UniProtKB - P53315 (SOL4_YEAST)
Protein
6-phosphogluconolactonase 4
Gene
SOL4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication
Miscellaneous
Present with 4320 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:3.1.1.31
: pentose phosphate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (ZWF1)
- 6-phosphogluconolactonase 3 (SOL3), 6-phosphogluconolactonase 4 (SOL4)
- 6-phosphogluconate dehydrogenase, decarboxylating 1 (GND1), 6-phosphogluconate dehydrogenase, decarboxylating 2 (GND2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
GO - Molecular functioni
- 6-phosphogluconolactonase activity Source: SGD
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- pentose-phosphate shunt, oxidative branch Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00409 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SOL4 Ordered Locus Names:YGR248W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003480, SOL4 |
VEuPathDBi | FungiDB:YGR248W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090085 | 1 – 255 | 6-phosphogluconolactonase 4Add BLAST | 255 |
Proteomic databases
MaxQBi | P53315 |
PaxDbi | P53315 |
PRIDEi | P53315 |
TopDownProteomicsi | P53315 |
PTM databases
iPTMneti | P53315 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33499, 70 interactors |
IntActi | P53315, 5 interactors |
MINTi | P53315 |
STRINGi | 4932.YGR248W |
Miscellaneous databases
RNActi | P53315, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG3147, Eukaryota |
GeneTreei | ENSGT00550000075110 |
HOGENOMi | CLU_053947_0_1_1 |
InParanoidi | P53315 |
OMAi | YQLFEFE |
Family and domain databases
CDDi | cd01400, 6PGL, 1 hit |
InterProi | View protein in InterPro IPR005900, 6-phosphogluconolactonase_DevB IPR006148, Glc/Gal-6P_isomerase IPR037171, NagB/RpiA_transferase-like IPR039104, PGLS |
PANTHERi | PTHR11054, PTHR11054, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR01198, pgl, 1 hit |
i Sequence
Sequence statusi: Complete.
P53315-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL
60 70 80 90 100
YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV
110 120 130 140 150
HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG
160 170 180 190 200
EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK
210 220 230 240 250
SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL
IPENC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73033 Genomic DNA Translation: CAA97277.1 BK006941 Genomic DNA Translation: DAA08339.1 |
PIRi | S64574 |
RefSeqi | NP_011764.3, NM_001181377.3 |
Genome annotation databases
EnsemblFungii | YGR248W_mRNA; YGR248W; YGR248W |
GeneIDi | 853163 |
KEGGi | sce:YGR248W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73033 Genomic DNA Translation: CAA97277.1 BK006941 Genomic DNA Translation: DAA08339.1 |
PIRi | S64574 |
RefSeqi | NP_011764.3, NM_001181377.3 |
3D structure databases
SMRi | P53315 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33499, 70 interactors |
IntActi | P53315, 5 interactors |
MINTi | P53315 |
STRINGi | 4932.YGR248W |
PTM databases
iPTMneti | P53315 |
Proteomic databases
MaxQBi | P53315 |
PaxDbi | P53315 |
PRIDEi | P53315 |
TopDownProteomicsi | P53315 |
Genome annotation databases
EnsemblFungii | YGR248W_mRNA; YGR248W; YGR248W |
GeneIDi | 853163 |
KEGGi | sce:YGR248W |
Organism-specific databases
SGDi | S000003480, SOL4 |
VEuPathDBi | FungiDB:YGR248W |
Phylogenomic databases
eggNOGi | KOG3147, Eukaryota |
GeneTreei | ENSGT00550000075110 |
HOGENOMi | CLU_053947_0_1_1 |
InParanoidi | P53315 |
OMAi | YQLFEFE |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00409 |
Miscellaneous databases
PROi | PR:P53315 |
RNActi | P53315, protein |
Family and domain databases
CDDi | cd01400, 6PGL, 1 hit |
InterProi | View protein in InterPro IPR005900, 6-phosphogluconolactonase_DevB IPR006148, Glc/Gal-6P_isomerase IPR037171, NagB/RpiA_transferase-like IPR039104, PGLS |
PANTHERi | PTHR11054, PTHR11054, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR01198, pgl, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOL4_YEAST | |
Accessioni | P53315Primary (citable) accession number: P53315 Secondary accession number(s): D6VV28 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names