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Protein

Fructose-bisphosphate aldolase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Smp_022400)
  3. ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (Smp_043670.1), ATP-dependent 6-phosphofructokinase (Smp_043670.2)
  4. Fructose-bisphosphate aldolase (Smp_042160.1), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (Smp_042160.2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BRENDAi4.1.2.13 5608
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169341 – 363Fructose-bisphosphate aldolaseAdd BLAST363

Proteomic databases

PRIDEiP53442

Expressioni

Gene expression databases

ExpressionAtlasiP53442 baseline

Structurei

3D structure databases

ProteinModelPortaliP53442
SMRiP53442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
HOGENOMiHOG000220876
KOiK01623
OMAiMILKPNM
OrthoDBiEOG091G0A9T
PhylomeDBiP53442

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P53442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE
60 70 80 90 100
NNEENRRLYR QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE
110 120 130 140 150
RNIIPGIKVD KGVVPLAGTD NETTTQGLDD LASRCAEYWR LGCRFAKWRC
160 170 180 190 200
VLKISSHTPS YLAMLENANV LARYASICQQ NGLVPIVEPE VLPDGDHDLL
210 220 230 240 250
TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC KKAYTPQENA
260 270 280 290 300
LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF
310 320 330 340 350
SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT
360
LGDKSLFVAN HAY
Length:363
Mass (Da):39,645
Last modified:October 1, 1996 - v1
Checksum:iAE16BBC2BD05C0B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38658 mRNA Translation: AAA57567.1
AF026805 mRNA Translation: AAB84014.1
RefSeqiXP_018652294.1, XM_018797232.1
UniGeneiSma.1174

Genome annotation databases

EnsemblMetazoaiSmp_042160.2; Smp_042160.2:pep; Smp_042160
GeneDBiSmp_042160.1:pep
Smp_042160.2:pep
GeneIDi8354313
KEGGismm:Smp_042160.1

Similar proteinsi

Entry informationi

Entry nameiALF_SCHMA
AccessioniPrimary (citable) accession number: P53442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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