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Protein

Ligase-interacting factor 1

Gene

LIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks.1 Publication

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-30590-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ligase-interacting factor 1
Gene namesi
Name:LIF1
Ordered Locus Names:YGL090W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003058 LIF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844191 – 421Ligase-interacting factor 1Add BLAST421

Proteomic databases

MaxQBiP53150
PaxDbiP53150
PRIDEiP53150

PTM databases

iPTMnetiP53150

Interactioni

Subunit structurei

Interacts with the BRCT domain of DNL4 and with NEJ1. The DNL4-LIF1 complex interacts with POL4.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi33161, 77 interactors
ComplexPortaliCPX-1665 DNA ligase IV complex
DIPiDIP-5477N
IntActiP53150, 10 interactors
MINTiP53150
STRINGi4932.YGL090W

Structurei

3D structure databases

ProteinModelPortaliP53150
SMRiP53150
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53150

Family & Domainsi

Phylogenomic databases

InParanoidiP53150
KOiK10982
OMAiYESELNI
OrthoDBiEOG092C2JP3

Family and domain databases

InterProiView protein in InterPro
IPR015381 XLF_fam
PfamiView protein in Pfam
PF09302 XLF, 1 hit

Sequencei

Sequence statusi: Complete.

P53150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLTEFISC IPVVNEEQNE EDERGLCKIQ IEDGAMLETL DENSLSGLRI
60 70 80 90 100
EKMLVSEGTG IFSKSSFGIN DLRIFTGENI DEESKKYVWY ELLKMLTGHK
110 120 130 140 150
VYIASLDEKV VFTKWTCRMQ DDEVWKVVME LESSAIIRKI AELTLHPVKK
160 170 180 190 200
GEIDLFEMAD KLYKDICCVN DSYRNIKESD SSNRNRVEQL ARERELLDKL
210 220 230 240 250
LETRDERTRA MMVTLLNEKK KKIRELHEIL RQNNIKLSDD DVLDSALINT
260 270 280 290 300
EVQKPISELN SPGKRMKRRK TVVEPQNLQK KLKDTSRRRA NRKISNQSVI
310 320 330 340 350
KMEDDDFDDF QFFGLSKRPI ITAKDKLSEK YDDITSFGDD TQSISFESDS
360 370 380 390 400
SSDVQKHLVS LEDNGIQISA GRSDEDYGDI SGSESETDAS AGEKKSSNHS
410 420
EQSGNDREPC LQTESETDIE T
Length:421
Mass (Da):48,259
Last modified:October 1, 1996 - v1
Checksum:i5BEDC72059E9996F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44S → G in AAU09724 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72612 Genomic DNA Translation: CAA96796.1
AY723807 Genomic DNA Translation: AAU09724.1
BK006941 Genomic DNA Translation: DAA08016.1
PIRiS64097
RefSeqiNP_011425.1, NM_001180955.1

Genome annotation databases

EnsemblFungiiYGL090W; YGL090W; YGL090W
GeneIDi852790
KEGGisce:YGL090W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72612 Genomic DNA Translation: CAA96796.1
AY723807 Genomic DNA Translation: AAU09724.1
BK006941 Genomic DNA Translation: DAA08016.1
PIRiS64097
RefSeqiNP_011425.1, NM_001180955.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z56X-ray3.92A/B1-246[»]
ProteinModelPortaliP53150
SMRiP53150
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33161, 77 interactors
ComplexPortaliCPX-1665 DNA ligase IV complex
DIPiDIP-5477N
IntActiP53150, 10 interactors
MINTiP53150
STRINGi4932.YGL090W

PTM databases

iPTMnetiP53150

Proteomic databases

MaxQBiP53150
PaxDbiP53150
PRIDEiP53150

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL090W; YGL090W; YGL090W
GeneIDi852790
KEGGisce:YGL090W

Organism-specific databases

SGDiS000003058 LIF1

Phylogenomic databases

InParanoidiP53150
KOiK10982
OMAiYESELNI
OrthoDBiEOG092C2JP3

Enzyme and pathway databases

BioCyciYEAST:G3O-30590-MONOMER

Miscellaneous databases

EvolutionaryTraceiP53150
PROiPR:P53150

Family and domain databases

InterProiView protein in InterPro
IPR015381 XLF_fam
PfamiView protein in Pfam
PF09302 XLF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIF1_YEAST
AccessioniPrimary (citable) accession number: P53150
Secondary accession number(s): D6VU55, E9P953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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