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Entry version 168 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Dicarboxylic amino acid permease

Gene

DIP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine.1 Publication

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-34148-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.10.13 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dicarboxylic amino acid permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIP5
Ordered Locus Names:YPL265W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YPL265W

Saccharomyces Genome Database

More...
SGDi
S000006186 DIP5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 119ExtracellularSequence analysis8
Transmembranei120 – 142HelicalSequence analysisAdd BLAST23
Topological domaini143 – 156CytoplasmicSequence analysisAdd BLAST14
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 231CytoplasmicSequence analysis9
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 285ExtracellularSequence analysisAdd BLAST33
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 322CytoplasmicSequence analysisAdd BLAST16
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 372ExtracellularSequence analysisAdd BLAST29
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 423CytoplasmicSequence analysisAdd BLAST30
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 454ExtracellularSequence analysis10
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 501CytoplasmicSequence analysisAdd BLAST26
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 530ExtracellularSequence analysis8
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 608CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541501 – 608Dicarboxylic amino acid permeaseAdd BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53388

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53388

PRoteomics IDEntifications database

More...
PRIDEi
P53388

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53388

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35948, 90 interactors

Database of interacting proteins

More...
DIPi
DIP-5540N

Protein interaction database and analysis system

More...
IntActi
P53388, 22 interactors

Molecular INTeraction database

More...
MINTi
P53388

STRING: functional protein association networks

More...
STRINGi
4932.YPL265W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53388 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi574 – 577Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007946_12_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53388

KEGG Orthology (KO)

More...
KOi
K16261

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMLYVEP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00913 2A0310, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMPLKKMFT STSPRNSSSL DSDHDAYYSK QNPDNFPVKE QEIYNIDLEE
60 70 80 90 100
NNVSSRSSTS TSPSARDDSF AVPDGKDENT RLRKDLKARH ISMIAIGGSL
110 120 130 140 150
GTGLLIGTGT ALLTGGPVAM LIAYAFVGLL VFYTMACLGE MASYIPLDGF
160 170 180 190 200
TSYASRYVDP ALGFAIGYTY LFKYFILPPN QLTAAALVIQ YWISRDRVNP
210 220 230 240 250
GVWITIFLVV IVAINVVGVK FFGEFEFWLS SFKVMVMLGL ILLLFIIMLG
260 270 280 290 300
GGPNHDRLGF RYWRDPGAFK EYSTAITGGK GKFVSFVAVF VYSLFSYTGI
310 320 330 340 350
ELTGIVCSEA ENPRKSVPKA IKLTVYRIIV FYLCTVFLLG MCVAYNDPRL
360 370 380 390 400
LSTKGKSMSA AASPFVVAIQ NSGIEVLPHI FNACVLVFVF SACNSDLYVS
410 420 430 440 450
SRNLYALAID GKAPKIFAKT SRWGVPYNAL ILSVLFCGLA YMNVSSGSAK
460 470 480 490 500
IFNYFVNVVS MFGILSWITI LIVYIYFDKA CRAQGIDKSK FAYVAPGQRY
510 520 530 540 550
GAYFALFFCI LIALIKNFTV FLGHKFDYKT FITGYIGLPV YIISWAGYKL
560 570 580 590 600
IYKTKVIKST DVDLYTFKEI YDREEEEGRM KDQEKEERLK SNGKNMEWFY

EKFLGNIF
Length:608
Mass (Da):68,097
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i488A382656039D0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95802 Genomic DNA Translation: CAA65074.1
Z73621 Genomic DNA Translation: CAA98000.1
BK006949 Genomic DNA Translation: DAA11171.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S65298

NCBI Reference Sequences

More...
RefSeqi
NP_015058.1, NM_001184079.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL265W_mRNA; YPL265W; YPL265W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL265W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95802 Genomic DNA Translation: CAA65074.1
Z73621 Genomic DNA Translation: CAA98000.1
BK006949 Genomic DNA Translation: DAA11171.1
PIRiS65298
RefSeqiNP_015058.1, NM_001184079.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35948, 90 interactors
DIPiDIP-5540N
IntActiP53388, 22 interactors
MINTiP53388
STRINGi4932.YPL265W

Protein family/group databases

TCDBi2.A.3.10.13 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiP53388

Proteomic databases

MaxQBiP53388
PaxDbiP53388
PRIDEiP53388

Genome annotation databases

EnsemblFungiiYPL265W_mRNA; YPL265W; YPL265W
GeneIDi855863
KEGGisce:YPL265W

Organism-specific databases

EuPathDBiFungiDB:YPL265W
SGDiS000006186 DIP5

Phylogenomic databases

HOGENOMiCLU_007946_12_1_1
InParanoidiP53388
KOiK16261
OMAiEMLYVEP

Enzyme and pathway databases

BioCyciYEAST:G3O-34148-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53388
RNActiP53388 protein

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIP5_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53388
Secondary accession number(s): D6W3A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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