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UniProtKB - P53624 (MA1A1_DROME)

>sp|P53624|MA1A1_DROME Mannosyl-oligosaccharide alpha-1,2-mannosidase IA OS=Drosophila melanogaster OX=7227 GN=alpha-Man-Ia PE=2 SV=2
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGP
EIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQ
QAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLP
LGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGS
YDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLY
AFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTL
HLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGD
SYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDH
LACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEAR
ALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQ
QEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVT
LPVSNAS

Entry version 177 (25 May 2022)
Sequence version 2 (15 Mar 2004)
Previous versions | rss

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Protein

Mannosyl-oligosaccharide alpha-1,2-mannosidase IA

Gene

alpha-Man-Ia

Organism

Drosophila melanogaster (Fruit fly)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man₉GlcNAc₂ to produce Man₅GlcNAc₂.

By similarity

Catalytic activityⁱ

4
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A_1,2,3B_1,2,3)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
= 4
β-D-mannose
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
EC:
3.2.1.113
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
4
H₂O
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A_1,2,3B_1,2,3)
N⁴-[α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc]-L-Asn residue
zoom
=
4
β-D-mannose
zoom
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-Asn residue
zoom
3
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A_1,2,3B_1,3)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
= 3
β-D-mannose
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
EC:
3.2.1.113
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
3
H₂O
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A_1,2,3B_1,3)
N⁴-{α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc}-L-Asn residue
zoom
=
3
β-D-mannose
zoom
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-Asn residue
zoom

Cofactorⁱ

Ca²⁺By similarity, Mg²⁺By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	529	Proton donorBy similarity		1
Metal bindingⁱ	640	CalciumBy similarity		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-DME-964827, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH47, Glycoside Hydrolase Family 47

CAZyⁱ

GH47, Glycoside Hydrolase Family 47

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannosyl-oligosaccharide alpha-1,2-mannosidase IAImported (EC:3.2.1.113By similarity) Alternative name(s): Man(9)-alpha-mannosidase Mannosidase-1
Gene namesⁱ	Name:alpha-Man-IaImported Synonyms:alpha-man-1Imported, mas-1Imported ORF Names:CG32684Imported
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0259170, alpha-Man-Ia
VEuPathDBⁱ	VectorBase:FBgn0259170

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 18	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	19 – 39	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	40 – 667	LumenalSequence analysisAdd BLAST	628

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1697673

ChEMBLⁱ

CHEMBL1697673

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210316	1 – 667	Mannosyl-oligosaccharide alpha-1,2-mannosidase IAAdd BLAST		667

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	278	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	483 ↔ 515	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEⁱ	P53624

PRIDEⁱ

P53624

PTM databases

GlyGenⁱ	P53624, 1 site

GlyGenⁱ

P53624, 1 site

Expressionⁱ

Tissue specificityⁱ

Complex spatial distribution during embryogenesis, including expression in lobula plate giant neurons. Also expressed in adult wing and eyes.1 Publication

Developmental stageⁱ

Expressed both maternally and zygotically during embryonic stages.1 Publication

Gene expression databases

Bgeeⁱ	FBgn0259170, Expressed in embryo and 36 other tissues
ExpressionAtlasⁱ	P53624, baseline and differential
Genevisibleⁱ	P53624, DM

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	58390, 3 interactors
IntActⁱ	P53624, 2 interactors
STRINGⁱ	7227.FBpp0288908

Chemistry databases

BindingDBⁱ

P53624

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	P53624
SMRⁱ	P53624
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	154 – 192	DisorderedSequence analysisAdd BLAST		39

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	155 – 182	Polar residuesSequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2204, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000167910
HOGENOMⁱ	CLU_003818_3_2_1
InParanoidⁱ	P53624
OMAⁱ	LIKMYLY
PhylomeDBⁱ	P53624

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01532, Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747, GLYHDRLASE47
SUPFAMⁱ	SSF48225, SSF48225, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative promoter usage. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform HImported (identifier: P53624-1) [UniParc]FASTA Add to basket

Also known as: A1 Publication, JImported, LImported, MImported, NImported, OImported

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRISPIGRK SNFHSREKCL IGLVLVTLCF LCFGGIFLLP DNFGSDRVLR 
        60         70         80         90        100
VYKHFRKAGP EIFIPAPPLA AHAPHRSEDP HFIGDRQRLE QKIRAELGDM 
       110        120        130        140        150
LDEPPAAGGG EPGQFQVLAQ QAQAPAPVAA LADQPLDQDE GHAAIPVLAA 
       160        170        180        190        200
PVQGDNAASQ ASSHPQSSAQ QHNQQQPQLP LGGGGNDQAP DTLDATLEER 
       210        220        230        240        250
RQKVKEMMEH AWHNYKLYAW GKNELRPLSQ RPHSASIFGS YDLGATIVDG 
       260        270        280        290        300
LDTLYIMGLE KEYREGRDWI ERKFSLDNIS AELSVFETNI RFVGGMLTLY 
       310        320        330        340        350
AFTGDPLYKE KAQHVADKLL PAFQTPTGIP YALVNTKTGV AKNYGWASGG 
       360        370        380        390        400
SSILSEFGTL HLEFAYLSDI TGNPLYRERV QTIRQVLKEI EKPKGLYPNF 
       410        420        430        440        450
LNPKTGKWGQ LHMSLGALGD SYYEYLLKAW LQSGQTDEEA REMFDEAMLA 
       460        470        480        490        500
ILDKMVRTSP GGLTYVSDLK FDRLEHKMDH LACFSGGLFA LGAATRQNDY 
       510        520        530        540        550
TDKYMEVGKG ITNTCHESYI RAPTQLGPEA FRFSEAVEAR ALRSQEKYYI 
       560        570        580        590        600
LRPETFESYF VLWRLTHDQK YRDWGWEAVL ALEKHCRTAH GYCGLRNVYQ 
       610        620        630        640        650
QEPQKDDVQQ SFFLAETLKY LYLLFSDDSV LPLDEWVFNT EAHPLPIKGA 
       660 
NAYYRQAPVT LPVSNAS

Length:667

Mass (Da):74,966

Last modified:March 15, 2004 - v2

Checksum:ⁱD707F491E4AE47F2

Isoform KImported (identifier: P53624-2) [UniParc] [UniParc]FASTA Add to basket

Also known as: B1 Publication, PImported

The sequence of this isoform differs from the canonical sequence as follows:
1-206: MYRISPIGRK...LEERRQKVKE → MCPKTSKTTP...DYEKRNQVVK

« Hide

        10         20         30         40         50
MCPKTSKTTP LLLIGGICFV IVLVGITGIT LINNINLSNI IRLNEKVASD 
        60         70         80         90        100
SVSNNENQIK ELNYVNNHPR NVYLKLNASS RDDEDDEQMQ KEQEQLELPK 
       110        120        130        140        150
ISAVIGGSKP KVEDNQVKES SEVISPSTST FSMRSSAGEL TSTSAPLSSI 
       160        170        180        190        200
VSVTAPPMPF GGVKYNQSSG LIDYEKRNQV VKMMEHAWHN YKLYAWGKNE 
       210        220        230        240        250
LRPLSQRPHS ASIFGSYDLG ATIVDGLDTL YIMGLEKEYR EGRDWIERKF 
       260        270        280        290        300
SLDNISAELS VFETNIRFVG GMLTLYAFTG DPLYKEKAQH VADKLLPAFQ 
       310        320        330        340        350
TPTGIPYALV NTKTGVAKNY GWASGGSSIL SEFGTLHLEF AYLSDITGNP 
       360        370        380        390        400
LYRERVQTIR QVLKEIEKPK GLYPNFLNPK TGKWGQLHMS LGALGDSYYE 
       410        420        430        440        450
YLLKAWLQSG QTDEEAREMF DEAMLAILDK MVRTSPGGLT YVSDLKFDRL 
       460        470        480        490        500
EHKMDHLACF SGGLFALGAA TRQNDYTDKY MEVGKGITNT CHESYIRAPT 
       510        520        530        540        550
QLGPEAFRFS EAVEARALRS QEKYYILRPE TFESYFVLWR LTHDQKYRDW 
       560        570        580        590        600
GWEAVLALEK HCRTAHGYCG LRNVYQQEPQ KDDVQQSFFL AETLKYLYLL 
       610        620        630        640 
FSDDSVLPLD EWVFNTEAHP LPIKGANAYY RQAPVTLPVS NAS

Show »

Length:643

Mass (Da):72,525

Checksum:ⁱ8725B99D31DE7AC3

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8IRL4	Q8IRL4_DROME		alpha-1,2-Mannosidase alpha-1,2-Mannosidase, EC 3.2.1.-	alpha-Man-Ia a-Man-Ia, alpha-Man-I, alpha-Man-l, CG17809, CG18799	684	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	21	I → T in CAA57962 (PubMed:7729592).Curated		1
Sequence conflictⁱ	568	D → E in CAA57962 (PubMed:7729592).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057904	1 – 206	MYRIS…QKVKE → MCPKTSKTTPLLLIGGICFV IVLVGITGITLINNINLSNI IRLNEKVASDSVSNNENQIK ELNYVNNHPRNVYLKLNASS RDDEDDEQMQKEQEQLELPK ISAVIGGSKPKVEDNQVKES SEVISPSTSTFSMRSSAGEL TSTSAPLSSIVSVTAPPMPF GGVKYNQSSGLIDYEKRNQV VK in isoform K. Add BLAST		206

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82640 mRNA Translation: CAA57962.1 X82641 mRNA Translation: CAA57963.1 AE014298 Genomic DNA Translation: AAF46570.1 AE014298 Genomic DNA Translation: AAF46571.3 AE014298 Genomic DNA Translation: AAS65302.1 AE014298 Genomic DNA Translation: AAS65303.1 AE014298 Genomic DNA Translation: AAS65304.1 AE014298 Genomic DNA Translation: AAS65305.1 AE014298 Genomic DNA Translation: AAS65306.1 AE014298 Genomic DNA Translation: AGB95245.1 BT011036 mRNA Translation: AAR30196.1
PIRⁱ	S60709
NCBI Reference Sequences More...RefSeqⁱ	NP_001259402.1, NM_001272473.2 [P53624-2] NP_511105.2, NM_078550.4 [P53624-2] NP_727407.1, NM_167223.3 [P53624-1] NP_996395.1, NM_206672.3 [P53624-1] NP_996396.1, NM_206673.3 [P53624-1] NP_996397.1, NM_206674.3 [P53624-1] NP_996398.1, NM_206675.3 [P53624-1] NP_996399.1, NM_206676.3 [P53624-1]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative promoter usage

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53624	alpha-1,2-Mannosidase		DROBP		622	UniRef50_P53624
alpha-1,2-Mannosidase		AEDAE		599
alpha-1,2-Mannosidase		AEDAL		599
alpha-1,2-Mannosidase		Ephemera danica		553
Isoform K of Mannosyl-oligosaccharide alpha-1,2-mannosidase IA		DROME		643
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82640 mRNA Translation: CAA57962.1 X82641 mRNA Translation: CAA57963.1 AE014298 Genomic DNA Translation: AAF46570.1 AE014298 Genomic DNA Translation: AAF46571.3 AE014298 Genomic DNA Translation: AAS65302.1 AE014298 Genomic DNA Translation: AAS65303.1 AE014298 Genomic DNA Translation: AAS65304.1 AE014298 Genomic DNA Translation: AAS65305.1 AE014298 Genomic DNA Translation: AAS65306.1 AE014298 Genomic DNA Translation: AGB95245.1 BT011036 mRNA Translation: AAR30196.1
PIRⁱ	S60709
RefSeqⁱ	NP_001259402.1, NM_001272473.2 [P53624-2] NP_511105.2, NM_078550.4 [P53624-2] NP_727407.1, NM_167223.3 [P53624-1] NP_996395.1, NM_206672.3 [P53624-1] NP_996396.1, NM_206673.3 [P53624-1] NP_996397.1, NM_206674.3 [P53624-1] NP_996398.1, NM_206675.3 [P53624-1] NP_996399.1, NM_206676.3 [P53624-1]

3D structure databases

AlphaFoldDBⁱ	P53624
SMRⁱ	P53624
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	58390, 3 interactors
IntActⁱ	P53624, 2 interactors
STRINGⁱ	7227.FBpp0288908

Chemistry databases

BindingDBⁱ	P53624
ChEMBLⁱ	CHEMBL1697673

Protein family/group databases

CAZyⁱ	GH47, Glycoside Hydrolase Family 47

CAZyⁱ

GH47, Glycoside Hydrolase Family 47

PTM databases

GlyGenⁱ	P53624, 1 site

GlyGenⁱ

P53624, 1 site

Proteomic databases

PRIDEⁱ	P53624

PRIDEⁱ

P53624

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	31957

DNASUⁱ

31957

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0299632; FBpp0288907; FBgn0259170 [P53624-1] FBtr0300511; FBpp0289738; FBgn0259170 [P53624-1] FBtr0300512; FBpp0289739; FBgn0259170 [P53624-2] FBtr0300513; FBpp0289740; FBgn0259170 [P53624-1] FBtr0300514; FBpp0289741; FBgn0259170 [P53624-1] FBtr0300515; FBpp0289742; FBgn0259170 [P53624-1] FBtr0300516; FBpp0289743; FBgn0259170 [P53624-1] FBtr0331759; FBpp0304147; FBgn0259170 [P53624-2]
GeneIDⁱ	31957
KEGGⁱ	dme:Dmel_CG42275

Organism-specific databases

CTDⁱ	31957
FlyBaseⁱ	FBgn0259170, alpha-Man-Ia
VEuPathDBⁱ	VectorBase:FBgn0259170

Phylogenomic databases

eggNOGⁱ	KOG2204, Eukaryota
GeneTreeⁱ	ENSGT00940000167910
HOGENOMⁱ	CLU_003818_3_2_1
InParanoidⁱ	P53624
OMAⁱ	LIKMYLY
PhylomeDBⁱ	P53624

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
Reactomeⁱ	R-DME-964827, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Miscellaneous databases

BioGRID-ORCSⁱ	31957, 1 hit in 3 CRISPR screens
ChiTaRSⁱ	alpha-Man-Ia, fly
GenomeRNAiⁱ	31957
Protein Ontology More...PROⁱ	PR:P53624

Gene expression databases

Bgeeⁱ	FBgn0259170, Expressed in embryo and 36 other tissues
ExpressionAtlasⁱ	P53624, baseline and differential
Genevisibleⁱ	P53624, DM

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases
Pfamⁱ	View protein in Pfam PF01532, Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747, GLYHDRLASE47
SUPFAMⁱ	SSF48225, SSF48225, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MA1A1_DROME
Accessionⁱ	P53624Primary (citable) accession number: P53624 Secondary accession number(s): A4V480 , M9PH54, P53625, Q9W2W6, Q9W2W7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	March 15, 2004
	Last modified:	May 25, 2022
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
Drosophila
Drosophila: entries, gene names and cross-references to FlyBase
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P53624 (MA1A1_DROME)

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Mannosyl-oligosaccharide alpha-1,2-mannosidase IA

alpha-Man-Ia

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

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Organism-specific databases

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Chemistry databases

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

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Gene expression databases

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Protein-protein interaction databases

Chemistry databases

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3D structure databases

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Region

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Keywords - Domaini

Phylogenomic databases

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Alternative sequence

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Genome annotation databases

Keywords - Coding sequence diversityi

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Chemistry databases

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ