UniProtKB - P53567 (CEBPG_HUMAN)
Protein
CCAAT/enhancer-binding protein gamma
Gene
CEBPG
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.By similarity1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Source: Ensembl
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: UniProtKB
GO - Biological processi
- B cell differentiation Source: UniProtKB
- enucleate erythrocyte differentiation Source: UniProtKB
- immune response Source: UniProtKB
- liver development Source: UniProtKB
- mRNA metabolic process Source: Ensembl
- natural killer cell mediated cytotoxicity Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of DNA binding Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P53567 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency |
SIGNORi | P53567 |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein gammaShort name: C/EBP gamma |
Gene namesi | Name:CEBPG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1837, CEBPG |
MIMi | 138972, gene |
neXtProti | NX_P53567 |
VEuPathDBi | HostDB:ENSG00000153879.8 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1054 |
OpenTargetsi | ENSG00000153879 |
PharmGKBi | PA26380 |
Miscellaneous databases
Pharosi | P53567, Tbio |
Genetic variation databases
BioMutai | CEBPG |
DMDMi | 1705750 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076628 | 1 – 150 | CCAAT/enhancer-binding protein gammaAdd BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 3 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P53567 |
jPOSTi | P53567 |
MassIVEi | P53567 |
MaxQBi | P53567 |
PaxDbi | P53567 |
PeptideAtlasi | P53567 |
PRIDEi | P53567 |
ProteomicsDBi | 56585 |
PTM databases
iPTMneti | P53567 |
PhosphoSitePlusi | P53567 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153879, Expressed in secondary oocyte and 239 other tissues |
Genevisiblei | P53567, HS |
Organism-specific databases
HPAi | ENSG00000153879, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB.
Interacts with ZNF638; this interaction increases transcriptional activation.
By similarityBinary interactionsi
Hide detailsP53567
GO - Molecular functioni
- identical protein binding Source: Ensembl
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107483, 45 interactors |
IntActi | P53567, 19 interactors |
MINTi | P53567 |
STRINGi | 9606.ENSP00000284000 |
Miscellaneous databases
RNActi | P53567, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 125 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 93 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 97 – 118 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P53567 |
OMAi | VSVIHTQ |
OrthoDBi | 1532157at2759 |
PhylomeDBi | P53567 |
TreeFami | TF105009 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
P53567-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQSISTEN TTADGDNAGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20240 mRNA Translation: AAC50201.1 AK313634 mRNA Translation: BAG36393.1 BT019819 mRNA Translation: AAV38622.1 BT019820 mRNA Translation: AAV38623.1 BC007582 mRNA Translation: AAH07582.1 BC013128 mRNA Translation: AAH13128.1 |
CCDSi | CCDS12432.1 |
PIRi | JC4243 |
RefSeqi | NP_001239225.1, NM_001252296.1 NP_001797.1, NM_001806.3 |
Genome annotation databases
Ensembli | ENST00000284000; ENSP00000284000; ENSG00000153879 ENST00000585933; ENSP00000466022; ENSG00000153879 ENST00000652630; ENSP00000499062; ENSG00000153879 |
GeneIDi | 1054 |
KEGGi | hsa:1054 |
UCSCi | uc002nup.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20240 mRNA Translation: AAC50201.1 AK313634 mRNA Translation: BAG36393.1 BT019819 mRNA Translation: AAV38622.1 BT019820 mRNA Translation: AAV38623.1 BC007582 mRNA Translation: AAH07582.1 BC013128 mRNA Translation: AAH13128.1 |
CCDSi | CCDS12432.1 |
PIRi | JC4243 |
RefSeqi | NP_001239225.1, NM_001252296.1 NP_001797.1, NM_001806.3 |
3D structure databases
SMRi | P53567 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107483, 45 interactors |
IntActi | P53567, 19 interactors |
MINTi | P53567 |
STRINGi | 9606.ENSP00000284000 |
PTM databases
iPTMneti | P53567 |
PhosphoSitePlusi | P53567 |
Genetic variation databases
BioMutai | CEBPG |
DMDMi | 1705750 |
Proteomic databases
EPDi | P53567 |
jPOSTi | P53567 |
MassIVEi | P53567 |
MaxQBi | P53567 |
PaxDbi | P53567 |
PeptideAtlasi | P53567 |
PRIDEi | P53567 |
ProteomicsDBi | 56585 |
Protocols and materials databases
Antibodypediai | 1652, 368 antibodies |
DNASUi | 1054 |
Genome annotation databases
Ensembli | ENST00000284000; ENSP00000284000; ENSG00000153879 ENST00000585933; ENSP00000466022; ENSG00000153879 ENST00000652630; ENSP00000499062; ENSG00000153879 |
GeneIDi | 1054 |
KEGGi | hsa:1054 |
UCSCi | uc002nup.4, human |
Organism-specific databases
CTDi | 1054 |
DisGeNETi | 1054 |
GeneCardsi | CEBPG |
HGNCi | HGNC:1837, CEBPG |
HPAi | ENSG00000153879, Low tissue specificity |
MIMi | 138972, gene |
neXtProti | NX_P53567 |
OpenTargetsi | ENSG00000153879 |
PharmGKBi | PA26380 |
VEuPathDBi | HostDB:ENSG00000153879.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P53567 |
OMAi | VSVIHTQ |
OrthoDBi | 1532157at2759 |
PhylomeDBi | P53567 |
TreeFami | TF105009 |
Enzyme and pathway databases
PathwayCommonsi | P53567 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency |
SIGNORi | P53567 |
Miscellaneous databases
BioGRID-ORCSi | 1054, 8 hits in 1013 CRISPR screens |
ChiTaRSi | CEBPG, human |
GeneWikii | CEBPG |
GenomeRNAii | 1054 |
Pharosi | P53567, Tbio |
PROi | PR:P53567 |
RNActi | P53567, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153879, Expressed in secondary oocyte and 239 other tissues |
Genevisiblei | P53567, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPG_HUMAN | |
Accessioni | P53567Primary (citable) accession number: P53567 Secondary accession number(s): B2R946, Q5U052 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families