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Entry version 167 (08 May 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Protein NRD1

Gene

NRD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.

Miscellaneous

Present with 19600 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33248-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NRD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRD1
Ordered Locus Names:YNL251C
ORF Names:N0868
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YNL251C

Saccharomyces Genome Database

More...
SGDi
S000005195 NRD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816881 – 575Protein NRD1Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53617

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53617

PRoteomics IDEntifications database

More...
PRIDEi
P53617

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53617

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35588, 292 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1316 NRD1 snoRNA termination complex

Database of interacting proteins

More...
DIPi
DIP-6778N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P53617

Protein interaction database and analysis system

More...
IntActi
P53617, 35 interactors

Molecular INTeraction database

More...
MINTi
P53617

STRING: functional protein association networks

More...
STRINGi
4932.YNL251C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LO6NMR-A1-153[»]
2M88NMR-A307-491[»]
2MOWNMR-A1-153[»]
3CLJX-ray2.10A6-151[»]
5O1TNMR-A290-468[»]
5O1WX-ray2.30A301-489[»]
5O1XX-ray1.60A290-468[»]
5O1YX-ray2.45A290-468[»]
5O1ZX-ray3.40A290-468[»]
5O20X-ray3.53A290-468[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53617

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53617

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 153CIDPROSITE-ProRule annotationAdd BLAST153
Domaini339 – 409RRMPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi541 – 544Poly-Ala4
Compositional biasi567 – 574Poly-Gln8

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173128

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000248757

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53617

KEGG Orthology (KO)

More...
KOi
K15560

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAPGTHK

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03562 CID, 1 hit
cd12331 RRM_NRD1_SEB1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR034894 Nrd1/Seb1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR006903 RNA_pol_II-bd
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818 CTD_bind, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQDDDFQNF VATLESFKDL KSGISGSRIK KLTTYALDHI DIESKIISLI
60 70 80 90 100
IDYSRLCPDS HKLGSLYIID SIGRAYLDET RSNSNSSSNK PGTCAHAINT
110 120 130 140 150
LGEVIQELLS DAIAKSNQDH KEKIRMLLDI WDRSGLFQKS YLNAIRSKCF
160 170 180 190 200
AMDISNNTAN TASQQLSLDP KQRSKQILSN LKKSPPLNLN ISLPTDLTST
210 220 230 240 250
DPAKQQAALF QVIAALQKHF KTLPSHTSVG TVAPPQAHTI TEYGSRRERE
260 270 280 290 300
RERERYNSRR NRSRSPPAPF SQPSTGRKDR YPSVAQDQYS IGAPNTTFGT
310 320 330 340 350
NNHHLYPDEL NVSNNPHYRP KPVSYDSTLP PDHIKVYSRT LFIGGVPLNM
360 370 380 390 400
KEWDLANVLK PFAEVQSVIL NNSRKHAFVK VYSRHEAENV LQNFNKDGAL
410 420 430 440 450
PLRTRWGVGF GPRDCCDYQH GYSIIPMHRL TDADKKWSVS AQWGGTSGQP
460 470 480 490 500
LVTGIVFEEP DIIVGEGVSS KAISQKMPTD SGRNGPRSGK PNKSGSISSI
510 520 530 540 550
SPVPYGNAPL ASPPPQQYVQ PMMQQPYGYA PNQPLPSQGP AAAAPPVPQQ
560 570
QFDPTAQLNS LMNMLNQQQQ QQQQS
Length:575
Mass (Da):63,859
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75082BDB0C42AE37
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28487 Genomic DNA Translation: AAC49568.1
X96722 Genomic DNA Translation: CAA65493.1
Z71527 Genomic DNA Translation: CAA96158.1
BK006947 Genomic DNA Translation: DAA10308.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59740

NCBI Reference Sequences

More...
RefSeqi
NP_014148.1, NM_001183089.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL251C_mRNA; YNL251C_mRNA; YNL251C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855470

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL251C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28487 Genomic DNA Translation: AAC49568.1
X96722 Genomic DNA Translation: CAA65493.1
Z71527 Genomic DNA Translation: CAA96158.1
BK006947 Genomic DNA Translation: DAA10308.1
PIRiS59740
RefSeqiNP_014148.1, NM_001183089.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LO6NMR-A1-153[»]
2M88NMR-A307-491[»]
2MOWNMR-A1-153[»]
3CLJX-ray2.10A6-151[»]
5O1TNMR-A290-468[»]
5O1WX-ray2.30A301-489[»]
5O1XX-ray1.60A290-468[»]
5O1YX-ray2.45A290-468[»]
5O1ZX-ray3.40A290-468[»]
5O20X-ray3.53A290-468[»]
SMRiP53617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35588, 292 interactors
ComplexPortaliCPX-1316 NRD1 snoRNA termination complex
DIPiDIP-6778N
ELMiP53617
IntActiP53617, 35 interactors
MINTiP53617
STRINGi4932.YNL251C

PTM databases

iPTMnetiP53617

Proteomic databases

MaxQBiP53617
PaxDbiP53617
PRIDEiP53617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL251C_mRNA; YNL251C_mRNA; YNL251C
GeneIDi855470
KEGGisce:YNL251C

Organism-specific databases

EuPathDBiFungiDB:YNL251C
SGDiS000005195 NRD1

Phylogenomic databases

GeneTreeiENSGT00940000173128
HOGENOMiHOG000248757
InParanoidiP53617
KOiK15560
OMAiKAPGTHK

Enzyme and pathway databases

BioCyciYEAST:G3O-33248-MONOMER

Miscellaneous databases

EvolutionaryTraceiP53617

Protein Ontology

More...
PROi
PR:P53617

Family and domain databases

CDDicd03562 CID, 1 hit
cd12331 RRM_NRD1_SEB1_like, 1 hit
Gene3Di1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR034894 Nrd1/Seb1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR006903 RNA_pol_II-bd
IPR000504 RRM_dom
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRD1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53617
Secondary accession number(s): D6W0U2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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