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UniProtKB - P53241 (VHT1_YEAST)
Protein
Vitamin H transporter
Gene
VHT1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in uptake of biotin with the concomitant entry of protons.
GO - Molecular functioni
- biotin transmembrane transporter activity Source: SGD
- symporter activity Source: UniProtKB-KW
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- biotin transport Source: SGD
Keywordsi
Biological process | Symport, Transport |
Ligand | Biotin |
Protein family/group databases
TCDBi | 2.A.1.14.12, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin H transporterAlternative name(s): H(+)/biotin symporter |
Gene namesi | Name:VHT1 Ordered Locus Names:YGR065C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003297, VHT1 |
VEuPathDBi | FungiDB:YGR065C |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
- intrinsic component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 121 | ExtracellularSequence analysisAdd BLAST | 121 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 143 – 166 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 190 | ExtracellularSequence analysis | 3 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 224 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 291 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 361 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 408 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 409 – 429 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 430 – 432 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 433 – 453 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 454 – 460 | ExtracellularSequence analysis | 7 | |
Transmembranei | 461 – 481 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 482 – 492 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 493 – 513 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 514 – 526 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 527 – 547 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 548 – 593 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121372 | 1 – 593 | Vitamin H transporterAdd BLAST | 593 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 43 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53241 |
PaxDbi | P53241 |
PRIDEi | P53241 |
PTM databases
iPTMneti | P53241 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33309, 230 interactors |
DIPi | DIP-5519N |
IntActi | P53241, 10 interactors |
MINTi | P53241 |
STRINGi | 4932.YGR065C |
Miscellaneous databases
RNActi | P53241, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2533, Eukaryota |
HOGENOMi | CLU_001265_4_2_1 |
InParanoidi | P53241 |
OMAi | CSWNNMT |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
i Sequence
Sequence statusi: Complete.
P53241-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTISNKSWRS YFPHLRKLPE DDQYLYSDDT NSSIIAEEEL HHSVDKSSKT
60 70 80 90 100
DVTAETTAVE PHPHNLRHDL PYEVRDEAGR KWWKYFDEFE YRVNKEYKKS
110 120 130 140 150
RKWYEFLYPN HTTQTKAERR LLYKLDIIIA LYFFMLCWSK SVDLNNYTNA
160 170 180 190 200
YVSNMKEDLN MKGNDYVYTS TIANVGAIVF QLPFMYLLPR FPSHIILPVM
210 220 230 240 250
DLGWTWFTFA CYRANSLAEL RAYRFILSAF GAAYYPVSQY ILGCWYAPDE
260 270 280 290 300
INSRVCLFFC GQQLGSVTSG LLQSRIFKSL NGVHGLAGWR WMFLIDAIAI
310 320 330 340 350
SLPTAIIGFF VIPGVPSKCY SLFLTDEEIR IARARNKRNQ IKDGVDKSKL
360 370 380 390 400
APLWSRKLWK KVFCTPAFWV LVVFDTCSWN NMTAYSGSYT LWLKSNTKYS
410 420 430 440 450
IAQVNNLSVI PACLGFAYVI FCAFGADLFR CKWIFMVFAA IMNTVSCALL
460 470 480 490 500
IKWDIPSKAK WYAFFTTYFS VAASPCLWSF INDFLRFDPQ VKAITWIAIY
510 520 530 540 550
SFSQSTYAWI PTLAWPTVES PRFKTGYTVS LIFGAIYGLW TFVVLFFYKR
560 570 580 590
NEKKHALGNG IILYDSNKGE ELPEFVKKNM EERDGYYYLK RSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72850 Genomic DNA Translation: CAA97067.1 BK006941 Genomic DNA Translation: DAA08160.1 |
PIRi | S64360 |
RefSeqi | NP_011579.1, NM_001181194.1 |
Genome annotation databases
EnsemblFungii | YGR065C_mRNA; YGR065C; YGR065C |
GeneIDi | 852956 |
KEGGi | sce:YGR065C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72850 Genomic DNA Translation: CAA97067.1 BK006941 Genomic DNA Translation: DAA08160.1 |
PIRi | S64360 |
RefSeqi | NP_011579.1, NM_001181194.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33309, 230 interactors |
DIPi | DIP-5519N |
IntActi | P53241, 10 interactors |
MINTi | P53241 |
STRINGi | 4932.YGR065C |
Protein family/group databases
TCDBi | 2.A.1.14.12, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P53241 |
Proteomic databases
MaxQBi | P53241 |
PaxDbi | P53241 |
PRIDEi | P53241 |
Genome annotation databases
EnsemblFungii | YGR065C_mRNA; YGR065C; YGR065C |
GeneIDi | 852956 |
KEGGi | sce:YGR065C |
Organism-specific databases
SGDi | S000003297, VHT1 |
VEuPathDBi | FungiDB:YGR065C |
Phylogenomic databases
eggNOGi | KOG2533, Eukaryota |
HOGENOMi | CLU_001265_4_2_1 |
InParanoidi | P53241 |
OMAi | CSWNNMT |
Miscellaneous databases
PROi | PR:P53241 |
RNActi | P53241, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VHT1_YEAST | |
Accessioni | P53241Primary (citable) accession number: P53241 Secondary accession number(s): D6VUJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families