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Protein

Nucleoside diphosphate-linked moiety X motif 6

Gene

NUDT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the regulation of cell proliferation.1 Publication

Miscellaneous

This protein is coded from a FGF2 (BFGF) gene antisense transcript.

Caution

The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no such activity, neither for the human nor the rat protein.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 6 (EC:3.6.1.-)
Short name:
Nudix motif 6
Alternative name(s):
Antisense basic fibroblast growth factor
Protein GFG
Gene namesi
Name:NUDT6
Synonyms:FGF2AS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000170917.13
HGNCiHGNC:8053 NUDT6
MIMi606261 gene
neXtProtiNX_P53370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11162
OpenTargetsiENSG00000170917
PharmGKBiPA31839

Polymorphism and mutation databases

BioMutaiNUDT6
DMDMi17380446

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571071 – 316Nucleoside diphosphate-linked moiety X motif 6Add BLAST316

Proteomic databases

EPDiP53370
MaxQBiP53370
PaxDbiP53370
PeptideAtlasiP53370
PRIDEiP53370
ProteomicsDBi56577
56578 [P53370-2]

PTM databases

iPTMnetiP53370
PhosphoSitePlusiP53370

Expressioni

Tissue specificityi

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.2 Publications

Gene expression databases

BgeeiENSG00000170917 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_NUDT6
ExpressionAtlasiP53370 baseline and differential
GenevisibleiP53370 HS

Organism-specific databases

HPAiHPA039202
HPA066115

Interactioni

Subunit structurei

Monomer and homodimer.1 Publication

Protein-protein interaction databases

BioGridi116333, 13 interactors
IntActiP53370, 4 interactors
STRINGi9606.ENSP00000306070

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53370
SMRiP53370
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53370

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 273Nudix hydrolasePROSITE-ProRule annotationAdd BLAST133

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 197Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG0648 Eukaryota
ENOG410Z4GH LUCA
GeneTreeiENSGT00390000008458
HOGENOMiHOG000231274
HOVERGENiHBG052692
InParanoidiP53370
OMAiLGFCFHH
OrthoDBiEOG091G0TZE
PhylomeDBiP53370
TreeFamiTF106346

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR01356 GFGPROTEIN
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53370-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL
60 70 80 90 100
DRFGGISVRL ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL
110 120 130 140 150
QSRFIAPAAS LGFCFHHAES DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV
160 170 180 190 200
FDESTRKILV VQDRNKLKNM WKFPGGLSEP EEDIGDTAVR EVFEETGIKS
210 220 230 240 250
EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ EECLRCEWMD
260 270 280 290 300
LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL
310
YHKELPENYK TMKGID
Length:316
Mass (Da):35,679
Last modified:November 16, 2001 - v2
Checksum:i41EC95893B52180A
GO
Isoform 2 (identifier: P53370-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:147
Mass (Da):17,082
Checksum:iA74B7E75EA979B4D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBZ9E9PBZ9_HUMAN
Nucleoside diphosphate-linked moiet...
NUDT6
104Annotation score:
H0Y9C0H0Y9C0_HUMAN
Nucleoside diphosphate-linked moiet...
NUDT6
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181E → G in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti198I → V in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti205V → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti213 – 214TN → RS in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti217A → R in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti220K → M in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti225I → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti230 – 232KPY → QPR in AAA67062 (PubMed:7984147).Curated3
Sequence conflicti241E → Q in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti245R → K in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti252 – 253ND → ES in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti256 – 259KTEN → RTKH in AAA67062 (PubMed:7984147).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050412114C → R. Corresponds to variant dbSNP:rs12648093Ensembl.1
Natural variantiVAR_021909209R → Q. Corresponds to variant dbSNP:rs1048201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037291 – 169Missing in isoform 2. CuratedAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019633 mRNA Translation: AAD01636.2
AF019632 mRNA Translation: AAD01635.1
AK291871 mRNA Translation: BAF84560.1
BC009842 mRNA Translation: AAH09842.1
L31408 mRNA Translation: AAA67062.1
CCDSiCCDS3729.1 [P53370-2]
CCDS43268.1 [P53370-1]
RefSeqiNP_009014.2, NM_007083.4 [P53370-1]
NP_932158.1, NM_198041.2 [P53370-2]
UniGeneiHs.558459

Genome annotation databases

EnsembliENST00000304430; ENSP00000306070; ENSG00000170917 [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917 [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917 [P53370-2]
GeneIDi11162
KEGGihsa:11162
UCSCiuc003iew.3 human [P53370-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019633 mRNA Translation: AAD01636.2
AF019632 mRNA Translation: AAD01635.1
AK291871 mRNA Translation: BAF84560.1
BC009842 mRNA Translation: AAH09842.1
L31408 mRNA Translation: AAA67062.1
CCDSiCCDS3729.1 [P53370-2]
CCDS43268.1 [P53370-1]
RefSeqiNP_009014.2, NM_007083.4 [P53370-1]
NP_932158.1, NM_198041.2 [P53370-2]
UniGeneiHs.558459

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FXTX-ray2.30A/B/C/D/E/F/G/H45-134[»]
3H95X-ray1.70A141-316[»]
ProteinModelPortaliP53370
SMRiP53370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116333, 13 interactors
IntActiP53370, 4 interactors
STRINGi9606.ENSP00000306070

PTM databases

iPTMnetiP53370
PhosphoSitePlusiP53370

Polymorphism and mutation databases

BioMutaiNUDT6
DMDMi17380446

Proteomic databases

EPDiP53370
MaxQBiP53370
PaxDbiP53370
PeptideAtlasiP53370
PRIDEiP53370
ProteomicsDBi56577
56578 [P53370-2]

Protocols and materials databases

DNASUi11162
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304430; ENSP00000306070; ENSG00000170917 [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917 [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917 [P53370-2]
GeneIDi11162
KEGGihsa:11162
UCSCiuc003iew.3 human [P53370-1]

Organism-specific databases

CTDi11162
DisGeNETi11162
EuPathDBiHostDB:ENSG00000170917.13
GeneCardsiNUDT6
HGNCiHGNC:8053 NUDT6
HPAiHPA039202
HPA066115
MIMi606261 gene
neXtProtiNX_P53370
OpenTargetsiENSG00000170917
PharmGKBiPA31839
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0648 Eukaryota
ENOG410Z4GH LUCA
GeneTreeiENSGT00390000008458
HOGENOMiHOG000231274
HOVERGENiHBG052692
InParanoidiP53370
OMAiLGFCFHH
OrthoDBiEOG091G0TZE
PhylomeDBiP53370
TreeFamiTF106346

Miscellaneous databases

EvolutionaryTraceiP53370
GeneWikiiNUDT6
GenomeRNAii11162
PROiPR:P53370
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170917 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_NUDT6
ExpressionAtlasiP53370 baseline and differential
GenevisibleiP53370 HS

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR01356 GFGPROTEIN
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUDT6_HUMAN
AccessioniPrimary (citable) accession number: P53370
Secondary accession number(s): A8K756, O95097, Q9UQD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: October 10, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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