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UniProtKB - P53214 (MTL1_YEAST)
Protein
Protein MTL1
Gene
MTL1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in cell integrity signaling during vegetative growth at elevated temperature. Acts positively on the PKC1-MAPK pathway. Cell membrane sensor of oxidative stress in the cell integrity pathway upstream of PKC1. Required to transmit the oxidative signal to SLT2 and to restore the correct actin organization following oxidative stress. Multicopy suppressor of 1,3-beta-glucan synthase (GS) mutation. Also suppresses RGD1 null mutations.
4 PublicationsGO - Biological processi
- cellular response to glucose starvation Source: SGD
- cellular response to oxidative stress Source: SGD
- fungal-type cell wall organization Source: SGD
- protein catabolic process in the vacuole Source: GO_Central
Keywordsi
Biological process | Stress response |
Names & Taxonomyi
Protein namesi | Recommended name: Protein MTL1Alternative name(s): MID two-like protein 1 |
Gene namesi | Name:MTL1 Ordered Locus Names:YGR023W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003255, MTL1 |
VEuPathDBi | FungiDB:YGR023W |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: SGD
- plasma membrane Source: SGD
Vacuole
- vacuole Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 36 – 361 | ExtracellularSequence analysisAdd BLAST | 326 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 551 | CytoplasmicSequence analysisAdd BLAST | 169 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
ChainiPRO_0000202787 | 36 – 551 | Protein MTL1Add BLAST | 516 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 481 | PhosphoserineCombined sources | 1 | |
Modified residuei | 482 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53214 |
PaxDbi | P53214 |
PTM databases
iPTMneti | P53214 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33264, 78 interactors |
DIPi | DIP-5509N |
STRINGi | 4932.YGR023W |
Miscellaneous databases
RNActi | P53214, protein |
Structurei
3D structure databases
AlphaFoldDBi | P53214 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 108 – 143 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 206 – 227 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 243 – 263 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 429 – 513 | DisorderedSequence analysisAdd BLAST | 85 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 429 – 443 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 481 – 512 | Polar residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the MID2 like cell wall stress sensor family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S2SW, Eukaryota |
GeneTreei | ENSGT00940000176476 |
HOGENOMi | CLU_476680_0_0_1 |
InParanoidi | P53214 |
OMAi | LIYMFCV |
Family and domain databases
InterProi | View protein in InterPro IPR007567, Mid2_dom |
Pfami | View protein in Pfam PF04478, Mid2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53214-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASCNPTRKK SSASSLSMWR TILMALTTLP LSVLSQELVP ANSTTSSTAP
60 70 80 90 100
SITSLSAVES FTSSTDATSS ASLSTPSIAS VSFTSFPQSS SLLTLSSTLS
110 120 130 140 150
SELSSSSMQV SSSSTSSSSS EVTSSSSSSS ISPSSSSSTI ISSSSSLPTF
160 170 180 190 200
TVASTSSTVA SSTLSTSSSL VISTSSSTFT FSSESSSSLI SSSISTSVST
210 220 230 240 250
SSVYVPSSST SSPPSSSSEL TSSSYSSSSS SSTLFSYSSS FSSSSSSSSS
260 270 280 290 300
SSSSSSSSSS SSSSYFTLST SSSSSIYSSS SYPSFSSSSS SNPTSSITST
310 320 330 340 350
SASSSITPAS EYSNLAKTIT SIIEGQTILS NYYTTITYSP TASASSGKNS
360 370 380 390 400
HHSGLSKKNR NIIIGCVVGI GAPLILILLI LIYMFCVQPK KTDFIDSDGK
410 420 430 440 450
IVTAYRSNIF TKIWYFLLGK KIGETERFSS DSPIGSNNIQ NFGDIDPEDI
460 470 480 490 500
LNNDNPYTPK HTNVEGYDDD DDDDANDENL SSNFHNRGID DQYSPTKSAS
510 520 530 540 550
YSMSNSNSQD YNDADEVMHD ENIHRVYDDS EASIDENYYT KPNNGLNITN
Y
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 264 | S → SSSSSSSSSSISLSSSSSSS SSSSSSSSS in strain: ATCC 204278. | 1 | |
Natural varianti | 427 | R → K in strain: SK1. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72807 Genomic DNA Translation: CAA97006.1 DQ115389 Genomic DNA Translation: AAZ22486.1 BK006941 Genomic DNA Translation: DAA08118.1 |
PIRi | S64314 |
RefSeqi | NP_011537.1, NM_001181152.1 |
Genome annotation databases
EnsemblFungii | YGR023W_mRNA; YGR023W; YGR023W |
GeneIDi | 852905 |
KEGGi | sce:YGR023W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72807 Genomic DNA Translation: CAA97006.1 DQ115389 Genomic DNA Translation: AAZ22486.1 BK006941 Genomic DNA Translation: DAA08118.1 |
PIRi | S64314 |
RefSeqi | NP_011537.1, NM_001181152.1 |
3D structure databases
AlphaFoldDBi | P53214 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33264, 78 interactors |
DIPi | DIP-5509N |
STRINGi | 4932.YGR023W |
PTM databases
iPTMneti | P53214 |
Proteomic databases
MaxQBi | P53214 |
PaxDbi | P53214 |
Genome annotation databases
EnsemblFungii | YGR023W_mRNA; YGR023W; YGR023W |
GeneIDi | 852905 |
KEGGi | sce:YGR023W |
Organism-specific databases
SGDi | S000003255, MTL1 |
VEuPathDBi | FungiDB:YGR023W |
Phylogenomic databases
eggNOGi | ENOG502S2SW, Eukaryota |
GeneTreei | ENSGT00940000176476 |
HOGENOMi | CLU_476680_0_0_1 |
InParanoidi | P53214 |
OMAi | LIYMFCV |
Miscellaneous databases
PROi | PR:P53214 |
RNActi | P53214, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007567, Mid2_dom |
Pfami | View protein in Pfam PF04478, Mid2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTL1_YEAST | |
Accessioni | P53214Primary (citable) accession number: P53214 Secondary accession number(s): D6VUF7, Q45U60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families