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Protein

Proliferating cell nuclear antigen

Gene

PCNA

Organism
Styela clava (Sea squirt)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Alternative name(s):
Cyclin
Gene namesi
Name:PCNA
OrganismiStyela clava (Sea squirt)
Taxonomic identifieri7725 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaStyelidaeStyela

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491721 – 264Proliferating cell nuclear antigenAdd BLAST264

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP53358
SMRiP53358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

HOVERGENiHBG000947

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P53358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEARLIQGS NLKKVQEALK DIVTEASWDC TSSGISLQAM DSSHVSLVQL
60 70 80 90 100
TLRADGFENF RCDRNLAMGI NMTSMAKIMK CAGNDDIITL RAEDNADMLE
110 120 130 140 150
LIFESSKGDK YSQYEMKLMD LDCEQLGIPE QDYSCCVTLP SQEFGRICRD
160 170 180 190 200
LSQIGECVVI TCTKDGVQFS AKGDLGAGKI KLKQNTGSDI KEEEQVTVEI
210 220 230 240 250
SEPVQLTFAI KYLNLFAKAS PLSPSVCLSM SNNVPLVVEY KVADMGHIKY
260
FLAPKIEDEE EQDS
Length:264
Mass (Da):29,260
Last modified:October 1, 1996 - v1
Checksum:i007B96B9BB5208D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42763 mRNA Translation: AAC37303.1

Similar proteinsi

Entry informationi

Entry nameiPCNA_STYCL
AccessioniPrimary (citable) accession number: P53358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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