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UniProtKB - P53290 (GTR2_YEAST)
Protein
GTP-binding protein GTR2
Gene
GTR2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.
2 PublicationsMiscellaneous
Present with 2610 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 16 – 23 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 124 – 127 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: SGD
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to amino acid stimulus Source: GO_Central
- cellular response to starvation Source: GO_Central
- endocytic recycling Source: ComplexPortal
- lysosomal microautophagy Source: SGD
- negative regulation of autophagy Source: SGD
- positive regulation of GTPase activity Source: SGD
- positive regulation of TORC1 signaling Source: SGD
- positive regulation of TOR signaling Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: SGD
- protein localization to vacuolar membrane Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of autophagy Source: GO_Central
Keywordsi
Biological process | Autophagy, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-165159, MTOR signalling R-SCE-9639288, Amino acids regulate mTORC1 |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein GTR2 |
Gene namesi | Name:GTR2 Ordered Locus Names:YGR163W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003395, GTR2 |
VEuPathDBi | FungiDB:YGR163W |
Subcellular locationi
Vacuole
- Vacuole membrane 2 Publications
Endosome
- late endosome Source: ComplexPortal
- late endosome membrane Source: SGD
- Ragulator complex Source: SGD
Nucleus
- nucleus Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
- Ragulator complex Source: SGD
Other locations
- chromatin Source: SGD
- cytoplasm Source: SGD
- Gtr1-Gtr2 GTPase complex Source: SGD
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122487 | 1 – 341 | GTP-binding protein GTR2Add BLAST | 341 |
Proteomic databases
MaxQBi | P53290 |
PaxDbi | P53290 |
PRIDEi | P53290 |
PTM databases
iPTMneti | P53290 |
Interactioni
Subunit structurei
Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1.
Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1.
2 PublicationsBinary interactionsi
P53290
With | #Exp. | IntAct |
---|---|---|
GTR1 [Q00582] | 4 | EBI-7962,EBI-7954 |
Protein-protein interaction databases
BioGRIDi | 33415, 221 interactors |
ComplexPortali | CPX-3172, EGO complex CPX-3233, GSE complex |
DIPi | DIP-4521N |
IntActi | P53290, 31 interactors |
MINTi | P53290 |
STRINGi | 4932.YGR163W |
Miscellaneous databases
RNActi | P53290, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P53290 |
SMRi | P53290 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GTR/RAG GTP-binding protein family.Curated
Phylogenomic databases
eggNOGi | KOG3887, Eukaryota |
GeneTreei | ENSGT00950000183031 |
HOGENOMi | CLU_047421_2_0_1 |
InParanoidi | P53290 |
OMAi | DTQRDIM |
Family and domain databases
CDDi | cd11385, RagC_like, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006762, Gtr1_RagA IPR027417, P-loop_NTPase IPR039400, RagC/D |
PANTHERi | PTHR11259, PTHR11259, 1 hit |
Pfami | View protein in Pfam PF04670, Gtr1_RagA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
P53290-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE
60 70 80 90 100
HFSTLIDLAV MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI
110 120 130 140 150
TNLAMIIEYA YKVNPSINIE VLIHKVDGLS EDFKVDAQRD IMQRTGEELL
160 170 180 190 200
ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ KLIPELSFLE NMLDNLIQHS
210 220 230 240 250
KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID LFDLYKAPVL
260 270 280 290 300
RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG
310 320 330 340
TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015239 Genomic DNA Translation: BAA28781.1 Z72948 Genomic DNA Translation: CAA97187.1 BK006941 Genomic DNA Translation: DAA08258.1 |
PIRi | S64474 |
RefSeqi | NP_011679.3, NM_001181292.3 |
Genome annotation databases
EnsemblFungii | YGR163W_mRNA; YGR163W; YGR163W |
GeneIDi | 853072 |
KEGGi | sce:YGR163W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015239 Genomic DNA Translation: BAA28781.1 Z72948 Genomic DNA Translation: CAA97187.1 BK006941 Genomic DNA Translation: DAA08258.1 |
PIRi | S64474 |
RefSeqi | NP_011679.3, NM_001181292.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3R7W | X-ray | 2.77 | B/D | 11-341 | [»] | |
4ARZ | X-ray | 3.10 | B | 1-341 | [»] | |
6JWP | X-ray | 3.20 | B/G | 1-341 | [»] | |
AlphaFoldDBi | P53290 | |||||
SMRi | P53290 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33415, 221 interactors |
ComplexPortali | CPX-3172, EGO complex CPX-3233, GSE complex |
DIPi | DIP-4521N |
IntActi | P53290, 31 interactors |
MINTi | P53290 |
STRINGi | 4932.YGR163W |
PTM databases
iPTMneti | P53290 |
Proteomic databases
MaxQBi | P53290 |
PaxDbi | P53290 |
PRIDEi | P53290 |
Genome annotation databases
EnsemblFungii | YGR163W_mRNA; YGR163W; YGR163W |
GeneIDi | 853072 |
KEGGi | sce:YGR163W |
Organism-specific databases
SGDi | S000003395, GTR2 |
VEuPathDBi | FungiDB:YGR163W |
Phylogenomic databases
eggNOGi | KOG3887, Eukaryota |
GeneTreei | ENSGT00950000183031 |
HOGENOMi | CLU_047421_2_0_1 |
InParanoidi | P53290 |
OMAi | DTQRDIM |
Enzyme and pathway databases
Reactomei | R-SCE-165159, MTOR signalling R-SCE-9639288, Amino acids regulate mTORC1 |
Miscellaneous databases
PROi | PR:P53290 |
RNActi | P53290, protein |
Family and domain databases
CDDi | cd11385, RagC_like, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006762, Gtr1_RagA IPR027417, P-loop_NTPase IPR039400, RagC/D |
PANTHERi | PTHR11259, PTHR11259, 1 hit |
Pfami | View protein in Pfam PF04670, Gtr1_RagA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR2_YEAST | |
Accessioni | P53290Primary (citable) accession number: P53290 Secondary accession number(s): D6VUU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families