | P53634-1 [P53634-1] |
Protocols and materials databases
Antibodypediai | 31473, 267 antibodies |
DNASUi | 1075 |
Genome annotation databases
Ensembli | ENST00000227266; ENSP00000227266; ENSG00000109861 [P53634-1] ENST00000524463; ENSP00000432541; ENSG00000109861 [P53634-2] ENST00000529974; ENSP00000433539; ENSG00000109861 [P53634-3] |
GeneIDi | 1075 |
KEGGi | hsa:1075 |
UCSCi | uc001pck.5, human [P53634-1] |
Organism-specific databases
CTDi | 1075 |
DisGeNETi | 1075 |
EuPathDBi | HostDB:ENSG00000109861.15 |
GeneCardsi | CTSC |
HGNCi | HGNC:2528, CTSC |
HPAi | ENSG00000109861, Tissue enhanced (lymphoid) |
MalaCardsi | CTSC |
MIMi | 170650, phenotype 245000, phenotype 245010, phenotype 602365, gene |
neXtProti | NX_P53634 |
OpenTargetsi | ENSG00000109861 |
Orphaneti | 2342, Haim-Munk syndrome 678, Papillon-Lefevre syndrome |
PharmGKBi | PA27028 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1543, Eukaryota |
GeneTreei | ENSGT00940000155787 |
HOGENOMi | CLU_048219_0_0_1 |
InParanoidi | P53634 |
OMAi | FVTPVRN |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P53634 |
TreeFami | TF313225 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03265-MONOMER |
BRENDAi | 3.4.14.1, 2681 |
PathwayCommonsi | P53634 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-2132295, MHC class II antigen presentation R-HSA-5694530, Cargo concentration in the ER R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P53634 |
Miscellaneous databases
BioGRID-ORCSi | 1075, 2 hits in 844 CRISPR screens |
ChiTaRSi | CTSC, human |
EvolutionaryTracei | P53634 |
GeneWikii | Cathepsin_C |
GenomeRNAii | 1075 |
Pharosi | P53634, Tchem |
PROi | PR:P53634 |
RNActi | P53634, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109861, Expressed in palpebral conjunctiva and 233 other tissues |
ExpressionAtlasi | P53634, baseline and differential |
Genevisiblei | P53634, HS |
Family and domain databases
CDDi | cd02621, Peptidase_C1A_CathepsinC, 1 hit |
Gene3Di | 2.40.128.80, 1 hit |
InterProi | View protein in InterPro IPR039412, CatC IPR014882, CathepsinC_exc IPR036496, CathepsinC_exc_dom_sf IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C |
Pfami | View protein in Pfam PF08773, CathepsinC_exc, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF75001, SSF75001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATC_HUMAN | |
Accessioni | P53634Primary (citable) accession number: P53634 Secondary accession number(s): A8K7V2 Q8WYA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries