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Protein

Nucleoside diphosphate-linked moiety X motif 6

Gene

NUDT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May contribute to the regulation of cell proliferation.1 Publication

Miscellaneous

This protein is coded from a FGF2 (BFGF) gene antisense transcript.

Caution

The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no such activity, neither for the human nor the rat protein.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ADP-ribose diphosphatase activity Source: GO_Central
  • NAD binding Source: GO_Central
  • NADH pyrophosphatase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 6 (EC:3.6.1.-)
Short name:
Nudix motif 6
Alternative name(s):
Antisense basic fibroblast growth factor
Protein GFG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUDT6
Synonyms:FGF2AS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170917.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8053 NUDT6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606261 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P53370

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11162

Open Targets

More...
OpenTargetsi
ENSG00000170917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31839

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUDT6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17380446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000571071 – 316Nucleoside diphosphate-linked moiety X motif 6Add BLAST316

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P53370

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53370

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53370

PeptideAtlas

More...
PeptideAtlasi
P53370

PRoteomics IDEntifications database

More...
PRIDEi
P53370

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56577
56578 [P53370-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53370

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P53370

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170917 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...
CleanExi
HS_NUDT6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P53370 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P53370 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039202
HPA066115

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116333, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P53370, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306070

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P53370

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53370

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 273Nudix hydrolasePROSITE-ProRule annotationAdd BLAST133

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi176 – 197Nudix boxAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0648 Eukaryota
ENOG410Z4GH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231274

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052692

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53370

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCFHHAE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TZE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P53370

TreeFam database of animal gene trees

More...
TreeFami
TF106346

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00293 NUDIX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01356 GFGPROTEIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55811 SSF55811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53370-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL
60 70 80 90 100
DRFGGISVRL ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL
110 120 130 140 150
QSRFIAPAAS LGFCFHHAES DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV
160 170 180 190 200
FDESTRKILV VQDRNKLKNM WKFPGGLSEP EEDIGDTAVR EVFEETGIKS
210 220 230 240 250
EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ EECLRCEWMD
260 270 280 290 300
LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL
310
YHKELPENYK TMKGID
Length:316
Mass (Da):35,679
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41EC95893B52180A
GO
Isoform 2 (identifier: P53370-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:147
Mass (Da):17,082
Checksum:iA74B7E75EA979B4D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBZ9E9PBZ9_HUMAN
Nucleoside diphosphate-linked moiet...
NUDT6
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9C0H0Y9C0_HUMAN
Nucleoside diphosphate-linked moiet...
NUDT6
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181E → G in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti198I → V in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti205V → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti213 – 214TN → RS in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti217A → R in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti220K → M in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti225I → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti230 – 232KPY → QPR in AAA67062 (PubMed:7984147).Curated3
Sequence conflicti241E → Q in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti245R → K in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti252 – 253ND → ES in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti256 – 259KTEN → RTKH in AAA67062 (PubMed:7984147).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050412114C → R. Corresponds to variant dbSNP:rs12648093Ensembl.1
Natural variantiVAR_021909209R → Q. Corresponds to variant dbSNP:rs1048201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0037291 – 169Missing in isoform 2. CuratedAdd BLAST169

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF019633 mRNA Translation: AAD01636.2
AF019632 mRNA Translation: AAD01635.1
AK291871 mRNA Translation: BAF84560.1
BC009842 mRNA Translation: AAH09842.1
L31408 mRNA Translation: AAA67062.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3729.1 [P53370-2]
CCDS43268.1 [P53370-1]

NCBI Reference Sequences

More...
RefSeqi
NP_009014.2, NM_007083.4 [P53370-1]
NP_932158.1, NM_198041.2 [P53370-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.558459

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304430; ENSP00000306070; ENSG00000170917 [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917 [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917 [P53370-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11162

UCSC genome browser

More...
UCSCi
uc003iew.3 human [P53370-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019633 mRNA Translation: AAD01636.2
AF019632 mRNA Translation: AAD01635.1
AK291871 mRNA Translation: BAF84560.1
BC009842 mRNA Translation: AAH09842.1
L31408 mRNA Translation: AAA67062.1
CCDSiCCDS3729.1 [P53370-2]
CCDS43268.1 [P53370-1]
RefSeqiNP_009014.2, NM_007083.4 [P53370-1]
NP_932158.1, NM_198041.2 [P53370-2]
UniGeneiHs.558459

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FXTX-ray2.30A/B/C/D/E/F/G/H45-134[»]
3H95X-ray1.70A141-316[»]
ProteinModelPortaliP53370
SMRiP53370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116333, 13 interactors
IntActiP53370, 4 interactors
STRINGi9606.ENSP00000306070

PTM databases

iPTMnetiP53370
PhosphoSitePlusiP53370

Polymorphism and mutation databases

BioMutaiNUDT6
DMDMi17380446

Proteomic databases

EPDiP53370
MaxQBiP53370
PaxDbiP53370
PeptideAtlasiP53370
PRIDEiP53370
ProteomicsDBi56577
56578 [P53370-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11162
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304430; ENSP00000306070; ENSG00000170917 [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917 [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917 [P53370-2]
GeneIDi11162
KEGGihsa:11162
UCSCiuc003iew.3 human [P53370-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11162
DisGeNETi11162
EuPathDBiHostDB:ENSG00000170917.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUDT6
HGNCiHGNC:8053 NUDT6
HPAiHPA039202
HPA066115
MIMi606261 gene
neXtProtiNX_P53370
OpenTargetsiENSG00000170917
PharmGKBiPA31839

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0648 Eukaryota
ENOG410Z4GH LUCA
GeneTreeiENSGT00390000008458
HOGENOMiHOG000231274
HOVERGENiHBG052692
InParanoidiP53370
OMAiFCFHHAE
OrthoDBiEOG091G0TZE
PhylomeDBiP53370
TreeFamiTF106346

Miscellaneous databases

EvolutionaryTraceiP53370

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUDT6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11162

Protein Ontology

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PROi
PR:P53370

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170917 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_NUDT6
ExpressionAtlasiP53370 baseline and differential
GenevisibleiP53370 HS

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR01356 GFGPROTEIN
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUDT6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53370
Secondary accession number(s): A8K756, O95097, Q9UQD9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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