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Protein

Vacuolar protein sorting-associated protein 73

Gene

VPS73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in vacuolar protein sorting.1 Publication

GO - Molecular functioni

  • transmembrane transporter activity Source: SGD

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30603-MONOMER

Protein family/group databases

TCDBi2.A.1.1.93 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 73
Gene namesi
Name:VPS73
Ordered Locus Names:YGL104C
ORF Names:G3090
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003072 VPS73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 90Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 119CytoplasmicSequence analysis8
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 146Mitochondrial intermembraneSequence analysis6
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 178CytoplasmicSequence analysisAdd BLAST11
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 208Mitochondrial intermembraneSequence analysis9
Transmembranei209 – 229Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini230 – 305CytoplasmicSequence analysisAdd BLAST76
Transmembranei306 – 326Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini327 – 342Mitochondrial intermembraneSequence analysisAdd BLAST16
Transmembranei343 – 363Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini364 – 366CytoplasmicSequence analysis3
Transmembranei367 – 387Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini388 – 396Mitochondrial intermembraneSequence analysis9
Transmembranei397 – 417Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini418 – 432CytoplasmicSequence analysisAdd BLAST15
Transmembranei433 – 453Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini454Mitochondrial intermembraneSequence analysis1
Transmembranei455 – 475Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini476 – 486CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504621 – 486Vacuolar protein sorting-associated protein 73Add BLAST486

Proteomic databases

PaxDbiP53142
PRIDEiP53142

PTM databases

iPTMnetiP53142

Interactioni

Protein-protein interaction databases

BioGridi33146, 79 interactors
DIPiDIP-1727N
IntActiP53142, 10 interactors
MINTiP53142
STRINGi4932.YGL104C

Structurei

3D structure databases

ProteinModelPortaliP53142
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000199277
InParanoidiP53142
OMAiHAIRINF
OrthoDBiEOG092C3L9H

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P53142-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRILSSASL LSNVSMPRQN KHKITKALCY AIIVASIGSI QFGYHLSELN
60 70 80 90 100
APQQVLSCSE FDIPMEGYPY DRTWLGKRGY KQCIPLNDEQ IGIVTSVFCI
110 120 130 140 150
GGILGSYFAT SLANIYGRKF SSLINCTLNI VGSLIIFNSN SYRGLIIGRI
160 170 180 190 200
LVGISCGSLI VIIPLFIKEV APSGWEGLLG SMTQICIRLG VLLTQGIALP
210 220 230 240 250
LTDSYRWRWI LFGSFLIAVL NFFMWFIVDE SPKWLLAHGR VTDAKLSLCK
260 270 280 290 300
LRGVTFDEAA QEIQDWQLQI ESGDPLIEPT TTNSISGSNS LWKYLRDRTN
310 320 330 340 350
VKSRHVITVL LFGQQFCGIN SIVLYGTKII SQLYPQHAIR INFFISMVNV
360 370 380 390 400
LVTILVSLLI HSLPRKPLLM TSTVLVSVTA FIMGIAMNHN KMNLLIVFSF
410 420 430 440 450
IYMGVFTMGL NPLPFIIMRE VSKPQDMVLA QRYGTICNWV GTFIIAYTFP
460 470 480
IIHDVLSGYV FIIFAIIACS ISAFIWKKVP ETKRSG
Length:486
Mass (Da):54,331
Last modified:October 1, 1996 - v1
Checksum:iD924D9112516450D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72626 Genomic DNA Translation: CAA96811.1
Z72625 Genomic DNA Translation: CAA96810.1
X97644 Genomic DNA Translation: CAA66249.1
BK006941 Genomic DNA Translation: DAA08003.1
PIRiS64111
RefSeqiNP_011411.3, NM_001180969.3

Genome annotation databases

EnsemblFungiiYGL104C; YGL104C; YGL104C
GeneIDi852774
KEGGisce:YGL104C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72626 Genomic DNA Translation: CAA96811.1
Z72625 Genomic DNA Translation: CAA96810.1
X97644 Genomic DNA Translation: CAA66249.1
BK006941 Genomic DNA Translation: DAA08003.1
PIRiS64111
RefSeqiNP_011411.3, NM_001180969.3

3D structure databases

ProteinModelPortaliP53142
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33146, 79 interactors
DIPiDIP-1727N
IntActiP53142, 10 interactors
MINTiP53142
STRINGi4932.YGL104C

Protein family/group databases

TCDBi2.A.1.1.93 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP53142

Proteomic databases

PaxDbiP53142
PRIDEiP53142

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL104C; YGL104C; YGL104C
GeneIDi852774
KEGGisce:YGL104C

Organism-specific databases

SGDiS000003072 VPS73

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000199277
InParanoidiP53142
OMAiHAIRINF
OrthoDBiEOG092C3L9H

Enzyme and pathway databases

BioCyciYEAST:G3O-30603-MONOMER

Miscellaneous databases

PROiPR:P53142

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS73_YEAST
AccessioniPrimary (citable) accession number: P53142
Secondary accession number(s): D6VU42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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