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Entry version 190 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

m7GpppN-mRNA hydrolase

Gene

DCP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:10508173, PubMed:11139489, PubMed:11741542). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12554866). Decapping is the major pathway of mRNA degradation in yeast and occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (PubMed:10508173, PubMed:11139489, PubMed:11741542). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:19779198).4 Publications

Miscellaneous

Present with 8530 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi149ManganeseBy similarity1
Metal bindingi153ManganeseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processmRNA processing, Nonsense-mediated mRNA decay
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.62, 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-430039, mRNA decay by 5' to 3' exoribonuclease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
m7GpppN-mRNA hydrolaseCurated (EC:3.6.1.621 Publication)
Alternative name(s):
Protein PSU1
mRNA-decapping enzyme subunit 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCP21 Publication
Synonyms:PSU1
Ordered Locus Names:YNL118CImported
ORF Names:N1917
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005062, DCP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL118C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increases autophagy activity through accumulation of autophagy-related proteins in nutrient-replete conditions (PubMed:19779198).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60N → D in DCP2-7; impairs mRNA decay at 37 degrees Celsius; when associated with V-68 and V-142. 1 Publication1
Mutagenesisi68I → V in DCP2-7; impairs mRNA decay at 37 degrees Celsius; when associated with D-60 and V-142. 1 Publication1
Mutagenesisi142D → V in DCP2-7; impairs mRNA decay at 37 degrees Celsius; when associated with D-60 and V-68. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000570541 – 970m7GpppN-mRNA hydrolaseAdd BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei677PhosphothreonineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P53550

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53550

PRoteomics IDEntifications database

More...
PRIDEi
P53550

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53550

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the decapping complex composed of DCP1 and DCP2 (PubMed:10508173, PubMed:11741542, PubMed:14758354).

Interacts with mRNA, LSM2, LSM4 and LSM8 (PubMed:10900456).

Interacts with EDC3 (PubMed:18678652).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
35708, 657 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1628, Decapping complex, DCP1-DCP2

Database of interacting proteins

More...
DIPi
DIP-969N

Protein interaction database and analysis system

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IntActi
P53550, 45 interactors

Molecular INTeraction database

More...
MINTi
P53550

STRING: functional protein association networks

More...
STRINGi
4932.YNL118C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53550, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1970
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P53550

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P53550

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 228Nudix hydrolasePROSITE-ProRule annotationAdd BLAST128

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi134 – 155Nudix boxAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi345 – 430Pro-richAdd BLAST86
Compositional biasi436 – 439Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nudix hydrolase family. DCP2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2937, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000018878

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_009571_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P53550

Identification of Orthologs from Complete Genome Data

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OMAi
NDATNNQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03672, Dcp2p, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.1050, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007722, DCP2_BoxA
IPR036189, DCP2_BoxA_sf
IPR044099, Dcp2_NUDIX
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR020084, NUDIX_hydrolase_CS
IPR000086, NUDIX_hydrolase_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF05026, DCP2, 1 hit
PF00293, NUDIX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01125, DCP2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF140586, SSF140586, 1 hit
SSF55811, SSF55811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51462, NUDIX, 1 hit
PS00893, NUDIX_BOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPLRHALE NVTSVDRILE DLLVRFIINC PNEDLSSVER ELFHFEEASW
60 70 80 90 100
FYTDFIKLMN PTLPSLKIKS FAQLIIKLCP LVWKWDIRVD EALQQFSKYK
110 120 130 140 150
KSIPVRGAAI FNENLSKILL VQGTESDSWS FPRGKISKDE NDIDCCIREV
160 170 180 190 200
KEEIGFDLTD YIDDNQFIER NIQGKNYKIF LISGVSEVFN FKPQVRNEID
210 220 230 240 250
KIEWFDFKKI SKTMYKSNIK YYLINSMMRP LSMWLRHQRQ IKNEDQLKSY
260 270 280 290 300
AEEQLKLLLG ITKEEQIDPG RELLNMLHTA VQANSNNNAV SNGQVPSSQE
310 320 330 340 350
LQHLKEQSGE HNQQKDQQSS FSSQQQPSIF PSLSEPFANN KNVIPPTMPM
360 370 380 390 400
ANVFMSNPQL FATMNGQPFA PFPFMLPLTN NSNSANPIPT PVPPNFNAPP
410 420 430 440 450
NPMAFGVPNM HNLSGPAVSQ PFSLPPAPLP RDSGYSSSSP GQLLDILNSK
460 470 480 490 500
KPDSNVQSSK KPKLKILQRG TDLNSIKQNN NDETAHSNSQ ALLDLLKKPT
510 520 530 540 550
SSQKIHASKP DTSFLPNDSV SGIQDAEYED FESSSDEEVE TARDERNSLN
560 570 580 590 600
VDIGVNVMPS EKDSRRSQKE KPRNDASKTN LNASAESNSV EWGPGKSSPS
610 620 630 640 650
TQSKQNSSVG MQNKYRQEIH IGDSDAYEVF ESSSDEEDGK KLEELEQTQD
660 670 680 690 700
NSKLISQDIL KENNFQDGEV PHRDMPTESN KSINETVGLS STTNTVKKVP
710 720 730 740 750
KVKILKRGET FASLANDKKA FDSSSNVSSS KDLLQMLRNP ISSTVSSNQQ
760 770 780 790 800
SPKSQHLSGD EEIMMMLKRN SVSKPQNSEE NASTSSINDA NASELLGMLK
810 820 830 840 850
QKEKDITAPK QPYNVDSYSQ KNSAKGLLNI LKKNDSTGYP RTEGGPSSEM
860 870 880 890 900
STSMKRNDAT NNQELDKNST ELLNYLKPKP LNDGYENISN KDSSHELLNI
910 920 930 940 950
LHGNKNSSAF NNNVYATDGY SLASDNNENS SNKLLNMLQN RSSAINEPNF
960 970
DVRSNGTSGS NELLSILHRK
Length:970
Mass (Da):108,667
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD53CA2C5A546FA4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti425P → L in AAA68866 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti188V → A in strain: YJM339. 1 Publication1
Natural varianti288Missing in strain: V1-09, YJM269, YJM270, YJM326, YJM339, YJM627 and YJM1129. 1 Publication1
Natural varianti301L → H in strain: YJM280, YJM 20 and YJM339. 1 Publication1
Natural varianti319S → P in strain: YJM627. 1 Publication1
Natural varianti494D → N in strain: YJM339. 1 Publication1
Natural varianti505I → T in strain: SK1, V1-09, YJM269, YJM270, YJM280, YJM320, YJM326, YJM339, YJM627 and YJM1129. 1 Publication1
Natural varianti522G → D in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti547N → T in strain: YJM280 and YJM320. 1 Publication1
Natural varianti567S → R in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti574N → S in strain: YJM269, YJM270, YJM280, YJM320, YJM326 and YJM1129. 1 Publication1
Natural varianti577S → N in strain: V1-09, YJM269, YJM270, YJM280, YJM320, YJM326, YJM339 and YJM1129. 1 Publication1
Natural varianti622G → S in strain: V1-09 and YJM339. 1 Publication1
Natural varianti650D → G in strain: YJM280 and YJM320. 1 Publication1
Natural varianti740P → S in strain: YJM269 and YJM270. 1 Publication1
Natural varianti807T → A in strain: YJM 69, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti823S → P in strain: YJM269, YJM270, YJM280, YJM320, YJM326 and YJM1129. 1 Publication1
Natural varianti835D → N in strain: YJM280 and YJM320. 1 Publication1
Natural varianti844G → V in strain: V1-09. 1 Publication1
Natural varianti851S → P in strain: YJM280, YJM320 and YJM627. 1 Publication1
Natural varianti854M → I in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti864E → Q in strain: YJM269 and YJM270. 1 Publication1
Natural varianti865L → S in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti866D → A in strain: YJM627. 1
Natural varianti909A → T in strain: YJM280 and YJM320. 1 Publication1
Natural varianti945I → L in strain: YJM627. 1 Publication1
Natural varianti951D → E in strain: V1-09. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31377 Genomic DNA Translation: AAC99860.1
L43065 Genomic DNA Translation: AAA68866.1
EF125216 Genomic DNA Translation: ABN58539.1
EF125217 Genomic DNA Translation: ABN58548.1
EF125218 Genomic DNA Translation: ABN58557.1
EF125219 Genomic DNA Translation: ABN58566.1
EF125220 Genomic DNA Translation: ABN58578.1
EF125221 Genomic DNA Translation: ABN58584.1
EF125222 Genomic DNA Translation: ABN58593.1
EF125223 Genomic DNA Translation: ABN58602.1
EF125224 Genomic DNA Translation: ABN58611.1
EF125225 Genomic DNA Translation: ABN58620.1
EF125226 Genomic DNA Translation: ABN58629.1
EF125228 Genomic DNA Translation: ABN58647.1
Z69382 Genomic DNA Translation: CAA93389.1
Z71394 Genomic DNA Translation: CAA95998.1
BK006947 Genomic DNA Translation: DAA10430.1

Protein sequence database of the Protein Information Resource

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PIRi
S63059

NCBI Reference Sequences

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RefSeqi
NP_014281.1, NM_001182956.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL118C_mRNA; YNL118C; YNL118C

Database of genes from NCBI RefSeq genomes

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GeneIDi
855605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL118C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31377 Genomic DNA Translation: AAC99860.1
L43065 Genomic DNA Translation: AAA68866.1
EF125216 Genomic DNA Translation: ABN58539.1
EF125217 Genomic DNA Translation: ABN58548.1
EF125218 Genomic DNA Translation: ABN58557.1
EF125219 Genomic DNA Translation: ABN58566.1
EF125220 Genomic DNA Translation: ABN58578.1
EF125221 Genomic DNA Translation: ABN58584.1
EF125222 Genomic DNA Translation: ABN58593.1
EF125223 Genomic DNA Translation: ABN58602.1
EF125224 Genomic DNA Translation: ABN58611.1
EF125225 Genomic DNA Translation: ABN58620.1
EF125226 Genomic DNA Translation: ABN58629.1
EF125228 Genomic DNA Translation: ABN58647.1
Z69382 Genomic DNA Translation: CAA93389.1
Z71394 Genomic DNA Translation: CAA95998.1
BK006947 Genomic DNA Translation: DAA10430.1
PIRiS63059
RefSeqiNP_014281.1, NM_001182956.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JVBNMR-A100-245[»]
4K6EX-ray2.10A102-245[»]
4KG3X-ray1.70A/B/C100-245[»]
4KG4X-ray1.80A/B100-245[»]
5LM5X-ray2.60C/D437-450[»]
5LMFX-ray2.15C/D484-500[»]
5LMGX-ray1.89C/D957-970[»]
6Y3ZX-ray3.49A1-271[»]
BMRBiP53550
SMRiP53550
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35708, 657 interactors
ComplexPortaliCPX-1628, Decapping complex, DCP1-DCP2
DIPiDIP-969N
IntActiP53550, 45 interactors
MINTiP53550
STRINGi4932.YNL118C

PTM databases

iPTMnetiP53550

Proteomic databases

MaxQBiP53550
PaxDbiP53550
PRIDEiP53550

Genome annotation databases

EnsemblFungiiYNL118C_mRNA; YNL118C; YNL118C
GeneIDi855605
KEGGisce:YNL118C

Organism-specific databases

SGDiS000005062, DCP2
VEuPathDBiFungiDB:YNL118C

Phylogenomic databases

eggNOGiKOG2937, Eukaryota
GeneTreeiENSGT00390000018878
HOGENOMiCLU_009571_0_0_1
InParanoidiP53550
OMAiNDATNNQ

Enzyme and pathway databases

BRENDAi3.6.1.62, 984
ReactomeiR-SCE-430039, mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCP2, yeast
EvolutionaryTraceiP53550

Protein Ontology

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PROi
PR:P53550
RNActiP53550, protein

Family and domain databases

CDDicd03672, Dcp2p, 1 hit
Gene3Di1.10.10.1050, 1 hit
InterProiView protein in InterPro
IPR007722, DCP2_BoxA
IPR036189, DCP2_BoxA_sf
IPR044099, Dcp2_NUDIX
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR020084, NUDIX_hydrolase_CS
IPR000086, NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF05026, DCP2, 1 hit
PF00293, NUDIX, 1 hit
SMARTiView protein in SMART
SM01125, DCP2, 1 hit
SUPFAMiSSF140586, SSF140586, 1 hit
SSF55811, SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462, NUDIX, 1 hit
PS00893, NUDIX_BOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCP2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53550
Secondary accession number(s): B0KZS6
, B0KZU4, B0KZW2, B0KZY0, B0KZY9, B0KZZ8, B0L007, D6W164, Q6LCS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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