Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P53367 (ARFP1_HUMAN)

Entry version 167 (10 Feb 2021)
Sequence version 2 (27 May 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Arfaptin-1

Gene

ARFIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53367

SIGNOR Signaling Network Open Resource

More...SIGNORi		P53367

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arfaptin-1
Alternative name(s):
ADP-ribosylation factor-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARFIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21496, ARFIP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605928, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53367

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164144.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi132S → A: Complete loss of phosphorylation by PRKD1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		27236

Open Targets

More...OpenTargetsi		ENSG00000164144

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134920621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53367, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARFIP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		21264399

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646652 – 373Arfaptin-1Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1 Publication1
Modified residuei361PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53367

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53367

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53367

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53367

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53367

PeptideAtlas

More...PeptideAtlasi		P53367

PRoteomics IDEntifications database

More...PRIDEi		P53367

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5003
56575 [P53367-1]
56576 [P53367-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53367

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P53367

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53367

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164144, Expressed in endometrium and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53367, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53367, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164144, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers or heterodimers with ARFIP2 (PubMed:21239483).

Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3 (PubMed:10413101).

Interacts with ARF1 (PubMed:10413101, PubMed:22981988). Binds with lower affinity to ARF5 and with very little affinity to ARF6 (PubMed:10413101).

Interacts with ARL1 (PubMed:22981988, PubMed:21239483).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118084, 76 interactors

Protein interaction database and analysis system

More...IntActi		P53367, 29 interactors

Molecular INTeraction database

More...MINTi		P53367

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000395083

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53367, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53367

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 353AHPROSITE-ProRule annotationAdd BLAST201

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3876, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183040

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047975_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53367

Identification of Orthologs from Complete Genome Data

More...OMAi		HLFQVHK

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53367

TreeFam database of animal gene trees

More...TreeFami		TF314945

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR030793, Arfaptin-1
IPR030798, Arfaptin_fam

The PANTHER Classification System

More...PANTHERi		PTHR12141, PTHR12141, 1 hit
PTHR12141:SF4, PTHR12141:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06456, Arfaptin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01015, Arfaptin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657, SSF103657, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50870, AH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P53367-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQESPKNSA AEIPVTSNGE VDDSREHSFN RDLKHSLPSG LGLSETQITS 
        60         70         80         90        100
HGFDNTKEGV IEAGAFQGSP APPLPSVMSP SRVAASRLAQ QGSDLIVPAG 
       110        120        130        140        150
GQRTQTKSGP VILADEIKNP AMEKLELVRK WSLNTYKCTR QIISEKLGRG 
       160        170        180        190        200
SRTVDLELEA QIDILRDNKK KYENILKLAQ TLSTQLFQMV HTQRQLGDAF 
       210        220        230        240        250
ADLSLKSLEL HEEFGYNADT QKLLAKNGET LLGAINFFIA SVNTLVNKTI 
       260        270        280        290        300
EDTLMTVKQY ESARIEYDAY RTDLEELNLG PRDANTLPKI EQSQHLFQAH 
       310        320        330        340        350
KEKYDKMRND VSVKLKFLEE NKVKVLHNQL VLFHNAIAAY FAGNQKQLEQ 
       360        370 
TLKQFHIKLK TPGVDAPSWL EEQ
Length:373
Mass (Da):41,738
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A315D0E67DECDBF
GO
Isoform A (identifier: P53367-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     69-100: Missing.

Show »
Length:341
Mass (Da):38,599
Checksum:i94675E3FF3FB9D08
GO
Isoform 3 (identifier: P53367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-211: Missing.

Show »
Length:193
Mass (Da):22,055
Checksum:iA8203E8608316921
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05742532 – 211Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_00408869 – 100Missing in isoform A. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U52521 mRNA Translation: AAA97923.1
AF124489 mRNA Translation: AAD29390.1
AK290472 mRNA Translation: BAF83161.1
AK299600 mRNA Translation: BAG61531.1
AC099339 Genomic DNA No translation available.
AC106882 Genomic DNA No translation available.
AC113155 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04968.1
CH471056 Genomic DNA Translation: EAX04969.1
BC103759 mRNA Translation: AAI03760.1
BC105114 mRNA Translation: AAI05115.1
BC105116 mRNA Translation: AAI05117.1
BC143675 mRNA Translation: AAI43676.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34080.1 [P53367-1]
CCDS3780.1 [P53367-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G02515

NCBI Reference Sequences

More...RefSeqi		NP_001020764.1, NM_001025593.2 [P53367-2]
NP_001020766.1, NM_001025595.2 [P53367-1]
NP_001274360.1, NM_001287431.1 [P53367-1]
NP_001274361.1, NM_001287432.1 [P53367-1]
NP_001274362.1, NM_001287433.1 [P53367-2]
NP_055262.1, NM_014447.3 [P53367-2]
XP_011530171.1, XM_011531869.2 [P53367-1]
XP_011530172.1, XM_011531870.2 [P53367-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000353617; ENSP00000296557; ENSG00000164144 [P53367-1]
ENST00000356064; ENSP00000348360; ENSG00000164144 [P53367-2]
ENST00000405727; ENSP00000384189; ENSG00000164144 [P53367-2]
ENST00000429148; ENSP00000396653; ENSG00000164144 [P53367-3]
ENST00000451320; ENSP00000395083; ENSG00000164144 [P53367-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27236

UCSC genome browser

More...UCSCi		uc003imz.5, human [P53367-1]
uc011cij.4, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52521 mRNA Translation: AAA97923.1
AF124489 mRNA Translation: AAD29390.1
AK290472 mRNA Translation: BAF83161.1
AK299600 mRNA Translation: BAG61531.1
AC099339 Genomic DNA No translation available.
AC106882 Genomic DNA No translation available.
AC113155 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04968.1
CH471056 Genomic DNA Translation: EAX04969.1
BC103759 mRNA Translation: AAI03760.1
BC105114 mRNA Translation: AAI05115.1
BC105116 mRNA Translation: AAI05117.1
BC143675 mRNA Translation: AAI43676.1
CCDSiCCDS34080.1 [P53367-1]
CCDS3780.1 [P53367-2]
PIRiG02515
RefSeqiNP_001020764.1, NM_001025593.2 [P53367-2]
NP_001020766.1, NM_001025595.2 [P53367-1]
NP_001274360.1, NM_001287431.1 [P53367-1]
NP_001274361.1, NM_001287432.1 [P53367-1]
NP_001274362.1, NM_001287433.1 [P53367-2]
NP_055262.1, NM_014447.3 [P53367-2]
XP_011530171.1, XM_011531869.2 [P53367-1]
XP_011530172.1, XM_011531870.2 [P53367-1]

3D structure databases

SMRiP53367
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118084, 76 interactors
IntActiP53367, 29 interactors
MINTiP53367
STRINGi9606.ENSP00000395083

PTM databases

iPTMnetiP53367
MetOSiteiP53367
PhosphoSitePlusiP53367

Genetic variation databases

BioMutaiARFIP1
DMDMi21264399

Proteomic databases

EPDiP53367
jPOSTiP53367
MassIVEiP53367
MaxQBiP53367
PaxDbiP53367
PeptideAtlasiP53367
PRIDEiP53367
ProteomicsDBi5003
56575 [P53367-1]
56576 [P53367-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3910, 238 antibodies

Genome annotation databases

EnsembliENST00000353617; ENSP00000296557; ENSG00000164144 [P53367-1]
ENST00000356064; ENSP00000348360; ENSG00000164144 [P53367-2]
ENST00000405727; ENSP00000384189; ENSG00000164144 [P53367-2]
ENST00000429148; ENSP00000396653; ENSG00000164144 [P53367-3]
ENST00000451320; ENSP00000395083; ENSG00000164144 [P53367-1]
GeneIDi27236
KEGGihsa:27236
UCSCiuc003imz.5, human [P53367-1]
uc011cij.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27236
DisGeNETi27236

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARFIP1
HGNCiHGNC:21496, ARFIP1
HPAiENSG00000164144, Low tissue specificity
MIMi605928, gene
neXtProtiNX_P53367
OpenTargetsiENSG00000164144
PharmGKBiPA134920621
VEuPathDBiHostDB:ENSG00000164144.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3876, Eukaryota
GeneTreeiENSGT00950000183040
HOGENOMiCLU_047975_2_0_1
InParanoidiP53367
OMAiHLFQVHK
PhylomeDBiP53367
TreeFamiTF314945

Enzyme and pathway databases

PathwayCommonsiP53367
SIGNORiP53367

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27236, 6 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARFIP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ARFIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27236
PharosiP53367, Tbio

Protein Ontology

More...PROi		PR:P53367
RNActiP53367, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164144, Expressed in endometrium and 231 other tissues
ExpressionAtlasiP53367, baseline and differential
GenevisibleiP53367, HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR030793, Arfaptin-1
IPR030798, Arfaptin_fam
PANTHERiPTHR12141, PTHR12141, 1 hit
PTHR12141:SF4, PTHR12141:SF4, 1 hit
PfamiView protein in Pfam
PF06456, Arfaptin, 1 hit
SMARTiView protein in SMART
SM01015, Arfaptin, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870, AH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARFP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53367
Secondary accession number(s): B4DS69
, Q2M2X4, Q3SYL4, Q9Y2X6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: February 10, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again