UniProtKB - P53539 (FOSB_HUMAN)
Protein FosB
FOSB
Functioni
Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703).
As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity).
Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758).
Exhibits transactivation activity in vitro (By similarity).
Involved in the display of nurturing behavior towards newborns (By similarity).
May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity).
Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
By similarity2 PublicationsExhibits lower transactivation activity than isoform 1 in vitro (By similarity).
The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (By similarity).
May be involved in the regulation of neurogenesis in the hippocampus (By similarity).
May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (By similarity).
Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: ProtInc
GO - Biological processi
- cellular response to calcium ion Source: Ensembl
- cellular response to hormone stimulus Source: Ensembl
- female pregnancy Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cAMP Source: Ensembl
- response to corticosterone Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to morphine Source: Ensembl
- response to progesterone Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P53539 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P53539 |
SIGNORi | P53539 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FosBCuratedAlternative name(s): FosB proto-oncogene, AP-1 transcription factor subunitImported G0/G1 switch regulatory protein 3 Transcription factor AP-1 subunit FosBCurated |
Gene namesi | Name:FOSB Synonyms:G0S3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3797, FOSB |
MIMi | 164772, gene |
neXtProti | NX_P53539 |
VEuPathDBi | HostDB:ENSG00000125740 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- chromatin Source: NTNU_SB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2354 |
OpenTargetsi | ENSG00000125740 |
PharmGKBi | PA28213 |
Miscellaneous databases
Pharosi | P53539, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4630821 |
Genetic variation databases
BioMutai | FOSB |
DMDMi | 1706888 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076476 | 1 – 338 | Protein FosBAdd BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 172 | Interchain (with C-285 in JUND)Combined sources1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
CPTACi | CPTAC-1760 |
EPDi | P53539 |
MassIVEi | P53539 |
MaxQBi | P53539 |
PaxDbi | P53539 |
PeptideAtlasi | P53539 |
PRIDEi | P53539 |
ProteomicsDBi | 17421 20551 56584 [P53539-1] |
PTM databases
GlyGeni | P53539, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P53539 |
PhosphoSitePlusi | P53539 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000125740, Expressed in mucosa of stomach and 210 other tissues |
ExpressionAtlasi | P53539, baseline and differential |
Genevisiblei | P53539, HS |
Organism-specific databases
HPAi | ENSG00000125740, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer; binds to DNA as heterodimer (PubMed:28981703).
Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (PubMed:28981703).
Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity).
Interacts with ARID1A and JUN (By similarity).
By similarity1 PublicationHomodimer under oxidizing conditions and monomer under reducing conditions (in vitro) (PubMed:32542236). Heterodimer; binds to DNA as heterodimer (By similarity). Forms heterodimers with JUNB, JUN or JUND; thereby binding to the AP-1 consensus sequence but does not stimulate transcription (By similarity). Forms heterodimers with JUND under oxidizing conditions (PubMed:32542236).
By similarity1 PublicationBinary interactionsi
P53539
GO - Molecular functioni
- transcription factor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 108637, 42 interactors |
CORUMi | P53539 |
DIPi | DIP-60013N |
IntActi | P53539, 28 interactors |
MINTi | P53539 |
STRINGi | 9606.ENSP00000245919 |
Chemistry databases
BindingDBi | P53539 |
Miscellaneous databases
RNActi | P53539, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P53539 |
SMRi | P53539 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 218 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 54 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 79 – 191 | DisorderedSequence analysisAdd BLAST | 113 | |
Regioni | 157 – 182 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 183 – 211 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 | |
Regioni | 222 – 276 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 316 – 338 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 38 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 103 – 132 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 140 – 163 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 172 – 190 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 253 – 269 | Pro residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_4_0_1 |
InParanoidi | P53539 |
OMAi | QGMMQEV |
PhylomeDBi | P53539 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (11+)i Sequence
Sequence statusi: Complete.
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED
260 270 280 290 300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
238-338: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ERZ8 | K7ERZ8_HUMAN | Protein FosB | FOSB | 188 | Annotation score: | ||
K7EKA0 | K7EKA0_HUMAN | Protein FosB | FOSB | 137 | Annotation score: | ||
K7EJ89 | K7EJ89_HUMAN | Protein FosB | FOSB | 177 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 338 | L → R in AAB53946 (PubMed:8985116).Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34730 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34731 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34732 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34733 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34734 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34735 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34736 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34737 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022286 | 33 | G → S1 PublicationCorresponds to variant dbSNP:rs28381241EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055562 | 1 – 49 | Missing in isoform 10. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_055563 | 42 – 80 | Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_055564 | 43 – 185 | Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST | 143 | |
Alternative sequenceiVSP_046167 | 150 – 185 | Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_061374 | 238 – 338 | Missing in isoform 11. Add BLAST | 101 | |
Alternative sequenceiVSP_055565 | 238 – 284 | Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1 |
CCDSi | CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2] |
PIRi | I53043 |
RefSeqi | NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1 |
CCDSi | CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2] |
PIRi | I53043 |
RefSeqi | NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5VPA | X-ray | 2.83 | A | 153-219 | [»] | |
5VPB | X-ray | 2.69 | A/C | 153-219 | [»] | |
5VPC | X-ray | 2.50 | A/C | 153-219 | [»] | |
5VPD | X-ray | 2.79 | A/C | 153-219 | [»] | |
5VPE | X-ray | 2.05 | A/C | 153-219 | [»] | |
5VPF | X-ray | 2.69 | A/C | 153-219 | [»] | |
6UCI | X-ray | 2.09 | A/B/C/D | 153-219 | [»] | |
6UCL | X-ray | 2.21 | A | 153-219 | [»] | |
6UCM | X-ray | 2.42 | A/B/C | 153-219 | [»] | |
AlphaFoldDBi | P53539 | |||||
SMRi | P53539 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108637, 42 interactors |
CORUMi | P53539 |
DIPi | DIP-60013N |
IntActi | P53539, 28 interactors |
MINTi | P53539 |
STRINGi | 9606.ENSP00000245919 |
Chemistry databases
BindingDBi | P53539 |
ChEMBLi | CHEMBL4630821 |
PTM databases
GlyGeni | P53539, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P53539 |
PhosphoSitePlusi | P53539 |
Genetic variation databases
BioMutai | FOSB |
DMDMi | 1706888 |
Proteomic databases
CPTACi | CPTAC-1760 |
EPDi | P53539 |
MassIVEi | P53539 |
MaxQBi | P53539 |
PaxDbi | P53539 |
PeptideAtlasi | P53539 |
PRIDEi | P53539 |
ProteomicsDBi | 17421 20551 56584 [P53539-1] |
Protocols and materials databases
Antibodypediai | 4139, 542 antibodies from 39 providers |
DNASUi | 2354 |
Genome annotation databases
Organism-specific databases
CTDi | 2354 |
DisGeNETi | 2354 |
GeneCardsi | FOSB |
HGNCi | HGNC:3797, FOSB |
HPAi | ENSG00000125740, Low tissue specificity |
MIMi | 164772, gene |
neXtProti | NX_P53539 |
OpenTargetsi | ENSG00000125740 |
PharmGKBi | PA28213 |
VEuPathDBi | HostDB:ENSG00000125740 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_4_0_1 |
InParanoidi | P53539 |
OMAi | QGMMQEV |
PhylomeDBi | P53539 |
TreeFami | TF326301 |
Enzyme and pathway databases
PathwayCommonsi | P53539 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P53539 |
SIGNORi | P53539 |
Miscellaneous databases
BioGRID-ORCSi | 2354, 11 hits in 1093 CRISPR screens |
ChiTaRSi | FOSB, human |
GeneWikii | FOSB |
GenomeRNAii | 2354 |
Pharosi | P53539, Tbio |
PROi | PR:P53539 |
RNActi | P53539, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125740, Expressed in mucosa of stomach and 210 other tissues |
ExpressionAtlasi | P53539, baseline and differential |
Genevisiblei | P53539, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSB_HUMAN | |
Accessioni | P53539Primary (citable) accession number: P53539 Secondary accession number(s): A8K9K5 Q49AD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families