FOSB

Functionⁱ

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 1900040
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: ProtInc
Traceable author statementⁱ
- 1900040

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to calcium ion Source: Ensembl
cellular response to hormone stimulus Source: Ensembl
female pregnancy Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 1900040
response to cAMP Source: Ensembl
response to corticosterone Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to morphine Source: Ensembl
response to progesterone Source: Ensembl
transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SIGNORⁱ	P53539

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein fosB Alternative name(s): G0/G1 switch regulatory protein 3
Gene namesⁱ	Name:FOSB Synonyms:G0S3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125740.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3797 FOSB
MIMⁱ	164772 gene
neXtProtⁱ	NX_P53539

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2354
Open Targets More...OpenTargetsⁱ	ENSG00000125740
PharmGKBⁱ	PA28213

Polymorphism and mutation databases

BioMutaⁱ	FOSB
DMDMⁱ	1706888

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076476	1 – 338	Protein fosBAdd BLAST		338

Proteomic databases

jPOSTⁱ	P53539
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53539
PaxDbⁱ	P53539
PeptideAtlas More...PeptideAtlasⁱ	P53539
PRIDEⁱ	P53539
ProteomicsDBⁱ	56584

PTM databases

iPTMnetⁱ	P53539
PhosphoSitePlusⁱ	P53539

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125740 Expressed in 194 organ(s), highest expression level in mucosa of stomach
CleanExⁱ	HS_FOSB
ExpressionAtlasⁱ	P53539 baseline and differential
Genevisibleⁱ	P53539 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010267 HPA054663

HPAⁱ

CAB010267
HPA054663

Interactionⁱ

Subunit structureⁱ

Heterodimer.By similarity

GO - Molecular functionⁱ

transcription factor binding
Source: ProtInc
Traceable author statementⁱ
- 1900040

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108637, 8 interactors
CORUMⁱ	P53539
Database of interacting proteins More...DIPⁱ	DIP-60013N
IntActⁱ	P53539, 27 interactors
Molecular INTeraction database More...MINTⁱ	P53539
STRINGⁱ	9606.ENSP00000245919

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	157 – 217	Combined sources		61

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5VPA	X-ray	2.83	A	153-219	[»]
	5VPB	X-ray	2.69	A/C	153-219	[»]
	5VPC	X-ray	2.50	A/C	153-219	[»]
	5VPD	X-ray	2.79	A/C	153-219	[»]
	5VPE	X-ray	2.05	A/C	153-219	[»]
	5VPF	X-ray	2.69	A/C	153-219	[»]
ProteinModelPortalⁱ	P53539
SMRⁱ	P53539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	155 – 218	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	157 – 182	Basic motifPROSITE-ProRule annotationAdd BLAST		26
Regionⁱ	183 – 211	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160358
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P53539
KEGG Orthology (KO) More...KOⁱ	K09029
OMAⁱ	PGCKIPF
Database of Orthologous Groups More...OrthoDBⁱ	1221590at2759
PhylomeDBⁱ	P53539
TreeFamⁱ	TF326301

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequences (10+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 10 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P53539-1) [UniParc]FASTA Add to basket

Also known as: FosB-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP 
       110        120        130        140        150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED 
       260        270        280        290        300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 
       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

Length:338

Mass (Da):35,928

Last modified:October 1, 1996 - v1

Checksum:ⁱDDFF827C5047850F

GO

Isoform 2 (identifier: P53539-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
150-185: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP 
       110        120        130        140        150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETE 
       160        170        180        190        200
TDQLEEEKAE LESEIAELQK EKERLEFVLV AHKPGCKIPY EEGPGPGPLA 
       210        220        230        240        250
EVRDLPGSAP AKEDGFSWLL PPPPPPPLPF QTSQDAPPNL TASLFTHSEV 
       260        270        280        290        300
QVLGDPFPVV NPSYTSSFVL TCPEVSAFAG AQRTSGSDQP SDPLNSPSLL 

AL

Show »

Length:302

Mass (Da):31,497

Checksum:ⁱACF3E1C9674BE57E

GO

Isoform 3 (identifier: P53539-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
42-80: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQSQGQPLAS 
        60         70         80         90        100
QPPVVDPYDM PGTSYSTPGM SGYSSGGASG SGGPSTSGTT SGPGPARPAR 
       110        120        130        140        150
ARPRRPREET LTPEEEEKRR VRRERNKLAA AKCRNRRREL TDRLQAETDQ 
       160        170        180        190        200
LEEEKAELES EIAELQKEKE RLEFVLVAHK PGCKIPYEEG PGPGPLAEVR 
       210        220        230        240        250
DLPGSAPAKE DGFSWLLPPP PPPPLPFQTS QDAPPNLTAS LFTHSEVQVL 
       260        270        280        290 
GDPFPVVNPS YTSSFVLTCP EVSAFAGAQR TSGSDQPSDP LNSPSLLAL

Show »

Length:299

Mass (Da):31,837

Checksum:ⁱB5F7EC8DD4C1ECDD

GO

Isoform 4 (identifier: P53539-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
238-284: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP 
       110        120        130        140        150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEEVQ VLGDPFPVVN 
       260        270        280        290 
PSYTSSFVLT CPEVSAFAGA QRTSGSDQPS DPLNSPSLLA L

Show »

Length:291

Mass (Da):30,953

Checksum:ⁱB4D7874B29D18ADC

GO

Isoform 5 (identifier: P53539-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
42-80: Missing.
150-185: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQSQGQPLAS 
        60         70         80         90        100
QPPVVDPYDM PGTSYSTPGM SGYSSGGASG SGGPSTSGTT SGPGPARPAR 
       110        120        130        140        150
ARPRRPREET ETDQLEEEKA ELESEIAELQ KEKERLEFVL VAHKPGCKIP 
       160        170        180        190        200
YEEGPGPGPL AEVRDLPGSA PAKEDGFSWL LPPPPPPPLP FQTSQDAPPN 
       210        220        230        240        250
LTASLFTHSE VQVLGDPFPV VNPSYTSSFV LTCPEVSAFA GAQRTSGSDQ 
       260 
PSDPLNSPSL LAL

Show »

Length:263

Mass (Da):27,406

Checksum:ⁱ0B7581F8500FECFF

GO

Isoform 6 (identifier: P53539-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
150-185: Missing.
238-284: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP 
       110        120        130        140        150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETE 
       160        170        180        190        200
TDQLEEEKAE LESEIAELQK EKERLEFVLV AHKPGCKIPY EEGPGPGPLA 
       210        220        230        240        250
EEVQVLGDPF PVVNPSYTSS FVLTCPEVSA FAGAQRTSGS DQPSDPLNSP 

SLLAL

Show »

Length:255

Mass (Da):26,522

Checksum:ⁱ245E95243A42402F

GO

Isoform 7 (identifier: P53539-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
42-80: Missing.
238-284: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQSQGQPLAS 
        60         70         80         90        100
QPPVVDPYDM PGTSYSTPGM SGYSSGGASG SGGPSTSGTT SGPGPARPAR 
       110        120        130        140        150
ARPRRPREET LTPEEEEKRR VRRERNKLAA AKCRNRRREL TDRLQAETDQ 
       160        170        180        190        200
LEEEKAELES EIAELQKEKE RLEFVLVAHK PGCKIPYEEG PGPGPLAEEV 
       210        220        230        240        250
QVLGDPFPVV NPSYTSSFVL TCPEVSAFAG AQRTSGSDQP SDPLNSPSLL 

AL

Show »

Length:252

Mass (Da):26,863

Checksum:ⁱEACED50D10710F4A

GO

Isoform 8 (identifier: P53539-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
43-185: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQETDQLEEE 
        60         70         80         90        100
KAELESEIAE LQKEKERLEF VLVAHKPGCK IPYEEGPGPG PLAEVRDLPG 
       110        120        130        140        150
SAPAKEDGFS WLLPPPPPPP LPFQTSQDAP PNLTASLFTH SEVQVLGDPF 
       160        170        180        190 
PVVNPSYTSS FVLTCPEVSA FAGAQRTSGS DQPSDPLNSP SLLAL

Show »

Length:195

Mass (Da):20,676

Checksum:ⁱE73A6C5BED524C6A

GO

Isoform 9 (identifier: P53539-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
43-185: Missing.
238-284: Missing.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQETDQLEEE 
        60         70         80         90        100
KAELESEIAE LQKEKERLEF VLVAHKPGCK IPYEEGPGPG PLAEEVQVLG 
       110        120        130        140 
DPFPVVNPSY TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

Show »

Length:148

Mass (Da):15,701

Checksum:ⁱ007A7723004E947A

GO

Isoform 10 (identifier: P53539-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.

« Hide

        10         20         30         40         50
MPGSFVPTVT AITTSQDLQW LVQPTLISSM AQSQGQPLAS QPPVVDPYDM 
        60         70         80         90        100
PGTSYSTPGM SGYSSGGASG SGGPSTSGTT SGPGPARPAR ARPRRPREET 
       110        120        130        140        150
LTPEEEEKRR VRRERNKLAA AKCRNRRREL TDRLQAETDQ LEEEKAELES 
       160        170        180        190        200
EIAELQKEKE RLEFVLVAHK PGCKIPYEEG PGPGPLAEVR DLPGSAPAKE 
       210        220        230        240        250
DGFSWLLPPP PPPPLPFQTS QDAPPNLTAS LFTHSEVQVL GDPFPVVNPS 
       260        270        280 
YTSSFVLTCP EVSAFAGAQR TSGSDQPSDP LNSPSLLAL

Note: No experimental confirmation available.

Show »

Length:289

Mass (Da):30,978

Checksum:ⁱ42091ABFABC7FDA1

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EKC1	K7EKC1_HUMAN	Protein fosB Protein fosB	FOSB	237	Annotation score:
K7ERZ8	K7ERZ8_HUMAN	Protein fosB Protein fosB	FOSB	188	Annotation score:
K7EKA0	K7EKA0_HUMAN	Protein fosB Protein fosB	FOSB	137	Annotation score:
K7EJ89	K7EJ89_HUMAN	Protein fosB Protein fosB	FOSB	177	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	338	L → R in AAB53946 (PubMed:8985116).Curated	1
Sequence conflictⁱ	338	L → R in ABW34730 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34731 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34732 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34733 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34734 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34735 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34736 (Ref. 3) Curated	1
Sequence conflictⁱ	338	L → R in ABW34737 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022286	33	G → S1 PublicationCorresponds to variant dbSNP:rs28381241Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055562	1 – 49	Missing in isoform 10. 1 PublicationAdd BLAST	49
Alternative sequenceⁱVSP_055563	42 – 80	Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_055564	43 – 185	Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST	143
Alternative sequenceⁱVSP_046167	150 – 185	Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_055565	238 – 284	Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST	47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2]
PIRⁱ	I53043
NCBI Reference Sequences More...RefSeqⁱ	NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1]
UniGeneⁱ	Hs.590958

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53539	FBJ murine osteosarcoma viral oncogene homolog B, isoform CRA_a		HUMAN		338	UniRef100_P53539
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		338
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		338
+14
P53539-2	FOSB isoform 5		PANTR		302	UniRef100_A0A2I3SZJ1
FOSB isoform 4		PONAB		302
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		302
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		302
FosB proto-oncogene, AP-1 transcription factor subunit		GORGO		302
P53539-3	FOSB isoform 3		PONAB		299	UniRef100_A0A2J8U6F6
FOSB isoform 4		PANTR		299
P53539-4	FOSB isoform 2		PONAB		291	UniRef100_A0A2J8U6J2
FOSB isoform 2		PANTR		291
P53539-5	FOSB isoform 1		PONAB		263	UniRef100_A0A2J8U6H6
FOSB isoform 1		PANTR		263
P53539-8	FOSB isoform 3		PANTR		195	UniRef100_A0A2I3TLP9
FOSB isoform 5		PONAB		195
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		195
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		195
FosB proto-oncogene, AP-1 transcription factor subunit		GORGO		195

Protein	Similar proteins		Species	Score	Length	Source
P53539	FBJ murine osteosarcoma viral oncogene homolog B, isoform CRA_a		HUMAN		338	UniRef90_P53539
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		338
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		338
+155
P53539-2	Protein fosB		MOUSE		302	UniRef90_A0A140LJH0
protein fosB isoform X2		LIPVE		305
FosB proto-oncogene, AP-1 transcription factor subunit		CAVPO		304
protein fosB isoform X2		ERIEU		303
FOSB isoform 5		PANTR		302
+39
P53539-3	Protein fosB		MOUSE		299	UniRef90_A0A140LHW0
protein fosB isoform X2		Yangtze finless porpoise		302
FosB proto-oncogene, AP-1 transcription factor subunit		CAVPO		301
FOSB isoform 3		PONAB		299
FOSB isoform 4		PANTR		299
+10
P53539-4	FosB proto-oncogene, AP-1 transcription factor subunit		SHEEP		299	UniRef90_W5PJT0
FOSB isoform 2		PONAB		291
FOSB isoform 2		PANTR		291
Protein fosB isoform 1		CAMFR		259
P53539-5	Protein fosB		MOUSE		263	UniRef90_A0A140LIT4
FOSB isoform 1		PONAB		263
FOSB isoform 1		PANTR		263
P53539-8	FOSB isoform 3		PANTR		195	UniRef90_A0A2I3TLP9
FOSB isoform 5		PONAB		195
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		195
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		195
FosB proto-oncogene, AP-1 transcription factor subunit		GORGO		195
+17

Protein	Similar proteins		Species	Score	Length	Source
P53539	FBJ murine osteosarcoma viral oncogene homolog B, isoform CRA_a		HUMAN		338	UniRef50_P53539
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		338
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		338
+201
P53539-2	Isoform 6 of Protein fosB		HUMAN		255	UniRef50_P53539-6
protein fosB isoform X2		DIPOR		296
Protein fosB		ALLMI		254
FOSB isoform 1		PONAB		263
FOSB isoform 1		PANTR		263
+50
P53539-5	Isoform 6 of Protein fosB		HUMAN		255	UniRef50_P53539-6
protein fosB isoform X2		DIPOR		296
Protein fosB		ALLMI		254
FOSB isoform 1		PONAB		263
FOSB isoform 1		PANTR		263
+50
P53539-6	protein fosB isoform X2		DIPOR		296	UniRef50_P53539-6
Protein fosB		ALLMI		254
Isoform 7 of Protein fosB		HUMAN		252
FOSB isoform 1		PONAB		263
FOSB isoform 1		PANTR		263
+50
P53539-7	Isoform 6 of Protein fosB		HUMAN		255	UniRef50_P53539-6
protein fosB isoform X2		DIPOR		296
Protein fosB		ALLMI		254
FOSB isoform 1		PONAB		263
FOSB isoform 1		PANTR		263
+50
P53539-8	FOSB isoform 3		PANTR		195	UniRef50_A0A2I3TLP9
FOSB isoform 5		PONAB		195
FosB proto-oncogene, AP-1 transcription factor subunit		PANPA		195
FosB proto-oncogene, AP-1 transcription factor subunit		NOMLE		195
FosB proto-oncogene, AP-1 transcription factor subunit		GORGO		195
+24
P53539-9	Protein fosB (Fragment)		CARIC		126	UniRef50_P53539-9
Protein fosB (Fragment)		East African grey crowned-crane		117

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1
CCDSⁱ	CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2]
PIRⁱ	I53043
RefSeqⁱ	NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1]
UniGeneⁱ	Hs.590958

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5VPA	X-ray	2.83	A	153-219	[»]
	5VPB	X-ray	2.69	A/C	153-219	[»]
	5VPC	X-ray	2.50	A/C	153-219	[»]
	5VPD	X-ray	2.79	A/C	153-219	[»]
	5VPE	X-ray	2.05	A/C	153-219	[»]
	5VPF	X-ray	2.69	A/C	153-219	[»]
ProteinModelPortalⁱ	P53539
SMRⁱ	P53539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108637, 8 interactors
CORUMⁱ	P53539
DIPⁱ	DIP-60013N
IntActⁱ	P53539, 27 interactors
MINTⁱ	P53539
STRINGⁱ	9606.ENSP00000245919

PTM databases

iPTMnetⁱ	P53539
PhosphoSitePlusⁱ	P53539

Polymorphism and mutation databases

BioMutaⁱ	FOSB
DMDMⁱ	1706888

Proteomic databases

jPOSTⁱ	P53539
MaxQBⁱ	P53539
PaxDbⁱ	P53539
PeptideAtlasⁱ	P53539
PRIDEⁱ	P53539
ProteomicsDBⁱ	56584

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2354
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1] ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2] ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8] ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5] ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10] ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3] ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4]
GeneIDⁱ	2354
KEGGⁱ	hsa:2354
UCSCⁱ	uc002pbx.5 human [P53539-1]

Organism-specific databases

CTDⁱ	2354
DisGeNETⁱ	2354
EuPathDBⁱ	HostDB:ENSG00000125740.13
GeneCardsⁱ	FOSB
H-InvDBⁱ	HIX0015233
HGNCⁱ	HGNC:3797 FOSB
HPAⁱ	CAB010267 HPA054663
MIMⁱ	164772 gene
neXtProtⁱ	NX_P53539
OpenTargetsⁱ	ENSG00000125740
PharmGKBⁱ	PA28213
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00940000160358
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P53539
KOⁱ	K09029
OMAⁱ	PGCKIPF
OrthoDBⁱ	1221590at2759
PhylomeDBⁱ	P53539
TreeFamⁱ	TF326301

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SIGNORⁱ	P53539

Miscellaneous databases

GeneWikiⁱ	FOSB
GenomeRNAiⁱ	2354
Protein Ontology More...PROⁱ	PR:P53539
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125740 Expressed in 194 organ(s), highest expression level in mucosa of stomach
CleanExⁱ	HS_FOSB
ExpressionAtlasⁱ	P53539 baseline and differential
Genevisibleⁱ	P53539 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOSB_HUMAN
Accessionⁱ	P53539Primary (citable) accession number: P53539 Secondary accession number(s): A8K9K5 Q49AD7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	January 16, 2019
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - P53539 (FOSB_HUMAN)

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ