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UniProtKB - P53539 (FOSB_HUMAN)

Entry version 168 (02 Dec 2020)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Protein fosB

Gene

FOSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53539

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9031628, NGF-stimulated transcription

SIGNOR Signaling Network Open Resource

More...SIGNORi		P53539

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein fosB
Alternative name(s):
G0/G1 switch regulatory protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOSB
Synonyms:G0S3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000125740.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:3797, FOSB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164772, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53539

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2354

Open Targets

More...OpenTargetsi		ENSG00000125740

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53539, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FOSB

Domain mapping of disease mutations (DMDM)

More...DMDMi		1706888

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764761 – 338Protein fosBAdd BLAST338

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1760

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53539

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53539

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53539

PeptideAtlas

More...PeptideAtlasi		P53539

PRoteomics IDEntifications database

More...PRIDEi		P53539

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17421
20551
56584 [P53539-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53539

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125740, Expressed in mucosa of stomach and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53539, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53539, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125740, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108637, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P53539

Database of interacting proteins

More...DIPi		DIP-60013N

Protein interaction database and analysis system

More...IntActi		P53539, 27 interactors

Molecular INTeraction database

More...MINTi		P53539

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000245919

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53539, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53539

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 218bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 182Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni183 – 211Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1414, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160358

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049742_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53539

Identification of Orthologs from Complete Genome Data

More...OMAi		QANCKIP

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53539

TreeFam database of animal gene trees

More...TreeFami		TF326301

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000837, AP-1
IPR004827, bZIP
IPR029813, FosB

The PANTHER Classification System

More...PANTHERi		PTHR23351, PTHR23351, 1 hit
PTHR23351:SF3, PTHR23351:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00170, bZIP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00042, LEUZIPPRFOS

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53539-1) [UniParc]FASTAAdd to basket
Also known as: FosB-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP 
       110        120        130        140        150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED 
       260        270        280        290        300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 
       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
Length:338
Mass (Da):35,928
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDFF827C5047850F
GO
Isoform 2 (identifier: P53539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.

Show »
Length:302
Mass (Da):31,497
Checksum:iACF3E1C9674BE57E
GO
Isoform 3 (identifier: P53539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.

Show »
Length:299
Mass (Da):31,837
Checksum:iB5F7EC8DD4C1ECDD
GO
Isoform 4 (identifier: P53539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-284: Missing.

Show »
Length:291
Mass (Da):30,953
Checksum:iB4D7874B29D18ADC
GO
Isoform 5 (identifier: P53539-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     150-185: Missing.

Show »
Length:263
Mass (Da):27,406
Checksum:i0B7581F8500FECFF
GO
Isoform 6 (identifier: P53539-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.
     238-284: Missing.

Show »
Length:255
Mass (Da):26,522
Checksum:i245E95243A42402F
GO
Isoform 7 (identifier: P53539-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     238-284: Missing.

Show »
Length:252
Mass (Da):26,863
Checksum:iEACED50D10710F4A
GO
Isoform 8 (identifier: P53539-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.

Show »
Length:195
Mass (Da):20,676
Checksum:iE73A6C5BED524C6A
GO
Isoform 9 (identifier: P53539-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.
     238-284: Missing.

Show »
Length:148
Mass (Da):15,701
Checksum:i007A7723004E947A
GO
Isoform 10 (identifier: P53539-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:289
Mass (Da):30,978
Checksum:i42091ABFABC7FDA1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKC1K7EKC1_HUMAN
Protein fosB
FOSB
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERZ8K7ERZ8_HUMAN
Protein fosB
FOSB
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKA0K7EKA0_HUMAN
Protein fosB
FOSB
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ89K7EJ89_HUMAN
Protein fosB
FOSB
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti338L → R in AAB53946 (PubMed:8985116).Curated1
Sequence conflicti338L → R in ABW34730 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34731 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34732 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34733 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34734 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34735 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34736 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34737 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02228633G → S1 PublicationCorresponds to variant dbSNP:rs28381241EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555621 – 49Missing in isoform 10. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_05556342 – 80Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_05556443 – 185Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_046167150 – 185Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_055565238 – 284Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L49169 mRNA Translation: AAB53946.1
EU178109 mRNA Translation: ABW34730.1
EU178110 mRNA Translation: ABW34731.1
EU178111 mRNA Translation: ABW34732.1
EU178112 mRNA Translation: ABW34733.1
EU178113 mRNA Translation: ABW34734.1
EU178114 mRNA Translation: ABW34735.1
EU178115 mRNA Translation: ABW34736.1
EU178116 mRNA Translation: ABW34737.1
AY898963 Genomic DNA Translation: AAW65374.1
AK292720 mRNA Translation: BAF85409.1
AC138128 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57351.1
BC036724 mRNA Translation: AAH36724.1
BC040197 mRNA Translation: AAH40197.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12664.1 [P53539-1]
CCDS46113.1 [P53539-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I53043

NCBI Reference Sequences

More...RefSeqi		NP_001107643.1, NM_001114171.1 [P53539-2]
NP_006723.2, NM_006732.2 [P53539-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2354

UCSC genome browser

More...UCSCi		uc002pbx.5, human [P53539-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA Translation: AAB53946.1
EU178109 mRNA Translation: ABW34730.1
EU178110 mRNA Translation: ABW34731.1
EU178111 mRNA Translation: ABW34732.1
EU178112 mRNA Translation: ABW34733.1
EU178113 mRNA Translation: ABW34734.1
EU178114 mRNA Translation: ABW34735.1
EU178115 mRNA Translation: ABW34736.1
EU178116 mRNA Translation: ABW34737.1
AY898963 Genomic DNA Translation: AAW65374.1
AK292720 mRNA Translation: BAF85409.1
AC138128 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57351.1
BC036724 mRNA Translation: AAH36724.1
BC040197 mRNA Translation: AAH40197.1
CCDSiCCDS12664.1 [P53539-1]
CCDS46113.1 [P53539-2]
PIRiI53043
RefSeqiNP_001107643.1, NM_001114171.1 [P53539-2]
NP_006723.2, NM_006732.2 [P53539-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VPAX-ray2.83A153-219[»]
5VPBX-ray2.69A/C153-219[»]
5VPCX-ray2.50A/C153-219[»]
5VPDX-ray2.79A/C153-219[»]
5VPEX-ray2.05A/C153-219[»]
5VPFX-ray2.69A/C153-219[»]
6UCIX-ray2.09A/B/C/D153-219[»]
6UCLX-ray2.21A153-219[»]
6UCMX-ray2.42A/B/C153-219[»]
SMRiP53539
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108637, 31 interactors
CORUMiP53539
DIPiDIP-60013N
IntActiP53539, 27 interactors
MINTiP53539
STRINGi9606.ENSP00000245919

PTM databases

iPTMnetiP53539
PhosphoSitePlusiP53539

Polymorphism and mutation databases

BioMutaiFOSB
DMDMi1706888

Proteomic databases

CPTACiCPTAC-1760
MassIVEiP53539
MaxQBiP53539
PaxDbiP53539
PeptideAtlasiP53539
PRIDEiP53539
ProteomicsDBi17421
20551
56584 [P53539-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4139, 519 antibodies

The DNASU plasmid repository

More...DNASUi		2354

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4]
GeneIDi2354
KEGGihsa:2354
UCSCiuc002pbx.5, human [P53539-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2354
DisGeNETi2354
EuPathDBiHostDB:ENSG00000125740.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		FOSB
HGNCiHGNC:3797, FOSB
HPAiENSG00000125740, Low tissue specificity
MIMi164772, gene
neXtProtiNX_P53539
OpenTargetsiENSG00000125740
PharmGKBiPA28213

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1414, Eukaryota
GeneTreeiENSGT00940000160358
HOGENOMiCLU_049742_4_0_1
InParanoidiP53539
OMAiQANCKIP
PhylomeDBiP53539
TreeFamiTF326301

Enzyme and pathway databases

PathwayCommonsiP53539
ReactomeiR-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9031628, NGF-stimulated transcription
SIGNORiP53539

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2354, 5 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FOSB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FOSB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2354
PharosiP53539, Tbio

Protein Ontology

More...PROi		PR:P53539
RNActiP53539, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125740, Expressed in mucosa of stomach and 209 other tissues
ExpressionAtlasiP53539, baseline and differential
GenevisibleiP53539, HS

Family and domain databases

InterProiView protein in InterPro
IPR000837, AP-1
IPR004827, bZIP
IPR029813, FosB
PANTHERiPTHR23351, PTHR23351, 1 hit
PTHR23351:SF3, PTHR23351:SF3, 1 hit
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
PRINTSiPR00042, LEUZIPPRFOS
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOSB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53539
Secondary accession number(s): A8K9K5
, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, K7EMJ6, Q49AD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 2, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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