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Protein

Methionine aminopeptidase 1

Gene

METAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.UniRule annotation2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Co2+UniRule annotation4 Publications, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei203SubstrateUniRule annotation3 Publications1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi220Divalent metal cation 1UniRule annotation4 Publications1
Metal bindingi231Divalent metal cation 1UniRule annotation4 Publications1
Metal bindingi231Divalent metal cation 2; catalyticUniRule annotation4 Publications1
Metal bindingi294Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation4 Publications1
Binding sitei301SubstrateUniRule annotation3 Publications1
Metal bindingi327Divalent metal cation 2; catalyticUniRule annotation4 Publications1
Metal bindingi358Divalent metal cation 1UniRule annotation4 Publications1
Metal bindingi358Divalent metal cation 2; catalyticUniRule annotation4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aminopeptidase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-UniRule
  • metalloaminopeptidase activity Source: UniProtKB-UniRule
  • metalloexopeptidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMetal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08982-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.11.18 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P53582

Protein family/group databases

MEROPS protease database

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MEROPSi
M24.017

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine aminopeptidase 1UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 1UniRule annotation
Short name:
MetAP 1UniRule annotation
Alternative name(s):
Peptidase M 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:METAP1
Synonyms:KIAA0094
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164024.11

Human Gene Nomenclature Database

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HGNCi
HGNC:15789 METAP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610151 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P53582

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23173

Open Targets

More...
OpenTargetsi
ENSG00000164024

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30764

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2474

Drug and drug target database

More...
DrugBanki
DB07901 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE
DB04324 Ovalicin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1572

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
METAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33302602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001489672 – 386Methionine aminopeptidase 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P53582

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P53582

MaxQB - The MaxQuant DataBase

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MaxQBi
P53582

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53582

PeptideAtlas

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PeptideAtlasi
P53582

PRoteomics IDEntifications database

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PRIDEi
P53582

ProteomicsDB human proteome resource

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ProteomicsDBi
56586

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P53582

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P53582

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164024 Expressed in 230 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_METAP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P53582 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P53582 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025485
HPA037997
HPA037998

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the 60S ribosomal subunit of the 80S translational complex.UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116785, 17 interactors

Protein interaction database and analysis system

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IntActi
P53582, 11 interactors

Molecular INTeraction database

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MINTi
P53582

STRING: functional protein association networks

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STRINGi
9606.ENSP00000296411

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P53582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B3HX-ray1.10A81-384[»]
2B3KX-ray1.55A81-384[»]
2B3LX-ray1.50A81-384[»]
2G6PX-ray1.90A81-384[»]
2GZ5X-ray1.10A81-384[»]
2NQ6X-ray1.50A81-384[»]
2NQ7X-ray1.60A81-384[»]
4FLIX-ray1.55A81-386[»]
4FLJX-ray1.74A81-386[»]
4FLKX-ray1.47A81-386[»]
4FLLX-ray1.50A81-386[»]
4HXXX-ray2.09A81-384[»]
4IKRX-ray1.78A81-384[»]
4IKSX-ray1.70A81-384[»]
4IKTX-ray1.60A81-384[»]
4IKUX-ray1.30A81-384[»]
4IU6X-ray1.90A1-384[»]
4U1BX-ray1.89A81-386[»]
4U69X-ray1.60A81-386[»]
4U6CX-ray1.91A81-386[»]
4U6EX-ray1.90A81-386[»]
4U6JX-ray1.56A81-386[»]
4U6WX-ray1.83A81-386[»]
4U6ZX-ray1.80A81-386[»]
4U70X-ray1.60A81-386[»]
4U71X-ray1.80A81-386[»]
4U73X-ray1.80A81-386[»]
4U75X-ray1.94A81-386[»]
4U76X-ray1.87A81-386[»]
5YKPX-ray1.68A81-384[»]
5YR4X-ray1.82A81-384[»]
5YR5X-ray1.60A81-384[»]
5YR6X-ray1.75A81-384[»]
5YR7X-ray2.06A81-386[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P53582

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P53582

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53582

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni9 – 52Zinc finger-like; important for proper ribosome associationUniRule annotationAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2738 Eukaryota
COG0024 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158205

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000030427

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG067178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53582

KEGG Orthology (KO)

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KOi
K01265

Identification of Orthologs from Complete Genome Data

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OMAi
GDHAYTF

Database of Orthologous Groups

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OrthoDBi
1002357at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P53582

TreeFam database of animal gene trees

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TreeFami
TF105753

Family and domain databases

Conserved Domains Database

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CDDi
cd01086 MetAP1, 1 hit

HAMAP database of protein families

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HAMAPi
MF_01974 MetAP_1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
IPR031615 Zfn-C6H2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00557 Peptidase_M24, 1 hit
PF15801 zf-C6H2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00599 MAPEPTIDASE

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55920 SSF55920, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00500 met_pdase_I, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00680 MAP_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P53582-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVETRVCE TDGCSSEAKL QCPTCIKLGI QGSYFCSQEC FKGSWATHKL
60 70 80 90 100
LHKKAKDEKA KREVSSWTVE GDINTDPWAG YRYTGKLRPH YPLMPTRPVP
110 120 130 140 150
SYIQRPDYAD HPLGMSESEQ ALKGTSQIKL LSSEDIEGMR LVCRLAREVL
160 170 180 190 200
DVAAGMIKPG VTTEEIDHAV HLACIARNCY PSPLNYYNFP KSCCTSVNEV
210 220 230 240 250
ICHGIPDRRP LQEGDIVNVD ITLYRNGYHG DLNETFFVGE VDDGARKLVQ
260 270 280 290 300
TTYECLMQAI DAVKPGVRYR ELGNIIQKHA QANGFSVVRS YCGHGIHKLF
310 320 330 340 350
HTAPNVPHYA KNKAVGVMKS GHVFTIEPMI CEGGWQDETW PDGWTAVTRD
360 370 380
GKRSAQFEHT LLVTDTGCEI LTRRLDSARP HFMSQF
Length:386
Mass (Da):43,215
Last modified:July 25, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i372879013C2BB01D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y955H0Y955_HUMAN
Methionine aminopeptidase 1
METAP1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9L0H0Y9L0_HUMAN
Methionine aminopeptidase 1
METAP1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y903H0Y903_HUMAN
Methionine aminopeptidase 1
METAP1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF24D6RF24_HUMAN
Methionine aminopeptidase 1
METAP1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAI3H0YAI3_HUMAN
Methionine aminopeptidase 1
METAP1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA07679 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D42084 mRNA Translation: BAA07679.1 Different initiation.
AK304239 mRNA Translation: BAG65108.1
CH471057 Genomic DNA Translation: EAX06083.1
BC030054 mRNA Translation: AAH30054.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47110.1

NCBI Reference Sequences

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RefSeqi
NP_055958.2, NM_015143.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.480364

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296411; ENSP00000296411; ENSG00000164024

Database of genes from NCBI RefSeq genomes

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GeneIDi
23173

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23173

UCSC genome browser

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UCSCi
uc003huf.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42084 mRNA Translation: BAA07679.1 Different initiation.
AK304239 mRNA Translation: BAG65108.1
CH471057 Genomic DNA Translation: EAX06083.1
BC030054 mRNA Translation: AAH30054.1 Different initiation.
CCDSiCCDS47110.1
RefSeqiNP_055958.2, NM_015143.2
UniGeneiHs.480364

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B3HX-ray1.10A81-384[»]
2B3KX-ray1.55A81-384[»]
2B3LX-ray1.50A81-384[»]
2G6PX-ray1.90A81-384[»]
2GZ5X-ray1.10A81-384[»]
2NQ6X-ray1.50A81-384[»]
2NQ7X-ray1.60A81-384[»]
4FLIX-ray1.55A81-386[»]
4FLJX-ray1.74A81-386[»]
4FLKX-ray1.47A81-386[»]
4FLLX-ray1.50A81-386[»]
4HXXX-ray2.09A81-384[»]
4IKRX-ray1.78A81-384[»]
4IKSX-ray1.70A81-384[»]
4IKTX-ray1.60A81-384[»]
4IKUX-ray1.30A81-384[»]
4IU6X-ray1.90A1-384[»]
4U1BX-ray1.89A81-386[»]
4U69X-ray1.60A81-386[»]
4U6CX-ray1.91A81-386[»]
4U6EX-ray1.90A81-386[»]
4U6JX-ray1.56A81-386[»]
4U6WX-ray1.83A81-386[»]
4U6ZX-ray1.80A81-386[»]
4U70X-ray1.60A81-386[»]
4U71X-ray1.80A81-386[»]
4U73X-ray1.80A81-386[»]
4U75X-ray1.94A81-386[»]
4U76X-ray1.87A81-386[»]
5YKPX-ray1.68A81-384[»]
5YR4X-ray1.82A81-384[»]
5YR5X-ray1.60A81-384[»]
5YR6X-ray1.75A81-384[»]
5YR7X-ray2.06A81-386[»]
ProteinModelPortaliP53582
SMRiP53582
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116785, 17 interactors
IntActiP53582, 11 interactors
MINTiP53582
STRINGi9606.ENSP00000296411

Chemistry databases

BindingDBiP53582
ChEMBLiCHEMBL2474
DrugBankiDB07901 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE
DB04324 Ovalicin
GuidetoPHARMACOLOGYi1572

Protein family/group databases

MEROPSiM24.017

PTM databases

iPTMnetiP53582
PhosphoSitePlusiP53582

Polymorphism and mutation databases

BioMutaiMETAP1
DMDMi33302602

Proteomic databases

EPDiP53582
jPOSTiP53582
MaxQBiP53582
PaxDbiP53582
PeptideAtlasiP53582
PRIDEiP53582
ProteomicsDBi56586

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296411; ENSP00000296411; ENSG00000164024
GeneIDi23173
KEGGihsa:23173
UCSCiuc003huf.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23173
DisGeNETi23173
EuPathDBiHostDB:ENSG00000164024.11

GeneCards: human genes, protein and diseases

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GeneCardsi
METAP1
HGNCiHGNC:15789 METAP1
HPAiCAB025485
HPA037997
HPA037998
MIMi610151 gene
neXtProtiNX_P53582
OpenTargetsiENSG00000164024
PharmGKBiPA30764

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2738 Eukaryota
COG0024 LUCA
GeneTreeiENSGT00940000158205
HOGENOMiHOG000030427
HOVERGENiHBG067178
InParanoidiP53582
KOiK01265
OMAiGDHAYTF
OrthoDBi1002357at2759
PhylomeDBiP53582
TreeFamiTF105753

Enzyme and pathway databases

BioCyciMetaCyc:HS08982-MONOMER
BRENDAi3.4.11.18 2681
ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
SABIO-RKiP53582

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
METAP1 human
EvolutionaryTraceiP53582

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
METAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23173

Protein Ontology

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PROi
PR:P53582

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164024 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_METAP1
ExpressionAtlasiP53582 baseline and differential
GenevisibleiP53582 HS

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
IPR031615 Zfn-C6H2
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PF15801 zf-C6H2, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53582
Secondary accession number(s): B4E2E6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 25, 2003
Last modified: January 16, 2019
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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