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Entry version 144 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene

CPD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.2 Publications

Miscellaneous

Present with 1520 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.97 mM for adenosine 1',2'-cyclic phosphate2 Publications
  2. KM=14.29 mM for guanosine 1',2'-cyclic phosphate2 Publications
  3. KM=12.18 mM for cytidine 1',2'-cyclic phosphate2 Publications
  4. KM=8.91 mM for uridine 1',2'-cyclic phosphate2 Publications
  5. KM=0.37 mM for ADP-ribose 1',2'-cyclic phosphate2 Publications
  6. KM=0.33 mM for ribose 1,3-cyclic phosphate2 Publications
  1. Vmax=353 µmol/min/mg enzyme toward adenosine 1',2'-cyclic phosphate2 Publications
  2. Vmax=390 µmol/min/mg enzyme toward guanosine 1',2'-cyclic phosphate2 Publications
  3. Vmax=598 µmol/min/mg enzyme toward cytidine 1',2'-cyclic phosphate2 Publications
  4. Vmax=296 µmol/min/mg enzyme toward uridine 1',2'-cyclic phosphate2 Publications
  5. Vmax=61 µmol/min/mg enzyme toward ADP-ribose 1',2'-cyclic phosphate2 Publications
  6. Vmax=0.02 µmol/min/mg enzyme toward ribose 1,3-cyclic phosphate2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei39Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41SubstrateBy similarity1
Active sitei150Proton donor/acceptorBy similarity1
Binding sitei152SubstrateBy similarity1
Binding sitei155SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:YGR247W-MONOMER
YEAST:YGR247W-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P53314

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC:3.1.4.37)
Short name:
CPDase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPD1
Ordered Locus Names:YGR247W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGR247W

Saccharomyces Genome Database

More...
SGDi
S000003479 CPD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39H → A: Abolishes cyclic nucleotide phosphodiesterase activity. 1 Publication1
Mutagenesisi41T → A: Reduces strongly cyclic nucleotide phosphodiesterase activity. 1 Publication1
Mutagenesisi150H → A: Abolishes cyclic nucleotide phosphodiesterase activity. 1 Publication1
Mutagenesisi152S → A: Reduces strongly cyclic nucleotide phosphodiesterase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002028591 – 2392',3'-cyclic-nucleotide 3'-phosphodiesteraseAdd BLAST239

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53314

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53314

PRoteomics IDEntifications database

More...
PRIDEi
P53314

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P53314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33498, 50 interactors

Database of interacting proteins

More...
DIPi
DIP-5558N

Protein interaction database and analysis system

More...
IntActi
P53314, 1 interactor

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53314 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_088289_0_0_1

KEGG Orthology (KO)

More...
KOi
K15435

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEPHITI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012386 Cyclic-nucl_3Pdiesterase
IPR009097 Cyclic_Pdiesterase

The PANTHER Classification System

More...
PANTHERi
PTHR28141 PTHR28141, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07823 CPDase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55144 SSF55144, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIALWYCPP QGSVAYETLQ MLIFSFQTLF PDSPVFEPHV TVTSHLVCNS
60 70 80 90 100
KDDVNKILTS CVAAIQSIRS HQTAKKGRKG QVSHAVAAPL VSFNGCSVGK
110 120 130 140 150
QYFKKIVLEC NKNKILYGVA QVMREMYVEI DPETRSSRAA TWVHEEFHPH
160 170 180 190 200
VSLLYSDIHP VSQASLRVVQ QRIEDALDVQ LVPREKRKGS GNADGSNEVQ
210 220 230
MRWDFDVSSS LSWNIPGTFK VVNCVGPVQE WEVLGRVDV
Length:239
Mass (Da):26,732
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE38A74FAD0E3A55
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y07703 Genomic DNA Translation: CAA68969.1
Z73032 Genomic DNA Translation: CAA97276.1
AY558381 Genomic DNA Translation: AAS56707.1
BK006941 Genomic DNA Translation: DAA08338.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64573

NCBI Reference Sequences

More...
RefSeqi
NP_011763.1, NM_001181376.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGR247W_mRNA; YGR247W; YGR247W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR247W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07703 Genomic DNA Translation: CAA68969.1
Z73032 Genomic DNA Translation: CAA97276.1
AY558381 Genomic DNA Translation: AAS56707.1
BK006941 Genomic DNA Translation: DAA08338.1
PIRiS64573
RefSeqiNP_011763.1, NM_001181376.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33498, 50 interactors
DIPiDIP-5558N
IntActiP53314, 1 interactor

Proteomic databases

MaxQBiP53314
PaxDbiP53314
PRIDEiP53314
TopDownProteomicsiP53314

Genome annotation databases

EnsemblFungiiYGR247W_mRNA; YGR247W; YGR247W
GeneIDi853162
KEGGisce:YGR247W

Organism-specific databases

EuPathDBiFungiDB:YGR247W
SGDiS000003479 CPD1

Phylogenomic databases

HOGENOMiCLU_088289_0_0_1
KOiK15435
OMAiFEPHITI

Enzyme and pathway databases

BioCyciMetaCyc:YGR247W-MONOMER
YEAST:YGR247W-MONOMER
SABIO-RKiP53314

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53314
RNActiP53314 protein

Family and domain databases

InterProiView protein in InterPro
IPR012386 Cyclic-nucl_3Pdiesterase
IPR009097 Cyclic_Pdiesterase
PANTHERiPTHR28141 PTHR28141, 1 hit
PfamiView protein in Pfam
PF07823 CPDase, 1 hit
SUPFAMiSSF55144 SSF55144, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPD1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53314
Secondary accession number(s): D6VV27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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