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Entry version 164 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
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Protein

U3 small nucleolar RNA-associated protein 22

Gene

UTP22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

Miscellaneous

Present with 3260 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 22
Short name:
U3 snoRNA-associated protein 22
Alternative name(s):
U three protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UTP22
Ordered Locus Names:YGR090W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGR090W

Saccharomyces Genome Database

More...
SGDi
S000003322, UTP22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002156511 – 1237U3 small nucleolar RNA-associated protein 22Add BLAST1237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei60PhosphothreonineCombined sources1
Modified residuei64PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53254

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53254

PRoteomics IDEntifications database

More...
PRIDEi
P53254

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53254

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with snoRNA U3 (PubMed:15590835).

Interacts with MPP10 (PubMed:15590835).

Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).

Interacts with UBP10 (PubMed:22902402, PubMed:26149687).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33333, 157 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-771, UTP-C complex variant 2
CPX-772, UTP-C complex variant 1
CPX-773, UTP-C complex variant 3
CPX-774, CURI complex variant 1
CPX-775, CURI complex variant 2
CPX-776, CURI complex variant 3

Database of interacting proteins

More...
DIPi
DIP-5304N

Protein interaction database and analysis system

More...
IntActi
P53254, 110 interactors

Molecular INTeraction database

More...
MINTi
P53254

STRING: functional protein association networks

More...
STRINGi
4932.YGR090W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53254, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53254

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2054, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003502_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53254

KEGG Orthology (KO)

More...
KOi
K14544

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWNQLAN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005554, NOL6/Upt22
IPR035082, Nrap_D1
IPR035367, Nrap_D2
IPR035368, Nrap_D3
IPR035369, Nrap_D4
IPR035370, Nrap_D5
IPR035371, Nrap_D6

The PANTHER Classification System

More...
PANTHERi
PTHR17972, PTHR17972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03813, Nrap, 1 hit
PF17403, Nrap_D2, 1 hit
PF17404, Nrap_D3, 1 hit
PF17405, Nrap_D4, 1 hit
PF17406, Nrap_D5, 1 hit
PF17407, Nrap_D6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSVKRKAS ETSDQNIVKV QKKHSTQDST TDNGSKENDH SSQAINERTV
60 70 80 90 100
PEQENDESDT SPESNEVATN TAATRHNGKV TATESYDIHI ARETAELFKS
110 120 130 140 150
NIFKLQIDEL LEQVKLKQKH VLKVEKFLHK LYDILQEIPD WEEKSLAEVD
160 170 180 190 200
SFFKNKIVSV PFVDPKPIPQ NTNYKFNYKK PDISLIGSFA LKAGIYQPNG
210 220 230 240 250
SSIDTLLTMP KELFEKKDFL NFRCLHKRSV YLAYLTHHLL ILLKKDKLDS
260 270 280 290 300
FLQLEYSYFD NDPLLPILRI SCSKPTGDSL SDYNFYKTRF SINLLIGFPY
310 320 330 340 350
KVFEPKKLLP NRNCIRIAQE SKEQSLPATP LYNFSVLSSS THENYLKYLY
360 370 380 390 400
KTKKQTESFV EATVLGRLWL QQRGFSSNMS HSGSLGGFGT FEFTILMAAL
410 420 430 440 450
LNGGGINSNK ILLHGFSSYQ LFKGVIKYLA TMDLCHDGHL QFHSNPENSS
460 470 480 490 500
SSPASKYIDE GFQTPTLFDK STKVNILTKM TVSSYQILKE YAGETLRMLN
510 520 530 540 550
NVVQDQFSNI FLTNISRFDN LKYDLCYDVQ LPLGKYNNLE TSLAATFGSM
560 570 580 590 600
ERVKFITLEN FLAHKITNVA RYALGDRIKY IQIEMVGQKS DFPITKRKVY
610 620 630 640 650
SNTGGNHFNF DFVRVKLIVN PSECDKLVTK GPAHSETMST EAAVFKNFWG
660 670 680 690 700
IKSSLRRFKD GSITHCCVWS TSSSEPIISS IVNFALQKHV SKKAQISNET
710 720 730 740 750
IKKFHNFLPL PNLPSSAKTS VLNLSSFFNL KKSFDDLYKI IFQMKLPLSV
760 770 780 790 800
KSILPVGSAF RYTSLCQPVP FAYSDPDFFQ DVILEFETSP KWPDEITSLE
810 820 830 840 850
KAKTAFLLKI QEELSANSST YRSFFSRDES IPYNLEIVTL NILTPEGYGF
860 870 880 890 900
KFRVLTERDE ILYLRAIANA RNELKPELEA TFLKFTAKYL ASVRHTRTLE
910 920 930 940 950
NISHSYQFYS PVVRLFKRWL DTHLLLGHIT DELAELIAIK PFVDPAPYFI
960 970 980 990 1000
PGSLENGFLK VLKFISQWNW KDDPLILDLV KPEDDIRDTF ETSIGAGSEL
1010 1020 1030 1040 1050
DSKTMKKLSE RLTLAQYKGI QMNFTNLRNS DPNGTHLQFF VASKNDPSGI
1060 1070 1080 1090 1100
LYSSGIPLPI ATRLTALAKV AVNLLQTHGL NQQTINLLFT PGLKDYDFVV
1110 1120 1130 1140 1150
DLRTPIGLKS SCGILSATEF KNITNDQAPS NFPENLNDLS EKMDPTYQLV
1160 1170 1180 1190 1200
KYLNLKYKNS LILSSRKYIG VNGGEKGDKN VITGLIKPLF KGAHKFRVNL
1210 1220 1230
DCNVKPVDDE NVILNKEAIF HEIAAFGNDM VINFETD
Length:1,237
Mass (Da):140,485
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A2B5C885493D7D3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z72875 Genomic DNA Translation: CAA97093.1
BK006941 Genomic DNA Translation: DAA08183.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64385

NCBI Reference Sequences

More...
RefSeqi
NP_011604.3, NM_001181219.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGR090W_mRNA; YGR090W; YGR090W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852982

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR090W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72875 Genomic DNA Translation: CAA97093.1
BK006941 Genomic DNA Translation: DAA08183.1
PIRiS64385
RefSeqiNP_011604.3, NM_001181219.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M5DX-ray1.97A1-1237[»]
5WLCelectron microscopy3.80NH1-1237[»]
5WYJelectron microscopy8.70CB1-1237[»]
5WYKelectron microscopy4.50CB1-1237[»]
SMRiP53254
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi33333, 157 interactors
ComplexPortaliCPX-771, UTP-C complex variant 2
CPX-772, UTP-C complex variant 1
CPX-773, UTP-C complex variant 3
CPX-774, CURI complex variant 1
CPX-775, CURI complex variant 2
CPX-776, CURI complex variant 3
DIPiDIP-5304N
IntActiP53254, 110 interactors
MINTiP53254
STRINGi4932.YGR090W

PTM databases

iPTMnetiP53254

Proteomic databases

MaxQBiP53254
PaxDbiP53254
PRIDEiP53254

Genome annotation databases

EnsemblFungiiYGR090W_mRNA; YGR090W; YGR090W
GeneIDi852982
KEGGisce:YGR090W

Organism-specific databases

EuPathDBiFungiDB:YGR090W
SGDiS000003322, UTP22

Phylogenomic databases

eggNOGiKOG2054, Eukaryota
GeneTreeiENSGT00390000018619
HOGENOMiCLU_003502_1_0_1
InParanoidiP53254
KOiK14544
OMAiVWNQLAN

Enzyme and pathway databases

ReactomeiR-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53254
RNActiP53254, protein

Family and domain databases

InterProiView protein in InterPro
IPR005554, NOL6/Upt22
IPR035082, Nrap_D1
IPR035367, Nrap_D2
IPR035368, Nrap_D3
IPR035369, Nrap_D4
IPR035370, Nrap_D5
IPR035371, Nrap_D6
PANTHERiPTHR17972, PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813, Nrap, 1 hit
PF17403, Nrap_D2, 1 hit
PF17404, Nrap_D3, 1 hit
PF17405, Nrap_D4, 1 hit
PF17406, Nrap_D5, 1 hit
PF17407, Nrap_D6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUTP22_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53254
Secondary accession number(s): D6VUM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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