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UniProtKB - P53568 (CEBPG_MOUSE)
Protein
CCAAT/enhancer-binding protein gamma
Gene
Cebpg
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272).
Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606).
Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121).
Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity).
Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: UniProtKB
- double-stranded DNA binding Source: MGI
- protein-containing complex binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Source: MGI
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- B cell differentiation Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- enucleate erythrocyte differentiation Source: UniProtKB
- immune response Source: UniProtKB
- liver development Source: UniProtKB
- mRNA metabolic process Source: MGI
- natural killer cell mediated cytotoxicity Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- nucleosome disassembly Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein gammaShort name: C/EBP gamma Alternative name(s): Granulocyte colony-stimulating factor promoter element 1-binding protein Short name: GPE1-BP1 Publication Short name: GPE1-binding protein Immunoglobulin enhancer-binding protein 11 Publication Short name: IG/EBP-1 |
Gene namesi | Name:Cebpg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104982, Cebpg |
VEuPathDBi | HostDB:ENSMUSG00000056216 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication1 Publication
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076629 | 1 – 150 | CCAAT/enhancer-binding protein gammaAdd BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 3 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P53568 |
PaxDbi | P53568 |
PeptideAtlasi | P53568 |
PRIDEi | P53568 |
ProteomicsDBi | 279996 |
PTM databases
iPTMneti | P53568 |
PhosphoSitePlusi | P53568 |
Expressioni
Tissue specificityi
Ubiquitous.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000056216, Expressed in olfactory epithelium and 321 other tissues |
Genevisiblei | P53568, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198671, 4 interactors |
IntActi | P53568, 2 interactors |
STRINGi | 10090.ENSMUSP00000118588 |
Miscellaneous databases
RNActi | P53568, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 125 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 94 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 66 – 93 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 97 – 118 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 | |
Regioni | 129 – 150 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 94 | Basic and acidic residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 131 – 150 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P53568 |
OMAi | HAHNFAD |
OrthoDBi | 1008736at2759 |
PhylomeDBi | P53568 |
TreeFami | TF105009 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
P53568-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHSLA DNVQPISTET TATNSDNPGQ
Sequence cautioni
The sequence CAA39116 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55499 mRNA Translation: CAA39116.1 Different initiation. BC011319 mRNA Translation: AAH11319.1 |
CCDSi | CCDS21144.1 |
PIRi | A36673 |
RefSeqi | NP_034014.1, NM_009884.3 |
Genome annotation databases
Ensembli | ENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216 ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216 |
GeneIDi | 12611 |
KEGGi | mmu:12611 |
UCSCi | uc009gjk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55499 mRNA Translation: CAA39116.1 Different initiation. BC011319 mRNA Translation: AAH11319.1 |
CCDSi | CCDS21144.1 |
PIRi | A36673 |
RefSeqi | NP_034014.1, NM_009884.3 |
3D structure databases
SMRi | P53568 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198671, 4 interactors |
IntActi | P53568, 2 interactors |
STRINGi | 10090.ENSMUSP00000118588 |
PTM databases
iPTMneti | P53568 |
PhosphoSitePlusi | P53568 |
Proteomic databases
EPDi | P53568 |
PaxDbi | P53568 |
PeptideAtlasi | P53568 |
PRIDEi | P53568 |
ProteomicsDBi | 279996 |
Protocols and materials databases
Antibodypediai | 1652, 375 antibodies from 35 providers |
DNASUi | 12611 |
Genome annotation databases
Ensembli | ENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216 ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216 |
GeneIDi | 12611 |
KEGGi | mmu:12611 |
UCSCi | uc009gjk.1, mouse |
Organism-specific databases
CTDi | 1054 |
MGIi | MGI:104982, Cebpg |
VEuPathDBi | HostDB:ENSMUSG00000056216 |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P53568 |
OMAi | HAHNFAD |
OrthoDBi | 1008736at2759 |
PhylomeDBi | P53568 |
TreeFami | TF105009 |
Miscellaneous databases
BioGRID-ORCSi | 12611, 5 hits in 103 CRISPR screens |
ChiTaRSi | Cebpg, mouse |
PROi | PR:P53568 |
RNActi | P53568, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056216, Expressed in olfactory epithelium and 321 other tissues |
Genevisiblei | P53568, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPG_MOUSE | |
Accessioni | P53568Primary (citable) accession number: P53568 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families