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UniProtKB - P53241 (VHT1_YEAST)

Entry version 151 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Vitamin H transporter

Gene

VHT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in uptake of biotin with the concomitant entry of protons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport
LigandBiotin

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.14.12, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin H transporter
Alternative name(s):
H(+)/biotin symporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VHT1
Ordered Locus Names:YGR065C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000003297, VHT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YGR065C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 121ExtracellularSequence analysisAdd BLAST121
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 166CytoplasmicSequence analysisAdd BLAST24
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 190ExtracellularSequence analysis3
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 224CytoplasmicSequence analysisAdd BLAST13
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 291ExtracellularSequence analysisAdd BLAST46
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 361CytoplasmicSequence analysisAdd BLAST49
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 408ExtracellularSequence analysisAdd BLAST26
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 432CytoplasmicSequence analysis3
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 460ExtracellularSequence analysis7
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 492CytoplasmicSequence analysisAdd BLAST11
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 526ExtracellularSequence analysisAdd BLAST13
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 593CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001213721 – 593Vitamin H transporterAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53241

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53241

PRoteomics IDEntifications database

More...PRIDEi		P53241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		33309, 230 interactors

Database of interacting proteins

More...DIPi		DIP-5519N

Protein interaction database and analysis system

More...IntActi		P53241, 10 interactors

Molecular INTeraction database

More...MINTi		P53241

STRING: functional protein association networks

More...STRINGi		4932.YGR065C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53241, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Allantoate permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2533, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001265_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53241

Identification of Orthologs from Complete Genome Data

More...OMAi		CSWNNMT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTISNKSWRS YFPHLRKLPE DDQYLYSDDT NSSIIAEEEL HHSVDKSSKT 
        60         70         80         90        100
DVTAETTAVE PHPHNLRHDL PYEVRDEAGR KWWKYFDEFE YRVNKEYKKS 
       110        120        130        140        150
RKWYEFLYPN HTTQTKAERR LLYKLDIIIA LYFFMLCWSK SVDLNNYTNA 
       160        170        180        190        200
YVSNMKEDLN MKGNDYVYTS TIANVGAIVF QLPFMYLLPR FPSHIILPVM 
       210        220        230        240        250
DLGWTWFTFA CYRANSLAEL RAYRFILSAF GAAYYPVSQY ILGCWYAPDE 
       260        270        280        290        300
INSRVCLFFC GQQLGSVTSG LLQSRIFKSL NGVHGLAGWR WMFLIDAIAI 
       310        320        330        340        350
SLPTAIIGFF VIPGVPSKCY SLFLTDEEIR IARARNKRNQ IKDGVDKSKL 
       360        370        380        390        400
APLWSRKLWK KVFCTPAFWV LVVFDTCSWN NMTAYSGSYT LWLKSNTKYS 
       410        420        430        440        450
IAQVNNLSVI PACLGFAYVI FCAFGADLFR CKWIFMVFAA IMNTVSCALL 
       460        470        480        490        500
IKWDIPSKAK WYAFFTTYFS VAASPCLWSF INDFLRFDPQ VKAITWIAIY 
       510        520        530        540        550
SFSQSTYAWI PTLAWPTVES PRFKTGYTVS LIFGAIYGLW TFVVLFFYKR 
       560        570        580        590 
NEKKHALGNG IILYDSNKGE ELPEFVKKNM EERDGYYYLK RSS
Length:593
Mass (Da):69,083
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B91D6247867386D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z72850 Genomic DNA Translation: CAA97067.1
BK006941 Genomic DNA Translation: DAA08160.1

Protein sequence database of the Protein Information Resource

More...PIRi		S64360

NCBI Reference Sequences

More...RefSeqi		NP_011579.1, NM_001181194.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YGR065C_mRNA; YGR065C; YGR065C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		852956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YGR065C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72850 Genomic DNA Translation: CAA97067.1
BK006941 Genomic DNA Translation: DAA08160.1
PIRiS64360
RefSeqiNP_011579.1, NM_001181194.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33309, 230 interactors
DIPiDIP-5519N
IntActiP53241, 10 interactors
MINTiP53241
STRINGi4932.YGR065C

Protein family/group databases

TCDBi2.A.1.14.12, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP53241

Proteomic databases

MaxQBiP53241
PaxDbiP53241
PRIDEiP53241

Genome annotation databases

EnsemblFungiiYGR065C_mRNA; YGR065C; YGR065C
GeneIDi852956
KEGGisce:YGR065C

Organism-specific databases

SGDiS000003297, VHT1
VEuPathDBiFungiDB:YGR065C

Phylogenomic databases

eggNOGiKOG2533, Eukaryota
HOGENOMiCLU_001265_4_2_1
InParanoidiP53241
OMAiCSWNNMT

Miscellaneous databases

Protein Ontology

More...PROi		PR:P53241
RNActiP53241, protein

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVHT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53241
Secondary accession number(s): D6VUJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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