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Entry version 158 (10 Feb 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Protein SOK2

Gene

SOK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.

Miscellaneous

Present with 314 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi448 – 469H-T-H motifPROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: SGD
  • sequence-specific DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SOK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOK2
Ordered Locus Names:YMR016C
ORF Names:YM9711.03C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000004618, SOK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YMR016C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720361 – 785Protein SOK2Add BLAST785

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei771PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53438

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53438

PRoteomics IDEntifications database

More...
PRIDEi
P53438

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35187, 247 interactors

Protein interaction database and analysis system

More...
IntActi
P53438, 2 interactors

Molecular INTeraction database

More...
MINTi
P53438

STRING: functional protein association networks

More...
STRINGi
4932.YMR016C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53438, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53438

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini414 – 520HTH APSES-typePROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 45Poly-Gln8
Compositional biasi148 – 151Poly-Tyr4
Compositional biasi169 – 172Poly-Tyr4
Compositional biasi206 – 217Poly-GlnAdd BLAST12
Compositional biasi331 – 335Poly-Gln5
Compositional biasi526 – 532Poly-Ser7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EFG1/PHD1/stuA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QW2C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_357582_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53438

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029790, EFG1/Phd1/StuA
IPR036887, HTH_APSES_sf
IPR018004, KilA_N/APSES_HTH
IPR003163, Tscrpt_reg_HTH_APSES-type

The PANTHER Classification System

More...
PANTHERi
PTHR47792, PTHR47792, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01252, KilA-N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54616, SSF54616, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51299, HTH_APSES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53438-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS
60 70 80 90 100
VQPLMPVSYQ YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS
110 120 130 140 150
GSDSNASNPP STSVGVPSNA TATALPNGSA ITTKKSNNST NISNNVPYYY
160 170 180 190 200
YFPQMQAQQS MAYSYPQAYY YYPANGDGTT NGATPSVTSN QVQNPNLEKT
210 220 230 240 250
YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP PSDSSSGSMS
260 270 280 290 300
PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP
310 320 330 340 350
PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK
360 370 380 390 400
PSTDQETYLT ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG
410 420 430 440 450
SNTSGTSASI IRPRVTTTMW EDEKTLCYQV EANGISVVRR ADNDMVNGTK
460 470 480 490 500
LLNVTKMTRG RRDGILKAEK IRHVVKIGSM HLKGVWIPFE RALAIAQREK
510 520 530 540 550
IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP RTYYQPINNY
560 570 580 590 600
QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP
610 620 630 640 650
NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI
660 670 680 690 700
TPADSKPLTP SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE
710 720 730 740 750
ADSGNTVPDN QTLKEPRSSQ LPISALTSTD TDKIKTSTSD EATQPNEPSE
760 770 780
AEPVKESESS KSQVDGAGDV SNEEIAADDT KKQEK
Length:785
Mass (Da):85,643
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4E0F224BE84645F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S80522 Genomic DNA Translation: AAB35749.1
Z49211 Genomic DNA Translation: CAA89117.1
BK006946 Genomic DNA Translation: DAA09914.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54016

NCBI Reference Sequences

More...
RefSeqi
NP_013729.1, NM_001182512.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR016C_mRNA; YMR016C; YMR016C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR016C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80522 Genomic DNA Translation: AAB35749.1
Z49211 Genomic DNA Translation: CAA89117.1
BK006946 Genomic DNA Translation: DAA09914.1
PIRiS54016
RefSeqiNP_013729.1, NM_001182512.1

3D structure databases

SMRiP53438
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35187, 247 interactors
IntActiP53438, 2 interactors
MINTiP53438
STRINGi4932.YMR016C

PTM databases

iPTMnetiP53438

Proteomic databases

MaxQBiP53438
PaxDbiP53438
PRIDEiP53438

Genome annotation databases

EnsemblFungiiYMR016C_mRNA; YMR016C; YMR016C
GeneIDi855030
KEGGisce:YMR016C

Organism-specific databases

SGDiS000004618, SOK2
VEuPathDBiFungiDB:YMR016C

Phylogenomic databases

eggNOGiENOG502QW2C, Eukaryota
GeneTreeiENSGT00940000176596
HOGENOMiCLU_357582_0_0_1
InParanoidiP53438

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53438
RNActiP53438, protein

Family and domain databases

Gene3Di3.10.260.10, 1 hit
InterProiView protein in InterPro
IPR029790, EFG1/Phd1/StuA
IPR036887, HTH_APSES_sf
IPR018004, KilA_N/APSES_HTH
IPR003163, Tscrpt_reg_HTH_APSES-type
PANTHERiPTHR47792, PTHR47792, 1 hit
SMARTiView protein in SMART
SM01252, KilA-N, 1 hit
SUPFAMiSSF54616, SSF54616, 1 hit
PROSITEiView protein in PROSITE
PS51299, HTH_APSES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOK2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53438
Secondary accession number(s): D6VZJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 10, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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