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UniProtKB - P53253 (NNF2_YEAST)

Entry version 133 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
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Protein

Protein NNF2

Gene

NNF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NNF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NNF2
Ordered Locus Names:YGR089W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000003321, NNF2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YGR089W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41LumenalSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 120CytoplasmicSequence analysisAdd BLAST58
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 245LumenalSequence analysisAdd BLAST104
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 936CytoplasmicSequence analysisAdd BLAST670

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002028091 – 936Protein NNF2Add BLAST936

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53253

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53253

PRoteomics IDEntifications database

More...PRIDEi		P53253

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53253

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33331, 282 interactors

Database of interacting proteins

More...DIPi		DIP-2984N

Protein interaction database and analysis system

More...IntActi		P53253, 14 interactors

Molecular INTeraction database

More...MINTi		P53253

STRING: functional protein association networks

More...STRINGi		4932.YGR089W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53253, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53253

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni297 – 351DisorderedSequence analysisAdd BLAST55
Regioni387 – 437DisorderedSequence analysisAdd BLAST51
Regioni512 – 533DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi512 – 528Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSPS, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013934_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53253

Identification of Orthologs from Complete Genome Data

More...OMAi		CSYDIQF

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEQFTNQKK VSHLQSLMNT KRSEQPTEFA KKHRFKDTLA LFLVFLSFNH 
        60         70         80         90        100
FTSLCLLVSF IVATKCKDFL ANCFIILFLS KKPSRHIGEV AHIDISTSKV 
       110        120        130        140        150
TNGSSNRKSN SRFFGNSKNS FVIPIPVLIC EILFAMLLKI YGGDYFVKPI 
       160        170        180        190        200
KNLAISIIAS FLINDPSDCL SYATSCSVLY AVSTNTFQRV SHFFDIIQLF 
       210        220        230        240        250
DMSLRGTGQS IKLFTVFRKY SQFFKKLFSL FLPMPFKMLG KHSDSMIYYL 
       260        270        280        290        300
SFHILFFSFA SSLLHPHRQT AENKPLKKGF NSTKPDVARV QGLQKMRISS 
       310        320        330        340        350
SSSVSADSNT LEDQSPMIPN DPGGLSSSNQ TIHPSQQNNS PVPLSSHSNI 
       360        370        380        390        400
LNPAASYPTD ATSSFPYFTS MVKEYKSYQP SVISAEGSNS QAVTTTTSTT 
       410        420        430        440        450
TSPTTFNFSG DNTSLSNEIS LSDSSNGNSK KDSDFFSPSN DKYTNQLFEL 
       460        470        480        490        500
NVDFGNMFSS SKLSSDISVT SNLENFIRLL FRRKNQHLIA PLWSMVVTLK 
       510        520        530        540        550
TTNFEKKYLQ ETSENSLTPT NSNTSYVSNQ EKHDKDLDTI NTHSVSSRIS 
       560        570        580        590        600
FTHAGKFKKS VFNNFEPSNT MALIAKTTSD DYNLLNLVST NENIFNRNDN 
       610        620        630        640        650
DYKVCIIDIS TNSITFHIEN LHDGELIVLV NGVIWSEVSC ALILEHVGEE 
       660        670        680        690        700
YVVVNGLVPS CSYDIQFINR LNHRDDYLVS DLIVRTCGNN NAIAGKFENL 
       710        720        730        740        750
DFSFPSYYHR KFLSPLLTLK HSVLTTNANL SDERTKLKKT KKEFSKKLSL 
       760        770        780        790        800
LRQEIDYFKG RISQNATHDE KSTLKVENLK VALQQSETAV NKLEMQLKTL 
       810        820        830        840        850
TEKELELEEE YLKKKDLHLK NQLEFSKLEE SLSKDLKNSE GRFQKVNQEL 
       860        870        880        890        900
VQLGSKLDKL NARNEKLQKE VDQNAEEIEK FSTQFLSKRE KDRFRRKEYR 
       910        920        930 
IREANKFELT IKGLEQDINR LENENENIHS LIGNSY
Length:936
Mass (Da):106,466
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1F7D631DE73D4D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z72874 Genomic DNA Translation: CAA97092.1
BK006941 Genomic DNA Translation: DAA08182.1

Protein sequence database of the Protein Information Resource

More...PIRi		S64384

NCBI Reference Sequences

More...RefSeqi		NP_011603.1, NM_001181218.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YGR089W_mRNA; YGR089W; YGR089W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		852980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YGR089W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72874 Genomic DNA Translation: CAA97092.1
BK006941 Genomic DNA Translation: DAA08182.1
PIRiS64384
RefSeqiNP_011603.1, NM_001181218.1

3D structure databases

SMRiP53253
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33331, 282 interactors
DIPiDIP-2984N
IntActiP53253, 14 interactors
MINTiP53253
STRINGi4932.YGR089W

PTM databases

iPTMnetiP53253

Proteomic databases

MaxQBiP53253
PaxDbiP53253
PRIDEiP53253

Genome annotation databases

EnsemblFungiiYGR089W_mRNA; YGR089W; YGR089W
GeneIDi852980
KEGGisce:YGR089W

Organism-specific databases

SGDiS000003321, NNF2
VEuPathDBiFungiDB:YGR089W

Phylogenomic databases

eggNOGiENOG502QSPS, Eukaryota
HOGENOMiCLU_013934_0_0_1
InParanoidiP53253
OMAiCSYDIQF

Miscellaneous databases

Protein Ontology

More...PROi		PR:P53253
RNActiP53253, protein

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNNF2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53253
Secondary accession number(s): D6VUM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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