UniProtKB - P53624 (MA1A1_DROME)

BLAST

>sp|P53624|MA1A1_DROME Mannosyl-oligosaccharide alpha-1,2-mannosidase IA OS=Drosophila melanogaster OX=7227 GN=alpha-Man-Ia PE=2 SV=2
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGP
EIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQ
QAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLP
LGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGS
YDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLY
AFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTL
HLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGD
SYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDH
LACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEAR
ALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQ
QEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVT
LPVSNAS

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History
Entry version 160 (12 Sep 2018)
Sequence version 2 (15 Mar 2004)
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Protein

Mannosyl-oligosaccharide alpha-1,2-mannosidase IA

Gene

alpha-Man-Ia

Organism

Drosophila melanogaster (Fruit fly)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man₉GlcNAc₂ to produce Man₅GlcNAc₂.By similarity

Catalytic activityⁱ

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man₉(GlcNAc)₂.By similarity

Cofactorⁱ

Ca²⁺By similarity, Mg²⁺By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	529	Proton donorBy similarity		1
Metal bindingⁱ	640	CalciumBy similarity		1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Source: FlyBase
Inferred from direct assayⁱ
- 23979800

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

determination of adult lifespan
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 19302370
encapsulation of foreign target
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 22829770
N-glycan processing Source: GO_Central
protein glycosylation Source: UniProtKB-UniPathway
response to anesthetic
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 19863272

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-DME-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH47 Glycoside Hydrolase Family 47

CAZyⁱ

GH47 Glycoside Hydrolase Family 47

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannosyl-oligosaccharide alpha-1,2-mannosidase IAImported (EC:3.2.1.113By similarity) Alternative name(s): Man(9)-alpha-mannosidase Mannosidase-1
Gene namesⁱ	Name:alpha-Man-IaImported Synonyms:alpha-man-1Imported, mas-1Imported ORF Names:CG32684Imported
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0259170 alpha-Man-Ia

FlyBaseⁱ

FBgn0259170 alpha-Man-Ia

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 18	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	19 – 39	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	40 – 667	LumenalSequence analysisAdd BLAST	628

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1697673

ChEMBLⁱ

CHEMBL1697673

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210316	1 – 667	Mannosyl-oligosaccharide alpha-1,2-mannosidase IAAdd BLAST		667

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	278	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	483 ↔ 515	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEⁱ	P53624

PRIDEⁱ

P53624

Expressionⁱ

Tissue specificityⁱ

Complex spatial distribution during embryogenesis, including expression in lobula plate giant neurons. Also expressed in adult wing and eyes.1 Publication

Developmental stageⁱ

Expressed both maternally and zygotically during embryonic stages.1 Publication

Gene expression databases

Bgeeⁱ	FBgn0259170 Expressed in 28 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	P53624 baseline and differential
Genevisibleⁱ	P53624 DM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	58390, 2 interactors
IntActⁱ	P53624, 2 interactors

Chemistry databases

BindingDBⁱ

P53624

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P53624
SMRⁱ	P53624
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016529
InParanoidⁱ	P53624
KEGG Orthology (KO) More...KOⁱ	K01230
OMAⁱ	QYGWGHN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04C8
PhylomeDBⁱ	P53624

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341 6hp_glycosidase-like_sf IPR001382 Glyco_hydro_47 IPR036026 Seven-hairpin_glycosidases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01532 Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747 GLYHDRLASE47
SUPFAMⁱ	SSF48225 SSF48225, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative promoter usage. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform HImported (identifier: P53624-1) [UniParc]FASTA Add to basket

Also known as: A1 Publication, JImported, LImported, MImported, NImported, OImported

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRISPIGRK SNFHSREKCL IGLVLVTLCF LCFGGIFLLP DNFGSDRVLR 
        60         70         80         90        100
VYKHFRKAGP EIFIPAPPLA AHAPHRSEDP HFIGDRQRLE QKIRAELGDM 
       110        120        130        140        150
LDEPPAAGGG EPGQFQVLAQ QAQAPAPVAA LADQPLDQDE GHAAIPVLAA 
       160        170        180        190        200
PVQGDNAASQ ASSHPQSSAQ QHNQQQPQLP LGGGGNDQAP DTLDATLEER 
       210        220        230        240        250
RQKVKEMMEH AWHNYKLYAW GKNELRPLSQ RPHSASIFGS YDLGATIVDG 
       260        270        280        290        300
LDTLYIMGLE KEYREGRDWI ERKFSLDNIS AELSVFETNI RFVGGMLTLY 
       310        320        330        340        350
AFTGDPLYKE KAQHVADKLL PAFQTPTGIP YALVNTKTGV AKNYGWASGG 
       360        370        380        390        400
SSILSEFGTL HLEFAYLSDI TGNPLYRERV QTIRQVLKEI EKPKGLYPNF 
       410        420        430        440        450
LNPKTGKWGQ LHMSLGALGD SYYEYLLKAW LQSGQTDEEA REMFDEAMLA 
       460        470        480        490        500
ILDKMVRTSP GGLTYVSDLK FDRLEHKMDH LACFSGGLFA LGAATRQNDY 
       510        520        530        540        550
TDKYMEVGKG ITNTCHESYI RAPTQLGPEA FRFSEAVEAR ALRSQEKYYI 
       560        570        580        590        600
LRPETFESYF VLWRLTHDQK YRDWGWEAVL ALEKHCRTAH GYCGLRNVYQ 
       610        620        630        640        650
QEPQKDDVQQ SFFLAETLKY LYLLFSDDSV LPLDEWVFNT EAHPLPIKGA 
       660 
NAYYRQAPVT LPVSNAS

Length:667

Mass (Da):74,966

Last modified:March 15, 2004 - v2

Checksum:ⁱD707F491E4AE47F2

Isoform KImported (identifier: P53624-2) [UniParc] [UniParc]FASTA Add to basket

Also known as: B1 Publication, PImported

The sequence of this isoform differs from the canonical sequence as follows:
1-206: MYRISPIGRK...LEERRQKVKE → MCPKTSKTTP...DYEKRNQVVK

« Hide

        10         20         30         40         50
MCPKTSKTTP LLLIGGICFV IVLVGITGIT LINNINLSNI IRLNEKVASD 
        60         70         80         90        100
SVSNNENQIK ELNYVNNHPR NVYLKLNASS RDDEDDEQMQ KEQEQLELPK 
       110        120        130        140        150
ISAVIGGSKP KVEDNQVKES SEVISPSTST FSMRSSAGEL TSTSAPLSSI 
       160        170        180        190        200
VSVTAPPMPF GGVKYNQSSG LIDYEKRNQV VKMMEHAWHN YKLYAWGKNE 
       210        220        230        240        250
LRPLSQRPHS ASIFGSYDLG ATIVDGLDTL YIMGLEKEYR EGRDWIERKF 
       260        270        280        290        300
SLDNISAELS VFETNIRFVG GMLTLYAFTG DPLYKEKAQH VADKLLPAFQ 
       310        320        330        340        350
TPTGIPYALV NTKTGVAKNY GWASGGSSIL SEFGTLHLEF AYLSDITGNP 
       360        370        380        390        400
LYRERVQTIR QVLKEIEKPK GLYPNFLNPK TGKWGQLHMS LGALGDSYYE 
       410        420        430        440        450
YLLKAWLQSG QTDEEAREMF DEAMLAILDK MVRTSPGGLT YVSDLKFDRL 
       460        470        480        490        500
EHKMDHLACF SGGLFALGAA TRQNDYTDKY MEVGKGITNT CHESYIRAPT 
       510        520        530        540        550
QLGPEAFRFS EAVEARALRS QEKYYILRPE TFESYFVLWR LTHDQKYRDW 
       560        570        580        590        600
GWEAVLALEK HCRTAHGYCG LRNVYQQEPQ KDDVQQSFFL AETLKYLYLL 
       610        620        630        640 
FSDDSVLPLD EWVFNTEAHP LPIKGANAYY RQAPVTLPVS NAS

Show »

Length:643

Mass (Da):72,525

Checksum:ⁱ8725B99D31DE7AC3

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8IRL4	Q8IRL4_DROME		alpha-1,2-Mannosidase alpha-1,2-Mannosidase, EC 3.2.1.-	alpha-Man-Ia a-Man-Ia, alpha-Man-I, alpha-Man-l, CG17809, CG18799	684	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	21	I → T in CAA57962 (PubMed:7729592).Curated		1
Sequence conflictⁱ	568	D → E in CAA57962 (PubMed:7729592).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057904	1 – 206	MYRIS…QKVKE → MCPKTSKTTPLLLIGGICFV IVLVGITGITLINNINLSNI IRLNEKVASDSVSNNENQIK ELNYVNNHPRNVYLKLNASS RDDEDDEQMQKEQEQLELPK ISAVIGGSKPKVEDNQVKES SEVISPSTSTFSMRSSAGEL TSTSAPLSSIVSVTAPPMPF GGVKYNQSSGLIDYEKRNQV VK in isoform K. Add BLAST		206

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82640 mRNA Translation: CAA57962.1 X82641 mRNA Translation: CAA57963.1 AE014298 Genomic DNA Translation: AAF46570.1 AE014298 Genomic DNA Translation: AAF46571.3 AE014298 Genomic DNA Translation: AAS65302.1 AE014298 Genomic DNA Translation: AAS65303.1 AE014298 Genomic DNA Translation: AAS65304.1 AE014298 Genomic DNA Translation: AAS65305.1 AE014298 Genomic DNA Translation: AAS65306.1 AE014298 Genomic DNA Translation: AGB95245.1 BT011036 mRNA Translation: AAR30196.1
PIRⁱ	S60709
NCBI Reference Sequences More...RefSeqⁱ	NP_001259402.1, NM_001272473.2 [P53624-2] NP_511105.2, NM_078550.4 [P53624-2] NP_727407.1, NM_167223.3 [P53624-1] NP_996395.1, NM_206672.3 [P53624-1] NP_996396.1, NM_206673.3 [P53624-1] NP_996397.1, NM_206674.3 [P53624-1] NP_996398.1, NM_206675.3 [P53624-1] NP_996399.1, NM_206676.3 [P53624-1]
UniGeneⁱ	Dm.7316

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative promoter usage

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53624	alpha-1,2-Mannosidase		DROYA		672	UniRef90_P53624
alpha-1,2-Mannosidase		DROFC		670
alpha-1,2-Mannosidase		DROAN		670
alpha-1,2-Mannosidase		DROER		666
UPI0007E80504		DRORH		675
+8
P53624-2	alpha-1,2-Mannosidase		DROSE		647	UniRef90_P53624-2
alpha-1,2-Mannosidase		DROER		641
UPI00078AE0C4		DROSI		647
UPI0007E735C5		DROEU		646
UPI0007E60B61		DRORH		642
+2

Protein	Similar proteins		Species	Score	Length	Source
P53624	alpha-1,2-Mannosidase		DROYA		672	UniRef50_P53624
alpha-1,2-Mannosidase		DROFC		670
alpha-1,2-Mannosidase		DROAN		670
alpha-1,2-Mannosidase		DROER		666
alpha-1,2-Mannosidase		CIOIN		614
+151

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82640 mRNA Translation: CAA57962.1 X82641 mRNA Translation: CAA57963.1 AE014298 Genomic DNA Translation: AAF46570.1 AE014298 Genomic DNA Translation: AAF46571.3 AE014298 Genomic DNA Translation: AAS65302.1 AE014298 Genomic DNA Translation: AAS65303.1 AE014298 Genomic DNA Translation: AAS65304.1 AE014298 Genomic DNA Translation: AAS65305.1 AE014298 Genomic DNA Translation: AAS65306.1 AE014298 Genomic DNA Translation: AGB95245.1 BT011036 mRNA Translation: AAR30196.1
PIRⁱ	S60709
RefSeqⁱ	NP_001259402.1, NM_001272473.2 [P53624-2] NP_511105.2, NM_078550.4 [P53624-2] NP_727407.1, NM_167223.3 [P53624-1] NP_996395.1, NM_206672.3 [P53624-1] NP_996396.1, NM_206673.3 [P53624-1] NP_996397.1, NM_206674.3 [P53624-1] NP_996398.1, NM_206675.3 [P53624-1] NP_996399.1, NM_206676.3 [P53624-1]
UniGeneⁱ	Dm.7316

3D structure databases

ProteinModelPortalⁱ	P53624
SMRⁱ	P53624
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	58390, 2 interactors
IntActⁱ	P53624, 2 interactors

Chemistry databases

BindingDBⁱ	P53624
ChEMBLⁱ	CHEMBL1697673

Protein family/group databases

CAZyⁱ	GH47 Glycoside Hydrolase Family 47

CAZyⁱ

GH47 Glycoside Hydrolase Family 47

Proteomic databases

PRIDEⁱ	P53624

PRIDEⁱ

P53624

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0299632; FBpp0288907; FBgn0259170 [P53624-1] FBtr0300511; FBpp0289738; FBgn0259170 [P53624-1] FBtr0300512; FBpp0289739; FBgn0259170 [P53624-2] FBtr0300513; FBpp0289740; FBgn0259170 [P53624-1] FBtr0300514; FBpp0289741; FBgn0259170 [P53624-1] FBtr0300515; FBpp0289742; FBgn0259170 [P53624-1] FBtr0300516; FBpp0289743; FBgn0259170 [P53624-1] FBtr0331759; FBpp0304147; FBgn0259170 [P53624-2]
GeneIDⁱ	31957
KEGGⁱ	dme:Dmel_CG42275

Organism-specific databases

CTDⁱ	31957
FlyBaseⁱ	FBgn0259170 alpha-Man-Ia

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000016529
InParanoidⁱ	P53624
KOⁱ	K01230
OMAⁱ	QYGWGHN
OrthoDBⁱ	EOG091G04C8
PhylomeDBⁱ	P53624

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
Reactomeⁱ	R-DME-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Miscellaneous databases

ChiTaRSⁱ	alpha-Man-Ia fly
GenomeRNAiⁱ	31957
Protein Ontology More...PROⁱ	PR:P53624

Gene expression databases

Bgeeⁱ	FBgn0259170 Expressed in 28 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	P53624 baseline and differential
Genevisibleⁱ	P53624 DM

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341 6hp_glycosidase-like_sf IPR001382 Glyco_hydro_47 IPR036026 Seven-hairpin_glycosidases
Pfamⁱ	View protein in Pfam PF01532 Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747 GLYHDRLASE47
SUPFAMⁱ	SSF48225 SSF48225, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MA1A1_DROME
Accessionⁱ	P53624Primary (citable) accession number: P53624 Secondary accession number(s): A4V480 , M9PH54, P53625, Q9W2W6, Q9W2W7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	March 15, 2004
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Drosophila
Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P53624 (MA1A1_DROME)

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Mannosyl-oligosaccharide alpha-1,2-mannosidase IA

alpha-Man-Ia

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ