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Protein

60S ribosomal protein L26-B

Gene

RPL26B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 33200 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL24 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit biogenesis Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30756-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-B1 Publication
Alternative name(s):
L33
YL33
Gene namesi
Name:RPL26B1 Publication
Synonyms:RPL33B
Ordered Locus Names:YGR034W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003266 RPL26B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001308022 – 12760S ribosomal protein L26-BAdd BLAST126

Proteomic databases

MaxQBiP53221
PaxDbiP53221
PRIDEiP53221
TopDownProteomicsiP53221

PTM databases

iPTMnetiP53221

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33279, 140 interactors
DIPiDIP-5757N
IntActiP53221, 8 interactors
MINTiP53221
STRINGi4932.YGR034W

Structurei

3D structure databases

ProteinModelPortaliP53221
SMRiP53221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014165
HOGENOMiHOG000216571
InParanoidiP53221
KOiK02898
OMAiVRIMRGD
OrthoDBiEOG092C5U93

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11143 PTHR11143, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01080 rplX_A_E, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQSLDVSS DRRKARKAYF TAPSSERRVL LSAPLSKELR AQYGIKALPI
60 70 80 90 100
RRDDEVLVVR GSKKGQEGKI SSVYRLKFAV QVDKVTKEKV NGASVPINLH
110 120
PSKLVITKLH LDKDRKALIQ RKGGKLE
Length:127
Mass (Da):14,235
Last modified:January 23, 2007 - v2
Checksum:i29CD710BC5447F52
GO

Sequence cautioni

The sequence AAZ22449 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA97022 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115390 Genomic DNA Translation: AAZ22449.1 Sequence problems.
Z72819 Genomic DNA Translation: CAA97022.1 Sequence problems.
DQ881451 mRNA Translation: ABI95878.1
BK006941 Genomic DNA Translation: DAA08131.1
PIRiS64325
RefSeqiNP_011548.2, NM_001181163.1

Genome annotation databases

EnsemblFungiiYGR034W; YGR034W; YGR034W
GeneIDi852922
KEGGisce:YGR034W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115390 Genomic DNA Translation: AAZ22449.1 Sequence problems.
Z72819 Genomic DNA Translation: CAA97022.1 Sequence problems.
DQ881451 mRNA Translation: ABI95878.1
BK006941 Genomic DNA Translation: DAA08131.1
PIRiS64325
RefSeqiNP_011548.2, NM_001181163.1

3D structure databases

ProteinModelPortaliP53221
SMRiP53221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33279, 140 interactors
DIPiDIP-5757N
IntActiP53221, 8 interactors
MINTiP53221
STRINGi4932.YGR034W

PTM databases

iPTMnetiP53221

Proteomic databases

MaxQBiP53221
PaxDbiP53221
PRIDEiP53221
TopDownProteomicsiP53221

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR034W; YGR034W; YGR034W
GeneIDi852922
KEGGisce:YGR034W

Organism-specific databases

SGDiS000003266 RPL26B

Phylogenomic databases

GeneTreeiENSGT00390000014165
HOGENOMiHOG000216571
InParanoidiP53221
KOiK02898
OMAiVRIMRGD
OrthoDBiEOG092C5U93

Enzyme and pathway databases

BioCyciYEAST:G3O-30756-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:P53221

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11143 PTHR11143, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01080 rplX_A_E, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL26B_YEAST
AccessioniPrimary (citable) accession number: P53221
Secondary accession number(s): D6VUH0, Q06HN2, Q45U50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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