UniProtKB - P53355 (DAPK1_HUMAN)
Death-associated protein kinase 1
DAPK1
Functioni
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.
Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 42 | ATP | 1 | |
Binding sitei | 100 | ATP | 1 | |
Active sitei | 139 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 161 | ATP | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 19 – 27 | ATP | 9 | |
Nucleotide bindingi | 94 – 96 | ATP | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
- calmodulin-dependent protein kinase activity Source: UniProtKB
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- syntaxin-1 binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- apoptotic signaling pathway Source: UniProtKB
- cellular response to hydroperoxide Source: ParkinsonsUK-UCL
- cellular response to interferon-gamma Source: UniProtKB
- defense response to tumor cell Source: ARUK-UCL
- extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- intracellular signal transduction Source: UniProtKB
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of translation Source: UniProtKB
- positive regulation of apoptotic process Source: ComplexPortal
- positive regulation of autophagic cell death Source: ComplexPortal
- positive regulation of autophagy Source: ParkinsonsUK-UCL
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of autophagy Source: UniProtKB
- regulation of NMDA receptor activity Source: UniProtKB
- regulation of response to tumor cell Source: ComplexPortal
Keywordsi
Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Translation regulation |
Ligand | ATP-binding, GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P53355 |
Reactomei | R-HSA-418889, Caspase activation via Dependence Receptors in the absence of ligand |
SignaLinki | P53355 |
SIGNORi | P53355 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DAPK1 Synonyms:DAPK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2674, DAPK1 |
MIMi | 600831, gene |
neXtProti | NX_P53355 |
VEuPathDBi | HostDB:ENSG00000196730 |
Subcellular locationi
Cytoplasm and Cytosol
Cytoskeleton
Note: Colocalizes with MAP1B in the microtubules and cortical actin fibers.
Cytoplasm and Cytosol
Cytoskeleton
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- DAPK1-calmodulin complex Source: ComplexPortal
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 42 | K → A: Loss of activity, apoptotic function and of autophosphorylation. 2 Publications | 1 | |
Mutagenesisi | 289 | S → A: Loss of phosphorylation and significant increase in proapoptotic activity. | 1 | |
Mutagenesisi | 289 | S → E: Reduction in proapoptotic activity. | 1 | |
Mutagenesisi | 308 | S → A: Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. 1 Publication | 1 | |
Mutagenesisi | 308 | S → D: Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. 1 Publication | 1 | |
Mutagenesisi | 313 | S → A: Minimal effect on activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1612 |
OpenTargetsi | ENSG00000196730 |
PharmGKBi | PA27142 |
Miscellaneous databases
Pharosi | P53355, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2558 |
DrugBanki | DB04069, 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine DB07444, 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE DB12010, Fostamatinib DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
DrugCentrali | P53355 |
GuidetoPHARMACOLOGYi | 2002 |
Genetic variation databases
BioMutai | DAPK1 |
DMDMi | 317373595 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085910 | 1 – 1430 | Death-associated protein kinase 1Add BLAST | 1430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 289 | Phosphoserine; by RPS6KA1 and RPS6KA31 Publication | 1 | |
Modified residuei | 308 | Phosphoserine; by autocatalysis3 Publications | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 333 | PhosphoserineCombined sources | 1 | |
Modified residuei | 734 | Phosphoserine; by MAPK11 Publication | 1 | |
Modified residuei | 1115 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P53355 |
jPOSTi | P53355 |
MassIVEi | P53355 |
MaxQBi | P53355 |
PaxDbi | P53355 |
PeptideAtlasi | P53355 |
PRIDEi | P53355 |
ProteomicsDBi | 56570 [P53355-1] 56571 [P53355-2] 56572 [P53355-3] 7221 |
PTM databases
iPTMneti | P53355 |
PhosphoSitePlusi | P53355 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196730, Expressed in amniotic fluid and 224 other tissues |
ExpressionAtlasi | P53355, baseline and differential |
Genevisiblei | P53355, HS |
Organism-specific databases
HPAi | ENSG00000196730, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with KLHL20 (PubMed:20389280).
Interacts (via death domain) with MAPK1 and MAPK3 (PubMed:15616583).
Interacts with MAP1B (via N-terminus) (PubMed:18195017).
Interacts with PRKD1 in an oxidative stress-regulated manner (PubMed:17703233).
Interacts with PIN1, PDCD6, BECN1, TSC2 and STX1A (PubMed:12730201, PubMed:16132846, PubMed:18974095, PubMed:19180116, PubMed:21497122).
Interacts (via kinase domain) with DAPK3 (via kinase domain) (PubMed:15367680).
Interacts with GRINB (By similarity).
Interacts (via death domain) with UNC5B (via death domain) (PubMed:15729359).
Interacts with UNC5C (via death domain) (PubMed:27068745).
By similarity12 PublicationsBinary interactionsi
P53355
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: IntAct
- syntaxin-1 binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107982, 147 interactors |
ComplexPortali | CPX-102, DAPK1 - calmodulin complex |
IntActi | P53355, 123 interactors |
MINTi | P53355 |
STRINGi | 9606.ENSP00000386135 |
Chemistry databases
BindingDBi | P53355 |
Miscellaneous databases
RNActi | P53355, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P53355 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53355 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 275 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 263 | |
Repeati | 378 – 407 | ANK 1Add BLAST | 30 | |
Repeati | 411 – 440 | ANK 2Add BLAST | 30 | |
Repeati | 444 – 473 | ANK 3Add BLAST | 30 | |
Repeati | 477 – 506 | ANK 4Add BLAST | 30 | |
Repeati | 510 – 539 | ANK 5Add BLAST | 30 | |
Repeati | 543 – 572 | ANK 6Add BLAST | 30 | |
Repeati | 576 – 605 | ANK 7Add BLAST | 30 | |
Repeati | 609 – 638 | ANK 8Add BLAST | 30 | |
Domaini | 681 – 955 | RocPROSITE-ProRule annotationAdd BLAST | 275 | |
Repeati | 875 – 904 | ANK 9Add BLAST | 30 | |
Repeati | 1162 – 1196 | ANK 10Add BLAST | 35 | |
Domaini | 1312 – 1396 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 267 – 334 | Calmodulin-bindingAdd BLAST | 68 | |
Regioni | 292 – 301 | Autoinhibitory domainBy similarity | 10 |
Domaini
Sequence similaritiesi
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000153424 |
HOGENOMi | CLU_002849_2_0_1 |
InParanoidi | P53355 |
OrthoDBi | 67579at2759 |
PhylomeDBi | P53355 |
TreeFami | TF314166 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR020676, DAPK1 IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR011009, Kinase-like_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020859, ROC_dom IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24342:SF17, PTHR24342:SF17, 1 hit |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00005, DEATH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 7 hits PS50017, DEATH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51424, ROC, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK
60 70 80 90 100
SSRRGVSRED IEREVSILKE IQHPNVITLH EVYENKTDVI LILELVAGGE
110 120 130 140 150
LFDFLAEKES LTEEEATEFL KQILNGVYYL HSLQIAHFDL KPENIMLLDR
160 170 180 190 200
NVPKPRIKII DFGLAHKIDF GNEFKNIFGT PEFVAPEIVN YEPLGLEADM
210 220 230 240 250
WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEDEY FSNTSALAKD
260 270 280 290 300
FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA
310 320 330 340 350
ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH
360 370 380 390 400
AINDDNVPGL QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK
410 420 430 440 450
RGSRIDVQDK GGSNAVYWAA RHGHVDTLKF LSENKCPLDV KDKSGEMALH
460 470 480 490 500
VAARYGHADV AQLLCSFGSN PNIQDKEEET PLHCAAWHGY YSVAKALCEA
510 520 530 540 550
GCNVNIKNRE GETPLLTASA RGYHDIVECL AEHGADLNAC DKDGHIALHL
560 570 580 590 600
AVRRCQMEVI KTLLSQGCFV DYQDRHGNTP LHVACKDGNM PIVVALCEAN
610 620 630 640 650
CNLDISNKYG RTPLHLAANN GILDVVRYLC LMGASVEALT TDGKTAEDLA
660 670 680 690 700
RSEQHEHVAG LLARLRKDTH RGLFIQQLRP TQNLQPRIKL KLFGHSGSGK
710 720 730 740 750
TTLVESLKCG LLRSFFRRRR PRLSSTNSSR FPPSPLASKP TVSVSINNLY
760 770 780 790 800
PGCENVSVRS RSMMFEPGLT KGMLEVFVAP THHPHCSADD QSTKAIDIQN
810 820 830 840 850
AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSIHVVVF SLEEPYEIQL
860 870 880 890 900
NQVIFWLSFL KSLVPVEEPI AFGGKLKNPL QVVLVATHAD IMNVPRPAGG
910 920 930 940 950
EFGYDKDTSL LKEIRNRFGN DLHISNKLFV LDAGASGSKD MKVLRNHLQE
960 970 980 990 1000
IRSQIVSVCP PMTHLCEKII STLPSWRKLN GPNQLMSLQQ FVYDVQDQLN
1010 1020 1030 1040 1050
PLASEEDLRR IAQQLHSTGE INIMQSETVQ DVLLLDPRWL CTNVLGKLLS
1060 1070 1080 1090 1100
VETPRALHHY RGRYTVEDIQ RLVPDSDVEE LLQILDAMDI CARDLSSGTM
1110 1120 1130 1140 1150
VDVPALIKTD NLHRSWADEE DEVMVYGGVR IVPVEHLTPF PCGIFHKVQV
1160 1170 1180 1190 1200
NLCRWIHQQS TEGDADIRLW VNGCKLANRG AELLVLLVNH GQGIEVQVRG
1210 1220 1230 1240 1250
LETEKIKCCL LLDSVCSTIE NVMATTLPGL LTVKHYLSPQ QLREHHEPVM
1260 1270 1280 1290 1300
IYQPRDFFRA QTLKETSLTN TMGGYKESFS SIMCFGCHDV YSQASLGMDI
1310 1320 1330 1340 1350
HASDLNLLTR RKLSRLLDPP DPLGKDWCLL AMNLGLPDLV AKYNTSNGAP
1360 1370 1380 1390 1400
KDFLPSPLHA LLREWTTYPE STVGTLMSKL RELGRRDAAD FLLKASSVFK
1410 1420 1430
INLDGNGQEA YASSCNSGTS YNSISSVVSR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WCQ3 | F8WCQ3_HUMAN | Death-associated protein kinase 1 | DAPK1 | 188 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 490 | Y → H in BAC87163 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1217 | S → G in CAH18690 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033235 | 416 | V → I1 PublicationCorresponds to variant dbSNP:rs12343465Ensembl. | 1 | |
Natural variantiVAR_040420 | 461 | A → S1 Publication | 1 | |
Natural variantiVAR_040421 | 519 | S → A1 Publication | 1 | |
Natural variantiVAR_040422 | 540 | C → Y1 PublicationCorresponds to variant dbSNP:rs56327474Ensembl. | 1 | |
Natural variantiVAR_060693 | 591 | P → L1 PublicationCorresponds to variant dbSNP:rs36214022Ensembl. | 1 | |
Natural variantiVAR_060694 | 622 | I → M1 PublicationCorresponds to variant dbSNP:rs36215047Ensembl. | 1 | |
Natural variantiVAR_040423 | 941 | M → T1 Publication | 1 | |
Natural variantiVAR_040424 | 977 | R → W1 Publication | 1 | |
Natural variantiVAR_040425 | 978 | K → N1 Publication | 1 | |
Natural variantiVAR_040426 | 993 | Y → C1 Publication | 1 | |
Natural variantiVAR_040427 | 994 | D → E1 Publication | 1 | |
Natural variantiVAR_040428 | 1005 | E → Q1 Publication | 1 | |
Natural variantiVAR_040429 | 1007 | D → Y1 Publication | 1 | |
Natural variantiVAR_040430 | 1008 | L → P1 Publication | 1 | |
Natural variantiVAR_040431 | 1010 | R → C1 PublicationCorresponds to variant dbSNP:rs371784492Ensembl. | 1 | |
Natural variantiVAR_040432 | 1018 | T → A1 Publication | 1 | |
Natural variantiVAR_040433 | 1272 | M → I1 PublicationCorresponds to variant dbSNP:rs56169226EnsemblClinVar. | 1 | |
Natural variantiVAR_040434 | 1346 | S → N5 PublicationsCorresponds to variant dbSNP:rs1056719Ensembl. | 1 | |
Natural variantiVAR_040435 | 1405 | G → V2 PublicationsCorresponds to variant dbSNP:rs36220450EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042053 | 1 – 446 | Missing in isoform 2. 1 PublicationAdd BLAST | 446 | |
Alternative sequenceiVSP_042054 | 742 – 783 | VSVSI…APTHH → GRNLHAGPVSPAGVGFRTLS FQGLGGKGVVFGSLGLYWTL WP in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_042055 | 784 – 1430 | Missing in isoform 2. 1 PublicationAdd BLAST | 647 | |
Alternative sequenceiVSP_054478 | 805 – 870 | Missing in isoform 4. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_042056 | 1430 | R → RRNSHVWNPTV in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76104 mRNA Translation: CAA53712.1 Frameshift. AK127855 mRNA Translation: BAC87163.1 CR749834 mRNA Translation: CAH18690.1 DQ436495 Genomic DNA Translation: ABD96827.1 AL160279 Genomic DNA No translation available. AL161787 Genomic DNA No translation available. AL591852 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62727.1 BC113660 mRNA Translation: AAI13661.1 BC143733 mRNA Translation: AAI43734.1 BC143759 mRNA Translation: AAI43760.1 BT006935 mRNA Translation: AAP35581.1 Sequence problems. |
CCDSi | CCDS43842.1 [P53355-1] |
PIRi | I37275 |
RefSeqi | NP_001275658.1, NM_001288729.1 [P53355-1] NP_001275659.1, NM_001288730.1 [P53355-1] NP_001275660.1, NM_001288731.1 [P53355-1] NP_004929.2, NM_004938.3 [P53355-1] |
Genome annotation databases
Ensembli | ENST00000358077; ENSP00000350785; ENSG00000196730 ENST00000408954; ENSP00000386135; ENSG00000196730 ENST00000469640; ENSP00000418885; ENSG00000196730 [P53355-4] ENST00000472284; ENSP00000417076; ENSG00000196730 ENST00000491893; ENSP00000419026; ENSG00000196730 [P53355-4] ENST00000622514; ENSP00000484267; ENSG00000196730 |
GeneIDi | 1612 |
KEGGi | hsa:1612 |
MANE-Selecti | ENST00000408954.8; ENSP00000386135.3; NM_004938.4; NP_004929.2 |
UCSCi | uc004apc.5, human [P53355-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76104 mRNA Translation: CAA53712.1 Frameshift. AK127855 mRNA Translation: BAC87163.1 CR749834 mRNA Translation: CAH18690.1 DQ436495 Genomic DNA Translation: ABD96827.1 AL160279 Genomic DNA No translation available. AL161787 Genomic DNA No translation available. AL591852 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62727.1 BC113660 mRNA Translation: AAI13661.1 BC143733 mRNA Translation: AAI43734.1 BC143759 mRNA Translation: AAI43760.1 BT006935 mRNA Translation: AAP35581.1 Sequence problems. |
CCDSi | CCDS43842.1 [P53355-1] |
PIRi | I37275 |
RefSeqi | NP_001275658.1, NM_001288729.1 [P53355-1] NP_001275659.1, NM_001288730.1 [P53355-1] NP_001275660.1, NM_001288731.1 [P53355-1] NP_004929.2, NM_004938.3 [P53355-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IG1 | X-ray | 1.80 | A | 2-285 | [»] | |
1JKK | X-ray | 2.40 | A | 2-285 | [»] | |
1JKL | X-ray | 1.62 | A | 2-285 | [»] | |
1JKS | X-ray | 1.50 | A | 2-285 | [»] | |
1JKT | X-ray | 3.50 | A/B | 2-285 | [»] | |
1P4F | X-ray | 1.90 | A | 2-285 | [»] | |
1WVW | X-ray | 2.40 | A | 1-278 | [»] | |
1WVX | X-ray | 2.60 | A | 1-278 | [»] | |
1WVY | X-ray | 2.80 | A | 1-278 | [»] | |
1YR5 | X-ray | 1.70 | B | 302-320 | [»] | |
2W4J | X-ray | 1.30 | A | 1-277 | [»] | |
2W4K | X-ray | 1.90 | A | 1-302 | [»] | |
2X0G | X-ray | 2.20 | A | 1-334 | [»] | |
2XUU | X-ray | 1.80 | A | 1-334 | [»] | |
2XZS | X-ray | 2.00 | A/B | 2-312 | [»] | |
2Y0A | X-ray | 2.60 | A | 2-304 | [»] | |
2Y4P | X-ray | 2.65 | A/B/C/D | 1-285 | [»] | |
2Y4V | X-ray | 1.80 | B | 302-320 | [»] | |
2YAK | X-ray | 2.20 | A | 1-285 | [»] | |
3DFC | X-ray | 1.90 | B | 1-285 | [»] | |
3DGK | X-ray | 1.70 | A | 1-285 | [»] | |
3EH9 | X-ray | 1.70 | A | 2-285 | [»] | |
3EHA | X-ray | 1.60 | A | 2-285 | [»] | |
3F5G | X-ray | 1.85 | A | 2-285 | [»] | |
3F5U | X-ray | 2.00 | A | 1-285 | [»] | |
3GU4 | X-ray | 1.35 | A | 1-285 | [»] | |
3GU5 | X-ray | 1.65 | A | 1-285 | [»] | |
3GU6 | X-ray | 1.49 | A | 1-285 | [»] | |
3GU7 | X-ray | 1.90 | A | 1-285 | [»] | |
3GU8 | X-ray | 1.60 | A | 1-285 | [»] | |
3GUB | X-ray | 1.71 | A | 1-285 | [»] | |
3ZXT | X-ray | 2.65 | A/B/C/D | 1-285 | [»] | |
4B4L | X-ray | 1.75 | A | 1-334 | [»] | |
4PF4 | X-ray | 1.13 | A | 1-277 | [»] | |
4TL0 | X-ray | 2.70 | A | 1-334 | [»] | |
4TXC | X-ray | 1.95 | A | 1-285 | [»] | |
4UV0 | X-ray | 2.49 | A | 1-321 | [»] | |
4YO4 | X-ray | 1.60 | A | 2-285 | [»] | |
4YPD | X-ray | 1.40 | A | 2-285 | [»] | |
5AUT | X-ray | 1.70 | A | 1-285 | [»] | |
5AUU | X-ray | 1.70 | A | 1-285 | [»] | |
5AUV | X-ray | 1.50 | A | 1-285 | [»] | |
5AUW | X-ray | 1.50 | A | 1-285 | [»] | |
5AUX | X-ray | 1.50 | A | 1-285 | [»] | |
5AUY | X-ray | 2.00 | A | 1-285 | [»] | |
5AUZ | X-ray | 1.60 | A | 1-285 | [»] | |
5AV0 | X-ray | 1.85 | A | 1-285 | [»] | |
5AV1 | X-ray | 1.50 | A | 1-285 | [»] | |
5AV2 | X-ray | 1.50 | A | 1-285 | [»] | |
5AV3 | X-ray | 1.90 | A | 1-285 | [»] | |
5AV4 | X-ray | 1.40 | A | 1-285 | [»] | |
6AAR | X-ray | 1.95 | A | 1-285 | [»] | |
6FHA | X-ray | 2.30 | A | 2-334 | [»] | |
6FHB | X-ray | 1.75 | A | 2-334 | [»] | |
6GY5 | X-ray | 1.09 | U | 1334-1344 | [»] | |
6IN4 | X-ray | 1.80 | A | 1-285 | [»] | |
6QMO | X-ray | 1.87 | A | 2-310 | [»] | |
6QN4 | X-ray | 2.50 | A | 2-310 | [»] | |
7CCU | X-ray | 1.65 | A | 1-285 | [»] | |
7CCV | X-ray | 1.75 | A | 1-285 | [»] | |
7CCW | X-ray | 1.40 | A | 1-285 | [»] | |
SMRi | P53355 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107982, 147 interactors |
ComplexPortali | CPX-102, DAPK1 - calmodulin complex |
IntActi | P53355, 123 interactors |
MINTi | P53355 |
STRINGi | 9606.ENSP00000386135 |
Chemistry databases
BindingDBi | P53355 |
ChEMBLi | CHEMBL2558 |
DrugBanki | DB04069, 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine DB07444, 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE DB12010, Fostamatinib DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
DrugCentrali | P53355 |
GuidetoPHARMACOLOGYi | 2002 |
PTM databases
iPTMneti | P53355 |
PhosphoSitePlusi | P53355 |
Genetic variation databases
BioMutai | DAPK1 |
DMDMi | 317373595 |
Proteomic databases
EPDi | P53355 |
jPOSTi | P53355 |
MassIVEi | P53355 |
MaxQBi | P53355 |
PaxDbi | P53355 |
PeptideAtlasi | P53355 |
PRIDEi | P53355 |
ProteomicsDBi | 56570 [P53355-1] 56571 [P53355-2] 56572 [P53355-3] 7221 |
Protocols and materials databases
Antibodypediai | 6771, 405 antibodies from 37 providers |
DNASUi | 1612 |
Genome annotation databases
Ensembli | ENST00000358077; ENSP00000350785; ENSG00000196730 ENST00000408954; ENSP00000386135; ENSG00000196730 ENST00000469640; ENSP00000418885; ENSG00000196730 [P53355-4] ENST00000472284; ENSP00000417076; ENSG00000196730 ENST00000491893; ENSP00000419026; ENSG00000196730 [P53355-4] ENST00000622514; ENSP00000484267; ENSG00000196730 |
GeneIDi | 1612 |
KEGGi | hsa:1612 |
MANE-Selecti | ENST00000408954.8; ENSP00000386135.3; NM_004938.4; NP_004929.2 |
UCSCi | uc004apc.5, human [P53355-1] |
Organism-specific databases
CTDi | 1612 |
DisGeNETi | 1612 |
GeneCardsi | DAPK1 |
HGNCi | HGNC:2674, DAPK1 |
HPAi | ENSG00000196730, Low tissue specificity |
MIMi | 600831, gene |
neXtProti | NX_P53355 |
OpenTargetsi | ENSG00000196730 |
PharmGKBi | PA27142 |
VEuPathDBi | HostDB:ENSG00000196730 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000153424 |
HOGENOMi | CLU_002849_2_0_1 |
InParanoidi | P53355 |
OrthoDBi | 67579at2759 |
PhylomeDBi | P53355 |
TreeFami | TF314166 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P53355 |
Reactomei | R-HSA-418889, Caspase activation via Dependence Receptors in the absence of ligand |
SignaLinki | P53355 |
SIGNORi | P53355 |
Miscellaneous databases
BioGRID-ORCSi | 1612, 5 hits in 1078 CRISPR screens |
ChiTaRSi | DAPK1, human |
EvolutionaryTracei | P53355 |
GeneWikii | DAPK1 |
GenomeRNAii | 1612 |
Pharosi | P53355, Tchem |
PROi | PR:P53355 |
RNActi | P53355, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196730, Expressed in amniotic fluid and 224 other tissues |
ExpressionAtlasi | P53355, baseline and differential |
Genevisiblei | P53355, HS |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR020676, DAPK1 IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR011009, Kinase-like_dom_sf IPR027417, P-loop_NTPase IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR020859, ROC_dom IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24342:SF17, PTHR24342:SF17, 1 hit |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00005, DEATH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 7 hits PS50017, DEATH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS51424, ROC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DAPK1_HUMAN | |
Accessioni | P53355Primary (citable) accession number: P53355 Secondary accession number(s): B7ZLD2 Q9BTL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 223 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families