UniProtKB - P53539 (FOSB_HUMAN)
Protein
Protein fosB
Gene
FOSB
Organism
Homo sapiens (Human)
Status
Functioni
FosB interacts with Jun proteins enhancing their DNA binding activity.
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: ProtInc
GO - Biological processi
- cellular response to calcium ion Source: Ensembl
- cellular response to hormone stimulus Source: Ensembl
- female pregnancy Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cAMP Source: Ensembl
- response to corticosterone Source: Ensembl
- response to drug Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to morphine Source: Ensembl
- response to progesterone Source: Ensembl
- transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P53539 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9031628, NGF-stimulated transcription |
SIGNORi | P53539 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein fosBAlternative name(s): G0/G1 switch regulatory protein 3 |
Gene namesi | Name:FOSB Synonyms:G0S3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125740.13 |
HGNCi | HGNC:3797, FOSB |
MIMi | 164772, gene |
neXtProti | NX_P53539 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2354 |
OpenTargetsi | ENSG00000125740 |
PharmGKBi | PA28213 |
Miscellaneous databases
Pharosi | P53539, Tbio |
Polymorphism and mutation databases
BioMutai | FOSB |
DMDMi | 1706888 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076476 | 1 – 338 | Protein fosBAdd BLAST | 338 |
Proteomic databases
CPTACi | CPTAC-1760 |
MassIVEi | P53539 |
MaxQBi | P53539 |
PaxDbi | P53539 |
PeptideAtlasi | P53539 |
PRIDEi | P53539 |
ProteomicsDBi | 17421 20551 56584 [P53539-1] |
PTM databases
iPTMneti | P53539 |
PhosphoSitePlusi | P53539 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125740, Expressed in mucosa of stomach and 209 other tissues |
ExpressionAtlasi | P53539, baseline and differential |
Genevisiblei | P53539, HS |
Organism-specific databases
HPAi | ENSG00000125740, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer.
By similarityBinary interactionsi
Hide detailsP53539
GO - Molecular functioni
- transcription factor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 108637, 31 interactors |
CORUMi | P53539 |
DIPi | DIP-60013N |
IntActi | P53539, 27 interactors |
MINTi | P53539 |
STRINGi | 9606.ENSP00000245919 |
Miscellaneous databases
RNActi | P53539, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P53539 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 218 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 182 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 183 – 211 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_4_0_1 |
InParanoidi | P53539 |
OMAi | QANCKIP |
PhylomeDBi | P53539 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (10+)i Sequence
Sequence statusi: Complete.
This entry describes 10 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P53539-1) [UniParc]FASTAAdd to basket
Also known as: FosB-L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED
260 270 280 290 300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
Isoform 10 (identifier: P53539-10) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKC1 | K7EKC1_HUMAN | Protein fosB | FOSB | 237 | Annotation score: | ||
K7ERZ8 | K7ERZ8_HUMAN | Protein fosB | FOSB | 188 | Annotation score: | ||
K7EKA0 | K7EKA0_HUMAN | Protein fosB | FOSB | 137 | Annotation score: | ||
K7EJ89 | K7EJ89_HUMAN | Protein fosB | FOSB | 177 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 338 | L → R in AAB53946 (PubMed:8985116).Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34730 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34731 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34732 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34733 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34734 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34735 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34736 (Ref. 3) Curated | 1 | |
Sequence conflicti | 338 | L → R in ABW34737 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022286 | 33 | G → S1 PublicationCorresponds to variant dbSNP:rs28381241EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055562 | 1 – 49 | Missing in isoform 10. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_055563 | 42 – 80 | Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_055564 | 43 – 185 | Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST | 143 | |
Alternative sequenceiVSP_046167 | 150 – 185 | Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_055565 | 238 – 284 | Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1 |
CCDSi | CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2] |
PIRi | I53043 |
RefSeqi | NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1] |
Genome annotation databases
Ensembli | ENST00000353609; ENSP00000245919; ENSG00000125740 [P53539-1] ENST00000417353; ENSP00000407207; ENSG00000125740 [P53539-2] ENST00000443841; ENSP00000414177; ENSG00000125740 [P53539-8] ENST00000585836; ENSP00000467497; ENSG00000125740 [P53539-5] ENST00000586615; ENSP00000468207; ENSG00000125740 [P53539-10] ENST00000591858; ENSP00000466530; ENSG00000125740 [P53539-3] ENST00000615753; ENSP00000485018; ENSG00000125740 [P53539-4] |
GeneIDi | 2354 |
KEGGi | hsa:2354 |
UCSCi | uc002pbx.5, human [P53539-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49169 mRNA Translation: AAB53946.1 EU178109 mRNA Translation: ABW34730.1 EU178110 mRNA Translation: ABW34731.1 EU178111 mRNA Translation: ABW34732.1 EU178112 mRNA Translation: ABW34733.1 EU178113 mRNA Translation: ABW34734.1 EU178114 mRNA Translation: ABW34735.1 EU178115 mRNA Translation: ABW34736.1 EU178116 mRNA Translation: ABW34737.1 AY898963 Genomic DNA Translation: AAW65374.1 AK292720 mRNA Translation: BAF85409.1 AC138128 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57351.1 BC036724 mRNA Translation: AAH36724.1 BC040197 mRNA Translation: AAH40197.1 |
CCDSi | CCDS12664.1 [P53539-1] CCDS46113.1 [P53539-2] |
PIRi | I53043 |
RefSeqi | NP_001107643.1, NM_001114171.1 [P53539-2] NP_006723.2, NM_006732.2 [P53539-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5VPA | X-ray | 2.83 | A | 153-219 | [»] | |
5VPB | X-ray | 2.69 | A/C | 153-219 | [»] | |
5VPC | X-ray | 2.50 | A/C | 153-219 | [»] | |
5VPD | X-ray | 2.79 | A/C | 153-219 | [»] | |
5VPE | X-ray | 2.05 | A/C | 153-219 | [»] | |
5VPF | X-ray | 2.69 | A/C | 153-219 | [»] | |
6UCI | X-ray | 2.09 | A/B/C/D | 153-219 | [»] | |
6UCL | X-ray | 2.21 | A | 153-219 | [»] | |
6UCM | X-ray | 2.42 | A/B/C | 153-219 | [»] | |
SMRi | P53539 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108637, 31 interactors |
CORUMi | P53539 |
DIPi | DIP-60013N |
IntActi | P53539, 27 interactors |
MINTi | P53539 |
STRINGi | 9606.ENSP00000245919 |
PTM databases
iPTMneti | P53539 |
PhosphoSitePlusi | P53539 |
Polymorphism and mutation databases
BioMutai | FOSB |
DMDMi | 1706888 |
Proteomic databases
CPTACi | CPTAC-1760 |
MassIVEi | P53539 |
MaxQBi | P53539 |
PaxDbi | P53539 |
PeptideAtlasi | P53539 |
PRIDEi | P53539 |
ProteomicsDBi | 17421 20551 56584 [P53539-1] |
Protocols and materials databases
Antibodypediai | 4139, 519 antibodies |
DNASUi | 2354 |
Genome annotation databases
Organism-specific databases
CTDi | 2354 |
DisGeNETi | 2354 |
EuPathDBi | HostDB:ENSG00000125740.13 |
GeneCardsi | FOSB |
HGNCi | HGNC:3797, FOSB |
HPAi | ENSG00000125740, Low tissue specificity |
MIMi | 164772, gene |
neXtProti | NX_P53539 |
OpenTargetsi | ENSG00000125740 |
PharmGKBi | PA28213 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_4_0_1 |
InParanoidi | P53539 |
OMAi | QANCKIP |
PhylomeDBi | P53539 |
TreeFami | TF326301 |
Enzyme and pathway databases
PathwayCommonsi | P53539 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9031628, NGF-stimulated transcription |
SIGNORi | P53539 |
Miscellaneous databases
BioGRID-ORCSi | 2354, 5 hits in 865 CRISPR screens |
ChiTaRSi | FOSB, human |
GeneWikii | FOSB |
GenomeRNAii | 2354 |
Pharosi | P53539, Tbio |
PROi | PR:P53539 |
RNActi | P53539, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125740, Expressed in mucosa of stomach and 209 other tissues |
ExpressionAtlasi | P53539, baseline and differential |
Genevisiblei | P53539, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSB_HUMAN | |
Accessioni | P53539Primary (citable) accession number: P53539 Secondary accession number(s): A8K9K5 Q49AD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations