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Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272). Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606). Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • chromatin remodeling Source: UniProtKB
  • enucleate erythrocyte differentiation Source: UniProtKB
  • immune response Source: UniProtKB
  • liver development Source: UniProtKB
  • mRNA metabolic process Source: MGI
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • negative regulation of DNA binding transcription factor activity Source: UniProtKB
  • nucleosome disassembly Source: UniProtKB
  • positive regulation of DNA repair Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Alternative name(s):
Granulocyte colony-stimulating factor promoter element 1-binding protein
Short name:
GPE1-BP1 Publication
Short name:
GPE1-binding protein
Immunoglobulin enhancer-binding protein 11 Publication
Short name:
IG/EBP-1
Gene namesi
Name:Cebpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104982 Cebpg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766291 – 150CCAAT/enhancer-binding protein gammaAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP53568
PaxDbiP53568
PeptideAtlasiP53568
PRIDEiP53568

PTM databases

iPTMnetiP53568
PhosphoSitePlusiP53568

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSMUSG00000056216
CleanExiMM_CEBPG
ExpressionAtlasiP53568 baseline and differential
GenevisibleiP53568 MM

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with CEBPA (PubMed:2121606). Can form stable heterodimers with CEBPB (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198671, 2 interactors
STRINGi10090.ENSMUSP00000064963

Structurei

3D structure databases

ProteinModelPortaliP53568
SMRiP53568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 125bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 93Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni97 – 118Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISXZ Eukaryota
ENOG41128ZN LUCA
GeneTreeiENSGT00530000063192
HOGENOMiHOG000057291
HOVERGENiHBG050880
InParanoidiP53568
KOiK10049
OMAiADNVQPS
OrthoDBiEOG091G11FC
PhylomeDBiP53568
TreeFamiTF105009

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

P53568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHSLA DNVQPISTET TATNSDNPGQ
Length:150
Mass (Da):16,400
Last modified:October 1, 1996 - v1
Checksum:i697602DA2BD3F8B6
GO

Sequence cautioni

The sequence CAA39116 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55499 mRNA Translation: CAA39116.1 Different initiation.
BC011319 mRNA Translation: AAH11319.1
CCDSiCCDS21144.1
PIRiA36673
RefSeqiNP_034014.1, NM_009884.3
UniGeneiMm.273090

Genome annotation databases

EnsembliENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216
ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216
GeneIDi12611
KEGGimmu:12611
UCSCiuc009gjk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCEBPG_MOUSE
AccessioniPrimary (citable) accession number: P53568
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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