UniProtKB - P53569 (CEBPZ_MOUSE)
Protein
CCAAT/enhancer-binding protein zeta
Gene
Cebpz
Organism
Mus musculus (Mouse)
Status
Functioni
Stimulates transcription from the HSP70 promoter.
GO - Molecular functioni
- transcription coactivator activity Source: MGI
GO - Biological processi
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein zetaAlternative name(s): CCAAT-box-binding transcription factor Short name: CBF Short name: CCAAT-binding factor |
Gene namesi | Name:Cebpz Synonyms:Cbf2, Cebpa-rs1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109386, Cebpz |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173471 | 1 – 1052 | CCAAT/enhancer-binding protein zetaAdd BLAST | 1052 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 629 | PhosphoserineCombined sources | 1 | |
Modified residuei | 641 | PhosphoserineCombined sources | 1 | |
Modified residuei | 837 | PhosphoserineBy similarity | 1 | |
Modified residuei | 958 | PhosphoserineBy similarity | 1 | |
Modified residuei | 972 | PhosphoserineBy similarity | 1 | |
Modified residuei | 977 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P53569 |
jPOSTi | P53569 |
MaxQBi | P53569 |
PaxDbi | P53569 |
PeptideAtlasi | P53569 |
PRIDEi | P53569 |
PTM databases
iPTMneti | P53569 |
PhosphoSitePlusi | P53569 |
Expressioni
Tissue specificityi
Ubiquitous.
Interactioni
Protein-protein interaction databases
BioGRIDi | 198668, 41 interactors |
CORUMi | P53569 |
IntActi | P53569, 2 interactors |
MINTi | P53569 |
STRINGi | 10090.ENSMUSP00000024885 |
Miscellaneous databases
RNActi | P53569, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CBF/MAK21 family.Curated
Phylogenomic databases
eggNOGi | KOG2038, Eukaryota |
InParanoidi | P53569 |
OrthoDBi | 551907at2759 |
PhylomeDBi | P53569 |
TreeFami | TF105010 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005612, CCAAT-binding_factor IPR040155, CEBPZ/Mak21-like |
PANTHERi | PTHR12048, PTHR12048, 1 hit |
Pfami | View protein in Pfam PF03914, CBF, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG
60 70 80 90 100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL
110 120 130 140 150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP
160 170 180 190 200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD
210 220 230 240 250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA
260 270 280 290 300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD
310 320 330 340 350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL
360 370 380 390 400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT
410 420 430 440 450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL
460 470 480 490 500
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG
510 520 530 540 550
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR
560 570 580 590 600
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP
610 620 630 640 650
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD
660 670 680 690 700
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF
710 720 730 740 750
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD
760 770 780 790 800
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF
810 820 830 840 850
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI
860 870 880 890 900
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV
910 920 930 940 950
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE
960 970 980 990 1000
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA
1010 1020 1030 1040 1050
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ
RK
Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
455-461: SELANKL → KRCWIQA
462-1052: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J046 | A0A0R4J046_MOUSE | CCAAT/enhancer-binding protein zeta | Cebpz | 1,052 | Annotation score: | ||
A0A3B2WCE8 | A0A3B2WCE8_MOUSE | CCAAT/enhancer-binding protein zeta | Cebpz | 461 | Annotation score: |
Sequence cautioni
The sequence AAB01503 differs from that shown. Reason: Frameshift.Curated
The sequence BAE34799 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 112 | A → T in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 112 | A → T in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 146 | A → P in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 146 | A → P in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 196 | P → L in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 196 | P → L in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 318 | M → L in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 318 | M → L in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 422 | G → A in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 422 | G → A in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 471 | T → S in AAB01503 (PubMed:8604343).Curated | 1 | |
Sequence conflicti | 652 | G → E in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 652 | G → E in BAE34655 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 875 | T → A in BAE22857 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 875 | T → A in BAE34655 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000853 | 455 – 461 | SELANKL → KRCWIQA in isoform CBF2. 1 Publication | 7 | |
Alternative sequenceiVSP_000854 | 462 – 1052 | Missing in isoform CBF2. 1 PublicationAdd BLAST | 591 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19891 mRNA Translation: AAB01503.1 Frameshift. U19892 mRNA Translation: AAB01504.1 AK136173 mRNA Translation: BAE22857.1 AK158771 mRNA Translation: BAE34655.1 AK159081 mRNA Translation: BAE34799.1 Frameshift. |
CCDSi | CCDS28981.1 [P53569-1] |
PIRi | JC6067 |
RefSeqi | NP_001019977.1, NM_001024806.2 |
Genome annotation databases
GeneIDi | 12607 |
KEGGi | mmu:12607 |
UCSCi | uc008dpk.1, mouse [P53569-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19891 mRNA Translation: AAB01503.1 Frameshift. U19892 mRNA Translation: AAB01504.1 AK136173 mRNA Translation: BAE22857.1 AK158771 mRNA Translation: BAE34655.1 AK159081 mRNA Translation: BAE34799.1 Frameshift. |
CCDSi | CCDS28981.1 [P53569-1] |
PIRi | JC6067 |
RefSeqi | NP_001019977.1, NM_001024806.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 198668, 41 interactors |
CORUMi | P53569 |
IntActi | P53569, 2 interactors |
MINTi | P53569 |
STRINGi | 10090.ENSMUSP00000024885 |
PTM databases
iPTMneti | P53569 |
PhosphoSitePlusi | P53569 |
Proteomic databases
EPDi | P53569 |
jPOSTi | P53569 |
MaxQBi | P53569 |
PaxDbi | P53569 |
PeptideAtlasi | P53569 |
PRIDEi | P53569 |
Protocols and materials databases
DNASUi | 12607 |
Genome annotation databases
GeneIDi | 12607 |
KEGGi | mmu:12607 |
UCSCi | uc008dpk.1, mouse [P53569-1] |
Organism-specific databases
CTDi | 10153 |
MGIi | MGI:109386, Cebpz |
Phylogenomic databases
eggNOGi | KOG2038, Eukaryota |
InParanoidi | P53569 |
OrthoDBi | 551907at2759 |
PhylomeDBi | P53569 |
TreeFami | TF105010 |
Miscellaneous databases
BioGRID-ORCSi | 12607, 9 hits in 17 CRISPR screens |
ChiTaRSi | Cebpz, mouse |
PROi | PR:P53569 |
RNActi | P53569, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005612, CCAAT-binding_factor IPR040155, CEBPZ/Mak21-like |
PANTHERi | PTHR12048, PTHR12048, 1 hit |
Pfami | View protein in Pfam PF03914, CBF, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPZ_MOUSE | |
Accessioni | P53569Primary (citable) accession number: P53569 Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | April 18, 2006 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families