UniProtKB - P53187 (HOP2_YEAST)
Protein
Homologous-pairing protein 2
Gene
HOP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation required for the resolution of meiotic double-strand breaks.4 Publications
GO - Molecular functioni
- double-stranded DNA binding Source: SGD
GO - Biological processi
- homologous chromosome pairing at meiosis Source: SGD
- reciprocal meiotic recombination Source: SGD
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA recombination, Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: Homologous-pairing protein 2 |
Gene namesi | Name:HOP2 Ordered Locus Names:YGL033W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003001, HOP2 |
VEuPathDBi | FungiDB:YGL033W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- condensed nuclear chromosome Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084027 | 1 – 214 | Homologous-pairing protein 2Add BLAST | 214 |
Proteomic databases
PaxDbi | P53187 |
PRIDEi | P53187 |
PTM databases
CarbonylDBi | P53187 |
Interactioni
Subunit structurei
Heterodimer with MND1. MND1-HOP2 binds preferentially to dsDNA.
Protein-protein interaction databases
BioGRIDi | 33213, 52 interactors |
ComplexPortali | CPX-1644, HOP2-MND1 complex |
IntActi | P53187, 1 interactor |
STRINGi | 4932.YGL033W |
Miscellaneous databases
RNActi | P53187, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 97 – 160 | Sequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the HOP2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4603, Eukaryota |
HOGENOMi | CLU_063266_2_0_1 |
InParanoidi | P53187 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR040461, Hop2 IPR010776, Hop2_WH_dom IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR15938, PTHR15938, 1 hit |
Pfami | View protein in Pfam PF07106, TBPIP, 1 hit |
i Sequence
Sequence statusi: Complete.
P53187-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPKKKSNDR AIQAKGSEAE QLIEDYLVSQ YKPFSVNDIV QNLHNKVTKT
60 70 80 90 100
TATKALENLV NEKRIVSKTF GKIIIYSCNE QDTALPSNID PSQFDFETVL
110 120 130 140 150
QLRNDLIELE RDKSTAKDAL DSVTKEPENE DLLTIIENEE NELKKIESKL
160 170 180 190 200
QSLQDDWDPA NDEIVKRIMS EDTLLQKEIT KRSKICKNLI ATIKDSVCPK
210
NMNEFLEEIG FEDI
Sequence cautioni
The sequence AAC31823 differs from that shown. Reason: Frameshift.Curated
The sequence AAC31823 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA96734 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | G → A in AAC31823 (PubMed:9708739).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72555 Genomic DNA Translation: CAA96734.1 Sequence problems. AF078740 Genomic DNA Translation: AAC31823.1 Sequence problems. BK006941 Genomic DNA Translation: DAA08066.2 |
PIRi | S64035 |
RefSeqi | NP_011482.3, NM_001180898.2 |
Genome annotation databases
EnsemblFungii | YGL033W_mRNA; YGL033W; YGL033W |
GeneIDi | 852850 |
KEGGi | sce:YGL033W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72555 Genomic DNA Translation: CAA96734.1 Sequence problems. AF078740 Genomic DNA Translation: AAC31823.1 Sequence problems. BK006941 Genomic DNA Translation: DAA08066.2 |
PIRi | S64035 |
RefSeqi | NP_011482.3, NM_001180898.2 |
3D structure databases
SMRi | P53187 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33213, 52 interactors |
ComplexPortali | CPX-1644, HOP2-MND1 complex |
IntActi | P53187, 1 interactor |
STRINGi | 4932.YGL033W |
PTM databases
CarbonylDBi | P53187 |
Proteomic databases
PaxDbi | P53187 |
PRIDEi | P53187 |
Genome annotation databases
EnsemblFungii | YGL033W_mRNA; YGL033W; YGL033W |
GeneIDi | 852850 |
KEGGi | sce:YGL033W |
Organism-specific databases
SGDi | S000003001, HOP2 |
VEuPathDBi | FungiDB:YGL033W |
Phylogenomic databases
eggNOGi | KOG4603, Eukaryota |
HOGENOMi | CLU_063266_2_0_1 |
InParanoidi | P53187 |
Miscellaneous databases
PROi | PR:P53187 |
RNActi | P53187, protein |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR040461, Hop2 IPR010776, Hop2_WH_dom IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR15938, PTHR15938, 1 hit |
Pfami | View protein in Pfam PF07106, TBPIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HOP2_YEAST | |
Accessioni | P53187Primary (citable) accession number: P53187 Secondary accession number(s): D6VUA5, O74245 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 14, 2015 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families