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Protein

Protein fosB

Gene

FOSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiP53539

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Alternative name(s):
G0/G1 switch regulatory protein 3
Gene namesi
Name:FOSB
Synonyms:G0S3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125740.13
HGNCiHGNC:3797 FOSB
MIMi164772 gene
neXtProtiNX_P53539

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2354
OpenTargetsiENSG00000125740
PharmGKBiPA28213

Polymorphism and mutation databases

BioMutaiFOSB
DMDMi1706888

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764761 – 338Protein fosBAdd BLAST338

Proteomic databases

MaxQBiP53539
PaxDbiP53539
PeptideAtlasiP53539
PRIDEiP53539
ProteomicsDBi56584

PTM databases

iPTMnetiP53539
PhosphoSitePlusiP53539

Expressioni

Gene expression databases

BgeeiENSG00000125740 Expressed in 194 organ(s), highest expression level in mucosa of stomach
CleanExiHS_FOSB
ExpressionAtlasiP53539 baseline and differential
GenevisibleiP53539 HS

Organism-specific databases

HPAiCAB010267
HPA054663

Interactioni

Subunit structurei

Heterodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108637, 8 interactors
CORUMiP53539
DIPiDIP-60013N
IntActiP53539, 27 interactors
MINTiP53539
STRINGi9606.ENSP00000245919

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53539
SMRiP53539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 218bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 182Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni183 – 211Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP53539
KOiK09029
OMAiYPEGACG
OrthoDBiEOG091G0GGW
PhylomeDBiP53539
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029813 FosB
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF3 PTHR23351:SF3, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (10+)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53539-1) [UniParc]FASTAAdd to basket
Also known as: FosB-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED
260 270 280 290 300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
Length:338
Mass (Da):35,928
Last modified:October 1, 1996 - v1
Checksum:iDDFF827C5047850F
GO
Isoform 2 (identifier: P53539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.

Show »
Length:302
Mass (Da):31,497
Checksum:iACF3E1C9674BE57E
GO
Isoform 3 (identifier: P53539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.

Show »
Length:299
Mass (Da):31,837
Checksum:iB5F7EC8DD4C1ECDD
GO
Isoform 4 (identifier: P53539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-284: Missing.

Show »
Length:291
Mass (Da):30,953
Checksum:iB4D7874B29D18ADC
GO
Isoform 5 (identifier: P53539-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     150-185: Missing.

Show »
Length:263
Mass (Da):27,406
Checksum:i0B7581F8500FECFF
GO
Isoform 6 (identifier: P53539-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.
     238-284: Missing.

Show »
Length:255
Mass (Da):26,522
Checksum:i245E95243A42402F
GO
Isoform 7 (identifier: P53539-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     238-284: Missing.

Show »
Length:252
Mass (Da):26,863
Checksum:iEACED50D10710F4A
GO
Isoform 8 (identifier: P53539-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.

Show »
Length:195
Mass (Da):20,676
Checksum:iE73A6C5BED524C6A
GO
Isoform 9 (identifier: P53539-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.
     238-284: Missing.

Show »
Length:148
Mass (Da):15,701
Checksum:i007A7723004E947A
GO
Isoform 10 (identifier: P53539-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):30,978
Checksum:i42091ABFABC7FDA1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKC1K7EKC1_HUMAN
Protein fosB
FOSB
237Annotation score:
K7ERZ8K7ERZ8_HUMAN
Protein fosB
FOSB
188Annotation score:
K7EKA0K7EKA0_HUMAN
Protein fosB
FOSB
137Annotation score:
K7EJ89K7EJ89_HUMAN
Protein fosB
FOSB
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338L → R in AAB53946 (PubMed:8985116).Curated1
Sequence conflicti338L → R in ABW34730 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34731 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34732 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34733 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34734 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34735 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34736 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34737 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02228633G → S1 PublicationCorresponds to variant dbSNP:rs28381241Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555621 – 49Missing in isoform 10. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_05556342 – 80Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_05556443 – 185Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_046167150 – 185Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_055565238 – 284Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA Translation: AAB53946.1
EU178109 mRNA Translation: ABW34730.1
EU178110 mRNA Translation: ABW34731.1
EU178111 mRNA Translation: ABW34732.1
EU178112 mRNA Translation: ABW34733.1
EU178113 mRNA Translation: ABW34734.1
EU178114 mRNA Translation: ABW34735.1
EU178115 mRNA Translation: ABW34736.1
EU178116 mRNA Translation: ABW34737.1
AY898963 Genomic DNA Translation: AAW65374.1
AK292720 mRNA Translation: BAF85409.1
AC138128 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57351.1
BC036724 mRNA Translation: AAH36724.1
BC040197 mRNA Translation: AAH40197.1
CCDSiCCDS12664.1 [P53539-1]
CCDS46113.1 [P53539-2]
PIRiI53043
RefSeqiNP_001107643.1, NM_001114171.1 [P53539-2]
NP_006723.2, NM_006732.2 [P53539-1]
UniGeneiHs.590958

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4]
GeneIDi2354
KEGGihsa:2354
UCSCiuc002pbx.5 human [P53539-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA Translation: AAB53946.1
EU178109 mRNA Translation: ABW34730.1
EU178110 mRNA Translation: ABW34731.1
EU178111 mRNA Translation: ABW34732.1
EU178112 mRNA Translation: ABW34733.1
EU178113 mRNA Translation: ABW34734.1
EU178114 mRNA Translation: ABW34735.1
EU178115 mRNA Translation: ABW34736.1
EU178116 mRNA Translation: ABW34737.1
AY898963 Genomic DNA Translation: AAW65374.1
AK292720 mRNA Translation: BAF85409.1
AC138128 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57351.1
BC036724 mRNA Translation: AAH36724.1
BC040197 mRNA Translation: AAH40197.1
CCDSiCCDS12664.1 [P53539-1]
CCDS46113.1 [P53539-2]
PIRiI53043
RefSeqiNP_001107643.1, NM_001114171.1 [P53539-2]
NP_006723.2, NM_006732.2 [P53539-1]
UniGeneiHs.590958

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VPAX-ray2.83A153-219[»]
5VPBX-ray2.69A/C153-219[»]
5VPCX-ray2.50A/C153-219[»]
5VPDX-ray2.79A/C153-219[»]
5VPEX-ray2.05A/C153-219[»]
5VPFX-ray2.69A/C153-219[»]
ProteinModelPortaliP53539
SMRiP53539
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108637, 8 interactors
CORUMiP53539
DIPiDIP-60013N
IntActiP53539, 27 interactors
MINTiP53539
STRINGi9606.ENSP00000245919

PTM databases

iPTMnetiP53539
PhosphoSitePlusiP53539

Polymorphism and mutation databases

BioMutaiFOSB
DMDMi1706888

Proteomic databases

MaxQBiP53539
PaxDbiP53539
PeptideAtlasiP53539
PRIDEiP53539
ProteomicsDBi56584

Protocols and materials databases

DNASUi2354
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4]
GeneIDi2354
KEGGihsa:2354
UCSCiuc002pbx.5 human [P53539-1]

Organism-specific databases

CTDi2354
DisGeNETi2354
EuPathDBiHostDB:ENSG00000125740.13
GeneCardsiFOSB
H-InvDBiHIX0015233
HGNCiHGNC:3797 FOSB
HPAiCAB010267
HPA054663
MIMi164772 gene
neXtProtiNX_P53539
OpenTargetsiENSG00000125740
PharmGKBiPA28213
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP53539
KOiK09029
OMAiYPEGACG
OrthoDBiEOG091G0GGW
PhylomeDBiP53539
TreeFamiTF326301

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiP53539

Miscellaneous databases

GeneWikiiFOSB
GenomeRNAii2354
PROiPR:P53539
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125740 Expressed in 194 organ(s), highest expression level in mucosa of stomach
CleanExiHS_FOSB
ExpressionAtlasiP53539 baseline and differential
GenevisibleiP53539 HS

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029813 FosB
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF3 PTHR23351:SF3, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOSB_HUMAN
AccessioniPrimary (citable) accession number: P53539
Secondary accession number(s): A8K9K5
, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, K7EMJ6, Q49AD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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