The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P53178 (ALG13_YEAST)
Protein
UDP-N-acetylglucosamine transferase subunit ALG13
Gene
ALG13
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.
2 PublicationsMiscellaneous
Present with 1950 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- N-acetyl-α-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-α-D-glucosamine = H+ + N,N'-diacetylchitobiosyl diphosphodolichol + UDPEC:2.4.1.141
GO - Molecular functioni
- identical protein binding Source: IntAct
- N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
GO - Biological processi
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.1.141, 984 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylglucosamine transferase subunit ALG13 (EC:2.4.1.141)Alternative name(s): Asparagine-linked glycosylation protein 13 |
Gene namesi | Name:ALG13 Ordered Locus Names:YGL047W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003015, ALG13 |
VEuPathDBi | FungiDB:YGL047W |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 2 Publications
Cytosol
- cytosol Source: SGD
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: ComplexPortal
- extrinsic component of endoplasmic reticulum membrane Source: SGD
- UDP-N-acetylglucosamine transferase complex Source: SGD
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215605 | 1 – 202 | UDP-N-acetylglucosamine transferase subunit ALG13Add BLAST | 202 |
Proteomic databases
MaxQBi | P53178 |
PaxDbi | P53178 |
PRIDEi | P53178 |
Interactioni
Subunit structurei
Heterodimer with ALG14 to form a functional enzyme.
Binary interactionsi
P53178
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-23770,EBI-23770 |
ALG14 [P38242] | 3 | EBI-23770,EBI-21477 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 33201, 97 interactors |
ComplexPortali | CPX-1643, UDP-N-acetylglucosamine transferase complex |
DIPi | DIP-4726N |
IntActi | P53178, 1 interactor |
STRINGi | 4932.YGL047W |
Miscellaneous databases
RNActi | P53178, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P53178 |
BMRBi | P53178 |
SMRi | P53178 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53178 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 28 family.Curated
Phylogenomic databases
eggNOGi | KOG3349, Eukaryota |
GeneTreei | ENSGT00510000047493 |
HOGENOMi | CLU_085408_2_0_1 |
InParanoidi | P53178 |
OMAi | NYLYYCK |
Family and domain databases
InterProi | View protein in InterPro IPR007235, Glyco_trans_28_C |
Pfami | View protein in Pfam PF04101, Glyco_tran_28_C, 1 hit |
i Sequence
Sequence statusi: Complete.
P53178-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIIEEKALF VTCGATVPFP KLVSCVLSDE FCQELIQYGF VRLIIQFGRN
60 70 80 90 100
YSSEFEHLVQ ERGGQRESQK IPIDQFGCGD TARQYVLMNG KLKVIGFDFS
110 120 130 140 150
TKMQSIIRDY SDLVISHAGT GSILDSLRLN KPLIVCVNDS LMDNHQQQIA
160 170 180 190 200
DKFVELGYVW SCAPTETGLI AGLRASQTEK LKPFPVSHNP SFERLLVETI
YS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72569 Genomic DNA Translation: CAA96749.1 BK006941 Genomic DNA Translation: DAA08054.1 |
PIRi | S64051 |
RefSeqi | NP_011468.1, NM_001180912.1 |
Genome annotation databases
EnsemblFungii | YGL047W_mRNA; YGL047W; YGL047W |
GeneIDi | 852835 |
KEGGi | sce:YGL047W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72569 Genomic DNA Translation: CAA96749.1 BK006941 Genomic DNA Translation: DAA08054.1 |
PIRi | S64051 |
RefSeqi | NP_011468.1, NM_001180912.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JZC | NMR | - | A | 2-202 | [»] | |
2KS6 | NMR | - | A | 2-202 | [»] | |
AlphaFoldDBi | P53178 | |||||
BMRBi | P53178 | |||||
SMRi | P53178 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33201, 97 interactors |
ComplexPortali | CPX-1643, UDP-N-acetylglucosamine transferase complex |
DIPi | DIP-4726N |
IntActi | P53178, 1 interactor |
STRINGi | 4932.YGL047W |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Proteomic databases
MaxQBi | P53178 |
PaxDbi | P53178 |
PRIDEi | P53178 |
Genome annotation databases
EnsemblFungii | YGL047W_mRNA; YGL047W; YGL047W |
GeneIDi | 852835 |
KEGGi | sce:YGL047W |
Organism-specific databases
SGDi | S000003015, ALG13 |
VEuPathDBi | FungiDB:YGL047W |
Phylogenomic databases
eggNOGi | KOG3349, Eukaryota |
GeneTreei | ENSGT00510000047493 |
HOGENOMi | CLU_085408_2_0_1 |
InParanoidi | P53178 |
OMAi | NYLYYCK |
Enzyme and pathway databases
BRENDAi | 2.4.1.141, 984 |
Miscellaneous databases
EvolutionaryTracei | P53178 |
PROi | PR:P53178 |
RNActi | P53178, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007235, Glyco_trans_28_C |
Pfami | View protein in Pfam PF04101, Glyco_tran_28_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG13_YEAST | |
Accessioni | P53178Primary (citable) accession number: P53178 Secondary accession number(s): D6VU93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families