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Protein

Actin-7

Gene

ACT7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation.1 Publication

Miscellaneous

There are 8 actin genes in A.thaliana.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  • cell division Source: TAIR
  • response to auxin Source: TAIR
  • response to light stimulus Source: TAIR
  • response to wounding Source: TAIR
  • root development Source: TAIR
  • root epidermal cell differentiation Source: TAIR
  • root hair elongation Source: TAIR
  • seed germination Source: TAIR

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2029482 Regulation of actin dynamics for phagocytic cup formation
R-ATH-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-7
Alternative name(s):
Actin-2
Gene namesi
Name:ACT7
Ordered Locus Names:At5g09810
ORF Names:MYH9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G09810
TAIRilocus:2178128 AT5G09810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000888922 – 377Actin-7Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP53492
PRIDEiP53492

PTM databases

iPTMnetiP53492
SwissPalmiP53492

Expressioni

Tissue specificityi

Constitutively expressed at high levels in young expanding vegetative tissues. Also strongly expressed in the hypocotyl and seed coat. Little or no expression is detected in mature pollen sacs, ovules, embryos or seeds.

Inductioni

Differentially regulated in response to exogenous hormone treatment. In particular, auxin is a strong inducer.1 Publication

Gene expression databases

ExpressionAtlasiP53492 baseline and differential
GenevisibleiP53492 AT

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. The binding of profilin to monomeric G-actin cause the sequestration of actin into profilactin complexes, and prevents the polymerization.

Protein-protein interaction databases

BioGridi16119, 11 interactors
IntActiP53492, 11 interactors
MINTiP53492
STRINGi3702.AT5G09810.1

Structurei

3D structure databases

ProteinModelPortaliP53492
SMRiP53492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
HOGENOMiHOG000233339
InParanoidiP53492
KOiK10355
OMAiMERGYPF
OrthoDBiEOG09360BTG
PhylomeDBiP53492

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGEDIQPL VCDNGTGMVK AGFAGDDAPR AVFPSIVGRP RHTGVMVGMG
60 70 80 90 100
QKDAYVGDEA QSKRGILTLK YPIEHGIVSN WDDMEKIWHH TFYNELRVAP
110 120 130 140 150
EEHPVLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VSHTVPIYEG YALPHAILRL DLAGRDLTDS LMKILTERGY
210 220 230 240 250
MFTTTAEREI VRDIKEKLAY VALDYEQELE TAKSSSSVEK NYELPDGQVI
260 270 280 290 300
TIGAERFRCP EVLFQPSLIG MEAPGIHETT YNSIMKCDVD IRKDLYGNIV
310 320 330 340 350
LSGGSTMFPG IADRMSKEIT ALAPSSMKIK VVAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIS KSEYDESGPS IVHRKCF
Length:377
Mass (Da):41,736
Last modified:October 1, 1996 - v1
Checksum:i0BED4053EDA9F916
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37281 mRNA Translation: AAA80356.1
U27811 Genomic DNA Translation: AAB52506.1
AB016893 Genomic DNA Translation: BAB09402.1
CP002688 Genomic DNA Translation: AED91450.1
AY062702 mRNA Translation: AAL32780.1
AY063980 mRNA Translation: AAL36336.1
AY096397 mRNA Translation: AAM20037.1
AY114679 mRNA Translation: AAM47998.1
AY120779 mRNA Translation: AAM53337.1
PIRiS68107
RefSeqiNP_196543.1, NM_121018.4
UniGeneiAt.23346
At.23605
At.24396
At.65835

Genome annotation databases

EnsemblPlantsiAT5G09810.1; AT5G09810.1; AT5G09810
GeneIDi830841
GrameneiAT5G09810.1; AT5G09810.1; AT5G09810
KEGGiath:AT5G09810

Similar proteinsi

Entry informationi

Entry nameiACT7_ARATH
AccessioniPrimary (citable) accession number: P53492
Secondary accession number(s): P53495
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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