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Protein

Transaldolase NQM1

Gene

NQM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.PROSITE-ProRule annotation1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase NQM1 (NQM1), Transaldolase (TAL1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144Schiff-base intermediate with substratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • cellular response to oxidative stress Source: SGD
  • chronological cell aging Source: SGD
  • pentose-phosphate shunt, non-oxidative branch Source: GO_Central

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

BioCyciYEAST:YGR043C-MONOMER
BRENDAi2.2.1.2 984
ReactomeiR-SCE-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-SCE-71336 Pentose phosphate pathway
UniPathwayi
UPA00115;UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase NQM1 (EC:2.2.1.2)
Alternative name(s):
Non-quiescent mutant protein 1
Gene namesi
Name:NQM1
Ordered Locus Names:YGR043C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003275 NQM1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735751 – 333Transaldolase NQM1Add BLAST333

Proteomic databases

MaxQBiP53228
PaxDbiP53228
PRIDEiP53228

PTM databases

iPTMnetiP53228

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi33290, 51 interactors
MINTiP53228
STRINGi4932.YGR043C

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53228
SMRiP53228
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53228

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
InParanoidiP53228
KOiK00616
OMAiFAIDQRK
OrthoDBiEOG092C3F92

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P53228-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEPSEKKQK VATSSLEQLK KAGTHVVADS GDFEAISKYE PQDSTTNPSL
60 70 80 90 100
ILAASKLEKY ARFIDAAVEY GRKHGKTDHE KIENAMDKIL VEFGTQILKV
110 120 130 140 150
VPGRVSTEVD ARLSFDKKAT VKKALHIIKL YKDAGVPKER VLIKIASTWE
160 170 180 190 200
GIQAARELEV KHGIHCNMTL LFSFTQAVAC AEANVTLISP FVGRIMDFYK
210 220 230 240 250
ALSGKDYTAE TDPGVLSVKK IYSYYKRHGY ATEVMAASFR NLDELKALAG
260 270 280 290 300
IDNMTLPLNL LEQLYESTDP IENKLNSESA KEEGVEKVSF INDEPHFRYV
310 320 330
LNEDQMATEK LSDGIRKFSA DIEALYKLVE EKM
Length:333
Mass (Da):37,254
Last modified:October 1, 1996 - v1
Checksum:i6492030A7DA3D343
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290F → S in AAS56158 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72828 Genomic DNA Translation: CAA97042.1
AY557832 Genomic DNA Translation: AAS56158.1
BK006941 Genomic DNA Translation: DAA08142.1
PIRiS64337
RefSeqiNP_011557.1, NM_001181172.1

Genome annotation databases

EnsemblFungiiYGR043C; YGR043C; YGR043C
GeneIDi852934
KEGGisce:YGR043C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72828 Genomic DNA Translation: CAA97042.1
AY557832 Genomic DNA Translation: AAS56158.1
BK006941 Genomic DNA Translation: DAA08142.1
PIRiS64337
RefSeqiNP_011557.1, NM_001181172.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CQ0X-ray1.90A/B1-333[»]
ProteinModelPortaliP53228
SMRiP53228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33290, 51 interactors
MINTiP53228
STRINGi4932.YGR043C

PTM databases

iPTMnetiP53228

Proteomic databases

MaxQBiP53228
PaxDbiP53228
PRIDEiP53228

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR043C; YGR043C; YGR043C
GeneIDi852934
KEGGisce:YGR043C

Organism-specific databases

SGDiS000003275 NQM1

Phylogenomic databases

GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
InParanoidiP53228
KOiK00616
OMAiFAIDQRK
OrthoDBiEOG092C3F92

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00414

BioCyciYEAST:YGR043C-MONOMER
BRENDAi2.2.1.2 984
ReactomeiR-SCE-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-SCE-71336 Pentose phosphate pathway

Miscellaneous databases

EvolutionaryTraceiP53228
PROiPR:P53228

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL2_YEAST
AccessioniPrimary (citable) accession number: P53228
Secondary accession number(s): D6VUI1, Q6Q5P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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